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22

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8946	Indophagolin	P2X Receptor; 5-HT Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Indophagolin 是一种有效的含有二氢吲哚的自噬抑制剂，IC50 为 140 nM。它拮抗 Gq 蛋白偶联的 P2Y4、P2Y6和 P2Y11受体。它还拮抗嘌呤能受体 P2X4 以及 P2X1 和 P2X3，IC50 分别为 2.71、2.40 和 3.49 μM。
T80209	Human membrane-bound PD-L1 polypeptide	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Human membrane-bound PD-L1 polypeptide 作为抗原，可诱导生成相应的PD-L1抗体。
T0313	Evans blue Direct Blue 53,C.I. 23860,伊文思蓝	GluR	Neuroscience
	Evans blue (C.I. 23860) 是一种突触泡谷氨酸吸收的有效抑制剂，同时也是一种AMPA/kainate 受体拮抗剂。
T36433	A2ti-2 A2ti-2	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	A2ti-2 是一种亲和力较低且具有选择性的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂（IC50 : 230 μM)。A2ti-2 具有抗病毒活性，可选择性破坏 A2 和 S100A10 之间的蛋白质相互作用，可防止人乳头瘤病毒 16 型 (HPV16) 感染。
T77780	Zamaporvint RXC004	Others	Others
	Zamaporvint (RXC004) 是一种具有选择性、口服活性和有效性的 Wnt 途径抑制剂，作用于膜结合脂肪酰转移酶 Porcupine，阻断 Wnt 配体棕榈酰化、分泌及通路活化。Zamaporvint 在多种癌细胞系中显示出抗肿瘤和抗增殖活性。
T28466	PSMA-11 HBED-CC-PSMA,Psma-hbed-CC,PSMA11
	PSMA-11 (HBED-CC-PSMA)通过与前列腺特异性膜抗原(PSMA)的细胞外结构域结合来检测前列腺癌的复发和转移。PSMA-11常被用作正电子发射断层扫描(PET)中用作表达PSMA 的肿瘤的示踪剂，通过静脉注射镓Ga 68标记的PSMA-11，Glu-urea-Lys(Ahx)分子靶向并结合表达PSMA 的肿瘤细胞。内化后，PSMA 表达的肿瘤细胞可在PET 成像中被检测到。
T37871	Octaethylene glycol monododecyl ether
	C12E8 is a nonionic surfactant formed by the ethoxylation of dodecanol, yielding a compound with eight repeated units of ethylene glycol. It can be used for solubilization of membrane-bound proteins.
T69868	ZIKV-IN-K22
	ZIKV-IN-K22 is a potent antiviral agent against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibiting ZIKV with IC50 of 2.1 μM.
T81948	Latartoxin-1a LtTx-1a
	Latartoxin-1a (LtTx-1a) 是从L. tarabaevi中分离的肽毒素，对昆虫具备麻痹及致死效果，并显示膜结合活性。
TP2254	GTP-Binding Protein Fragment, G alpha	Others	Others
	Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a si
T63291	Pranlukast hemihydrate
	Pranlukast hemihydrate 是选择性的、高效的、竞争性的 leukotriene 拮抗剂。Pranlukast 能够抑制 [3H]LTE4 (Ki: 0.63±0.11 nM)，[3H]LTD4 (Ki: 0.99±0.19 nM)和 [3H]LTC4 (Ki: 5640±680 nM)与肺膜结合。
T78432	Suc-AAPF-pNA Suc-Ala-Ala-Pro-Phe-pNA
	Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA)为一种对硝基苯胺（pNA）显色底物，具备 1.7 mM 的Km值。它适用于定量分析人中性粒细胞内的游离及膜结合形式的组织蛋白酶G活性。
T80587	Alunacedase alfa HrsACE2,GSK 2586881	SARS-CoV	Microbiology/Virology
	Alunacedase alfa (HrsACE2; GSK 2586881) 是一种人源重组的可溶性血管紧张素转化酶 2（hrsACE2）。作为转基因可溶性形态的 ACE2，Alunacedase alfa 能够减少 SARS-CoV-2 与细胞膜结合 ACE2 的竞争性进入，因此具有研究 SARS-CoV-2 的可能性。
T37118	ADP-Glucose (sodium salt) ADPG,Adenosine-5'-diphosphoglucose,ADP-Glucose (sodium salt)
	ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.[1],[2] It is used by amylose synthases or starch synthases in plastids in the production of amylose, amylopectins, starch, and other polysaccharides. ADPG is normally generated within plastids, although it can be biosynthesized in the cytoplasm of certain grasses and imported in...
T76762	Tabalumab
	Tabalumab (LY2127399) 是一种人源化的抗BAFF(B 细胞激活因子) 单克隆抗体 (IgG4 型)，对膜结合和可溶性BAFF 具有中和活性。Tabalumab 可用于自身免疫性疾病，如类风湿性关节炎、肾衰竭和系统性红斑狼疮的研究。
T79753	hCAIX/XII-IN-8	Carbonic Anhydrase	Metabolism
	hCAIX/XII-IN-8（compound 3g）是一种对人类（碳酸酐酶）CA IX和XII高效的抑制剂，Ki值分别为8.5和6.7 nM。该化合物对与肿瘤相关的膜结合异构体hCA IX和XII表现出显著的抑制作用，且相对于胞内异构体hCA I和II具有较高的选择性。
T37651	5(S),6(R)-11-trans DiHETE
	5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue. The isomerase activity responsible for the conversion of leukotriene B4 (LTB4) to 6-trans LTB4 in rat kidney homogenates has also been implicated in its formation. 5(S),6(R)-11-trans DiHETE...
T75389	Catechol O-methyltransferase
	Catechol O-methyltransferase (COMT) 在镁的作用下，通过将 S-腺苷甲硫氨酸的甲基转移至多巴胺的羟基，生成3-甲氧基酪胺，从而参与调节大脑中肾上腺素、去甲肾上腺素和多巴胺的水平。存在于组织中的Catechol O-methyltransferase有两种形态：可溶性形式(S-COMT)和膜结合形式(MB-COMT)。
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T35790	Palmitic acid-1,2,3,4-13C4 Palmitic Acid-13C (C1, C2, C3, and C4 labeled)
	Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...
T37582	Ganglioside GM1 Mixture (ovine) (ammonium salt)
	Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i...

化合物

Cat.No: T8946

Target: P2X Receptor, 5-HT Receptor, Autophagy

Human membrane-bound PD-L1 polypeptide

Cat.No: T80209

Target: PD-1/PD-L1

Cat.No: T0313

Synonym: Direct Blue 53,C.I. 23860,伊文思蓝

Target: GluR

Cat.No: T36433

Synonym: A2ti-2

Target: Virus Protease, Antiviral

Cat.No: T77780

Synonym: RXC004

Target: Others

Cat.No: T28466

Synonym: HBED-CC-PSMA,Psma-hbed-CC,PSMA11

Octaethylene glycol monododecyl ether

Cat.No: T37871

Cat.No: T69868

Cat.No: T81948

Synonym: LtTx-1a

GTP-Binding Protein Fragment, G alpha

Cat.No: TP2254

Target: Others

Pranlukast hemihydrate

Cat.No: T63291

Cat.No: T78432

Synonym: Suc-Ala-Ala-Pro-Phe-pNA

Alunacedase alfa

Cat.No: T80587

Synonym: HrsACE2,GSK 2586881

Target: SARS-CoV

ADP-Glucose (sodium salt)

Cat.No: T37118

Synonym: ADPG,Adenosine-5'-diphosphoglucose,ADP-Glucose (sodium salt)

Cat.No: T76762

Cat.No: T79753

Target: Carbonic Anhydrase

5(S),6(R)-11-trans DiHETE

Cat.No: T37651

Catechol O-methyltransferase

Cat.No: T75389

Palmitic acid-1-13C

Cat.No: T35789

Palmitic acid-1,2,3,4-13C4

Cat.No: T35790

Synonym: Palmitic Acid-13C (C1, C2, C3, and C4 labeled)

Palmitic acid-13C

Cat.No: T35791

Ganglioside GM1 Mixture (ovine) (ammonium salt)

Cat.No: T37582

Cat. No.	Product Name	Target	Signaling Pathways
T35951	Alkaline Phosphatase	Others	Others
	Alkaline phosphatase 是一种膜结合糖蛋白，在碱性条件下可催化磷酸单酯的水解。它可用于分子生物学和酶免分析。
T4889	2,6-Diaminoheptanedioic acid	Others; Endogenous Metabolite	Metabolism; Others
	2,6-Diaminoheptanedioic acid 是内源性代谢产物的一种。
TN4697	Odoroside H	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.

天然产物

Alkaline Phosphatase

Cat.No: T35951

Target: Others

2,6-Diaminoheptanedioic acid

Cat.No: T4889

Target: Others, Endogenous Metabolite

Cat.No: TN4697

Target: ATPase, Potassium Channel, Sodium Channel

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