首页工具

登录

搜索结果

Search Results for " cognition "

41

抑制剂 & 化合物

4

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T27475	GSK356278 GSK-356278,GSK 356278	PDE	Metabolism
	GSK356278 是一种有效的特异性磷酸二酯酶 4 (PDE4) 抑制剂，对人 PDE4A、PDE4B 和 PDE4D 的 pIC50 分别为 8.6、8.8 和 8.7。 GSK356278 具有抗炎、抗焦虑和增强认知的作用。
TQ0046	Bavisant JNJ-31001074	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bavisant (JNJ-31001074) 是一种特异性和口服活性的人 H3 受体拮抗剂。 Bavisant 可用于作用机制的研究，包括觉醒和认知以及 ADHD 的治疗。
T23256	RS-25344 hydrochloride	PDE	Metabolism
	RS 25344 hydrochloride 是 cAMP-磷酸二酯酶 4 的选择性抑制剂，在人淋巴细胞中的 IC50为 0.28 nM，对 PDE I、II、III 仅具有微弱的抑制作用，IC50分别为 >100 μM、160 μM、330 μM。它具有抗炎、增强记忆力和认知能力以及抗肿瘤活性。
T15758	Linopirdine 利诺吡啶,DuP 996	Potassium Channel; TRP/TRPV Channel	Membrane transporter/Ion channel
	Linopirdine (DuP 996) 是一种口服有效的，选择性 M 型 K+电流 (IM；Kv7；KCNQ Channels) 抑制剂，IC50为 2.4 μM。Linopirdine 是TRPV1激活剂。Linopirdine 是一种公认的认知增强药物，可增加大鼠脑组织中乙酰胆碱的释放。
T2663	GTS-21 dihydrochloride GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂，具有抗炎和增强认知的活性。它也是一种拮抗剂，对人α4β2的 Ki 为20 nM，对5-HT3A 受体的 IC50为3.1 μM。
TP1117	IFN-α Receptor Recognition Peptide 1 IRRP1
	IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions.
T8725	A 582941 HCl (848591-90-2(free base))	AChR	Neuroscience
	A 582941 HCl (848591-90-2(free base)) 是一种具有广谱认知增强特性的 alpha7 神经元烟碱受体激动剂。
T28722	SCH 57790 SCH57790,SCH-57790	AChR	Neuroscience
	SCH 57790 是一种新型且具有选择性的毒蕈碱 M（2）受体拮抗剂，可释放乙酰胆碱并增强实验动物的认知能力，可用于治疗阿尔茨海默病。
T16881	SIB-1553A hydrochloride	AChR	Neuroscience
	SIB-1553A hydrochloride 是一种可口服且具有选择性的烟碱乙酰胆碱受体激动剂，还是一种选择性神经元 nAChR 配体。SIB-1553A hydrochloride 可增强认知，可用于研究阿尔茨海默病和认知障碍。
T28531	Facinicline hydrochloride RG3487	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	Facinicline hydrochloride (RG3487) 是一种口服有效的烟碱α7 receptor 部分激动剂，对人 nAChR 的 Ki 值为 6 nM。它可改善啮齿类动物的认知和感觉运动门控。它与5-HT3受体结合的 Ki 为 1.2 nM。
T1401	Meclofenoxate hydrochloride Meclofenoxate (Centrophenoxine) HCl,Lucidril,盐酸甲氯芬酯,Cerutil,盐酸甲氯酚酯,Meclofenoxate HCl	Lipoxygenase; COX; AChR; iGluR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Meclofenoxate hydrochloride (Lucidril) 是二甲基氨基乙醇和对氯苯氧乙酸的酯，有刺激记忆和提高认知的活性。
T8720	PRX-07034 hydrochloride PRX-07034	5-HT Receptor	GPCR/G Protein; Neuroscience
	PRX-07034 hydrochloride 是一种有效的高度选择性5-HT6受体拮抗剂，Ki 为 4-8 nM，IC50为 19 nM，可用于增强工作记忆和认知灵活性的研究。
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T5051	Isopropamide Iodide	AChR	Neuroscience
	Isopropamide iodide 是长效季铵盐抗胆碱能药物。它用于研究消化性溃疡和其他胃肠道疾病，尤其是胃酸过多和运动过度。
T32191	Irdabisant CEP-26401,CEP 26401,CEP26401	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Irdabisant (CEP-26401) 是选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂。Irdabisant 显示人 H3R 和大鼠 H3R 的 Ki 分别为 2.0 nM 和 7.2 nM。Irdabisant 抑制 hERG 电流的活性相对较低 (IC50= 13.8 μM)。在大鼠社会认知模型中，Irdabisant 具有认知增强和唤醒作用。Irdabisant 可用于研究精神分裂症或认知障碍。
T10093L	E1R	Others	Others
	E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity.
T70283	SK 946
	SK 946 is a cognition activator.
T69226	A-688057
	A-688057 is an H3 antagonist/inverse agonist that may play a role in cognition.
T23584	5a 5a Series 1,Compund 5a
	5a is an agonist of 5-HT4R partial. It displayed cognition-enhancing properties in animal models.
T12665	(Rac)-E1R	Others	Others
	(Rac)-E1R is the racemate of E1R. (Rac)-E1R is a sigma-1 receptor positive allosteric (Sig1R PAM) modulator of for the treatment of cognition/memory disorders.
T38610	Pirepemat IRL752
	Pirepemat (IRL752) is a cortical-preferring catecholamine agent that enhances cognition. It is utilized in the investigation of Parkinson's disease.
T69328	A-320436
	A-320436 is an H3 receptor antagonist that may affect cognition.
T25525	IDT
	IDT is an orally active TNFα modulator. It acts by altering neutrophil infiltration, improving cognition and diminishing tau and amyloid pathology in the 3xTgAD mouse model.
T10097	(2S,3S)-E1R	Others	Others
	(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator for the treatment of cognition/memory disorders.
T10094	(2R,3S)-E1R	Others	Others
	(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator for the treatment of cognition/memory disorders.
T26691	AVN-322 AVN 322
	AVN-322 is a 5-HT6 receptor antagonist. 5-HT6R antagonists improves cognition in animal models of cognitive impairment.
T23809	BMT-108908 BMT108908
	BMT-108908 is a Negative Allosteric Modulator. It is selective for the NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains.
T26862	BMS-902483
	BMS-902483 is a potent α7 partial agonist. BMS-902483 improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm.
T68135	sabcomeline SB-202026,SB-202026 ; Memric,Memric
	Sabcomeline 是一种有效的功能性选择性 M1 毒蕈碱受体受体 (muscarinic M1 receptor) 部分激动剂，可以改善认知功能。Sabcomeline 可用于阿尔茨海默症的研究。
T10462	Bavisant dihydrochloride	Others	Others
	Bavisant (JNJ-310010740) dihydrochloride is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition.
T10093	(2R,3R)-E1R	Others	Others
	(2R,3R)-E1R is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator for the treatment of cognition/memory disorders.
T70772	Milameline CI-979,CI-979 ; RU35926,RU35926
	Milameline 是一种改善认知的毒蕈碱受体激动剂。
T19628	GSK 189254 HCl GSK-189254A,GSK 189254A,GSK 189254 hydrochloride,GSK189254A
	GSK 189254A is a histamine H3 receptor antagonist for the treatment of narcolepsy. Histamine H3 receptor antagonists have been shown to increase the release of neurotransmitters in the brain and to enhance cognition in vivo. The compound may also be usefu
T69595	Ispronicline hemigalactarate
	Ispronicline, also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potentially useful for the treatment of attention-deficit/hyperactivity disorder in adults.
T60950	Pirepemat fumarate
	Pirepemat (IRL752) fumarate 可用于研究帕金森病。Pireemat fumarate 是一种偏向皮质的儿茶酚胺传递剂和认知促进剂。
T68655	PAN12314
	PAN12314, also known as Compound 5a, is a 5-HT4R partial agonists that displayed cognition-enhancing properties in animal models. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T10462L	Bavisant dihydrochloride hydrate JNJ31001074AAC	Others	Others
	Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. in vivo: Mean change
T26366L	Prasterone sulfate sodium hydrate Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate
	Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working me
T79333	LZWL02003	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	LZWL02003为抗神经炎症化合物，对MPP+引起的神经元损害展示保护效果，有效降低ROS水平。此外，LZWL02003能改善鱼藤酮诱导的帕金森病(PD)大鼠模型在认知、记忆、学习及运动能力方面的缺陷。该化合物在神经退行性疾病的研究中具有应用潜力。
T61197	Irdabisant hydrochloride
	Irdabisant (CEP-26401) hydrochloride 是一种选择性、口服活性的组胺H3受体拮抗剂/逆激动剂，具备良好的血脑屏障渗透性。该化合物对大鼠和人类的H3受体具有高亲和力，其Ki值分别为7.2 nM和2.0 nM。此外，Irdabisant hydrochloride在抑制hERG电流方面表现出较低的活性，IC50为13.8 μM。在大鼠社会认知模型中，它展现了认知增强和唤醒的效果，可作为精神分裂症或认知障碍研究的潜在工具。
T36521	Alaproclate (hydrochloride)
	Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio...

化合物

Cat.No: T27475

Synonym: GSK-356278,GSK 356278

Target: PDE

Cat.No: TQ0046

Synonym: JNJ-31001074

Target: Histamine Receptor

RS-25344 hydrochloride

Cat.No: T23256

Target: PDE

Cat.No: T15758

Synonym: 利诺吡啶,DuP 996

Target: Potassium Channel, TRP/TRPV Channel

GTS-21 dihydrochloride

Cat.No: T2663

Synonym: GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine

Target: 5-HT Receptor, AChR

IFN-α Receptor Recognition Peptide 1

Cat.No: TP1117

Synonym: IRRP1

A 582941 HCl (848591-90-2(free base))

Cat.No: T8725

Target: AChR

Cat.No: T28722

Synonym: SCH57790,SCH-57790

Target: AChR

SIB-1553A hydrochloride

Cat.No: T16881

Target: AChR

Facinicline hydrochloride

Cat.No: T28531

Synonym: RG3487

Target: 5-HT Receptor, AChR

Meclofenoxate hydrochloride

Cat.No: T1401

Synonym: Meclofenoxate (Centrophenoxine) HCl,Lucidril,盐酸甲氯芬酯,Cerutil,盐酸甲氯酚酯,Meclofenoxate HCl

Target: Lipoxygenase, COX, AChR, iGluR

PRX-07034 hydrochloride

Cat.No: T8720

Synonym: PRX-07034

Target: 5-HT Receptor

Cat.No: T38192

Target: Others

Isopropamide Iodide

Cat.No: T5051

Target: AChR

Cat.No: T32191

Synonym: CEP-26401,CEP 26401,CEP26401

Target: Histamine Receptor

Cat.No: T10093L

Target: Others

Cat.No: T70283

Cat.No: T69226

Cat.No: T23584

Synonym: 5a Series 1,Compund 5a

Cat.No: T12665

Target: Others

Cat.No: T38610

Synonym: IRL752

Cat.No: T69328

Cat.No: T25525

Cat.No: T10097

Target: Others

Cat.No: T10094

Target: Others

Cat.No: T26691

Synonym: AVN 322

Cat.No: T23809

Synonym: BMT108908

Cat.No: T26862

Cat.No: T68135

Synonym: SB-202026,SB-202026 ; Memric,Memric

Bavisant dihydrochloride

Cat.No: T10462

Target: Others

Cat.No: T10093

Target: Others

Cat.No: T70772

Synonym: CI-979,CI-979 ; RU35926,RU35926

Cat.No: T19628

Synonym: GSK-189254A,GSK 189254A,GSK 189254 hydrochloride,GSK189254A

Ispronicline hemigalactarate

Cat.No: T69595

Pirepemat fumarate

Cat.No: T60950

Cat.No: T68655

Bavisant dihydrochloride hydrate

Cat.No: T10462L

Synonym: JNJ31001074AAC

Target: Others

Prasterone sulfate sodium hydrate

Cat.No: T26366L

Synonym: Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate

Cat.No: T79333

Target: Reactive Oxygen Species

Irdabisant hydrochloride

Cat.No: T61197

Alaproclate (hydrochloride)

Cat.No: T36521

Cat. No.	Product Name	Target	Signaling Pathways
T2230	Paeoniflorin 芍药苷,Peoniflorin	HSP; COX	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
	Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷，具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂，通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
T3344	Ciwujianoside B yemuoside YM,刺五加皂苷 B,acanthopanax senticosides B,刺五加皂甙 B,Ciwujianoside-B	BCL; Others	Apoptosis; Others
	Ciwujianoside B (acanthopanax senticosides B) 是刺五加的主要成分，能缓解疲劳，增强记忆力，提高人的认知能力。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T13143	Theogallin 3-Galloylquinic acid	Others	Others
	Theogallin is an active ingredient in decaffeinated green tea extract, has cognition enhancing effect and antidepressive.

天然产物

Cat.No: T2230

Synonym: 芍药苷,Peoniflorin

Target: HSP, COX

Ciwujianoside B

Cat.No: T3344

Synonym: yemuoside YM,刺五加皂苷 B,acanthopanax senticosides B,刺五加皂甙 B,Ciwujianoside-B

Target: BCL, Others

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Cat.No: T13143

Synonym: 3-Galloylquinic acid

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼