Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10566 是选择性的、口服具有活性的硬脂酰辅酶 A 去饱和酶 1 抑制剂,在小鼠和人酶测定中IC50分别为 4.5 和 26 nM。它具有显著的细胞活性,可阻断 HepG2 细胞中饱和长链脂肪酸-CoAs (LCFA-CoAs) 向单不饱和 LCFA-CoAs 的转化 。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 472 | 现货 | ||
5 mg | ¥ 1,580 | 现货 | ||
10 mg | ¥ 2,990 | 现货 | ||
25 mg | ¥ 4,930 | 现货 | ||
50 mg | ¥ 6,910 | 现货 | ||
100 mg | ¥ 9,480 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,730 | 现货 |
产品描述 | CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.. |
靶点活性 | SCD1 in human:26 nM (IC50), SCD1 in mouse:4.5 nM (IC50) |
体外活性 | CAY10566 (0.0001-10 μM; 24 hours) concentration-dependently decreases Swiss 3T3 cell proliferation [3]. |
体内活性 | After the establishment of palpable tumors, the mice are treated with a vehicle or SCD1 inhibitor (2.5 mg/kg CAY10566 orally twice daily). The effect of SCD1 inhibition on the Akt-driven tumors is greater than on the Ras-driven tumors. With the mean tumor volume at day 13 or 14 post-therapy, relative to untreated tumors, 0.5±0.04 and 0.67±0.05 respectively (P=0.01 for Ras-Akt comparison, by two-tailed t-test) [4]. |
分子量 | 389.81 |
分子式 | C18H17ClFN5O2 |
CAS No. | 944808-88-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24 mg/mL (61.57 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5654 mL | 12.8268 mL | 25.6535 mL | 64.1338 mL |
5 mM | 0.5131 mL | 2.5654 mL | 5.1307 mL | 12.8268 mL | |
10 mM | 0.2565 mL | 1.2827 mL | 2.5654 mL | 6.4134 mL | |
20 mM | 0.1283 mL | 0.6413 mL | 1.2827 mL | 3.2067 mL | |
50 mM | 0.0513 mL | 0.2565 mL | 0.5131 mL | 1.2827 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CAY10566 944808-88-2 Metabolism Dehydrogenase Stearoyl-CoA Desaturase (SCD) Inhibitor inhibit CAY 10566 CAY-10566 inhibitor