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18
Cat. No. | Product Name | Target | Signaling Pathways |
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T23521 |
VULM 1457
|
Acyltransferase | Metabolism |
VULM 1457 是有效的胆固醇酰基转移酶抑制剂,具有显著的降血脂活性,并改善了整体心肌缺血再灌注损伤结果。VULM 1457 显著降低肾上腺髓质素的产生和分泌,并下调人肝母细胞上的 AM 受体。VULM 1457 具有研究糖尿病和高胆固醇血症的潜力。 | |||
T22225 |
4-Methylsalicylic acid
|
Others | Others |
4-Methylsalicylic acid 用于抑制中链酰基辅酶A 合成酶。 | |||
T4681 |
T863
DGAT-3,DGAT-1 inhibitor |
Acyltransferase; Transferase | Metabolism |
T863 (DGAT-3) 是口服有效的二酰基甘油酰基转移酶1 选择性抑制剂。T863结合DGAT1的酰基辅酶A 结合位点,抑制三酰甘油在细胞内的合成。 | |||
T29457L |
5-Hydroxydecanoate sodium
|
Potassium Channel | Membrane transporter/Ion channel |
5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂,IC50 约为 30 μM。 它是线粒体外膜酰基辅酶A 合成酶的底物,具有抗氧化性。 | |||
T12425 |
PF-06424439 methanesulfonate
|
Acyltransferase; Transferase | Metabolism |
PF-06424439 methanesulfonate 是一种口服有效咪唑并吡啶二酰基甘油酰基转移酶 2 (DGAT2)选择性抑制剂,IC50是14 nM。PF-06424439 methanesulfonate 具有缓慢可逆,时间依赖性的特点,其相对于酰基-CoA 底物以非竞争性模式抑制 DGAT2。 | |||
T11016 |
DGAT-1 inhibitor 2
|
Transferase | Metabolism |
DGAT-1 inhibitor 2是有效的DGAT-1抑制剂,具有减肥功效。 | |||
T35666 |
PRGL493
|
Others | Others |
PRGL493为高效、选择性的长链酰基辅酶a合成酶4 (ACSL4) 抑制剂,能在乳腺和前列腺细胞以及动物模型中抑制细胞增殖和肿瘤生长,主要应用于癌症研究。 | |||
T60060 |
ACSS2-IN-2
MTB-9655 |
Fatty Acid Synthase | Metabolism |
ACSS2-IN-2 (MTB-9655) 是酰基辅酶 A 合成酶短链家族成员 2 (ACSS2) 抑制剂。ACSS2-IN-2 可抑制 ACSS2 活性,IC50 为 3.8 nM。ACSS2-IN-2 可用于多种疾病的研究,如病毒感染、代谢紊乱、神经精神疾病、炎症/自身免疫疾病和癌症。 | |||
T14523 |
Beauvericin
|
Others; Acyltransferase | Metabolism; Others |
Beauvericin 是一种镰刀菌霉菌毒素。Beauvericin 在大鼠肝微粒体酶实验中对酰基-CoA:胆固醇酰基转移酶(ACAT)有抑制作用,其 IC50 值为 3 μM。 | |||
T10035 |
10,12-Tricosadiynoic acid
TDA,TCDA |
Acyltransferase | Metabolism |
10,12-Tricosadiynoic acid 是一种口服有效的酰基辅酶 A 氧化酶-1 (ACOX1) 抑制剂,具有高特异性,选择性,高亲和力的特点。10,12-Tricosadiynoic acid 可改善线粒体脂质和 ROS 代谢,在高脂饮食或肥胖引起的代谢性疾病中有研究的价值。 | |||
T38905 |
FATP1-IN-1
FATP1-IN-1 |
Others | Others |
FATP1-IN-1 是一种强效的脂肪酸转运蛋白1(FATP1)抑制剂。它能有效抑制对FATP1功能至关重要的重组人类或小鼠的酰辅酶A合成酶活性。其抑制特征通过IC50值体现,分别为人类FATP1的0.046 μM 和小鼠FATP1的0.60 μM。 | |||
T13262 | FCE 28654 | ||
FCE 28654 is a water-soluble acyl-CoA inhibitor. | |||
T37405 | Octanoyl Coenzyme A (sodium salt) | ||
Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase. | |||
T32768 |
Linoleoyl-coenzyme A
Coenzyme A,linoleoyl- |
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Linoleoyl-coenzyme A is a substrate used to investigate the specificity and kinetics of acyl-CoA. | |||
T28820 |
SMP-797 HCl
SMP-797,SMP 797,SMP797 |
||
SMP-797 HCl, an ACAT (acyl-CoA-cholesterol acyltransferase) inhibitor, is used potentially for the treatment of Hyperlipidemia. | |||
T26548 |
Acaterin
|
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Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774. | |||
T68618 |
S-(-)-Etomoxir
|
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S-(-)-Etomoxir is an inhibitor of carnitine palmitoyltransferase A (CPT1) -- a molecule required for the oxidation of long-chain acyl CoA esters. | |||
T73766 | Isobutyryl-L-carnitine chloride | ||
Isobutyryl-L-carnitine chloride 是酰基辅酶 A 脱氢酶的产物。 | |||
T36842 |
Isobutyryl Coenzyme A (sodium salt)
|
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Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency. | |||
T40557 |
Simvastatin Acyl-β-D-glucuronide
|
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Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM. | |||
T73918 |
Lauroyl coenzyme A lithium
|
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Lauroyl coenzyme A lithium salt 是一种辅酶 A。辅酶 A 作为酰基载体,即乙酰辅酶 A。十二烷酰辅酶 A (C12-CoA) 是一种长链 (C-12) 饱和脂肪酰辅酶 A,用作脂质代谢的中间体,参与脂质生物合成和脂肪酸转运。月桂酰辅酶 A 是底物用于 FAM34A 蛋白和萤火虫荧光素酶的产物。 | |||
T32598 |
Lauroyl-coenzyme A
Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa |
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Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport. | |||
T38025 |
Cyclohexanoyl Coenzyme A
|
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Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. It is the activated form of cyclohexane carboxylic acid (CHC) in R. palustris. CHC is converted to CHCoA by a succinyl-CoA CHC CoA transferase, and CHCoA is then degraded by a dehydrogenase. CHCoA is converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver. | |||
T78225 |
3-Butynoic acid
|
Endogenous Metabolite | Metabolism |
3-Butynoic acid 是一种有效的酰基辅酶A脱氢酶 (acyl CoA dehydrogenase) 抑制剂,是Zn依赖性黄素酶D-乳酸脱氢酶的底物,可用于研究乳酸代谢。 | |||
T74038 | Palmitoyl coenzyme A lithium | ||
Palmitoyl coenzyme A lithium,一种酰基-CoA 硫酯,通过肉碱穿梭系统转运至线粒体基质,参与β-氧化,亦作为鞘氨醇生物合成底物。 | |||
T73790 | 3-Hydroxysebacic acid | ||
3-Hydroxysebacic acid 是存在于尿中的内源代谢物,可用于研究中链酰基钴 A 脱氢酶缺乏症。 | |||
T31300 |
Decan-2-ol
2-Hydroxydecane,EINECS 214-296-6,AI3-11545,NSC 67349 |
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Decan-2-ol is used to study the substrate spectrum of phytanoyl-CoA hydroxylase with regard to the length of both the acyl chain and the branch at position. It is used to develop a miniature catalytic reactor for the oxidation of alcohols with O2 in super | |||
T37677 |
3-hydroxy Docosanoic Acid
|
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3-hydroxy Docosanoic acid is a hydroxylated form of the 22-carbon saturated docosanoic acid . It is found in lipopolysaccharides from C. trachomatis and C. psittaci and in S. synnaedendra. 3-hydroxy Docosanoic acid, in the form of an acyl-CoA metabolite, is an intermediate in fatty acid chain elongation from arachidic acid to docosanoic acid (C22:0). | |||
T37678 |
3-hydroxy Lignoceric Acid
|
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3-hydroxy Lignoceric acid is a hydroxylated form of the 24-carbon saturated lignoceric acid . 3-hydroxy Lignoceric acid is found in minor amounts in Methyloligella, a novel Gram-negative bacteria. 3-hydroxy Lignoceric acid, in the form of an acyl-CoA metabolite, is an intermediate in fatty acid chain elongation from docosanoic acid to lignoceric acid (C24:0). | |||
T37905 | Hexanoyl Glycine | ||
Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase. Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation. Levels of hexanyl glycine can also be elevated during... | |||
T21842 |
2-fluoro Palmitic Acid
|
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2-Fluoropalmitic acid, 是一种酰基辅酶 A 合成酶抑制剂,是一种候选的抗神经胶质瘤的药物。 2-Fluoropalmitic acid 抑制胶质瘤干细胞 (GSC) 活力和干细胞样表型。 2-Fluoropalmitic acid 还抑制神经胶质瘤细胞系的增殖和侵袭。 | |||
T73783 | D-Ribofuranose | ||
D-Ribofuranose (D-Ribose) 是一种在脑脊液中发现的内源性代谢物,用于磷酸 5 核糖异构酶缺乏症和中链酰基 CoA 脱氢酶缺乏症的研究。 | |||
T35698 |
Octanoic Acid-13C
|
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Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d... | |||
T37679 |
3-hydroxy Palmitic Acid
|
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3-hydroxy Palmitic acid is a form of the 16:0 lipid palmitic acid . The lipid A part of lipopolysaccharides contain various 3-hydroxy fatty acids, making oxylipins such as 3-hydroxy palmitic acid useful as chemical markers of endotoxins. In R. solanacearum, 3-hydroxy palmitic acid is converted by an S-adenosyl methionine-dependent methyltransferase to 3-hydroxy palmitic acid methyl ester, which acts as a quorum sensing signal molecule for post-transcriptional modulation of genes involved in viru... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN1474 |
Caulilexin C
板蓝根,1-甲氧基-3-吲哚乙腈 |
Others; Antifungal | Microbiology/Virology; Others |
Caulilexin C 是一种来自十字花科植物的植物抗毒素,具有抗真菌活性。 | |||
T5215 |
N-(3-Phenylpropionyl)glycine
N-(3-苯基丙酰基)甘氨酸,Phenylpropionylglycine |
Others | Others |
N-(3-Phenylpropionyl)glycine (Phenylpropionylglycine) 是一种酰基甘氨酸。酰基甘氨酸通常是脂肪酸的次要代谢物。 | |||
T5245 |
N-Isovaleroylglycine
N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine |
Others; Endogenous Metabolite | Metabolism; Others |
N-Isovaleroylglycine (Isovaleroylglycine) 是酰基甘氨酸,能够作为体重提高和肥胖的生物标记物。 | |||
T4734 |
Suberic acid
Octanedioic acid,1,8-Octanedioic acid,辛二酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Suberic acid (1,8-Octanedioic acid) 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏(丙二醇-羧基酶缺乏症)有关。 | |||
T5279 |
Ethylmalonic acid
alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ethylmalonic acid (alpha-Carboxybutyrate) 是潜在有毒物质,非致癌性,与神经性厌食和甲氧基脱羧酶缺乏症有关。 | |||
T4867 |
Erucic acid
Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid |
PI3K; Endogenous Metabolite | Metabolism; PI3K/Akt/mTOR signaling |
Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸,分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障,使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。 | |||
T4947 |
3-Hydroxybutyric acid
Butanoic acid,3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物,在 I 型糖尿病中升高。它能够调节膜脂的性质。 | |||
T5267 |
N-Acetyl-L-glutamic acid
Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸,是动物细胞培养基的组成成分,是一种酿酒酵母和人类的代谢物。 | |||
T24117 |
Guineesine
Pipyahyine |
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Guineesine is an Acyl-CoA. It acts by inhibiting cholesterol acyltransferase. | |||
T13199 |
Triacsin C
WS 1228A,FR 900190 |
Others | Others |
Triacsin C, from Streptomyces aureofaciens, is a natural intracellular long-chain inhibitor of acyl-CoA synthetases (ACSL). | |||
T13678 |
Enniatin A
|
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Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes. | |||
TN2834 |
27-p-Coumaroyloxyursolic acid
|
Others | Others |
27-trans-p-Coumaroyloxyursolic acid and 27-cis-p-coumaroyloxyursolic acid show potent inhibitory activity in the acyl CoA cholesteryl acyl transferase (ACAT) assay. | |||
T13679 |
Enniatin B
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ERK | MAPK |
Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes. | |||
T75696 | Ilexoside XLVIII | ||
Ilexoside XLVIII为一种三萜皂苷,自苦冬青叶片水提物分离而得,功能为抑制酰基辅酶A胆固醇酰基转移酶(ACAT)。 | |||
T11202 |
Enniatin complex
|
Others | Others |
Enniatin complex, a mixture of cyclohexadepsipeptides predominantly derived from various Fusarium species of fungi, exhibits inhibitory effects on enzymes such as acyl-CoA: cholesterol acyl transferase. Furthermore, it has demonstrated the ability to induce apoptosis in multiple cancer cell lines. In addition to these activities, the Enniatin complex possesses ionophoric, antibiotic, and in vitro hypolipidemic properties. | |||
T19381 |
Isobutyryl-L-carnitine
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases. | |||
T13680 |
Enniatin B1
恩镰孢菌素 B1 |
ERK | MAPK |
Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. | |||
T37690 |
Phenylpyropene A
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Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... |