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Search Results for " lactate (1:1) "

27

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T11829	LDH-IN-1	Dehydrogenase	Metabolism
	LDH-IN-1 是新型的基于吡唑的人乳酸脱氢酶抑制剂，对于 LDHA 和 LDHB 的 IC50 分别为32和27 nM。
T11546	hDHODH-IN-1	Dehydrogenase	Metabolism
	hDHODH-IN-1 是有效的人二氢乳清酸脱氢酶抑制剂，显示出抗炎作用。
T12438	PfDHODH-IN-1	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	PfDHODH-IN-1 是 Leflunomide 活性代谢物的类似物，具有抗疟疾活性。它是恶性疟原虫二氢乳清酸脱氢酶抑制剂。
T26300	Tylosin, lactate lactate (1:1),Tylosin
	Tylosin, lactate is a bacteriostat feed additive used in veterinary medicine. It is a macrolide antibiotic that has a broad spectrum of activity against Gram-positive organisms but a limited range of Gram-negative organisms. It is found naturally as a fer
T81962	Lactate transportor 1	Monocarboxylate transporter	Membrane transporter/Ion channel
	Lactate transporter 1 (compound 1) 作为一种活性乳酸运输蛋白，主要在活细胞内发挥作用。在Hela、CAL27、MCF7和MCF10A细胞系中，Lactate transporter 1 均显示出了明显的毒性，其半抑制浓度（IC50）值依次为3.36、3.27、5.58和7.66 μM。此外，在HeLa细胞中，Lactate transporter 1 与Cisplatin表现出了协同抑制的作用。
T6479	Dovitinib lactate hydrate Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258	VEGFR; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Dovitinib lactate hydrate (TKI258) 是一种多靶点的酪氨酸激酶抑制剂，抑制 FLT3，c-Kit，FGFR1/3，VEGFR1/2/3和 PDGFRα/β的 IC50值分别为 1，2，8/9，10/13/8，27/210 nM。
T39805	LDHA-IN-3 PSTMB,1-(phenylseleno)-4-(trifluoromethyl) benzene	Dehydrogenase	Metabolism
	LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) 是一种有效的非竞争性乳酸脱氢酶(LDHA) 抑制剂，IC50值为 145.2 nM。LDHA-IN-3 是一种硒苯化合物，可用于研究癌症。
T60165	VB124	Monocarboxylate transporter	Membrane transporter/Ion channel
	VB124 是一种具有口服活性的、有效且选择性的MCT4抑制剂。VB124 可特异性抑制 MDA-MB-231 细胞中乳酸的涌入和流出，IC50分别为 8.6 nM 和 19 nM。VB124 对 MCT4 的选择性高于 MCT1。VB124可用于心脏肥大、心力衰竭和代谢的研究。
T77579	JC2-11	IL Receptor; Dehydrogenase; ROS; Caspase; NOD-like Receptor (NLR); AIM2	Apoptosis; Immunology/Inflammation; Metabolism; Proteases/Proteasome
	JC2-11 是一种对炎症有抑制作用的化合物。JC2-11 对含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体有抑制作用，通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌、gasdermin D (GSDMD) 的裂解、IL-1β 和乳酸脱氢酶 (LDH) 的释放。
T78348	Lactate oxidase
	Lactate oxidase是一种FMN依赖性酶，能催化乳酸转化为丙酮酸并同时释放过氧化氢，常用于乳酸的检测。
T76116	L-Lactate dehydrogenase
	L-Lactate dehydrogenase (L-乳酸脱氢酶) 是一种氧化还原酶。L-Lactate dehydrogenase 在体内催化 NADH 将丙酮酸还原为 L-乳酸。
T12117	MSI-1436 lactate Trodusquemine lactate,Aminosterol-1436 lactate	Others	Others
	MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)
T79874	CHK-336
	CHK-336（Example 1）为口服活性LDHA抑制剂（IC50＜1 nM），有效抑制小鼠肝细胞产生乳酸。该化合物适用于高草酸尿症相关研究。
T61339	LDHA/PDKs-IN-1
	LDHA/PDKs-IN-1 (compound 20e) is a highly effective dual inhibitor of PDKs and LDHA, displaying IC50 values of 0.8 μM and 0.15 μM, respectively. It significantly suppresses A549 cell proliferation (EC50 = 13.2 μM), reduces lactate formation, and enhances oxygen consumption. This compound holds great promise for cancer research [1].
T37824	MCT4-IN-1 MCT4-IN-1
	MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MCT4-IN-1 has the potential for MCT4 transporter inhibition research[1].
T39767	AR-C141990 hydrochloride AR-C141990 hydrochloride
	AR-C141990 hydrochloride is a potent inhibitor of lactate transporters known as monocarboxylate transporters (MCTs). It has pK i values of 7.6 and 6.6 for MCT-1 and MCT-2, respectively. Additionally, this compound exhibits immunosuppressive properties and effectively inhibits the graft versus host response.
T79204	Anticancer agent 122
	Anticanceragent 122，作为一种hLDHA抑制剂，表现出显著的抗癌活性，主要应用于抗肿瘤研究。
T36498	CAY10762 CAY10762
	CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain. 1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(...
T79203	Anticancer agent 121
	Anticanceragent 121作为一种hLDHA (人类乳酸脱氢酶 A) 抑制剂，展现出卓越的抗癌活性，适用于抗肿瘤研究。
T76146	D-Lactate dehydrogenase
	D-Lactate dehydrogenase(D-LDH)为一种氧化还原酶，以NAD+或NADP+作为受体，特异性作用于供体的CH-OH基团，催化D-乳酸氧化成丙酮酸。该酶主要分布于细菌和真菌中，是生化研究中常用的酶。
T70032	NCI-006
	NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
T79732	CD38 inhibitor 3	CD38	Immunology/Inflammation
	CD38 inhibitor3（化合物1）是一种高效的CD38抑制剂，具有IC50为11 nM。它能够促进线粒体生物发生，同时降低乳酸水平并增加NAD+含量以及Nrf2的表达。在线粒体肌瘤病模型中，CD38 inhibitor3能显著改善Pus1-/-小鼠的肌肉收缩功能和发育，并提升其运动耐力。
T82373	FPR2 agonist 3
	FPR2 agonist 3 能够抑制 LPS 刺激下的培养物中乳酸脱氢酶的释放，并减少促炎性因子IL-1β和IL-6的表达水平。此外，FPR2 agonist 3 还可以通过作用于 STAT3/SOCS3 信号通路来降低 STAT3 的磷酸化水平。
T61312	Antioxidant agent-3
	Antioxidant agent-3 (Compound 14q) 是一种抗氧化剂，具有有效的DPPH 自由基清除活性和ABTS+清除活性，IC50分别为 26.58 和 30.31 μM。Antioxidant agent-3 作用于 H2O2处理的 HepG2 细胞，可增加活性氧 (ROS)、超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH)，并减少乳酸脱氢酶(LDH)。
T60995	LDHA/PDKs-IN-2
	LDHA/PDKs-IN-2 (compound 20k) 是有效的 LDHA 和 PDKs 的双重抑制剂，IC50 值分别为 0.7 和 1.6 μM。LDHA/PDKs-IN-2 会增加耗氧量并且减少乳酸的形成。LDHA/PDKs-IN-2 显示了癌症研究的潜力，它可以减少 A549 细胞的增殖，EC50值为 15.7 μM。
T72017	6(5H)-Phenanthridinone
	6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimenta...
T83768	Zofenoprilat Zofenopril-SH,SQ 26,333
	Zofenoprilat是一种血管紧张素转换酶(ACE; IC50 = 8 nM for the rabbit lung enzyme)的抑制剂，同时也是前体药zofenopril的活性代谢产物。它能够抑制分离的豚鼠小肠中由血管紧张素I或缓激肽诱导的收缩(EC50s = 3 and 1 nM, respectively)。在人类脐静脉内皮细胞(HUVECs)中，Zofenoprilat (10 nM)降低基础内皮素-1分泌和一氧化氮(NO)生成，并阻止TNF-α诱导的活性氧种(ROS)增加以及谷胱甘肽(GSH)水平降低。Zofenoprilat (10 µM)保护初级人类心脏微血管内皮细胞免受多柔比星诱导的细胞毒性。此外，Zofenoprilat (10 µM)还能增加HUVECs中的硫化氢(H2S)生成，以及细胞的黏着、迁移和增殖。在以400 µM浓度使用时，它可以减少Langendorff分离的大鼠心脏灌流缺血再灌注损伤模型中的舒张末压和乳酸脱氢酶(LDH)释放。

化合物

Cat.No: T11829

Target: Dehydrogenase

Cat.No: T11546

Target: Dehydrogenase

Cat.No: T12438

Target: Dehydrogenase, Parasite

Tylosin, lactate

Cat.No: T26300

Synonym: lactate (1:1),Tylosin

Lactate transportor 1

Cat.No: T81962

Target: Monocarboxylate transporter

Dovitinib lactate hydrate

Cat.No: T6479

Synonym: Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Cat.No: T39805

Synonym: PSTMB,1-(phenylseleno)-4-(trifluoromethyl) benzene

Target: Dehydrogenase

Cat.No: T60165

Target: Monocarboxylate transporter

Cat.No: T77579

Target: IL Receptor, Dehydrogenase, ROS, Caspase, NOD-like Receptor (NLR), AIM2

Lactate oxidase

Cat.No: T78348

L-Lactate dehydrogenase

Cat.No: T76116

MSI-1436 lactate

Cat.No: T12117

Synonym: Trodusquemine lactate,Aminosterol-1436 lactate

Target: Others

Cat.No: T79874

Cat.No: T61339

Cat.No: T37824

Synonym: MCT4-IN-1

AR-C141990 hydrochloride

Cat.No: T39767

Synonym: AR-C141990 hydrochloride

Anticancer agent 122

Cat.No: T79204

Cat.No: T36498

Synonym: CAY10762

Anticancer agent 121

Cat.No: T79203

D-Lactate dehydrogenase

Cat.No: T76146

Cat.No: T70032

CD38 inhibitor 3

Cat.No: T79732

Target: CD38

Cat.No: T82373

Antioxidant agent-3

Cat.No: T61312

Cat.No: T60995

6(5H)-Phenanthridinone

Cat.No: T72017

Cat.No: T83768

Synonym: Zofenopril-SH,SQ 26,333

Cat. No.	Product Name	Target	Signaling Pathways
T2S2211	Tenuifoliside C	Dehydrogenase	Metabolism
	Tenuifoliside C 是从野生的 polygala tenuifolia 中分离得到的。它对 CYP2E1 催化氯唑酮 6-羟基化反应具有抑制作用。

天然产物

Tenuifoliside C

Cat.No: T2S2211

Target: Dehydrogenase

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