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19

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19399	L-Ornithine L-aspartate Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸	Others	Others
	L-Ornithine L-aspartate (Ornithine Aspartate) 由鸟氨酸和天冬氨酸组成。它能够减少血氨浓度，并消除与肝硬化相关的肝性脑病的症状。
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T3611	Sodium Glucuronic Acid 葡醛酸钠,Sodium Glucoronic,4-FLUOROCINNAMONITRILE	Others	Others
	Sodium Glucuronic Acid (4-FLUOROCINNAMONITRILE) 用于治疗肝炎和肝硬化。
T60226	CT52923	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	CT52923 is a selective, orally active antagonist of platelet-derived growth factor receptor (PDGFR), functioning as an ATP-competitive inhibitor. It has versatile applications for researching an array of pathological diseases such as atherosclerosis, glomerulonephritis, liver cirrhosis, pulmonary fibrosis, and cancer.
T6576	Malotilate Malotilatum,NKK 105,马洛替酯,Kantec	Lipoxygenase	Metabolism
	Malotilate (Kantec) 是一种抗纤维化物质，是一种口服活性的促肝药，可选择性抑制5-lipoxygenase (5-LOX)(IC50=4.7 μM)。它通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中，从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。
T6993	Tauroursodeoxycholate sodium 牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC)	Apoptosis; ERK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	Tauroursodeoxycholate sodium (TUDC) 是一种内质网应激抑制剂。Tauroursodeoxycholate sodium (TUDC) 抑制ERK，显著降低凋亡分子表达，如caspase-3和caspase-12。
T63751	Selvigaltin GB1211	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Selvigaltin (GB1211) 是一种具有口服活性的口服半乳糖凝集素-3 (Gal-3)抑制剂，具有潜在的抗癌活性。Selvigaltin 可用于研究肝硬化和癌症。
T73446	BI‑3231	Dehydrogenase	Metabolism
	BI‑3231 是一种具有选择性和高效性的羟基类固醇 17ß-脱氢酶 13 HSD17B13 抑制剂，抑制 hHSD17B13 和 mHSD17B13。BI‑3231 可用于研究酒精相关肝损伤、纤维化和肝硬化。
T62882	Ezurpimtrostat hydrochloride
	Ezurpimtrostat hydrochloride (compound 2-3) 是一种口服具有活力的抗纤维化剂，可以显著减少 DEN (二乙基亚硝胺) 肝硬化大鼠的肝纤维化。Ezurpimtrostat hydrochloride 能够用于研究纤维化、癌症、自噬和CTSB、CTSL 和 CTSD 相关疾病。
T76700	Simtuzumab GS 6624,AB 0024	Monoamine Oxidase	Neuroscience
	Simtuzumab 是一种针对赖氨酰氧化酶样蛋白 2 (LOXL2) 的单克隆抗体。Simtuzumab 可用于治疗原发性硬化性胆管炎 (PSC)，对非酒精性脂肪性肝炎引起的桥接性纤维化或代偿性肝硬化患者无效。
T28664	Satavaptan SR121463,SR 121463,SR-121463
	Satavaptan is a vasopressin V2 receptor antagonist. Satavaptan improves the control of ascites in cirrhosis.
T34773	TAK-044 TAK044
	TAK-044 is an endotheliin receptor antagonist that prevents and reverses the development of carbon tetrachloride induced cirrhosis in rats. TAK-044 showed a protective effect on neuronal activity in vitro hypoxic glucose deprivation model of stroke.
T34107	Polythiazide P2525,NSC-108161,NSC 108161,P-2525,NSC108161
	Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication.
T37846	Taurohyocholic Acid (sodium salt)
	Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.3THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4
T80270	Invopressin OCE-205	Vasopressin Receptor	GPCR/G Protein
	Invopressin (Compound 42)，一种vasopressin V1A 受体部分激动剂（EC50: 1.0 nM），主要应用于肝硬化相关症状如细菌性腹膜炎、HRS2 及难治性腹水的研究。
T73155	BMS-986339
	BMS-986339 是一种具有口服活性的FXR 激动剂。BMS-986339 可与 His298 和 ASN287 残基形成氢键。BMS-986339 可用于原发性胆汁性肝硬化 (PBC)、原发性硬化性胆管炎 (PSC)、非酒精性脂肪性肝炎 (NASH)，和抗纤维化研究。
T16376	Odevixibat A4250	Others	Others
	Odevixibat (A4250) (A4250) 是一种有效的选择性回肠胆汁酸转运蛋白 (IBAT) 抑制剂。Odevixibat (A4250) 可减轻小鼠模型中的胆汁淤积性肝和胆管损伤。Odevixibat (A4250)可用于原发性胆汁性肝硬化的研究。
T69133	Etozolin HCl
	Etozolin HCl is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vascular tone but inhibited noradrenaline- and histamine-induced contractions. Dexetozoline has a very high bioavailability after oral administration and is fairly lipohilic. The half-life of etozolin is 2.5 h. Dexetozoline accumulates in cirrhosis.
T65387	Paromomycin, sulfate (1:1)
	Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10...

化合物

L-Ornithine L-aspartate

Cat.No: T19399

Synonym: Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸

Target: Others

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Sodium Glucuronic Acid

Cat.No: T3611

Synonym: 葡醛酸钠,Sodium Glucoronic,4-FLUOROCINNAMONITRILE

Target: Others

Cat.No: T60226

Target: PDGFR

Cat.No: T6576

Synonym: Malotilatum,NKK 105,马洛替酯,Kantec

Target: Lipoxygenase

Tauroursodeoxycholate sodium

Cat.No: T6993

Synonym: 牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC)

Target: Apoptosis, ERK, Caspase

Cat.No: T63751

Synonym: GB1211

Target: Neuropeptide Y Receptor

Cat.No: T73446

Target: Dehydrogenase

Ezurpimtrostat hydrochloride

Cat.No: T62882

Cat.No: T76700

Synonym: GS 6624,AB 0024

Target: Monoamine Oxidase

Cat.No: T28664

Synonym: SR121463,SR 121463,SR-121463

Cat.No: T34773

Synonym: TAK044

Cat.No: T34107

Synonym: P2525,NSC-108161,NSC 108161,P-2525,NSC108161

Taurohyocholic Acid (sodium salt)

Cat.No: T37846

Cat.No: T80270

Synonym: OCE-205

Target: Vasopressin Receptor

Cat.No: T73155

Cat.No: T16376

Synonym: A4250

Target: Others

Cat.No: T69133

Paromomycin, sulfate (1:1)

Cat.No: T65387

Cat. No.	Product Name	Target	Signaling Pathways
T8117	Metenolone acetate Methenolone acetate,美替诺龙醋酸酯	Others; Androgen Receptor	Endocrinology/Hormones; Others
	Metenolone acetate (Methenolone acetate) 是一种合成代谢类固醇(AAS) 药物，是一种雄激素，主要用于治疗由于骨髓衰竭引起的贫血。
T5233	N-Methylnicotinamide N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺	Others; Endogenous Metabolite	Metabolism; Others
	N-Methylnicotinamide (Nicotinic Acid Methylamide) 是内源性代谢产物的一种。
T2532	Tauroursodeoxycholate Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis; ERK; P450; Caspase; Endogenous Metabolite	Apoptosis; MAPK; Metabolism; Proteases/Proteasome
	Tauroursodeoxycholate (UR 906)，又称 ursodoxicoltaurine，是一种高度亲水性的三级胆汁酸，在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式，而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病，如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
T37177	Norcholic Acid
	Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4
T7475	S-Adenosyl-L-methionine AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸	Others; Endogenous Metabolite	Metabolism; Others
	S-Adenosyl-L-methionine (Ademetionine) 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂，是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的口服具有活力的甲基供体，能够用于肝病和骨关节炎的研究。

天然产物

Metenolone acetate

Cat.No: T8117

Synonym: Methenolone acetate,美替诺龙醋酸酯

Target: Others, Androgen Receptor

N-Methylnicotinamide

Cat.No: T5233

Synonym: N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺

Target: Others, Endogenous Metabolite

Tauroursodeoxycholate

Cat.No: T2532

Synonym: Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA

Target: Apoptosis, ERK, P450, Caspase, Endogenous Metabolite

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Cat.No: T37177

S-Adenosyl-L-methionine

Cat.No: T7475

Synonym: AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸

Target: Others, Endogenous Metabolite

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