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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T38826	Vibozilimod Vibozilimod,SCD-044	S1P Receptor	GPCR/G Protein
	Vibozilimod (SCD-044) 是S1P 受体-1 (S1PR1)激动剂。
T5427	GSK1940029 SCD inhibitor 1	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	GSK1940029 (SCD inhibitor 1) 是酰基-辅酶A 去饱和酶 (SCD) 抑制剂。
T10525	SCD1 inhibitor-4	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	SCD1 inhibitor-4 是一种具有口服活性的 stearoylCoA desaturase-1 抑制剂，可用于研究糖尿病。
T38683	SCD1 inhibitor-3 SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a	Dehydrogenase	Metabolism
	SCD1 inhibitor-3 (ML-270) 是一种高效、口服的化合物，可以抑制SCD1，且安全性极高。 SCD1 inhibitor-3 显示出在代谢疾病(包括肥胖、二型糖尿病和血脂异常，以及痤疮和癌症等各种皮肤病)方面的巨大研究潜力。
T2650	MK-8245	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	MK8245 是肝靶向的硬脂酰 -CoA 去饱和酶(SCD)抑制剂，对人 SCD1 和鼠 SCD1 的IC50值分别为 1 nM 和 3 nM，具有抗糖尿病和抗血脂异常的作用。
T13356	XEN723	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	XEN723 是新型的硬脂酰辅酶 A 去饱和酶的噻唑基咪唑烷酮抑制剂，能够抑制小鼠和 HepG2 细胞的活性，它们的 IC50值分别为 45 和 524 nM。
T16068	MF-438	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	MF-438 是一种口服具有活力的 stearoyl-CoA desaturase 1 抑制剂，其对 rSCD1 的 EC50值为 2.3 nM。
T6412	CVT-12012	Stearoyl-CoA Desaturase (SCD)	Metabolism
	CVT-12012 是口服具有活性的硬脂酰-CoA 去饱和酶抑制剂，能够抑制大鼠微粒体和人 HEPG2 的活性，它们的IC50值分别为 38 nM，6.1 nM。
T4515	A939572	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	A939572 是口服具有活性的硬脂酰 CoA 去饱和酶 1SCD1抑制剂，对mSCD1和hSCD1的IC50分别为 <4 nM 和 37 nM。
T14878	CAY10566	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	CAY10566 是选择性的、口服具有活性的硬脂酰辅酶 A 去饱和酶 1 抑制剂，在小鼠和人酶测定中IC50分别为 4.5 和 26 nM。它具有显著的细胞活性，可阻断 HepG2 细胞中饱和长链脂肪酸-CoAs (LCFA-CoAs) 向单不饱和 LCFA-CoAs 的转化。
T9722	YTX-465	Stearoyl-CoA Desaturase (SCD)	Metabolism
	YTX-465 是有效的硬脂酰辅酶 A 去饱和酶 (Ole1/SCD) 抑制剂，抑制 Ole1 和 SCD1的IC50=分别为 0.039 μM 和 30.4 μM。YTX-465在帕金森病和其他突触核蛋白病领域有研究的价值。
T7581	voxelotor GBT 440	Others	Others
	Voxelotor (GBT 440) 是镰状血红蛋白 (HbS) 聚合抑制剂，有用于镰状细胞贫血病研究的潜力。
T1869	PluriSIn 1 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1	Apoptosis; Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Apoptosis; Metabolism
	PluriSIn 1 (NSC 14613) 是一种酰基-辅酶 A 去饱和酶抑制剂，是一种多能细胞特异性的抑制剂。
T12863	SCD1 inhibitor-1	Others	Others
	SCD1 inhibitor-1 is a potent and liver-selective inhibitor of stearoyl-CoA desaturase-1 (SCD1).
T71175	SCD1 Inhibitor
	SCD1 Inhibitor is a novel stearoyl-CoA desaturase1 (SCD1) inhibitor.
T61841	SCD1-IN-1
	SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1].
T9003	CVT-11127 N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺	Dehydrogenase	Metabolism
	CVT-11127 是 SCD 抑制剂。它将细胞周期阻滞在 G1/S 期，诱导细胞凋亡。它可用于肺癌的研究。
T75396	Sphingolipid ceramide N-deacylase (SCDase)
	Sphingolipid ceramide N-deacylase (SCDase) 催化糖鞘脂中的脂肪酸与鞘氨醇碱基间的N-酰基键断裂，进而生成溶血糖鞘脂。
T20950	MK-8245 analog MK-8245-analog,MK 8245 analog	Others	Others
	MK-8245 analog 是 MK-8245 的类似物，MK-8245 是一种肝脏靶向的硬脂酰辅酶 A 去饱和酶 (SCD) 抑制剂。它可用于治疗血脂异常和糖尿病。
T39520	Vamifeport VIT-2763	Ferroptosis	Apoptosis
	Vamifeport (VIT-2763) 是一种新型具有口服活性且靶向铁转运蛋白的抑制剂，可降低 SCD Townes 模型中的溶血标志物。VIT-2763 可改善贫血和红细胞生成，可改善血管炎症，可研究 β-地中海贫血。
T13054	T-3764518	Dehydrogenase	Metabolism
	T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
T73188	RK-0133114
	RK-0133114 是G9a 抑制剂，也是RK-701 的 R-对映体。RK-0133114 抑制 G9a 的IC50值为 3.7 μM。RK-0133114 可用于镰状细胞病 (SCD) 的研究。
T28892	SW208108 SW 208108,SW-208108
	SW208108 is a tumor-specific irreversible inhibitor of stearoyl CoA desaturase (SCD).
T64171	LXR antagonist 2
	LXR antagonist 2 (compound 10rr) 是一种有效的 LXR (肝 X 受体) 反向激动剂，能够作用于 LXRβ (IC50: 0.36 μM) 和 LXRα (IC50: 2.25 μM)。 LXR antagonist 2 是一种脂肪生成抑制剂，能够下调 LXR 靶基因 SREBP-1c、ACC、FAS 和 SCD-1。LXR antagonist 2 对 Triton WR-1339 诱导的高脂血症小鼠表现出降脂活性。
T81500	PF-07059013
	PF-07059013是口服活性的镰状血红蛋白(HbS)非共价调制剂，具有纳摩尔级别的亲和力特异性结合Hb，展现出显著的红细胞(RBCs)分裂作用，适用于镰状细胞病(SCD)的研究。
T61975	Pociredir
	Pociredir (FTX-6058) 是一种有效的、选择性的、具有口服活性的胚胎外胚层发育蛋白 (EED) 小分子抑制剂（KD= 0.163 nM）。Pociredir (FTX-6058) 在研究炎症或血红蛋白病中具有研究价值，如镰状细胞病 (SCD)。
T69671	SR1903 TFA
	SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-190...
T38844	MK-8245 Trifluoroacetate
	MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK...
T35638	SR 1903
	SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 209 nM) but does not activate it. SR 1903 (10 μM) inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1) in RAW 264.7 cells. It also inhibits LPS-induced expression of th...
T36130	22(S)-hydroxy Cholesterol 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
	22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22...

化合物

Cat.No: T38826

Synonym: Vibozilimod,SCD-044

Target: S1P Receptor

Cat.No: T5427

Synonym: SCD inhibitor 1

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

SCD1 inhibitor-4

Cat.No: T10525

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

SCD1 inhibitor-3

Cat.No: T38683

Synonym: SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a

Target: Dehydrogenase

Cat.No: T2650

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T13356

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T16068

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T6412

Target: Stearoyl-CoA Desaturase (SCD)

Cat.No: T4515

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T14878

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T9722

Target: Stearoyl-CoA Desaturase (SCD)

Cat.No: T7581

Synonym: GBT 440

Target: Others

Cat.No: T1869

Synonym: 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1

Target: Apoptosis, Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

SCD1 inhibitor-1

Cat.No: T12863

Target: Others

SCD1 Inhibitor

Cat.No: T71175

Cat.No: T61841

Cat.No: T9003

Synonym: N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺

Target: Dehydrogenase

Sphingolipid ceramide N-deacylase (SCDase)

Cat.No: T75396

Cat.No: T20950

Synonym: MK-8245-analog,MK 8245 analog

Target: Others

Cat.No: T39520

Synonym: VIT-2763

Target: Ferroptosis

Cat.No: T13054

Target: Dehydrogenase

Cat.No: T73188

Cat.No: T28892

Synonym: SW 208108,SW-208108

LXR antagonist 2

Cat.No: T64171

Cat.No: T81500

Cat.No: T61975

Cat.No: T69671

MK-8245 Trifluoroacetate

Cat.No: T38844

Cat.No: T35638

22(S)-hydroxy Cholesterol

Cat.No: T36130

Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol

Cat. No.	Product Name	Target	Signaling Pathways
T3341	Elemicin Elemicine,3,4,5-trimethoxyallylbenzene,榄香素	Influenza Virus; 5-HT Receptor; Stearoyl-CoA Desaturase (SCD)	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Elemicin (Elemicine) 是广泛分布于许多草药和香料中的一种烯基苯。它是芳香族食品中的主要成分之一，具有抗微生物，抗氧化剂和抗病毒活性，有遗传毒性和致癌性。它通过代谢激活抑制硬脂酰辅酶 A 去饱和酶 1。

天然产物

Cat.No: T3341

Synonym: Elemicine,3,4,5-trimethoxyallylbenzene,榄香素

Target: Influenza Virus, 5-HT Receptor, Stearoyl-CoA Desaturase (SCD)

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