91
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1155L |
Human growth hormone-releasing factor acetate
|
GHSR | GPCR/G Protein |
Human growth hormone-releasing factor acetate 是一种下丘脑多肽,通过与垂体前叶细胞上的 GHRH 受体 (GHRHR) 结合来刺激 GH 的产生和释放。 | |||
TP1155 |
Human growth hormone-releasing factor
Growth Hormone Releasing Factor human |
||
Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.Growth hormone-releasing hormone is a hormone produced in the hypothalamus. The main role of growth hormo | |||
T17103 |
TM-N1324
|
Others; GHSR | GPCR/G Protein; Others |
TM-N1324 是一种 GPR39 激动剂。 TM-N1324 在没有和存在 Zn2+ 的情况下分别以 280 nM 和 9 nM 的高效率和效力激活人 GPR39。 TM-N1324 对鼠 GPR39 表现出相似的效力,EC50 分别为 180 nM 和 5 nM。 | |||
T4384 |
Halofenozide
|
Others | Others |
Halofenozide 是一种新的昆虫生长调节剂 (IGR),具有苯甲酰肼结构,也是一种蜕皮激素 (ecdysteroid) 激动剂。可模拟天然昆虫蜕皮激素 20-羟基蜕皮激素的作用, | |||
T16044 |
Methoprene
烯虫酯,ZR-515 |
Others | Others |
Methoprene (ZR-515) 是一种保幼激素模拟物和一种生物杀虫剂。Methoprene 作为昆虫生长调节剂,干扰昆虫的生命周期并阻止其成熟或繁殖。 | |||
T4648 |
TC-G-1008
GPR39-C3 |
GHSR | GPCR/G Protein |
TC-G-1008 (GPR39-C3) 是一种口服有活性的 GPR39激动剂,可作用于大鼠受体(EC50: 0.4 nM)和人类受体(EC50:0.8 nM)的。 | |||
T16508 |
PF-5190457
PF-05190457 |
GHSR | GPCR/G Protein |
PF-5190457 是具有选择性的、有效的生长素释放肽受体选择性的反向激动剂(pKi:8.36)。 | |||
TQ0022 |
Capromorelin Tartrate
卡普瑞林酒石酸盐,CP 424391-18 |
GHSR | GPCR/G Protein |
Capromorelin Tartrate (CP 424391-18) 是口服有活性的 growth hormone secretagogue receptor 有效激动剂,能够作用于 hGHS-R1a(Ki:7 nM)。 | |||
TP1035L |
Cyclic somatostatin Acetate(38916-34-6(free base))
Somatostatin (sheep), monoacetate (salt),Somatostatin-14,SRIF-14,monoacetate (salt) |
Others | Others |
Cyclic somatostatin Acetate(38916-34-6(free base)) (Somatostatin-14) 是一种环状十四肽,可调节许多内分泌和神经系统功能。 | |||
T34684 |
Somatotropin (6-13)
Human growth hormone (6-13) |
||
Somatotropin (6-13) is a growth hormone. | |||
T75713 |
Human growth hormone-releasing factor TFA
|
||
Growth Hormone Releasing Factor human TFA 是下丘脑多肽,通过与GHRHR结合,刺激生长激素生成和释放。 | |||
T10319 |
Anamorelin
RC-1291,阿拉莫林,ONO-7643 |
GHSR | GPCR/G Protein |
Anamorelin (ONO-7643) 是新型ghrelin receptor 激动剂,根据FLIPR 检测,得到其EC50=0.74 nM。 | |||
T82322 |
GHRF, mouse
Mouse growth hormone-releasing factor |
||
GHRF, mouse为含44个氨基酸的小鼠生长激素释放肽,能够促进生长激素的释放与合成。 | |||
T7112 |
Ibutamoren Mesylate
MK-0677,伊布莫仑甲磺酸盐,MK-677 |
GHSR | GPCR/G Protein |
Ibutamoren Mesylate (MK-0677) 是非肽段类生长激素促分泌素受体 (GHSR) 激动剂,也是一种口服有活性的生长激素 (GH) 促分泌素。 | |||
TP1035 |
Cyclic somatostatin
SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14 |
Others | Others |
Cyclic somatostatin (SRIF-14) 是生长激素释放抑制因子,可用于研究胃十二指肠溃疡出血。 | |||
T7225 |
AnaMorelin hydrochloride
RC-1291 hydrochloride,阿拉莫林盐酸盐,ONO-7643 hydrochloride |
GHSR | GPCR/G Protein |
AnaMorelin hydrochloride (RC-1291 hydrochloride) 是生长素受体激动剂,根据 FLIPR 检测,得到 EC50=0.74 nM。 | |||
TP2328L |
CJC-1295 acetate(863288-34-0 free base)
DAC:GRF acetate |
GHSR | GPCR/G Protein |
CJC-1295 acetate(863288-34-0 free base) (DAC:GRF acetate) 是生长激素释放激素 (GHRH)(也称为生长激素释放因子 (GRF))和生长激素促分泌素 (GHS) 的合成类似物。 | |||
T34281 |
Relamorelin
BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131 |
GHSR | GPCR/G Protein |
Relamorelin (RM-131)是一种具有选择性和有效性的生长素释放肽/生长激素促分泌素受体 (GHSR) 激动剂,是一种有效的生长素释放肽模拟物,对 GHS-1a 受体具有很高的亲和力。Relamorelin 是一种具有中枢渗透性的五肽,可增加生长激素水平,加速胃排空,具有研究恶病质的潜力。 | |||
TP2236L |
Cortistatin-8 acetate
Cortistatin-8 acetate(485803-62-1 Free base) |
GHSR | GPCR/G Protein |
Cortistatin-8 acetate 是一种皮质抑素类似物,是一种GHS-R拮抗剂,对生长激素促分泌素受体有抑制作用。Cortistatin-8 acetate 是一种合成皮质抑素衍生的生长素释放肽受体配体,不会改变人类对酰化生长素释放肽或海沙瑞林的内分泌反应。 | |||
T2584 |
Octreotide
SMS 201-995,奥曲肽 |
Somatostatin | GPCR/G Protein |
Octreotide (SMS 201-995) 是一种有效的生长激素、胰高血糖素和胰岛素抑制剂。它主要与生长抑素 2、3 和 5 亚型受体结合,可增强 Gi 活性,降低胞内 cAMP 的产生。 | |||
T7809L |
Ipamorelin 2 Pivalic acid
NNC-26-0161 |
Others | Others |
Ipamorelin 2 Pivalic acid (NNC-26-0161) 是一种生长激素释放肽,可诱导大鼠纵向骨生长。 | |||
TP1426 |
His-[D-2-ME-Trp]-Ala
|
Others | Others |
His-[D-2-ME-Trp]-Ala 是生长激素海沙瑞林的一个片段。 | |||
T7815L |
AOD9604 acetate(221231-10-3 free base)
AOD-9604 acetate,AOD9604 acetate,AOD 9604 acetate |
Others | Others |
AOD9604 acetate(221231-10-3 free base) 是一种基于人类生长激素的潜在抗肥胖肽。 | |||
T4119 |
Octreotide Acetate
醋酸奥曲肽,SMS 201995,Longastatin,Sandostatin,SMS 201-995 (acetate) |
Somatostatin | GPCR/G Protein |
Octreotide Acetate (Sandostatin) 是一种长期有效的合成生长抑素八肽类似物,可抑制生长激素的分泌。 | |||
T3630 |
Relugolix
RVT-601,瑞卢戈利,TAK-385 |
GNRH Receptor | GPCR/G Protein |
Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比,它对人和猴子的受体具有高亲和力和强拮抗活性,它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病,如子宫肌瘤、子宫内膜异位症、前列腺癌等。 | |||
T11719 |
JMV 2959 hydrochloride (925238-89-7 free base)
JMV 2959 hydrochloride |
GHSR | GPCR/G Protein |
JMV 2959 hydrochloride (925238-89-7 free base) 是一种生长激素促分泌素受体 1a 型 (GHS-R1a) 拮抗剂,在 LLC-PK1 细胞中的 IC50 为 32±3 nM。 | |||
TP1125 |
Insulin(cattle)
牛胰岛素,Insulin from bovine pancreas,胰岛素 |
IGF-1R | Tyrosine Kinase/Adaptors |
Insulin cattle (Insulin from bovine pancreas) 是一种在胰腺 β 细胞中产生的两链多肽激素,在很多哺乳动物细胞培养体系中用作生长因子。 | |||
T1669 |
Liothyronine sodium
3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,三碘代甲状腺素钠盐,Sodium L-3,3',5-triiodothyronine,Cytomel |
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Liothyronine sodium (3,3',5-Triiodo-L-thyronine sodium) 是甲状腺激素,能够结合并激活 β1 甲状腺激素受体。 | |||
TP1570 |
Cortistatin-14
|
Somatostatin | GPCR/G Protein |
Cortistatin-14 是一种与生长抑素-14结构相似的神经肽,具有抗惊厥和神经保护作用,通过激活 sst(2)、生长素释放肽和 GABA(A/B) 受体损害小鼠的识别记忆巩固,可用于研究脓毒症引发的认知障碍。 | |||
T1167 |
Cyproterone acetate
Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮 |
Androgen Receptor | Endocrinology/Hormones |
Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。 | |||
T11798 |
L-692429
MK-0751 |
GHSR; GPCR19 | GPCR/G Protein |
L-692429 (MK-0751) 是一种有效的非肽基生长激素促分泌素 (GHS) 激动剂,是一种苯并内酰胺的衍生物,可逆转糖皮质激素对 GH 分泌的抑制。L-692429 对 G 蛋白偶联受体 (G protein-coupled receptor)具有很高的亲和力,可用于研究肢端肥大症和肥胖。 | |||
T28812 |
SM-130686
SM 130686,SM130,686,SM 130,686 |
||
SM-130,686 is a potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and growth hormone secretagogue. It has around half the potency of the endogenous agonist ghrelin as a stimulator of growth hormone release. | |||
T32507 |
L-739943
L 739943,L739943 |
||
L-739943 is a growth hormone secretagogue. | |||
T36377 |
Somatorelin (1-44) amide (human) (trifluoroacetate salt)
|
||
Somatorelin (1-44) amide is a synthetic peptide that corresponds to the full 44-amino acid sequence of growth hormone-releasing hormone (GHRH), a hormone that stimulates the production of growth hormone from the pituitary gland and is involved in the regulation of cell proliferation and differentiation.1,2Somatorelin induces growth hormone release similarly to GHRHin vitroandin vivo.1 | |||
T32435 |
L 163255
L-163255,L163255,L163,255,L-163,255,L 163,255 |
||
L 163255 is a type of growth hormone secretagogue (GHS). | |||
T5025L2 |
Pralmorelin HCl
WAY-GPA 748,WAY-GPA-748 WAY-GPA748,Pralmorelin dihydrochloride |
||
Pralmorelin HCl is regarded as a Growth Hormone Releasing Factor. | |||
T26295 |
Trioxifene mesylate
LY 133314,LY-133314,LY133314 |
||
Trioxifene mesylate is an antiestrogen that suppresses growth hormone secretion. | |||
T31734 |
BMS-604992
EX1314,EX-1314 HCl,EX-1314,BMS604992,EX-1314 hydrochloride, BMS-604992,EX 1314 |
||
EX-1314 (BMS-604992) is a growth hormone secretagogue receptor (GHSR) agonist. | |||
T19567 | Substituted piperidines-1 | Others | Others |
Substituted piperidines-1 can promote the release of growth hormone in humans and animals. | |||
T76318 |
GHRF, porcine
|
||
GHRF, porcine 是一种生长激素释放激素 (GHRH) 多肽 (porcine)。GHRF, porcine 与 GHRHR 受体结合并促进生长激素的释放。 | |||
T76317 |
[His1,Nle27] GHRF (1-32), amide, human
|
||
[His1,Nle27] GHRF (1-32), amide, human为一种生长激素释放激素(GHRH)类似物,对GHRHR受体具有较好的亲和力。 | |||
T32499 |
L-692429 HCl
L692,429,L-692429,L 692429,L-692,429,L692429,L 692,429 |
||
L-692,429 is a novel non-peptide growth hormone secretagin. | |||
T11719L |
JMV 2959
|
Others | Others |
JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM). | |||
TP1302 |
Somatostatin
|
||
Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and | |||
T70634 | Psycholeine | ||
Psycholeine is isolated from the tropical plant Psychotria oleoides; exhibits somatostatin antagonistic activity on growth hormone secretion. | |||
T2584L1 |
Octreotide HCl
Octreotide hydrochloride, (-)-,Octreotide hydrochloride |
||
Octreotide HCl is a potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits the secretion of growth hormone. | |||
T35793 |
JMV3002
JMV3002 |
||
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. At 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when test... | |||
TNU0430 | N6-(p-Methoxybenzyl)adenosine | ||
Nucleoside Derivatives - 6-Modified purine nucleosides; Drugs and Inhibitors; plant growth regulator, plant hormone | |||
T75157L |
Cimdelirsen sodium
|
||
Cimdelirsen (sodium) 为针对肝脏的反义寡核苷酸,通过减少生长激素受体(GHr)合成,抑制生长激素(GH)的过度分泌效应,进而降低肢端肥大症患者体内循环胰岛素样生长因子-1 (IGF-1)水平。 | |||
T78039 |
Acetyl-(D-Arg2)-GRF (1-29) amide (human)
|
||
Acetyl-(D-Arg2)-GRF (1-29) amide (human) 是一种针对人体的生长激素释放因子(GRF)拮抗剂,其主要作用是抑制生长激素(GH)的释放,广泛应用于内分泌学领域的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20945 |
2,4-D
Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2,4-Dichlorophenoxyacetic acid (Hedonal) 是一种合成生长素,用作植物生长调节剂,也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分,用于破坏肌动蛋白细胞骨架,以控制根系伸长和细胞生成。 | |||
T7931 |
16a,17a-Epoxy-4-Pregnen-3,20-Dione
|
Others | Others |
16a,17a-Epoxy-4-Pregnen-3,20-Dione 是一种合成孕激素,是黄体酮激素的代谢产物,它通过与黄体酮受体结合发挥作用,已被用于研究孕激素对生殖器官的影响,激素对细胞生长和发育的影响,以及激素对免疫系统的影响。 | |||
T2O2791 |
3-Indoleacetic acid
3-IAA,Indole-3-acetic acid,1H-Indole-3-acetic acid,3-吲哚乙酸,indolylacetic acid,IAA,indoleacetic acid |
Others; Endogenous Metabolite | Metabolism; Others |
3-Indoleacetic acid (indolylacetic acid) 是常见的天然植物生长激素。它可以诱导植物细胞的伸长和分裂。 | |||
TMS2181 |
trans-Zeatin
(E)-Zeatin,玉米素 |
ERK; MEK; Endogenous Metabolite | MAPK; Metabolism |
trans-Zeatin ((E)-Zeatin) 是植物细胞分裂素,可抑制紫外线诱导的MEK/ERK 的活化,在细胞生长、分化和分裂中起着重要的作用。 | |||
T3S0507 |
Homovanillic acid
Homovaniuic acid,Vanilacetic acid,高香草酸,Vanillacetic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Homovanillic acid (Vanillacetic acid) 是一种多巴胺代谢物,它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。 | |||
T7990 |
9-hydroxy-4-androstene-3,17-dione
|
Others | Others |
9-hydroxy-4-androstene-3,17-dione 是一种类固醇激素,具有抗肿瘤活性,可以抑制多种癌症细胞的生长,包括乳腺癌、前列腺癌和肺癌细胞。 | |||
T3O2749 |
L-Leucine
(S)-Leucine,Leu,L-亮氨酸,亮氨酸 |
mTOR | PI3K/Akt/mTOR signaling |
L-Leucine ((S)-Leucine) 是必需的支链氨基酸,能够激活 mTOR 信号通路。 | |||
T4939 |
Indole-3-pyruvic acid
3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid |
Others | Others |
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物,Indole-3-acetic acid 是一种植物激素,在调节生长和对环境变化的反应中起重要作用。 | |||
T5088 |
3-Indoleacetic acid sodium
Indole-3-Acetic Acid sodium salt,Sodium 2-(1H-indol-3-yl)acetate,IAA sodium salt,吲哚乙酸钠,Heteroauxin sodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
3-Indoleacetic acid sodium (Heteroauxin sodium salt) 是一种天然存在的植物生长素类激素。能刺激细胞伸长和分裂,促进植物生长发育。然而,高浓度时,它表现出生长抑制作用,包括生长和阻止茎和根的生长。后一种效应形成了合成生长素被开发为农业除草剂和生物调节剂的基础。 | |||
T6368 |
Abscisic Acid
Abscisin II,Dormin,(+)-脱落酸,(+)-ABA,Abscisic Acid (Dormin) |
Others; Proton pump; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Others |
Abscisic Acid (Dormin) 是具有口服活性的植物激素,存在于蔬菜和水果中,也是内源性的哺乳动物激素。它是生长抑制剂,可以调节植物生长发育。他抑制质子泵,并导致 Ca2+依赖性的质膜去极化。它是 LANCL2 的天然配体,属于胰岛素敏感化合物,在糖尿病前期,2 型糖尿病和代谢综合征的研究中具有价值。 | |||
T3S0860 |
Gitogenin
|
UGT | Metabolism |
Gitogenin 是一种从Tribulus longipetalus 整株中分离出来的天然类固醇,是一种 UDP-葡萄糖醛酸转移酶 1A4 (UGT1A4) 和 α-葡萄糖苷酶的选择性抑制剂,其IC50分别为 0.69 µM (使用三氟拉嗪为底物) 和 37.2 μM,对人类主要细胞色素 P450 亚型的活性无抑制作用。 | |||
T80006 |
Emoghrelin
|
GHSR | GPCR/G Protein |
Emoghrelin是一种从Polygonum multiflorum(何首乌)提取的化合物,能够通过激活生长素释放肽受体来刺激生长激素的分泌。 | |||
T82277 | GM1a Ganglioside oligosaccharide | ||
GM1a Ganglioside oligosaccharide为ganglioside GM1的半合成形式,后者作为霍乱毒素的天然受体,在生长调节及激素诱导反应的耦合中具有关键功能。 | |||
T32326 |
Juvabione
|
||
Juvabione is the methyl ester of todomatuic acid, both of which are sesquiterpenes (C15) found in the wood of true firs of the genus Abies. They exist as part of a mixture of sesquiterpenes based on the bisabolane scaffold. Sesquiterpenes of this family, |