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16

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0154	Nebivolol hydrochloride R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。
T20843	Aplodan Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate	Others	Others
	Aplodan (creatinol-O-phosphate) 表现出抗缺血和抗心律失常的能力以及对细胞膜的保护作用。 Aplodan 可用于缺血性心脏病或伴有持续性室性早搏的缺血性心脏病的研究。
T29687	Afacifenacin Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986	AChR	Neuroscience
	Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂，可用于研究缺血性心脏病，尿失禁和膀胱炎和其他疾病。
T0080	Trapidil 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008	PDGFR; PDE	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Trapidil (Avantrin) 是一种抗血小板药物，是一种血管扩张剂，有特异性血小板衍生生长因子。
T0988	Trimetazidine dihydrochloride 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F	Autophagy; Fatty Acid Synthase	Autophagy; Metabolism
	Trimetazidine dihydrochloride (Vastarel F) 是细胞保护性抗缺血剂，也用作缺血性心脏病或心绞痛的血管扩张剂，具有抗氧化，抗炎，抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。
T24115	GSK854 GSK-854,GSK 854	Apoptosis	Apoptosis
	GSK854 是一种具有高选择性和有效性的肌钙蛋白 I 相互作用激酶 (TNNI3K) 抑制剂，抑制小鼠心肌梗死损伤细胞焦亡和细胞凋亡，可限制缺血性心脏的氧化应激、损伤和不良重塑。
T24239	K201 K-201,JTV 519,JTV-519,K 201	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	K201 (JTV-519) 是一种 Ca2+ 依赖性阻滞剂，通过稳定兰尼碱受体来防止缺血性心脏和骨骼肌 (SkM) 中的肌质网异常 Ca(2+) 泄漏。
T21757	BRL 52537 hydrochloride	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BRL 52537 hydrochloride 是一种选择性和特异性 KOR 激动剂，与缺血性神经元损伤的神经保护有关。它用于研究中风和心脏病发作的潜在治疗方法以及更一般的大脑研究。
T36569	KR-32568	Sodium Channel	Membrane transporter/Ion channel
	KR-32568是一种钠/氢交换器1（NHE-1）抑制剂（IC50：230 nM）。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时，它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568（0.3mg/kg）在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。
T21871	MMPSI Caspase-3/7 Inhibitor I	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	MMPSI (Caspase-3/7 Inhibitor I) 是一种新型的、非肽类的小分子 caspase 3 和 caspase 7 抑制剂，可减少离体兔心脏或心肌细胞缺血性损伤的作用，以浓度依赖性方式抑制 H16c2 细胞凋亡。MMPSI 可用于研究心脏保护和心肌损伤。
T36503	Sodium Hydrogen Sulfide (hydrate)	Others	Others
	Sodium Hydrogen Sulfide (hydrate) 与一氧化氮一样，是一种重要的气体介质，对哺乳动物的免疫、神经、心血管和肺系统有重要影响。Sodium Hydrogen Sulfide (hydrate)是一种H2S 供体，常用于细胞和整个动物实验系统。例如，它被用来证明H2S 促进中性粒细胞迁移，减少气道炎症，保护神经轴突、心脏和肠道免受化学或缺血再灌注损伤。
T27372	FR-168888 mesylate FR-168888,FR-168888 Free Base,FR168888,FR 168888
	FR-168888, a new Na+/H+ exchange inhibitor, can protect the heart from arrhythmia and myocardial cell death in ischemic and reperfused situations.
T26279	Tiracizine HCl AWD-19-166,AWD19166,Bonnecor,AWD 19 166,Tiracizine Hydrochloride
	Tiracizine HCl 是一种新的I 类抗心律失常药物，对缺血性心脏病患者进行了研究，结果表明该药物可降低心肌收缩功能。
T70278	FR-168888 free base
	FR-168888 free base is a new Na+/H+ exchange inhibitor. FR-168888 has a strong inhibitory effect on Na+/H+ exchange and has been shown to protect the heart from arrhythmia and myocardial cell death in ischemic and reperfused situations.
T33673	Niludipine Niludipina,BAY-a 7168,Bay a 7168,Niludipinum
	Nirudipine is a double (2-propoxyethyl) analogist of nifedipine and a calcium channel blocker, which is also a safe anti-angina Ca2+ antagonist with a broad range of efficacy for all types of angina. At the same time, Niludipine is a highly effective drug
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...

化合物

Nebivolol hydrochloride

Cat.No: T0154

Synonym: R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824

Target: Apoptosis, Adrenergic Receptor

Cat.No: T20843

Synonym: Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate

Target: Others

Cat.No: T29687

Synonym: Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986

Target: AChR

Cat.No: T0080

Synonym: 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

Target: PDGFR, PDE

Trimetazidine dihydrochloride

Cat.No: T0988

Synonym: 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F

Target: Autophagy, Fatty Acid Synthase

Cat.No: T24115

Synonym: GSK-854,GSK 854

Target: Apoptosis

Cat.No: T24239

Synonym: K-201,JTV 519,JTV-519,K 201

Target: Calcium Channel

BRL 52537 hydrochloride

Cat.No: T21757

Target: Opioid Receptor

Cat.No: T36569

Target: Sodium Channel

Cat.No: T21871

Synonym: Caspase-3/7 Inhibitor I

Target: Apoptosis, Caspase

Sodium Hydrogen Sulfide (hydrate)

Cat.No: T36503

Target: Others

FR-168888 mesylate

Cat.No: T27372

Synonym: FR-168888,FR-168888 Free Base,FR168888,FR 168888

Cat.No: T26279

Synonym: AWD-19-166,AWD19166,Bonnecor,AWD 19 166,Tiracizine Hydrochloride

FR-168888 free base

Cat.No: T70278

Cat.No: T33673

Synonym: Niludipina,BAY-a 7168,Bay a 7168,Niludipinum

Cat.No: T35463

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Cat. No.	Product Name	Target	Signaling Pathways
T6S1495	Ginsenoside Rk3 人参皂苷Rk3,人参皂甙 Rk3	Others; NF-κB	NF-κB; Others
	Ginsenoside Rk3 是存在于 Panax notoginseng 的根中。它能够抑制 HepG2 细胞中 TNF-α 诱导的 NF-κB 转录活性，IC50=14.24±1.30 μM。
TN1412	Astringin trans-Astringin,白皮杉醇葡萄糖苷	IL Receptor; Others	Immunology/Inflammation; Others
	Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be correlated with its antioxidant activity and upregulation of NO production.

天然产物

Ginsenoside Rk3

Cat.No: T6S1495

Synonym: 人参皂苷Rk3,人参皂甙 Rk3

Target: Others, NF-κB

Cat.No: TN1412

Synonym: trans-Astringin,白皮杉醇葡萄糖苷

Target: IL Receptor, Others

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