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Cat. No.	Product Name	Target	Signaling Pathways
T40581	TIE-2/VEGFR-2 kinase-IN-2
	TIE-2/VEGFR-2 kinase-IN-2 is a powerful inhibitor of both VEGFR2 and Tie-2 kinases, displaying noteworthy pIC 50 values of 8.61 and 8.56, respectively. This compound acts as an anti-angiogenic agent, making it highly relevant for cancer research.
T8817	TIE-2/VEGFR-2 kinase-IN-1
	TIE-2/VEGFR-2 kinase-IN-1 用于合成TIE-2或者VEGFR-2抑制剂，可用于研究不适当的血管生成的相关疾病。
T79860	TIE-2/VEGFR-2 kinase-IN-5	VEGFR; Tie-2	Angiogenesis; Tyrosine Kinase/Adaptors
	TIE-2/VEGFR-2 kinase-IN-5 是一种高效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂，具有的抗血管生成活性，常用于血管生成相关的生物医学研究领域。
T16724	Razuprotafib AKB-9778	Phosphatase; Others	Metabolism; Others
	Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂，抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外，它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化，增强 ANG1 诱导的 TIE2 活化，并刺激 TIE2 通路中信号分子的磷酸化。
T6335	Tie2 kinase inhibitor 1 Tie2 kinase inhibitor	Tie-2	Tyrosine Kinase/Adaptors
	Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM)，具有抗癌作用。
T36718	Tie2 Inhibitor 7
	Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.
T79859	TIE-2/VEGFR-2 kinase-IN-4
	TIE-2/VEGFR-2 kinase-IN-4，一种苯并咪唑衍生物，作为有效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂，其IC50值分别为5.2 nM和5.1 nM，适用于血管生成相关研究。
T79858	TIE-2/VEGFR-2 kinase-IN-3
	TIE-2/VEGFR-2 kinase-IN-3，为苯并咪唑衍生物，具备高效的抑制作用于TIE-2与VEGFR-2受体酪氨酸激酶，其IC50值分别达到6.9 nM和3.5 nM。本化合物主要用于血管生成相关研究。
T22259	AMG-Tie2-1 AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺	Others	Others
	AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2).
T6934	Pexmetinib ARRY-614	Tie-2; p38 MAPK; Autophagy	Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Pexmetinib (ARRY-614) 是一种口服生物可利用的双重 p38 MAPK/Tie-2 抑制剂，可研究急性骨髓性白血病。在 HEK-293 细胞系中的 IC50 为 4 nM/18 nM。
T38930	BAY-826	Tie-2	Tyrosine Kinase/Adaptors
	BAY-826 是一种新型、高效且具有选择性的 TIE-2 抑制剂，抑制 TIE-2 磷酸化，可用于研究肿瘤。
T4318	EOC317 ACTB-1003,ACTB1003,ACTB 1003	VEGFR; FGFR; Tie-2	Angiogenesis; Tyrosine Kinase/Adaptors
	EOC317 (ACTB-1003) 是一种口服可用的激酶抑制剂，能够抑制 FGFR1 (IC50:6 nM)，VEGFR2 (IC50:2 nM) 和 Tie-2 (IC50:4 nM)。
T2640	Rebastinib DCC2036,DCC 2036,DCC-2036	Apoptosis; FLT; Bcr-Abl; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Rebastinib (DCC-2036) 是一种口服有效的，非 ATP 竞争性的 Bcr-Abl 抑制剂，作用于 Abl1WT 和 Abl1T315I，IC50分别为 0.8 nM 和 4 nM，还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2，对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。
T2054	Altiratinib DCC-2701	VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂，能够抑制 MET (IC50:2.7 nM)，TIE2 (IC50:8 nM)，VEGFR2 (IC50:9.2 nM)，FLT3 (IC50:9.3 nM)，Trk1 (IC50:0.85 nM)，Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
T71979	TP-S1-68
	TP-S1-68 is a Type-I inhibitor of TIE-2.
T11519	GW768505A free base	Others	Others
	GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 (pIC50: 7.81 for VEGFR2) with anti-angiogenic activity.
T68484	2-MT-63
	2-MT 63 is a novel TIE-2 kinase inhibitor that demonstrates unique and improved kinase selectivity compared to other inhibitors known to interact with TIE-2. 2-MT 63 has a good kinase selectivity profile in enzyme assays with >30-fold selectivity (typically much greater) against the tested kinases. Importantly, the profile includes selectivity against other targets of relevance for angiogenesis (KDR, PDGFR, EPHB4).
T71819	RK-20448
	RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259
T68389	LY2457546
	LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge...

化合物

TIE-2/VEGFR-2 kinase-IN-2

Cat.No: T40581

TIE-2/VEGFR-2 kinase-IN-1

Cat.No: T8817

TIE-2/VEGFR-2 kinase-IN-5

Cat.No: T79860

Target: VEGFR, Tie-2

Cat.No: T16724

Synonym: AKB-9778

Target: Phosphatase, Others

Tie2 kinase inhibitor 1

Cat.No: T6335

Synonym: Tie2 kinase inhibitor

Target: Tie-2

Tie2 Inhibitor 7

Cat.No: T36718

TIE-2/VEGFR-2 kinase-IN-4

Cat.No: T79859

TIE-2/VEGFR-2 kinase-IN-3

Cat.No: T79858

Cat.No: T22259

Synonym: AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺

Target: Others

Cat.No: T6934

Synonym: ARRY-614

Target: Tie-2, p38 MAPK, Autophagy

Cat.No: T38930

Target: Tie-2

Cat.No: T4318

Synonym: ACTB-1003,ACTB1003,ACTB 1003

Target: VEGFR, FGFR, Tie-2

Cat.No: T2640

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

Cat.No: T2054

Synonym: DCC-2701

Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR

Cat.No: T71979

GW768505A free base

Cat.No: T11519

Target: Others

Cat.No: T68484

Cat.No: T71819

Cat.No: T68389

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