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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T82890	bFGF (119-126)
	bFGF (119-126) 为具备生物活性的肽段，对应人类、牛(119-126)、小鼠、大鼠(118-125)以及肝素结合生长因子2(118-125)的相应残基。该肽能够抑制bFGF受体的二聚化及其激活作用。
T1843	XMD8-92	ERK; BMI-1; Epigenetic Reader Domain	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK
	XMD8-92 是 ERK5 (BMK1)/BRD4的有效抑制剂，Kd 分别为80和190 nM。它抑制 DCAMKL2、PLK4 和 TNK1的 Kd 分别为190、600和890nm，具有抗癌活性。
T3714	SUN11602 SUN 11602	ERK; FGFR	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	SUN11602 是新型的碱性苯胺化合物，具有成纤维细胞生长因子特性。
T10870L	CP-547632	VEGFR; FGFR; PDGFR; BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	CP-547632是一种可口服且具有有效性、ATP 竞争性的血管内皮生长因子受体2（VEGFR-2 ）和碱性成纤维细胞生长因子（FGF）激酶F 双重抑制剂，IC50 分别为 11 nM 和 9 nM。CP-547632具有选择性，对 VEGFR2 和 bFGF 的选择性高于 EGFR，PDGFRβ 和相关的酪氨酸激酶 (TKs) 。 CP-547632具有抗肿瘤活性。
T2160	Suramin Sodium Salt 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060	Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K，是抗寄生虫，抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂，也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。
T37820	Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)
	Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF. bFGF is a peptide produced in bovine brain that is protective in a rat model of pressure-induced retinal ischemia. bFGF (1-24) corresponds to amino acid residues 1-24 of the full length peptide.
T67442	CGP-53716
	The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase inhibition has been shown to be effective in blocking tyrosine phosphorylation at the PDGF and bFGF receptors in cultured fibroblast and vascular smooth muscle cells which in turn inhibits their proliferation[1]. CGP 53716 is a specific PDGFR tyrosine kinase inhibitor on SMC (smoo...
T74000	CP-547632 TFA	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	CP-547632 TFA是一款口服效果显著的ATP競爭性抑制劑，针对VEGFR-2和FGF激酶具有高度选择性，IC50值分别为11 nM和9 nM。该化合物相较于EGFR和PDGFRβ，对VEGFR2和bFGF展现出更高的选择性，优于相关的酪氨酸激酶（TKs）。CP-547632 TFA还显示了显著的抗肿瘤活性。
T69599	ABT-510
	ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8).

化合物

Target: ERK, BMI-1, Epigenetic Reader Domain

SUN11602

Cat.No: T3714

Synonym: SUN 11602

Target: ERK, FGFR

CP-547632

Cat.No: T10870L

Synonym:

Target: VEGFR, FGFR, PDGFR, BTK

Suramin Sodium Salt

Cat.No: T2160

Synonym: 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)

Cat. No.	Product Name	Target	Signaling Pathways
T5S1103	Isoliensinine 异莲心碱,Isoliensinin	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Isoliensinine (Isoliensinin) 是从水芙蓉种子胚中提取的一种双苄基异喹啉生物碱，能诱导三阴性乳腺癌细胞凋亡，具有抗氧化、抗炎、抗癌活性。
T2787	Picroside I 6'-Cinnamoylcatalpol,胡黄连苦苷I	MMP; STAT	JAK/STAT signaling; Proteases/Proteasome; Stem Cells
	Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物，是有肝脏保护作用的代谢成分，可用于哮喘研究，有减轻炎症作用，还下调 pSTAT6 和 GATA3 表达。

天然产物

Isoliensinine

Cat.No: T5S1103

Synonym: 异莲心碱,Isoliensinin

Target: Apoptosis, Antioxidant

Picroside I

Cat.No: T2787

Synonym: 6'-Cinnamoylcatalpol,胡黄连苦苷I

Target: MMP, STAT

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