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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11722 |
JNJ-37822681 dihydrochloride
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的,可快速解离的多巴胺 D2受体拮抗剂,与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。 | |||
T1602 |
Valproic acid sodium salt
丙戊酸钠,Sodium Valproate |
Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells |
Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂,可抑制HDAC1的活性,诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。 | |||
T6474 |
Divalproex Sodium
Valproate semisodium,Epival,双丙戊酸钠 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶,其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成,具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。 | |||
T2342 |
Raxatrigine
CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802 |
Sodium Channel | Membrane transporter/Ion channel |
Raxatrigine (CNV 1014802) 是有效的钠离子通道 Nav1.7抑制剂。 | |||
T28809 |
SLV-310
SLV 310,SLV310 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
SLV-310 是一种强效的多巴胺 D2 受体拮抗剂和 5-HT 再摄取受体抑制剂,可用于研究躁郁症和精神分裂症等神经系统疾病。 | |||
T32633 |
Lensiprazine
SLV314,SLV-314,SLV 314 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Lensiprazine (SLV314)是一种有效的多巴胺 D(2)受体拮抗剂,可作为一种血清素再摄取抑制剂 ,可用于研究躁郁症和精神分裂症。 | |||
T1951 |
Asenapine Maleate
Org 5222 maleate,Org 5222,马来酸阿塞那平,阿塞那平马来酸盐 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Asenapine Maleate (Org 5222 maleate) 是5-HT 和D2的拮抗剂,Ki 值分别为 0.03-4.0 nM, 1.3 nM。它也是抗精神病药物,用于治疗与双相 1 型障碍相关的精神分裂症和躁狂或混合发作。 | |||
T1735 |
Lurasidone hydrochloride
Lurasidone HCl,SM-13496 (Hydrochloride),盐酸鲁拉西酮,SM-13496 |
Dopamine Receptor; 5-HT Receptor; Norepinephrine | GPCR/G Protein; Neuroscience |
Lurasidone hydrochloride (Lurasidone HCl) 是多巴胺 D2和5-HT7的拮抗剂,IC50值分别为 1.68 和 0.495 nM,用于治疗精神分裂症和双相情感障碍。它也是5-HT1A 受体的部分激动剂,IC50值为 6.75 nM。 | |||
T0162 |
Quetiapine
ICI204636,Quetiapin,喹硫平 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Quetiapine (ICI204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂,对人5-HT1A 的 pEC50值为 4.77,对人 D2的 pIC50值为 6.33。它用于治疗精神分裂症,以及治疗与 I 型双相情感障碍相关的急性躁狂发作。它对人 D2、HT1、5-HT2A、5-HT2C 受体具有中高等亲和力,pKi 值为 7.25、5.74、7.54和5.55。 | |||
T30131 |
Aripiprazole cavoxil
|
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Aripiprazole cavoxil is used in Treatment of Schizophrenia, Bipolar Disorder, and Clinical Depression. | |||
T22589 | Asenapine hydrochloride | Others | Others |
Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder. | |||
T68706 |
Olanzapine HCl
|
||
Olanzapine HCl is an atypical antipsychotic. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder. Olanzapine is structurally similar to clozapine and quetiapine. It is a dopamine antagonist and is classified as a thienobenzodiazepine. | |||
T70964 |
Olanzapine/Samidorphan
|
||
Olanzapine/Samidorphan is a combination of olanzapine and the opioid receptor antagonist samidorphan is under development for the treatment of schizophrenia and bipolar I disorder. The single-tablet combination treatment is intended to provide the efficacy of olanzapine while mitigating olanzapine-associated weight gain. | |||
T61804 | GSK-3β inhibitor 6 | ||
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1]. | |||
T63129 |
Asenapine citrate
|
||
Asenapine citrate 是非典型抗精神药物,是一种 5-羟色胺受体 (pKi: 8.4-10.5)、肾上腺素受体 (、pKi: 8.9-9.5)、多巴胺受体 (pKi: 8.9-9.4) 和组胺受体 (pKi: 8.2-9.0) 多种受体的拮抗剂。Asenapine citrate 能够用于研究精神分裂症和双相情感障碍。 | |||
T63866 | GSK-3β inhibitor 7 | ||
GSK-3β inhibitor 7 是一种 GSK-3β 抑制剂 (IC50: 5.25 μM)。GSK-3β inhibitor 7 通过插入 GSK-3β 的 ATP-binding binding 口袋并形成氢键发挥作用。GSK-3β inhibitor 7 具有较高的肝细胞葡萄糖摄取率 (83.5%),能够用于研究癌症、糖尿病、炎症、阿尔茨海默病和双相情感障碍等多种疾病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7064 |
Valproic Acid
Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid |
Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells |
Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂,可抑制 HDAC1 活性,诱导 HDAC2 降解,具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。 |