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Cat. No.	Product Name	Target	Signaling Pathways
T9925	Ofatumumab	Others	Others
	Ofatumumab 是一种人源化靶向抗 CD20单克隆抗体。它作用于表达 CD20 的 B 淋巴细胞，能够诱导产生抗体依赖性细胞介导的细胞毒性和补体依赖性细胞毒性的作用。
T9744	MP07-66	Phosphatase	Metabolism
	MP07-66 是 FTY720 的一种类似物，没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。
T12317	Orelabrutinib ICP-022	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Orelabrutinib (ICP-022) 是一种口服活性的、强效的、不可逆的 Bruton 酪氨酸激酶(BTK)抑制剂，具有潜在的抗肿瘤作用。它能够阻止 B 细胞抗原受体 (BCR) 信号通路的激活和 BTK 介导的下游生存通路的激活，抑制过度表达 BTK 的恶性 B 细胞的生长。
T3626	Acalabrutinib ACP-196,阿可替尼	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
T4976	Umbralisib TGR-1202,RP5264,TGR 1202,TGR1202	PI3K	PI3K/Akt/mTOR signaling
	Umbralisib (TGR 1202) 是一种PI3Kδ抑制剂，IC50=22.2 nM，EC50=24.3 nM。它同时可抑制CK1ε，EC50=6.0 μM。
T2558	Cladribine 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis; Adenosine deaminase	Apoptosis; Metabolism
	Cladribine (2CdA) 是一种嘌呤核苷类似物，是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂，可阻断受损 DNA 的修复。它可抑制 DNA 甲基化，具有抗淋巴瘤活性，可研究血液恶性肿瘤和多发性硬化。
TP1758L	LCMV gp33-41 acetate LCMV gp33-41 acetate（151705-84-9 Free base）	Others	Others
	LCMV gp33-41 acetate 是淋巴细胞性脉络丛脑膜炎病毒的序列，受主要组织相容性复合体 I 类 H-2Db 限制，呈递给细胞毒性 T 淋巴细胞。
T3099	Pinometostat EPZ-5676	Histone Methyltransferase	Chromatin/Epigenetic
	Pinometostat (EPZ-5676) 是有效的DOT1L 组蛋白甲基转移酶抑制剂，Ki 为 80 pM。它可用于研究多种白血病治疗的实验。
T15420	GS-9901	PI3K	PI3K/Akt/mTOR signaling
	GS-9901 是一种具有选择性、口服活性和高效性的 PI3Kδ 抑制剂（IC50：1 nM），可用于研究非霍奇金淋巴瘤和慢性淋巴细胞白血病。
T8380	Bendamustine SDX105,宾达氮芥	Apoptosis; Others; DNA Alkylator/Crosslinker	Apoptosis; DNA Damage/DNA Repair; Others
	Bendamustine (SDX105) 是一种嘌呤类似物，是一种 DNA 交联剂，具有烷基化、抗癌和抗代谢作用。它可激活 DNA 损伤反应和细胞凋亡。
T16157	MT-802	BTK; PROTACs	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	MT-802 是一种基于Cereblon 配体的、BTK 的降解剂，其 DC50=1 nM。它具有研究 C481S 突变型慢性淋巴细胞白血病的潜力。
T76794	Ulocuplumab BMS 936564,MDX 1338	Apoptosis; CXCR	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation
	Ulocuplumab (BMS-936564) 是一种完全人抗 CXCR4 的 IgG4 抗体。Ulocplumab 在急性髓系白血病 (AML)，非霍奇金淋巴瘤 (NHL) 和多发性骨髓瘤移植模型中展现出抗肿瘤活性。Ulocplumab 对 CXCL12 介导的慢性淋巴细胞白血病 (CLL) 细胞在 CXCR4 激活下的迁移有抑制作用，诱导癌细胞凋亡 (apoptosis)，。
T77093	Theralizumab TGN1412,TAB-08,TABO8	Others	Others
	Theralizumab (TGN1412) 是一种抗靶向 CD28 的单克隆抗体，可直接刺激 T 细胞。Theralizumab 具有抗肿瘤活性，用于治疗 B 细胞慢性淋巴细胞白血病和类风湿性关节炎。
T10483	Lisaftoclax Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL	Apoptosis
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50：2 nM 和 5.9 nM)，具有抗肿瘤活性。
T4564	Ethacrynic acid Edecrin,利尿酸,Etacrynic Acid,Hydromedin	Others; Calcium Channel; NF-κB; GST	Membrane transporter/Ion channel; Metabolism; NF-κB; Others; oxidation-reduction
	Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。
T38622	Bcl-xL antagonist 2	BCL	Apoptosis
	Bcl-xL antagonist 2 是一种有效的选择性 Bcl-xL 拮抗剂，IC50 为 91 nM，Ki 为 65 nM。 Bcl-xL antagonist 2 可诱导癌细胞凋亡，可用于慢性淋巴细胞白血病和非霍奇金淋巴瘤的研究。
T19661	8-Chloroadenosine NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	8-Chloroadenosine (NSC-354258) 是一种 5' AMP 激活的蛋白激酶激动剂，可能用于治疗慢性淋巴细胞白血病。它的活性与 mTOR 通路的抑制有关。它是一种核苷类似物。在体内代谢为 8-氯-ATP。在转录过程中掺入 RNA 并抑制 RNA 合成。在 MM.1S、RPMI-8226 和 U266 癌细胞系中表现出细胞毒性；在 A549 和 H1299 细胞中诱导 G2/M 细胞周期停滞和有丝分裂灾难。它已被证明可消耗 ATP 并抑制血液恶性肿瘤以及肺癌和乳腺癌细胞系中的肿瘤生长。
T71996	VU0621623
	VU0621623 is an arenavirus multiplication inhibitor which blocks lymphocytic choriomeningitis virus (LCMV) cell entry.
T70107	Olcorolimus
	Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5
T37602	GSK 143
	Spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines. Liddle et al (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 21 6188 PMID:21903390 \|Varghese et al (2018) Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 182 9...
TP1640	Glycoprotein (276-286) Glycoprotein 276-286
	Known Db-restricted peptide of lymphocytic choriomeningitis virus (LCMV).
TP1758	LCMV gp33-41
	LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes.This is the H-2Db restricted epitope derived from the lymphocytic
T64152	Purinostat mesylate
	Purinostat mesylate 是一种选择性的 HDAC 抑制剂。Purinostat mesylate 能够抑制 I 型和 IIb 型 HDACs (IC50: 0.81-11.5 nM)。Purinostat mesylate 能够影响LAMA84 和 188 BL-2 细胞的细胞周期，并诱导其凋亡，在体内显示出较强的抗白血病效果。Purinostat mesylate 能够用于研究淋巴细胞白血病。
T68865	Amoorastatin
	Amoorastatin is a natural product that has been studied in cancer research. Its derivative was found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell lines.
T36890	A 410099.1
	High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells. Oost et al (2004) Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem. 47 4417 PMID:15317454 \|Loeder et al (2009) A n...
TP1752	GP(33-41)
	GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM. GP33-41 Epitopeis a strong agonist of CD8 T cells
TP1629	LCMV gp33-41 (TFA) (151705-84-9 free base) LCMV gp33-41 (TFA)
	LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes[1].
TP2150	Nucleoprotein (396-404) (TFA) NP 396 TFA	Others	Others
	Nucleoprotein (396-404) TFA is the 396 to 404 fragment of the lymphocytic choriomeningitis virus (LCMV). It is the H-2D(b)-restricted immunodominant epitope used as a molecular model of viral antigen.
T75982	LCMV gp33-41 TFA
	LCMV gp33-41 (TFA)是一种带有羧基延伸的11-aa长肽，作为淋巴细胞脉络丛脑膜炎病毒序列，在MHC I类H-2Db分子的限制下，能够被呈递给细胞毒性T淋巴细胞。
TP1078	Nucleoprotein (396-404) Nucleoprotein 396-404,NP 396
	Nucleoprotein (396-404) refers to a specific fragment within the lymphocytic choriomeningitis virus (LCMV). This fragment, also known as the H-2D(b)-restricted immunodominant epitope, has been identified as a significant component of the viral antigen. It can be utilized as a valuable molecular model for studying viral antigens.
T70304	CI-898 HCl
	CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
T78295	Samalizumab ALXN 6000
	Samalizumab（ALXN 6000）是一种针对CD200具有特异性结合并能阻断CD200与CD200R（CD200受体）相互作用的人源化单克隆抗体。它目前被用于多发性骨髓瘤和B细胞慢性淋巴细胞白血病的研究中。
T76909	Apolizumab
	Apolizumab (Hu1D10)为人源化单克隆抗体，针对人类白细胞抗原-DR β链。该抗体能够介导慢性淋巴细胞白血病(CLL)细胞在体外的凋亡。
T69308	Spliceostatin A
	Spliceostatin A，是 FR901464 的甲基化衍生物，是一种有效的抗肿瘤药物。Spliceostatin A 通过结合 SF3B1抑制剪接并促进前体 mRNA 的积累。SF3B1是剪接体中 U2 小核核糖核蛋白的一个亚复合体。Spliceostatin A 诱导慢性淋巴细胞白血病 (CLL) 细胞凋亡 (Apoptosis)。
T75766	GP(33-41) TFA
	GP(33-41) TFA 是一种由 9 个氨基酸残基组成的多肽，它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的序列。GP(33-41) TFA 能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子，SC50值为 344 nM。
T38383	Altemicidin
	Altemicidin is a monoterpene alkaloid originally isolated fromS. sioyaensiswith acaricidal and anticancer activities.1It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s = 0.84 and 0.82 μg/ml, respectively). It is toxic to mice with an LD50value of 0.3 mg/kg. 1.Takahashi, A., Kurasawa, S., Ikeda, D., et al.Altemicidin, a new acari...
T68667	Oxanosine
	Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It al...
T73253	EIDD-2749 4'-Fluorouridine,4'-FlU ; 4'-Fluorouridine,4'-FlU
	EIDD-2749 (4'-Fluorouridine) 是一种口服有效的RdRp 抑制剂。EIDD-2749 能有效抑制RSV 和SARS-CoV-2的复制。EIDD-2749 还表现出抗HCV 和淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 的活性。EIDD-2749 是一种很有潜力的COVID-19口服治疗候选剂，也适用于其他 RNA 病毒的研究。
T36397	TAN 420E
	TAN 420E is a bacterial metabolite originally isolated from Streptomyces. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 1.3 μM) and reduces thiobarbituric acid reactive substances (TBARS) in rat liver microsomes by 72% when used at a concentration of 100 μg/ml. TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 μg/ml). It is cytotoxic to P388 and KB lymphocytic leukemia cells (EC50s = 0.022 and 0.3 μg/ml, respectively).
T70856	3-Oxobetulin Acetate
	3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto...
T72527	Umbralisib sulfate TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate
	Umbralisib (TGR-1202) sulfate 是一种口服有效、选择性的 PI3Kδ和酪蛋白激酶-1-ε (CK1ε) 双抑制剂，其 EC50分别为 22.2 nM 和 6.0 μM。 Umbralisib sulfate 显示出对慢性淋巴细胞白血病 (CLL) T 细胞独特的免疫调节作用。Umbralisib sulfate 可用于血液系统恶性肿瘤的研究。
T72465	Umbralisib tosylate RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate
	Umbralisib (TGR-1202) tosylate是一种口服有效、具有选择性的PI3Kδ和酪蛋白激酶-1-ε (CK1ε) 双重抑制剂，EC50值分别为22.2 nM和6.0 μM。该化合物针对慢性淋巴细胞白血病 (CLL) 中的T细胞显示出独特的免疫调节作用，适用于血液系统恶性肿瘤的研究。

化合物

Cat.No: T9925

Target: Others

Cat.No: T9744

Target: Phosphatase

Cat.No: T12317

Synonym: ICP-022

Target: BTK

Cat.No: T3626

Synonym: ACP-196,阿可替尼

Target: BTK

Cat.No: T4976

Synonym: TGR-1202,RP5264,TGR 1202,TGR1202

Target: PI3K

Cat.No: T2558

Synonym: 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA

Target: Apoptosis, Adenosine deaminase

LCMV gp33-41 acetate

Cat.No: TP1758L

Synonym: LCMV gp33-41 acetate（151705-84-9 Free base）

Target: Others

Cat.No: T3099

Synonym: EPZ-5676

Target: Histone Methyltransferase

Cat.No: T15420

Target: PI3K

Cat.No: T8380

Synonym: SDX105,宾达氮芥

Target: Apoptosis, Others, DNA Alkylator/Crosslinker

Cat.No: T16157

Target: BTK, PROTACs

Cat.No: T76794

Synonym: BMS 936564,MDX 1338

Target: Apoptosis, CXCR

Cat.No: T77093

Synonym: TGN1412,TAB-08,TABO8

Target: Others

Cat.No: T10483

Synonym: Bcl-2/Bcl-xl inhibitor 1,APG-2575

Target: BCL

Ethacrynic acid

Cat.No: T4564

Synonym: Edecrin,利尿酸,Etacrynic Acid,Hydromedin

Target: Others, Calcium Channel, NF-κB, GST

Bcl-xL antagonist 2

Cat.No: T38622

Target: BCL

8-Chloroadenosine

Cat.No: T19661

Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷

Target: AMPK

Cat.No: T71996

Cat.No: T70107

Cat.No: T37602

Glycoprotein (276-286)

Cat.No: TP1640

Synonym: Glycoprotein 276-286

Cat.No: TP1758

Purinostat mesylate

Cat.No: T64152

Cat.No: T68865

Cat.No: T36890

Cat.No: TP1752

LCMV gp33-41 (TFA) (151705-84-9 free base)

Cat.No: TP1629

Synonym: LCMV gp33-41 (TFA)

Nucleoprotein (396-404) (TFA)

Cat.No: TP2150

Synonym: NP 396 TFA

Target: Others

LCMV gp33-41 TFA

Cat.No: T75982

Nucleoprotein (396-404)

Cat.No: TP1078

Synonym: Nucleoprotein 396-404,NP 396

Cat.No: T70304

Cat.No: T78295

Synonym: ALXN 6000

Cat.No: T76909

Spliceostatin A

Cat.No: T69308

Cat.No: T75766

Cat.No: T38383

Cat.No: T68667

Cat.No: T73253

Synonym: 4'-Fluorouridine,4'-FlU ; 4'-Fluorouridine,4'-FlU

Cat.No: T36397

3-Oxobetulin Acetate

Cat.No: T70856

Umbralisib sulfate

Cat.No: T72527

Synonym: TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate

Umbralisib tosylate

Cat.No: T72465

Synonym: RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate

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