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Cat. No. | Product Name | Target | Signaling Pathways |
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T13009 |
STAT3-IN-1
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
STAT3-IN-1 是一种选择性的、口服有效的 STAT3的强效抑制剂,可诱导肿瘤细胞凋亡,其在 HT29 和MDA-MB 231 细胞中的IC50值分别为1.82 μM 和2.14 μM。 | |||
T4216 |
STAT5-IN-1
STAT5 Inhibitor |
STAT | JAK/STAT signaling; Stem Cells |
STAT5-IN-1 (STAT5 Inhibitor) 是STAT5的抑制剂,对 STAT5β 亚型的IC50值为 47 μM。 | |||
T3708 |
BP-1-102
|
STAT | JAK/STAT signaling; Stem Cells |
BP-1-102 是可口服的转录因子Stat3小分子抑制剂,IC50值为 6.8 μM。 | |||
T78607 |
JAK-STAT-IN-1
|
JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK-STAT-IN-1 是一种特异性 JAK-STAT 抑制剂,适用于研究自身免疫性疾病。 | |||
T9339 |
Stafia-1
|
STAT | JAK/STAT signaling; Stem Cells |
Stafia-1 是STAT5a 抑制剂,Ki 为 10.9 μM,IC50 为 22.2 μM。它与 STAT5b 和其他 STAT 家族成员相比,显示出高选择性。 | |||
T3049 |
TPCA-1
GW683965,IKK2 Inhibitor IV,TPCA1 |
Apoptosis; IκB/IKK; STAT | Apoptosis; JAK/STAT signaling; NF-κB; Stem Cells |
TPCA-1 (TPCA1) 是一种选择性IKK-2抑制剂,IC50值为 17.9 nM。它也是反式激活、DNA 结合以及STAT3磷酸化的一种抑制剂。 | |||
T8478 |
SC-43
|
Apoptosis; Phosphatase; STAT | Apoptosis; JAK/STAT signaling; Metabolism; Stem Cells |
SC-43 是一种具有口服活性的SHP-1 (PTPN6)激动剂。它是Sorafenib 的衍生物,可抑制STAT3的磷酸化并诱导细胞凋亡,具有抗纤维化和抗癌作用。 | |||
T22424 |
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
SC-1 是一种 Sorafenib 的衍生物,可抑制 STAT3磷酸化,通过依赖 SHP-1 的 STAT3失活诱导细胞凋亡,具有抗癌作用。 | |||
T9945 |
MNK8
3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione |
STAT | JAK/STAT signaling; Stem Cells |
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) 是一种有效的STAT3抑制剂,降低STAT3与DNA 结合的能力,对肝癌细胞也有良好的生长抑制作用。 | |||
T1127 |
Beclometasone dipropionate
Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase |
Glucocorticoid Receptor | Endocrinology/Hormones |
Beclometasone dipropionate (Vancenase) 是具有口服活性的糖皮质激素,具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物,Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。 | |||
T24838 |
Stafib-1
Stafib 1,Stafib1 |
STAT | JAK/STAT signaling; Stem Cells |
Stafib-1 是一种特异性的 STAT5β 抑制剂,靶向 SH2 结构域,IC50 为 154 nM,Ki 为 44 nM。 | |||
T2600 |
AG490
Zinc02557947,Tyrphostin AG 490,AG 490,AG-490,Tyrphostin B42 |
EGFR; JAK; STAT; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
AG490 (Tyrphostin B42) 是一种 EGFR 抑制剂 ,IC50为 0.1 μM。它对 EGFR 的选择性比 ErbB2 高 135 倍,还抑制 JAK2。 | |||
T35407 |
Ζ-Stat
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
ζ-Stat 是非典型的、特异性的PKC-ζ抑制剂,IC50为 5 μM。ζ-Stat 能够减少黑色素瘤细胞系的增殖并诱导细胞凋亡,在体外显示除抗肿瘤活性。 | |||
T1849 |
Momelotinib
CYT11387,CYT387,LM-1149 |
Apoptosis; JAK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Momelotinib (LM-1149) 是一种 ATP 竞争性的 JAK1/JAK2抑制剂,IC50值分别为 11 nM/18 nM。 | |||
T18680 |
SD-36
|
Others | Others |
SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-type and mutated STAT3 proteins in cells, inhibiting their transcriptional activity (IC50=10 nM). The compound, consisting of the STAT3 inhibitor SI-109, a linker, and a CRBN ligand Lenalidomide analog for E3 ubiquitin ligase[1], demonstrates significant anti-tumor effects and achieves complete, long-lasting tumor regression in mouse mod... | |||
T26596 |
Allylpyrocatechol
|
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Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways. | |||
T74800 | HAT-SIL-TG-1&AT | ||
HAT-SIL-TG-1&AT 是一种 Janus 酪氨酸激酶 (JAK) 抑制剂,具有抗肿瘤作用。HAT-SIL-TG-1&AT 是缺氧激活的前药,可抑制肿瘤组织中的JAK-STAT 信号传导。HAT-SIL-TG-1&AT 在低氧条件下抑制 HEL 细胞增殖并下调磷酸化的STAT3/5。 | |||
T26895 |
BRD0476
BRD-0476,ML 187,ML187,ML-187,BRD 0476 |
||
BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT | |||
T75535 |
5-epi-Arvestonate A
|
||
5-epi-Arvestonate A是一种从(Seriphidium transiliense)绢毛菊中提取的倍半萜化合物,能够通过激活(MITF)小眼相关转录因子和酪氨酸酶家族基因来促进黑色素的产生。此外,5-epi-Arvestonate A还能通过JAK/STAT信号通路,抑制永生化人角化细胞(HaCaT)中IFN-γ趋化因子的表达。 | |||
T77038 | Interferon alfa | ||
Interferon alfa 是 I 型干扰素,可激活新基因,对靶细胞产生有效抗病毒和抗增殖活性。Interferon alfa 的信号传导需要 Stat1和 Stat2 的受体依赖性激活,形成异源二聚化 STAT。STAT 复合物与 DNA 结合蛋白 IRF-9 (p48) 结合并形成 ISGF-3 (IFN 刺激基因因子 3)。随后由 ISGF-3 进一步激活驱动基因,实现抗病毒功能。 | |||
T37265 |
15(R)-Lipoxin A4
15(R)-Lipoxin A4,AT-Lipoxin A4 |
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Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may... | |||
T68306 |
INCB16562
|
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INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB16562 abrogated the protective effects of recombinant cytokines or bone marrow stromal cells and sensitized myeloma cells to cell death by exposure to dexamethasone, melphalan, or bortezomib. Oral administration of INCB16562 antagonized the growth of ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1413 |
Atranorin
荔枝素,巴美灵,荔枝素 |
Endogenous Metabolite; NO Synthase; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism |
Atranorin 是地衣的次生代谢产物,具有显着的抗伤害、抗炎和氧化还原活性,对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。 | |||
T5668 |
Triacetylresveratrol
乙酰化白藜芦醇,三乙酰基白藜芦醇,Acetyl-trans-resveratrol |
BCL; NF-κB; STAT | Apoptosis; JAK/STAT signaling; NF-κB; Stem Cells |
Triacetylresveratrol (Acetyl-trans-resveratrol) 是 Resveratrol 的乙酰化类似物,可降低 STAT3和 NF-κB 磷酸化,具有抗癌作用。 | |||
TN1237 |
3-O-Methylgallic acid
3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸 |
Apoptosis; NF-κB; OCT; DNA/RNA Synthesis; STAT | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Membrane transporter/Ion channel; NF-κB; Stem Cells |
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) 是一种花青素代谢产物,具有强大的抗氧化能力。它还诱导细胞凋亡并具有抗癌作用,可抑制 Caco-2 细胞增殖,IC50值为 24.1 μM。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T5S1897 |
Linderalactone
|
Apoptosis; Others; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells |
Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯,通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。 | |||
T6S1966 |
Curculigoside
Curculigoside A,仙茅苷 |
Antioxidant; NF-κB; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells |
Curculigoside (Curculigoside A) 是仙茅中的主要皂苷,具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径,具有抗关节炎作用。 |