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76

抑制剂 & 化合物

2

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Cat. No.	Product Name	Target	Signaling Pathways
T3700	SCH900776 (S-isomer) MK-8776 S-isomer,SCH900776 S-isomer	Chk; CDK	Cell Cycle/Checkpoint
	SCH900776 S-isomer (MK-8776 S-isomer) 是SCH900776的S 型同分异构体。
T60196	IHMT-PI3Kδ-372 S-isomer	PI3K	PI3K/Akt/mTOR signaling
	IHMT-PI3Kδ-372 S-isomer 是一种有效的选择性 PI3Kδ 抑制剂，IC50 为 14 nM。IHMT-PI3Kδ-372 S-isomer 对 PI3Kδ 的选择性高于其他 I 类 PI3K (56-83 倍) 和其他蛋白激酶。IHMT-PI3Kδ-372 S-isomer 可用于慢性阻塞性肺疾病 (COPD )的研究。
T63166L	(S, R)-LSN 3318839 (S, R)-LSN 3318839(Isomer-2764704-18-7)	Glucagon Receptor	GPCR/G Protein

T30261	AZD6482 (S-isomer) AZD-6482,AZD 6482,AZD6482 (S),AZD6482
	AZD6482 (S-isomer) is a potent, selective, ATP-competitive PI3Kβ inhibitor (IC(50) 0.01 μm), which can inhibit insulin-induced in vitro glucose uptake by human adipocytes (IC(50) is 4.4 μm).
T19571	T3-ATA (S-isomer)	Others	Others
	T3-ATA S-isomer, the S-isomer of T3-ATA, represents the active form of the thyroid hormone.
T19572	T4-ATA (S-isomer)	Others	Others
	T4-ATA S-isomer, the active form of the thyroid hormone, represents the S-isomer of T4-ATA.
T29007	Trichostatin A S-isomer (-)-Trichostatin A
	Trichostatin A S-isomer is the s-isomer of Trichostatin A. Trichostatin A is a histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Trichostatin A inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20
T27933	LY243246 LY249543 disodium,LY249543 sodium,LY 249543,LY-249543,S-isomer of lometrexol,DB04322,LY249543
	LY249543, the S-isomer of lometrexol, is an inhibitor of Methylenetetrahydrofolate Dehydrogenase/Cycl.
T10545	BIO-32546	PDE	Metabolism
	BIO-32546 (S-isomer) 是一种高效的 autotaxin (ATX) 的调节剂，IC50 值为 1 nM。
T12644L	(S)-Thalidomide (S)-(-)-Thalidomide	Apoptosis	Apoptosis
	(S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S 型异构体，具有免疫调节，抗炎，抗癌，抗血管生成活性和促凋亡活性，可用于研究麻风结节性红斑和骨髓瘤。
T22420	(S)-Viloxazine Hydrochloride (S)-Viloxazine HCl	Norepinephrine	Neuroscience
	(S)-Viloxazine Hydrochloride 是Viloxazine 的S 异构体。Viloxazine 是一种选择性去甲肾上腺素再摄取抑制剂（NRI），可用作抗抑郁药。
T50052	1,2-diphenylpropan-2-amine	Others	Others
	1,2-diphenylpropan-2-amine 是Remacemide 的（S，R）-异构体单盐酸盐代谢产物。1,2-diphenylpropan-2-amine 具有抗惊厥作用。
T20626	Esomeprazole	Proton pump; Cysteine Protease	Membrane transporter/Ion channel; Proteases/Proteasome
	Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体，抑制溶酶体半胱氨酸蛋白酶legumain，防止癌症转移。它是一种质子泵抑制剂（PPI）。
T0785	Dexchlorpheniramine Maleate S-(+)-Chlorpheniramine maleate salt,右泛醇,马来酸右氯苯那敏	Dopamine Receptor; 5-HT Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dexchlorpheniramine Maleate (S-(+)-Chlorpheniramine maleate salt) 是一种具有抗胆碱能特性的抗组胺药，用于治疗花粉热或荨麻疹等过敏性疾病。
T60224	1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-	GluR	Neuroscience
	1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-是S 18986的低活性异构体。S 18986是一种AMPA 受体阳性调节剂，EC2（浓度为AMPA 诱导电流强度的两倍）为35μM。
T2686L	Esomeprazole Sodium 埃索美拉唑钠,(S)-Omeprazole sodium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌，在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T2686	Esomeprazole Magnesium (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T13252L	(S)-Rasagiline mesylate TVP1022 (mesylate),(S)-雷沙吉兰甲磺酸,S-PAI mesylate	Others	Others
	(S)-Rasagiline mesylate is rasagiline S-isomer, and is an agent of anti-Parkinson.
T13252	(S)-Rasagiline TVP1022,(S)-雷沙吉兰,S-PAI	Others	Others
	(S)-Rasagiline is rasagiline S-isomer, and is an agent of anti-Parkinson.
T71319	Alpiropride, (S)-
	Alpiropride, (S)-, is the S isomer of Alpiropride --- a dopamine antagonist.
T70780	BW 737C89
	BW 737C89 is a highly potent dopamine D1 receptor antagonist; BW-737C is the (S)-isomer; BW-736C is the (R)-isomer.
T21271	(S)-AMPA L-AMPA, S-AMPA
	(S)-AMPA is an active isomer of AMPA and a selective agonist of AMPA.
T19612	(2S)-Octyl-α-hydroxyglutarate (2S)-Octyl-2-HG	Others	Others
	(2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a S-isomer 2-Hydroxyglutarate modified form.
T12801	(S)-IDO1-IN-5	Others	Others
	(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 µΜ).
T13869	Ribocil B Ribocil S enantiomer,ent-Ribocil A	Others	Others
	Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN,KD of 6.6 nM).
T13452	(S)-MCPG (+)-MCPG	Others	Others
	(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.
T31177	Dabelotine, (S)- UNII-494Y55877B
	Dabelotine, (S)- 是 Dabelotine 的 S 型异构体。Dabelotine 是一种肾上腺素能受体激动剂,可用于研究痴呆症。
T70757	8-Acetyl-2-(dipropylamino)tetralin
	8-Acetyl-2-(dipropylamino)tetralin is a 5-HT(1A) receptor agonist; both isomers are active, but the (S)-isomer is the most potent.
T69453	APC-0576
	APC-0576 is an (S,S)-isomer which inhibits NF-kappaB-dependent gene activation. APC-0576 may prevent pro-inflammatory cytokine-induced chemokine production in human endothelial cells.
T25416	Fenvalerate Evercide 2362
	Fenvalerate is used as an insecticide. It is a mixture of four optical isomers which have different insecticidal activities. The 2-S alpha (or SS) configuration, known as esfenvalerate, is the most insecticidally active isomer. There is about 23% this iso
T73802	(S,S)-J-113397
	(S,S)-J-113397 是 J-113397 的异构体。J-113397 是一种阿片类受体 (Opioid Receptor) 拮抗剂。
T13980	(S)-Gossypol (acetic acid) (S)-(+)-Gossypol acetic acid,(S)-Gossypol acetic acid	Others	Others
	(S)-Gossypol acetic acid is the isomer of a natural product Gossypol.
T25669	Lercanidipine, (S)- (S)-Lercanidipine,(+)-Lercanidipine
	Lercanidipine, (S)-是 Lercanidipine 的异构体，一种降压化合物。Lercanidipine 是二氢吡啶类的钙通道阻滞剂，具有持久的降压作用和肾脏保护作用。
T38148	(S)-KT109 (S)-KT109
	(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLβ (IC50 = 39.81 nM), DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 630.9 nM) than (R)-KT109 .
T71889	Esoxybutynin Chloride
	Esoxybutynin Chloride is (S)-enantiomer of oxybutynin. Esoxybutynin Chloride exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence.
T83925	(S)-(–)-Deoxyarbutin
	(S)-(–)-Deoxyarbutin是deoxyarbutin的异构体，具有酪氨酸酶抑制作用，在74 µM的浓度下可抑制酪氨酸酶活性。
T37227	(±)8(9)-DiHET
	Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
T71268	Esoxybutynin Free Base
	Esoxybutynin Free Base is (S)-enantiomer of oxybutynin. Esoxybutynin Free Base exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence.
T72753	RSV604 racemate A-60444 racemate
	RSV604 (A-60444) racemate 是一种外消旋混合物，与 S-异构体相比，RSV604 racemate 对呼吸道合胞病毒(RSV)菌株的作用效果弱很多。
T37654	5(S)-HETE lactone
	5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE. The ability of (±)5-HETE lactone to inhibit rat basophilic leukemia cell 5-lipoxygenase (IC50 = 27 μM) may be entirely due to the 5(S) isomer, but the enantiomers have not been tested separately.
T72971	(S)-JDQ-443 (S)-NVP-JDQ443
	(S)-JDQ-443 是 JDQ-443的异构体。JDQ-443 是一种口服有效和选择性的共价 KRAS G12C 抑制剂。JDQ-443 具有抗肿瘤活性。
T83828	Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium Sp-dCTP-α-S
	Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (Sp-dCTP-α-S) 是含硫核苷酸衍生物 dCTP-α-S 的异构体。它抑制解氧核苷酸三磷酸三磷酸水解酶 SAMHD1（Ki = 6.3 µM）。
T63390	(S,S)-TAPI-1
	(S,S)-TAPI-1 是一种 TAPI-1 的异构体。其中 TAPI-1是金属蛋白酶 (MMP) 抑制剂，也是 TACE(ADAM17) 抑制剂，对多种细胞表面蛋白脱落表现出有效的抑制作用。
T68523	AMG-628, (S)-
	AMG-628, (S)-, is the S isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
T83837	Rp-Thymidine-5'-O-(1-thiotriphosphate) sodium Rp-dTTP-α-S
	Rp-Thymidine-5'-O-(1-thiotriphosphate) (Rp-TTP-α-S) 是含硫核苷酸衍生物 TTP-α-S 的一个异构体。它能与HIV-1逆转录酶结合（在镁、锰酸盐和钴存在下的Kds分别为45.7、27.32和39.44 µM）。
T72809	(S)-Renzapride (S)-BRL 24924
	(S)-Renzapride ((S)-BRL 24924) 是 Renzapride 的异构体。Renzapride 是一种 5-HT4受体激动剂，Ki 值为 115 nM。Renzapride 还是一种5HT2b 和5HT3受体拮抗剂。Renzapride 可用于便秘型肠易激综合征（C-IBS）的研究。
T37460	Lipoxin B4 Lipoxin B4
	Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T83834	Sp-Guanosine-5'-O-(1-thiotriphosphate) sodium Sp-GTP-α-S,GTPαS(Sp),GTPαS(A)
	Sp-Guanosine-5'-O-(1-thiotriphosphate) (Sp-GTP-α-S) 是一种含硫核苷酸衍生物GTP-α-S的异构体。它能结合到微管蛋白上，在20 mM的浓度下用于无细胞实验时可诱导微管组装。
T36840	(R)-Omeprazole (sodium salt)
	(R)-Omeprazole is the inactive isomer of omeprazole , a gastric proton-pump inhibitor. A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxidation of the active (S)-enantiomer . (R)-Omeprazole has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 8.1 μM).
T36562	(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid
	(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.

化合物

SCH900776 (S-isomer)

Cat.No: T3700

Synonym: MK-8776 S-isomer,SCH900776 S-isomer

Target: Chk, CDK

IHMT-PI3Kδ-372 S-isomer

Cat.No: T60196

Target: PI3K

(S, R)-LSN 3318839

Cat.No: T63166L

Synonym: (S, R)-LSN 3318839(Isomer-2764704-18-7)

Target: Glucagon Receptor

AZD6482 (S-isomer)

Cat.No: T30261

Synonym: AZD-6482,AZD 6482,AZD6482 (S),AZD6482

T3-ATA (S-isomer)

Cat.No: T19571

Target: Others

T4-ATA (S-isomer)

Cat.No: T19572

Target: Others

Trichostatin A S-isomer

Cat.No: T29007

Synonym: (-)-Trichostatin A

Cat.No: T27933

Synonym: LY249543 disodium,LY249543 sodium,LY 249543,LY-249543,S-isomer of lometrexol,DB04322,LY249543

Cat.No: T10545

Target: PDE

(S)-Thalidomide

Cat.No: T12644L

Synonym: (S)-(-)-Thalidomide

Target: Apoptosis

(S)-Viloxazine Hydrochloride

Cat.No: T22420

Synonym: (S)-Viloxazine HCl

Target: Norepinephrine

1,2-diphenylpropan-2-amine

Cat.No: T50052

Target: Others

Cat.No: T20626

Target: Proton pump, Cysteine Protease

Dexchlorpheniramine Maleate

Cat.No: T0785

Synonym: S-(+)-Chlorpheniramine maleate salt,右泛醇,马来酸右氯苯那敏

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine, Histamine Receptor

1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-

Cat.No: T60224

Target: GluR

Esomeprazole Sodium

Cat.No: T2686L

Synonym: 埃索美拉唑钠,(S)-Omeprazole sodium

Target: ATPase, Proton pump

Esomeprazole Magnesium

Cat.No: T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

(S)-Rasagiline mesylate

Cat.No: T13252L

Synonym: TVP1022 (mesylate),(S)-雷沙吉兰甲磺酸,S-PAI mesylate

Target: Others

Cat.No: T13252

Synonym: TVP1022,(S)-雷沙吉兰,S-PAI

Target: Others

Alpiropride, (S)-

Cat.No: T71319

Cat.No: T70780

Cat.No: T21271

Synonym: L-AMPA, S-AMPA

(2S)-Octyl-α-hydroxyglutarate

Cat.No: T19612

Synonym: (2S)-Octyl-2-HG

Target: Others

Cat.No: T12801

Target: Others

Cat.No: T13869

Synonym: Ribocil S enantiomer,ent-Ribocil A

Target: Others

Cat.No: T13452

Synonym: (+)-MCPG

Target: Others

Dabelotine, (S)-

Cat.No: T31177

Synonym: UNII-494Y55877B

8-Acetyl-2-(dipropylamino)tetralin

Cat.No: T70757

Cat.No: T69453

Cat.No: T25416

Synonym: Evercide 2362

Cat.No: T73802

(S)-Gossypol (acetic acid)

Cat.No: T13980

Synonym: (S)-(+)-Gossypol acetic acid,(S)-Gossypol acetic acid

Target: Others

Lercanidipine, (S)-

Cat.No: T25669

Synonym: (S)-Lercanidipine,(+)-Lercanidipine

Cat.No: T38148

Synonym: (S)-KT109

Esoxybutynin Chloride

Cat.No: T71889

(S)-(–)-Deoxyarbutin

Cat.No: T83925

Cat.No: T37227

Esoxybutynin Free Base

Cat.No: T71268

RSV604 racemate

Cat.No: T72753

Synonym: A-60444 racemate

5(S)-HETE lactone

Cat.No: T37654

Cat.No: T72971

Synonym: (S)-NVP-JDQ443

Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83828

Synonym: Sp-dCTP-α-S

Cat.No: T63390

Cat.No: T68523

Rp-Thymidine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83837

Synonym: Rp-dTTP-α-S

Cat.No: T72809

Synonym: (S)-BRL 24924

Cat.No: T37460

Synonym: Lipoxin B4

Sp-Guanosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83834

Synonym: Sp-GTP-α-S,GTPαS(Sp),GTPαS(A)

(R)-Omeprazole (sodium salt)

Cat.No: T36840

(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid

Cat.No: T36562

Cat. No.	Product Name	Target	Signaling Pathways
T4765	L-Norleucine (S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid,L-2-氨基己酸	Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology
	L-Norleucine ((S)-Norleucine) 是亮氨酸的异构体，特异性影响骨骼肌中的蛋白质合成，具有抗病毒活性。
T0493	L-Tyrosine Tyrosine,P-Tyrosine,L-酪氨酸,L-p-Tyrosine,(S)-Tyrosine,酪氨酸	Amino Acids and Derivatives; Endogenous Metabolite	Metabolism
	L-Tyrosine ((S)-Tyrosine) 是一种非必需氨基酸，对后部皮层中柠檬酸合成酶具有抑制活性。

天然产物

Cat.No: T4765

Synonym: (S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid,L-2-氨基己酸

Target: Influenza Virus, Endogenous Metabolite

Cat.No: T0493

Synonym: Tyrosine,P-Tyrosine,L-酪氨酸,L-p-Tyrosine,(S)-Tyrosine,酪氨酸

Target: Amino Acids and Derivatives, Endogenous Metabolite

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