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Cat. No. | Product Name | Target | Signaling Pathways |
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T76702 |
Sutimlimab
|
Complement System | Immunology/Inflammation |
Sutimlimab 是一种新型靶向补体蛋白 C1 的单克隆抗体。Sutimlimab 常当作 C1 抑制剂使用,用于治疗冷凝集素病相关溶血。 | |||
T39520 |
Vamifeport
VIT-2763 |
Ferroptosis | Apoptosis |
Vamifeport (VIT-2763) 是一种新型具有口服活性且靶向铁转运蛋白的抑制剂,可降低 SCD Townes 模型中的溶血标志物。VIT-2763 可改善贫血和红细胞生成,可改善血管炎症,可研究 β-地中海贫血。 | |||
T76831 |
Tesidolumab
LFG316 |
Complement System | Immunology/Inflammation |
Tesidolumab (LFG316) 是一种全人IgG1/λ抗c5单克隆抗体。Tesidolumab (LFG316)对crovalimab和C5有抑制作用, 阻断C5的切割,防止膜攻击复合体的后续形成,可用于研究血管外溶血。 | |||
T83746 |
RW2 TFA
(RW)2-NH2,Arg-Trp-Arg-Trp-NH2 |
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RW2是一种抗微生物肽,对E. coli和S. aureus均有活性(IC50s分别为730和210 µM)。同时,RW2还能诱导分离的绵羊红细胞发生溶血。 | |||
T83748 |
RW4 TFA
(RW)4-NH2,Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2 |
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RW4为一种抗菌肽,对E. coli和S. aureus具有活性(IC50s分别为9.6和5.1 µM)。RW4同时能诱导分离的绵羊红细胞的溶血作用。 | |||
T36766 |
Palmitoylcholine (chloride)
|
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Palmitoylcholine is an acyl choline.1It inhibits protein kinase C activity when used at a concentration of 100 μM.2Palmitoylcholine induces hemolysis in rat erythrocytes.3Plasma levels of palmitoylcholine are decreased in female patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).1 1.Germain, A., Barupal, D.K., Levine, S.M., et al.Comprehensive circulatory metabolomics in ME/CFS reveals disrupted metabolism of acyl lipids and steroidsMetabolites10(1)34(2020) 2.Nakadate, T.,... | |||
T62020 | Pelecopan | ||
Pelecopan (BCX9930) 是有效的、选择性的口服补体因子D 抑制剂 (IC50= 14.3 nM)。Pelecopan 可以预防PNH 中的血管内和血管外溶血。 | |||
T77121 | Pozelimab | ||
Pozelimab (REGN3918)为一种针对component 5 (C5) 的人源IgG4单克隆抗体。其通过高亲和力结合C5及其变体,有效阻断补体介导的溶血作用,适用于对补体介导疾病进行研究。 | |||
T83747 |
RW3 TFA
(RW)3-NH2,Arg-Trp-Arg-Trp-Arg-Trp-NH2 |
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RW3是一种抗微生物肽,对大肠杆菌(E. coli)和金黄色葡萄球菌(S. aureus)具有活性,其半抑制浓度(IC50s)分别为16 µM和8 µM。RW3还能诱导分离的绵羊红细胞溶解。 | |||
T36784 |
Filipin II
|
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Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3] | |||
T83738 |
SMAP 29 (ovine) TFA
Sheep Myeloid Antimicrobial Peptide 29 |
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SMAP 29是一种抗微生物肽,同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下,对P. aeruginosa菌株PAO1具有杀菌作用,该作用在能量依赖的发光测定中表现出来(EC50s分别为0.05和0.06 µM)。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。 | |||
T69589 |
PX-316
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PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor activity against early human MCF-7 breast cancer and HT-29 colon cancer xenografts in mice. PX-316 formulated in 20% hydroxypropyl-beta-cyclodextrin for intravenous administration is well tolerated in mice and rats with no hemolysis and no hematological toxicity. Thus, PX-316 is the... | |||
T83853 |
L-K6L9 TFA
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L-K6L9 是由 L-亮氨酸和 L-赖氨酸的L-异构体组成的溶细胞肽。对LNCaP-CL1 雄激素独立型和22Rv1以及LNCaP雄激素依赖型人类前列腺癌细胞具有细胞毒性(LC50分别为4、4和6 µM),同时也对非癌性NIH3T3小鼠成纤维细胞和OL人类包皮成纤维细胞具有细胞毒性(LC50分别为7和5 µM)。在100 µM的浓度下,引起分离的人类红细胞溶血。 | |||
T83698 |
Cathelicidin-2 (128-153) (chicken) TFA
Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153) |
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Cathelicidin-2 (CATH-2) (128-153) 是一种合成抗菌肽,对应于鸡CATH-2的128至153个氨基酸。该化合物对E. coli、S. aureus、S. enteritidis和B. globigii展示出浓度依赖性的活性。CATH-2 (128-153) (40 µM) 可诱导孤立的鸡红细胞溶解,但对孤立的人外周血单个核细胞(PBMCs)无细胞毒性。它能促进化学因子(C-C-基序)配体2 (CCL2)的产生,并抑制LPS诱导的TNF-α、IL-6、IL-8和IL-10在孤立的人PBMCs中的产生。 | |||
T83750 |
Melittin (C-Term Cysteine labeled) TFA
Mel-Cys |
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Melittin (C-term cysteine labeled)是一种衍生自具有细胞毒性的蜂毒肽melittin的衍生物,其在C-末端具有一个半胱氨酸残基。它能够在内体和细胞外pH条件下引发人类红细胞的溶血作用(分别在pH 5.5和7.4时的EC50s为5和6 µM)。Melittin (C-term cysteine labeled)已被用于合成膜溶解性聚合物,这些聚合物已用于体外和体内质粒递送的polyplexes的生成。 | |||
T83706 |
BMAP 28 (bovine) TFA
Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28 |
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BMAP 28是一种合成抗菌肽,对应牛防御素-5的132-158氨基酸。对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)、耐甲氧西林金黄色葡萄球菌(MRSA)、表皮葡萄球菌(S. epidermidis)及白色念珠菌(C. albicans)具有活性(MICs分别为2、2、4、1和8 µM)。在200 nM浓度下,BMAP 28能够使大肠杆菌的内膜渗透。在5 µM浓度下,减少Vero 76细胞中单纯疱疹病毒1型(HSV-1)的复制。在30 µM浓度下,对分离的人类红细胞引起溶血,并对分离的人类嗜中性粒细胞具有细胞毒性。BMAP 28 (0.8 mg/kg)可提高大肠杆菌或MRSA感染的小鼠的生存率,但对铜绿假单胞菌(P. aeruginosa)感染的小鼠无效。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN1438 |
beta-Amyrin acetate
beta-香树脂醇乙酸酯 |
Antioxidant; HMG-CoA Reductase; Epoxide Hydrolase; Antifungal | Metabolism; Microbiology/Virology; oxidation-reduction |
beta-Amyrin acetate 抑制 HMG-CoA 还原酶 (HMGCR) 和 sEH 活性,IC50 为 3.4 μM。 beta-Amyrin acetate 具有抗炎、抗真菌、抗氧化和抗高血脂活性。 | |||
TN6909 |
Polyporusterone B
猪苓酮B,(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one |
Others | Others |
Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) 是一种三萜羧酸,从Polyporus umbellatusFries 中分离得到。它对自由基诱导的红细胞裂解 (溶血) 具有抑制作用。 | |||
TN1256 |
3-O-Acetyl-16α-hydroxytrametenolic acid
3-O-乙酰基-16Α-羟基-氢化松苓酸,3-O-Acetyl-16 alpha-hydroxytrametenolic acid |
Immunology/Inflammation related | Immunology/Inflammation |
3-O-Acetyl-16α-hydroxytrametenolic acid 是茯苓中的一种萜类物质,具有抗氧化、抗癌作用。 | |||
TN1369 |
Alloimperatorin
Prangenidin,别欧前胡素 |
Others | Others |
Alloimperatorin (Prangenidin) 是一种从Angelica dahurica 的提取得到的香豆素类化合物,具有抗肿瘤作用。 | |||
TN6908 |
Polyporusterone A
(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one |
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Polyporusterone A 是一种从 P. umbellatus 的子实体中提取出来的三萜羧酸。Polyporusterone A 抑制自由基诱导的红细胞裂解 (溶血) ,可用于研究头发再生和牛皮癣。 | |||
TN1125 |
Neonuezhenide
|
Antioxidant | oxidation-reduction |
Neonuezhenide 是一种从木犀科植物女贞中分离出来的酚类化合物,对自由基诱导的红血球溶血有较强的抗氧化作用。 | |||
TN1742 |
Homovanillyl alcohol
高香草醇,4-羟基-3-甲氧基苯乙醇 |
TNF; Drug Metabolite | Apoptosis; Metabolism |
Homovanillyl alcohol 是羟基酪醇的生物代谢物。Hydroxytyrosol 是存在于原始橄榄油和葡萄酒中的酚类化合物。它能够保护红细胞免受氧化损伤,并对心血管具有保护作用。 | |||
T3895 |
Polyphyllin I
重楼皂苷I,重楼皂甙 |
Apoptosis; Akt; JNK; PDK; mTOR; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。 | |||
T70891 |
Pyridoxatin
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Pyridoxatin is a fungal metabolite that inhibits production of thiobarbituric acid reactive substance (TBARS). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH and is active against C. albicans. | |||
TN1728 |
Hellebrigenin
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PARP; Akt; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against human HL-60, SF-295, MDA-MB-435, and HCT-8 cancer cell strains without hemolysis of mouse erythrocytes. | |||
T82682 |
Convicine
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Convicine为一种嘧啶糖苷,其与Vicine共同作为糖苷配基Divicine和Isouramil的前体。该化合物是蚕豆病的关键因素——一种因蚕豆摄入而触发的严重溶血遗传性疾病。Convicine能够从蚕豆中提取分离。 |