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22

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6516	Golgicide A	Others; Virus Protease	Microbiology/Virology; Others
	Golgicide A 可抑制柯萨奇病毒 B3 和其他人类肠道病毒的复制。它是一种高度特异性可逆的顺式高尔基体 ADP-核糖基化因子鸟嘌呤核苷酸交换因子抑制剂。
T4061	LY2334737	Nucleoside Antimetabolite/Analog; Others; Virus Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	LY2334737 是一种具有口服活性的 Gemcitabine 的前药，也是核苷类似物。它抑制肠道病毒 A71 感染，有抗病毒和抗癌活性。
T2432	PD 169316	Virus Protease; p38 MAPK; Autophagy	Autophagy; MAPK; Microbiology/Virology
	PD 169316 是一种细胞渗透性 p38 MAP 激酶抑制剂，IC50值为 89 nM。它可选择性地抑制磷酸化 p38 的激酶活性。
T1750	Pirodavir R77975,吡罗达韦	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pirodavir (R77975) 是一种广谱抗小核糖核酸病毒抑制剂，有效抑制人鼻病毒衣壳的结合。
T9350	IMP-1088	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	IMP-1088 是一种人N-肉豆蔻酰基转移酶NMT1和NMT2双重抑制剂，对 HsNMT1 和 HsNMT2 的IC50小于1 nM，对 HsNMT1 的Kd 小于210 pM。它有保护宿主细胞免受病毒感染的细胞毒作用，通过阻断鼻病毒的 N-肉豆蔻酰化蛋白来阻断鼻病毒的复制。
T18928	Brilliant Black BN 亮黑1,E 151	Others; Virus Protease	Microbiology/Virology; Others
	Brilliant Black BN (E 151) 是一种偶氮染料和一种食品着色剂。它抑制 EV71 与其细胞脱壳因子亲环蛋白 A 之间的相互作用，是一种很有前途的抗 EV71 感染的抗病毒药物。
T4536	Pleconaril VP 63843,Win 63843,Picovir,普可那利	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pleconaril (VP 63843) 是一种有潜力研究肠病毒的衣壳抑制剂,，它可有效抑制复制, IC50值为 50 nM。
T4492	pocapavir SCH-48973,V-073	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pocapavir (SCH-48973) 是一种具有口服活性的研究性肠道病毒衣壳抑制剂，可防止病毒粒子进入细胞后脱壳。
T0188	Fluticasone (propionate) 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate	Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Microbiology/Virology
	Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂，是一种局部抗炎激素，亲和力KD 为 0.5 nM。具有抗病毒活性。
T8498	EIDD-1931 Beta-d-N4-hydroxycytidine	Virus Protease; HCV Protease; SARS-CoV; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。
T26020	R 61837 R-61837,R61837	Antiviral	Immunology/Inflammation
	R 61837 是一种新型鼻病毒抑制剂，是一种取代的苯基哒嗪胺，具有抗病毒活性。
T61652	WIN 54954
	WIN 54954 is a potent, orally active, broad-spectrum antipicornavirus agent with demonstrated efficacy against human rhinovirus, echovirus 9, and enterovirus infections [1] [2].
T67792	BTA-188	Antiviral	Immunology/Inflammation
	BTA-188是一种新型的和具有口服活性的合成的苯并恶唑和苯并噻唑衍生物中有效的类似物，具有显著抗鼻病毒活性。
T16809	Rupintrivir AG-7088,AG7088,Rupintrivirvr	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Rupintrivirvr (AG7088) 是一种选择性鼻病毒 (HRV) 3C 半胱氨酸蛋白酶的拟肽抑制剂，具有抗病毒活性和免疫调节活性。Rupintrivirvr 抑制 EV71 和 EV-D68 复制，可用于研究病毒感染。
T31644	Enviroxime LY-122772,LY 122772,LY122772,LY122771-72,NSC 346230
	Enviroxime(LY 122772, NSC 346230) is an anti-infective and anti-disease agent. Enviroxime targets the 3A coding region of rhinovirus and poliovirus.
T27216	DU-34569 Maleate DU34569 Maleate,DU 34569,DU34569,DU-34569
	DU-34569 Maleate, an antiviral agent, acts against influenza A, parainfluenza Sendai, coxsackie A21, and rhinovirus.
T28550	Ro 09-0410 Ro-09-0410,Ro 09 0410
	Ro 09-0410 is an antivirus agent. Ro 09-0410 binds to human rhinovirus type 2 (HRV-2) and inactivates the virus.
T71856	FA-613
	FA-613 is a pyrimidine synthesis inhibitor which exhibits low micromolar antiviral activity against various influenza A and B virus strains, including the highly pathogenic influenza A strains H5N1 and H7N9, enterovirus A71, respiratory syncytial virus, human rhinovirus A, SARS- and MERS-coronavirus.
T36658	Boc-Glu-OBzl
	Boc-Glu-OBzl is an amino acid building block.1,2It has been used in the synthesis of peptide-based inhibitors of human caspases and human rhinovirus (HRV) 3C protease that have enzyme inhibitory activityin vitro. 1.Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49)32608-32613(1998) 2.Dragovich, P.S., Webber, S.E., Babine, R.E., et al.Structure-based design, synthesis, and biological evaluation of i...
T35705	20-hydroxy Arachidic Acid
	20-hydroxy Arachidic acid is a hydroxylated fatty acid that has been found in the suberin component of silver birch (B. pendula) outer bark as well as the leaves, roots, and wood of Q. ilex from Cala Violina and Colognole, Italy. 20-hydroxy Arachidic acid was identified as a potential inhibitor of human rhinovirus coat protein in a structure-based virtual screen.
T80469	Citrullinated LL-37 1cit
	Citrullinated LL-37 1cit 是一种Citrullinated形式的 LL-37 肽，保持了针对 human rhinovirus 的抗病毒 (antiviral) 功能，同时对S. aureus 表现出抗菌 (antibacterial) 活性。此外，Citrullinated LL-37 1cit 能够降低 RV1B 诱导的 IL-8、CCL5 和 IL-6mRNA 水平。
T80470	Citrullinated LL-37 2cit
	Citrullinated LL-37 2cit是瓜氨酸化的LL-37肽，在10 μg/mL浓度下可减弱LL-37对HRV活性的抑制，并降低LL-37的抗菌效果。此外，Citrullinated LL-37 2cit能显著降低RV1B诱导的IL-8、CCL5和IL-6 mRNA水平，并对HRV诱导的CCL5分泌能力有中度抑制作用。

化合物

Cat.No: T6516

Target: Others, Virus Protease

Cat.No: T4061

Target: Nucleoside Antimetabolite/Analog, Others, Virus Protease

Cat.No: T2432

Target: Virus Protease, p38 MAPK, Autophagy

Cat.No: T1750

Synonym: R77975,吡罗达韦

Target: Virus Protease, Antiviral

Cat.No: T9350

Target: Others, DNA/RNA Synthesis

Brilliant Black BN

Cat.No: T18928

Synonym: 亮黑1,E 151

Target: Others, Virus Protease

Cat.No: T4536

Synonym: VP 63843,Win 63843,Picovir,普可那利

Target: Virus Protease, Antiviral

Cat.No: T4492

Synonym: SCH-48973,V-073

Target: Virus Protease, Antiviral

Fluticasone (propionate)

Cat.No: T0188

Synonym: 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate

Target: Glucocorticoid Receptor, Virus Protease, Estrogen/progestogen Receptor, Phospholipase, Endogenous Metabolite

Cat.No: T8498

Synonym: Beta-d-N4-hydroxycytidine

Target: Virus Protease, HCV Protease, SARS-CoV, Topoisomerase

Cat.No: T26020

Synonym: R-61837,R61837

Target: Antiviral

Cat.No: T61652

Cat.No: T67792

Target: Antiviral

Cat.No: T16809

Synonym: AG-7088,AG7088,Rupintrivirvr

Target: Virus Protease, Antiviral

Cat.No: T31644

Synonym: LY-122772,LY 122772,LY122772,LY122771-72,NSC 346230

DU-34569 Maleate

Cat.No: T27216

Synonym: DU34569 Maleate,DU 34569,DU34569,DU-34569

Cat.No: T28550

Synonym: Ro-09-0410,Ro 09 0410

Cat.No: T71856

Cat.No: T36658

20-hydroxy Arachidic Acid

Cat.No: T35705

Citrullinated LL-37 1cit

Cat.No: T80469

Citrullinated LL-37 2cit

Cat.No: T80470

Cat. No.	Product Name	Target	Signaling Pathways
T5779	MOSLOFLAVONE	IL Receptor; Virus Protease; TNF; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Mosloflavone 从Scutellaria baicalensis Georgi 中分离出的类黄酮，具有抗EV71活性。它可抑制铜绿假单胞菌的毒力和生物膜形成，有作为杀菌剂的潜力。它在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达，并抑制病毒 VP2 衣壳蛋白合成。
T5S2360	Corydaline Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline	P450; Virus Protease; Opioid Receptor; AChE	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱，是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运，促进胃的调节，具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。
T8205	Norwogonin 5,7,8-Trihydroxyflavone,去甲汉黄芩素	Virus Protease	Microbiology/Virology
	Norwogonin (5,7,8-Trihydroxyflavone) 是从黄芩中分离出来的，对肠道病毒 71 具有抗病毒活性，IC50为 31.83 μg/ ml。
T3345	Hederasaponin B 常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B	Others; Virus Protease	Microbiology/Virology; Others
	Hederasaponin B (Hederacoside B) 是从Hedera helix 中分离的，有广谱抗病毒活性。
T1670	Lanatoside C Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C	ATPase; Virus Protease; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Lanatoside C (Ceglunate) 是一种可用于治疗充血性心力衰竭和心律失常的强心苷类药物。它作用于 HuH-7细胞，可抗登革病毒感染， IC50为0.19 μM。
TN2111	Prunin Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷	Phosphatase; Anti-infection; Virus Protease	Metabolism; Microbiology/Virology
	Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B，IC50值为 5.5 μM。

天然产物

Cat.No: T5779

Target: IL Receptor, Virus Protease, TNF, Antibacterial

Cat.No: T5S2360

Synonym: Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Cat.No: T8205

Synonym: 5,7,8-Trihydroxyflavone,去甲汉黄芩素

Target: Virus Protease

Hederasaponin B

Cat.No: T3345

Synonym: 常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B

Target: Others, Virus Protease

Cat.No: T1670

Synonym: Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C

Target: ATPase, Virus Protease, Autophagy

Cat.No: TN2111

Synonym: Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷

Target: Phosphatase, Anti-infection, Virus Protease

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