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24

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39437	Cevidoplenib dimesylate	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Cevidoplenib dimesylate 是一种脾酪氨酸激酶 (Syk) 抑制剂，具有抗炎和免疫调节特性。
T21459	Splenopentin diacetate Thymopoietin III pentapeptide (32-36),SP5,Splenopentin Acetate,醋酸脾脏五肽,Splenin pentapeptide (32-36),Arg-lys-glu-val-tyr	Others	Others
	Splenopentin diacetate (Splenin pentapeptide (32-36)) 是一种合成的免疫调节肽，可以再现脾和胸腺激素胸腺生成素的生物活性。
TP1029	Thymalfasin 胸腺法新,Thymosin α1,醋酸胸腺α1	Others	Others
	Thymalfasin (Thymosin α1) 是一种免疫调节化合物，可增强 Thl 的免疫应答。
T0208	Prednisolone disodium phosphate 泼尼松龙21-磷酸二钠,Prednisolone phosphate sodium,Prednisolone 21-phosphate disodium,泼尼松龙磷酸钠	Glucocorticoid Receptor	Endocrinology/Hormones
	Prednisolone disodium phosphate是一种合成的糖皮质素，具有抗炎和免疫调节作用。
T0337	Prednisolone acetate Omnipred,醋酸泼尼松龙,Prednisolone-21-acetate	Glucocorticoid Receptor	Endocrinology/Hormones
	Prednisolone acetate (Omnipred) 是一种肾上腺皮质激素类药物，具有抗炎、抗过敏和抑制免疫等多种药理活性。
T9789	Cevidoplenib dimesylate hydrochloride	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Cevidoplenib dimesylate hydrochloride 是一种脾酪氨酸激酶 (Syk) 抑制剂，具有潜在的免疫调节和抗炎特性。
T1988	Duvelisib INK1197,IPI-145,度维利塞	PI3K	PI3K/Akt/mTOR signaling
	Duvelisib (INK1197) 是 p100δ的选择性抑制剂，能够作用于 p110δ (IC50:2.5 nM)、p110γ (IC50:27.4 nM)、p110β (IC50:85 nM) 和 p110α (IC50:1602 nM)。
T7660	IDO inhibitor 1 4-[[2-[(氨基磺酰基)氨基]乙基]氨基]-N'-(3-溴-4-氟苯基)-N-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO inhibitor 1 是一种有效的吲哚胺-2,3 双加氧酶 (IDO) 抑制剂 (IC50 <100 nM)。具有潜在的免疫调节和抗肿瘤活性。
T3258	Ponesimod ACT-128800	S1P Receptor; LPL Receptor	GPCR/G Protein
	Ponesimod (ACT-128800) 是一种选择性 S1P1可口服激动剂，在放射性配体结合试验中的 IC50值为 6 nM。它可高效激活 S1P1介导的信号转导，EC50为5.7 nM。它可预防淋巴细胞介导的组织炎症，具有潜在的免疫调节活性。
T1127	Beclometasone dipropionate Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase	Glucocorticoid Receptor	Endocrinology/Hormones
	Beclometasone dipropionate (Vancenase) 是具有口服活性的糖皮质激素，具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物，Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。
T8396	Prednisone acetate Prednisone 21-acetate,醋酸泼尼松	Glucocorticoid Receptor	Endocrinology/Hormones
	Prednisone acetate (Prednisone 21-acetate) 是泼尼松的醋酸盐形式，它是一种糖皮质激素受体激动剂，具有抗炎和免疫调节作用。
T2485	Baricitinib INCB028050,LY3009104,巴瑞克替尼	Tyrosine Kinases; JAK; Chk	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Baricitinib (INCB028050) 是一种选择性，可口服的JAK1和JAK2抑制剂，IC50分别为5.9 nM 和 5.7 nM，具有潜在的抗炎、免疫调节和抗肿瘤活性。
T2605	Fostamatinib Disodium Tamatinib Fosdium,福他替尼二钠盐,R788(Disodium),R788 Disodium,R788 (Fostamatinib) Disodium	FLT; Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Fostamatinib Disodium (R788 Disodium) 是一种口服具有活力的 R406 前药。其中R406 是具有口服活性的，有效的，ATP 竞争性的Syk/FLT3抑制剂(Ki:30 nM，IC50:41 nM)，也能够抑制 Lyn (IC50:63 nM) 和 Lck (IC50:37 nM)。
T5128	RGX-104 hydrochloride SB742881,RGX-104 HCl,盐酸RGX-104	Liver X Receptor	Metabolism
	RGX-104 hydrochloride (SB742881) 是小分子LXR 激动剂，利用 ApoE 基因的转录激活，调节先天免疫。
T16240	N,N'-Diacetyl-L-cystine (Ac-Cys-OH)2,DiNAC	Others	Others
	N,N'-Diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。它在高脂血症兔中也具有抗动脉粥样硬化的作用。它是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。
T25897	OH-Ubenimex p-Hydroxyubenimex,p-Hydroxybestatin
	OH-Ubenimex is an orally active aminopeptidase inhibitor that has an immunomodulating action.
T34086	Platonin NK 19
	Platonin is a therapeutic immunomodulating medicine and a possible medicine against ischemic stroke.
T38550	Onilcamotide
	Onilcamotide, a cancer vaccine derived from the C-terminal peptide of the RhoC protein, exhibits potential immunomodulating and antineoplastic activities.
T4532L	Linrodostat mesylate ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205
	Linrodostat (BMS-986205, ONO-7701, and F001287) is a selective and orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. By inhibiting IDO1 and reducing kynurenine in tumor cells, BMS-986205 restores and promotes the
T70994	TAK-659 HCl
	TAK-659 is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Spleen tyrosine kinase inhibitor TAK-659 may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Note: TAK-659 free base is less stable. This product is supplied as dihydrochloride form.
T78366	Thymotrinan TFA RGH-0205 TFA,TP3 TFA
	Thymotrinan (RGH-0205) TFA 是胸腺生成素和免疫调节肽的生物活性片段，并天然存在于机体中。该化合物具备与TP5相似的免疫调节功能，能够调控体液及细胞免疫反应。
T71180	Oglufanide disodium
	Oglufanide disodium is t he disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections. Check for active clinical trials or closed clinical trials u...
T70802	Duvelisib hydrate
	Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike oth...
T11449	Golotimod hydrochloride (229305-39-9 free base) Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride	STAT	JAK/STAT signaling; Stem Cells
	Golotimod (SCV 07) hydrochloride 是一种免疫调节肽，具抗菌活性，能显著提升抗结核疾病研究效果。该化合物通过刺激胸腺和脾细胞增殖、改善巨噬细胞功能，展现其生物调节能力。此外，Golotimod hydrochloride 通过抑制STAT3信号传导，有效调节接受放疗或与顺铂联用治疗动物模型中的口腔粘膜炎持续时间和严重程度。还显示出对研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 具有潜在应用价值。

化合物

Cevidoplenib dimesylate

Cat.No: T39437

Target: Syk

Splenopentin diacetate

Cat.No: T21459

Synonym: Thymopoietin III pentapeptide (32-36),SP5,Splenopentin Acetate,醋酸脾脏五肽,Splenin pentapeptide (32-36),Arg-lys-glu-val-tyr

Target: Others

Cat.No: TP1029

Synonym: 胸腺法新,Thymosin α1,醋酸胸腺α1

Target: Others

Prednisolone disodium phosphate

Cat.No: T0208

Synonym: 泼尼松龙21-磷酸二钠,Prednisolone phosphate sodium,Prednisolone 21-phosphate disodium,泼尼松龙磷酸钠

Target: Glucocorticoid Receptor

Prednisolone acetate

Cat.No: T0337

Synonym: Omnipred,醋酸泼尼松龙,Prednisolone-21-acetate

Target: Glucocorticoid Receptor

Cevidoplenib dimesylate hydrochloride

Cat.No: T9789

Target: Syk

Cat.No: T1988

Synonym: INK1197,IPI-145,度维利塞

Target: PI3K

IDO inhibitor 1

Cat.No: T7660

Synonym: 4-[[2-[(氨基磺酰基)氨基]乙基]氨基]-N'-(3-溴-4-氟苯基)-N-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3258

Synonym: ACT-128800

Target: S1P Receptor, LPL Receptor

Beclometasone dipropionate

Cat.No: T1127

Synonym: Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase

Target: Glucocorticoid Receptor

Prednisone acetate

Cat.No: T8396

Synonym: Prednisone 21-acetate,醋酸泼尼松

Target: Glucocorticoid Receptor

Cat.No: T2485

Synonym: INCB028050,LY3009104,巴瑞克替尼

Target: Tyrosine Kinases, JAK, Chk

Fostamatinib Disodium

Cat.No: T2605

Synonym: Tamatinib Fosdium,福他替尼二钠盐,R788(Disodium),R788 Disodium,R788 (Fostamatinib) Disodium

Target: FLT, Syk

RGX-104 hydrochloride

Cat.No: T5128

Synonym: SB742881,RGX-104 HCl,盐酸RGX-104

Target: Liver X Receptor

N,N'-Diacetyl-L-cystine

Cat.No: T16240

Synonym: (Ac-Cys-OH)2,DiNAC

Target: Others

Cat.No: T25897

Synonym: p-Hydroxyubenimex,p-Hydroxybestatin

Cat.No: T34086

Synonym: NK 19

Cat.No: T38550

Linrodostat mesylate

Cat.No: T4532L

Synonym: ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205

Cat.No: T70994

Thymotrinan TFA

Cat.No: T78366

Synonym: RGH-0205 TFA,TP3 TFA

Oglufanide disodium

Cat.No: T71180

Duvelisib hydrate

Cat.No: T70802

Golotimod hydrochloride (229305-39-9 free base)

Cat.No: T11449

Synonym: Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride

Target: STAT

Cat. No.	Product Name	Target	Signaling Pathways
T1560	Prednisolone 氢化泼尼松,Predonine,Hydroretrocortine,泼尼松龙,Metacortandralone	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Prednisolone (Hydroretrocortine) 是有口服活性的皮质类固醇和糖皮质激素。它的抗炎特性约为氢化可的松的四倍，同时减少了水和盐的保留。它能够用于眼部抗炎研究。
TQ0054	Purpureaside C	Others	Others
	Purpureaside C 是一种酚类糖苷类，具有显着的促炎、免疫调节和抗菌作用。
T0034	Cortisone acetate 醋酸可的松,Cortisone 21-acetate,NSC 49420	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。
T6429	Caffeic Acid Phenethyl Ester Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE	Apoptosis; NF-κB	Apoptosis; NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) 是咖啡酸的苯乙醇酯，是蜂巢蜂胶的生物活性成分。它抑制核转录因子 NF-kappa B 的激活，具有抗肿瘤、细胞保护和免疫调节活性。它抑制 PDGF 诱导的血管平滑肌细胞增殖。
T0798	Triamcinolone Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone	Glucocorticoid Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂，也是一种合成的长效糖皮质激素，具有抗炎活性。
T2563	Acetyl-L-carnitine hydrochloride Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。
TN2287	Turkesterone	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodulating and antistress activity, can increase the adaptation capacity of mice under immobilization-induced stress conditions.
T72734	3-Fucosyllactose 3-Fucosyl-D-lactose
	3-Fucosyllactose (3-Fucosyl-D-lactose) 是人类母乳中的主要焦糖之一，具益生元、免疫调节、促进新生儿大脑发育及抗菌功能。

天然产物

Cat.No: T1560

Synonym: 氢化泼尼松,Predonine,Hydroretrocortine,泼尼松龙,Metacortandralone

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: TQ0054

Target: Others

Cortisone acetate

Cat.No: T0034

Synonym: 醋酸可的松,Cortisone 21-acetate,NSC 49420

Target: Glucocorticoid Receptor, Endogenous Metabolite

Caffeic Acid Phenethyl Ester

Cat.No: T6429

Synonym: Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE

Target: Apoptosis, NF-κB

Cat.No: T0798

Synonym: Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Acetyl-L-carnitine hydrochloride

Cat.No: T2563

Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: TN2287

Target: Calcium Channel

3-Fucosyllactose

Cat.No: T72734

Synonym: 3-Fucosyl-D-lactose

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