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Search Results for " paclitaxel "

62

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20864	7-Troc-paclitaxel	Others	Others
	7-Troc-paclitaxel 是紫杉醇的前体，紫杉醇具有抗肿瘤活性。
T28289	Paclitaxel-SMCC SMCC taxol, Taxol-SMCC, Taxol SMCC,Paclitaxel with SMCC linker,SMCC-Taxol,Paclitaxel ADC conjugate.
	Paclitaxel-SMCC is a paclitaxel derivative with a SMCC linker. (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate). Paclitaxel-SMCC can be used to synthesize Paclitaxel bioconjugates with enzymes, antobodies, antigens and other biopolymers. Pa
T33862	Paclitaxel-Succinic acid Paclitaxel-hemisuccinic acid
	Paclitaxel-Succinic acid (paclitaxel-succinate , paclitaxel-semisucinic acid)is a paclitaxel derivative with a succinic acid linker. Paclitaxel-Succinic acid can be used to prepare paclitaxel conjugates for drug delivery and nanomedicine research.
T36398	Paclitaxel octadecanedioate
	Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 μM. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft mo...
T70006	DHA-paclitaxel
	DHA-paclitaxel, also know as Taxoprexin, is prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the func...
T33861	Paclitaxel-MVCP
	Paclitaxel-MVCP ( MC-val-cit-pab-paclitaxel )is a paclitaxel derivative with an MC-Val-Cit-PAB linker, which can be used for the preparation of Paclitaxel conjugates for drug delivery and nanomedicine research.
T20265	Paclitaxel Poliglumex CT2103,Opaxio,PG-TXL,CT-2103,PPX,CT 2103
	Paclitaxel Poliglumex is cyclohexane isolated from the bark of the Pacific yew tree.
T36896	6α-hydroxy Paclitaxel 6alpha-hydroxypaclitaxel	Drug Metabolite	Metabolism
	6α-hydroxy Paclitaxel (6α-OH-PTX) 是抗癌化合物紫杉醇的主要代谢产物，具有部分细胞毒性。
T70114	Paclitaxel Ceribate
	Paclitaxel Ceribate is a mitotic inhibitor used in cancer chemotherapy.
T17343	7-O-(Amino-PEG4)-paclitaxel	Others	Others
	7-O-(Amino-PEG4)-paclitaxel is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T78546	Abraxane Nab-Paclitaxel
	Abraxane（Nab-Paclitaxel）为一种Paclitaxel纳米颗粒与白蛋白结合的制剂，展现出较高的疗效及耐受性。通过利用白蛋白传递Paclitaxel，Abraxane形成优异的药代动力学特性。
T17344	7-O-(Cbz-N-amido-PEG4)-paclitaxel	Others	Others
	7-O-(Cbz-N-amido-PEG4)-paclitaxel is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T24557	NSC756093 NSC-756093,NSC 756093	Others	Others
	NSC756093 可能抑制 GBP1:PIM1 相互作用。 NSC756093 可用于卵巢癌研究。
T70005	LY3325656
	LY3325656 is a GPR142 agonist suitable for clinical testing in human. LY3325656 demonstrated anti-diabetic benefits in pre-clinical studies and ADME/PK properties suitable for human dosing. LY3325656 is the first GPR142 agonist molecule advancing to phase 1 clinic trials for the treatment of Type 2 diabetes.
T64325	(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid	Others	Others
	(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid 又名多烯紫杉醇侧链，作为一种医药中间体，主要用于合成药物多烯紫杉醇。
T60009	YS-370	P-gp	Membrane transporter/Ion channel; Neuroscience
	YS-370 是一种具有口服活性的 P-gp 抑制剂，对 CYP3A4 有中度抑制作用。 YS-370 有效逆转对紫杉醇和秋水仙碱的多药耐药性，与紫杉醇联合应用表现出更强的抗肿瘤活性。
T15055	DB04760 MMP-13 Inhibitor	MMP	Proteases/Proteasome
	DB04760 是一种高选择性和有效的 MMP-13 非锌螯合抑制剂（IC50：8 nM）。DB04760 能明显降低紫杉醇的神经毒性，并具有抗癌活性。
T27405	GAT211 GAT-211,AZ-4,GAT 211,AZ 4,AZ4
	GAT211 is a CB1 positive allosteric modulator. GAT211 suppresses allodynia and produces synergistic antiallodynic effects with monoacylglycerol lipase and fatty acid amide hydrolase inhibitors in paclitaxel-treated mice.
T40781L	Geranylgeranyl pyrophosphate tetrabutylammonium(1:1.5)	Others	Others
	(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl dihydrogen diphosphate,tetrabutylammonium(1:1.5) 是紫杉二烯，如紫杉醇，的常见前体。
T9955	EX-A5758	NOS	Immunology/Inflammation
	EX-A5758是一种新型推定的小分子 nNOS-NOS1 AP 抑制剂，可抑制炎症性伤害感受和化疗引起的神经性疼痛，并与紫杉醇协同降低肿瘤细胞活力
T4286	Fmoc-Val-Ala-PAB-OH Fmoc-Val-Ala-PAB	Others; AChR	Neuroscience; Others
	Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) 是一种有用的接头，可用于制备用于靶向药物递送的抗体-药物偶联物。它还用于合成带有溶酶体可切割接头的 RGD 拟肽-紫杉醇缀合物。
T4595	YHO-13177 YHO 13177,YHO13177	BCRP	Membrane transporter/Ion channel
	YHO-13177 是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，可增强SN-38活性。
T77401	Bavituximab Anti-PS MAb 3G4	Others	Others
	Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) 是一种针对磷脂酰丝氨酸 (PS) 的单克隆抗体，具有血管靶向和免疫调节特性，能够重新激活抗肿瘤免疫来抑制肿瘤生长。Bavituximab 具有抗癌活性，常联合Paclitaxel 和 Carboplatin 来研究非小细胞肺癌。
T40781L1	Geranylgeranyl pyrophosphate tetrabutylammonium(1：2) Geranylgeranyl pyrophosphate tetrabutylammonium（1：2）(6699-20-3 Free base)	Others	Others
	Geranylgeranyl pyrophosphate tetrabutylammonium(1：2)是甲羟戊酸途径产生内源性胆固醇和中间体之一。Geranylgeranyl pyrophosphate tetrabutylammonium(1：2) 香叶基香叶基焦磷酸三铵是二萜类化合物的常见前体，例如紫杉醇，可用于癌症研究。
T83638	IR820-PTX	Others	Others
	IR820-PTX 是一种由 IR-820 和紫杉醇组成的纳米颗粒，具有高渗透性且可靶向肿瘤。IR820-PTX 可用于近红外荧光成像和肿瘤诊断。
T6075	Epothilone B 帕妥匹隆,Patupilone,EPO 906	Apoptosis; Microtubule Associated; Antibiotic; Antifungal	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology
	Epothilone B (EPO 906) 是微管稳定剂，Ki 为0.71 μM。它与αβ-微管蛋白异二聚体亚基结合，使αβ-微管蛋白解离减少。
T7055	Bz-RS-ISer(3-Ph)-Ome Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物，在低细胞毒性下抑制 HSV 复制周期，阻断 Vero 细胞的有丝分裂，影响 M-MSV 诱导的肿瘤大小，并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。
T8826	3-AMINO-1,2,4-TRIAZINE	Others	Others
	3-AMINO-1,2,4-TRIAZINE 是一种芳香族生物活性化合物，已用于合成各种药物，包括抗真菌药物氟康唑、抗炎药物布洛芬和抗癌药物紫杉醇；也被用于设计新药，如抗艾滋病药物齐多夫定和抗疟疾药物青蒿素；以及用于合成各种其他化合物，如抗糖尿病药物二甲双胍和抗高血压药物赖诺普利。
T41026	Biotin-LC-LC-NHS
	Biotin-LC-LC-NHS is a SMCC cross-linking reagent, which serves as a labeling agent for antibodies and small molecules, like Paclitaxel.
T68906	Miliusol
	Miliusol is a natural anti-tumor agent, demonstrating with tumor inhibitory efficacy comparable or even superior to the mainstay chemotherapeutics paclitaxel or fluorouracil.
T71875	OM-137
	OM137 is an inhibitor of Aurora kinases. which is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel.
T15514	Hydroxy-PEG10-Boc	Others	Others
	Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel or docetaxel [2].
T69415	CK0106023
	CK0106023 was specific inhibitor of KSP. In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. KSP was most abundant in proliferating human tissues and was absent from cultured postmitotic neurons.
T40781	Geranylgeranyl pyrophosphate
	Geranylgeranyl pyrophosphate, a key metabolite in protein geranylgeranylation, serves as the universal precursor for diterpenoids, such as Paclitaxel. Its role in cancer research stems from this critical function.
T21317	Avanbulin BAL27862,BAL-27862,BAL 27862
	Avanbulin is a potent inhibitor of tubulin polymerization with antitumor activity. It elicits a unique microtubule (MT) phenotype, distinct from colchicine, paclitaxel, and vinblastine has broad in vitro anti-proliferative activity against a diverse range
T72866	(Rac)-ZLc-002
	(Rac)-ZLc-002 是nNOS 与一氧化氮合酶 1 衔接蛋白 (NOS1AP) 相互作用的抑制剂，抑制炎症性痛觉和化疗诱导的神经性疼痛，并与 Paclitaxel 协同降低肿瘤细胞活力。
T79508	Microtubule stabilizing agent-1
	Microtubule stabilizing agent-1 (compound 3l)，作为一种紫杉醇衍生物，能够有效地促进微管蛋白聚合 (tubulin polymerization)，并且展现了显著的抗肿瘤效能。
T41179	CL 82198 hydrochloride
	CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibitsin vitroinvasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.
T68568	Encequidar, HCl
	Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials.
T73950	Flutax-2 (5/6-mixture)
	Flutax-2 (5/6-mixture)为紫杉醇的一种活性荧光衍生物，能与α,β微管蛋白二聚体发生结合。其激发/发射波长分别为496/524 nm。紫杉醇作为红豆杉属植物产生的二萜类次生代谢物，在多种癌症研究中有应用。Flutax-2的储存应避光处理。
T78974	P-gp inhibitor 13
	P-gp inhibitor 13为P-gp抑制剂，能够逆转A2780/T细胞中P-糖蛋白介导的紫杉醇耐药。该抑制剂主要用于研究晚期急性髓性白血病。
T69956	KR30031
	KR30031 is a novel P-glycoprotein inhibitor with potential anticancer activity. KR30031 is a verapamil analog with fewer cardiovascular effects. The ability of KR-30031 to reduce this efflux transport is equal to that of verapamil, a well-known P-glycoprotein inhibitor. The bioavailability of paclitaxel could be enhanced by coadministration of a P-glycoprotein inhibitor, KR-30031.
T71099	LLL12
	LLL12 是一种 STAT3小分子抑制剂，抑制 STAT3磷酸化。LLL12 增强顺铂和紫杉醇对卵巢癌症细胞生成、迁徙、和生长的抑制作用。
T64016	WS-898
	WS-898 是 ABCB1 的高效抑制剂，能够逆转耐药SW620/Ad300、KB-C2 和 HEK293/ABCB1 细胞对紫杉醇（PTX）的耐药性，他们的 IC50 值分别为 5.0、3.67 和 3.68 nM。
T76871	Navicixizumab
	Navicixizumab (OMP-305B83) 是一种双特异性抗 VEGF 和抗 DLL4抑制抗体。Navicixizumab 可以与紫杉醇结合用于癌症研究。Navicixizumab 可用于卵巢癌、原发性腹膜癌或输卵管癌的研究。
T73195	EAPB 02303
	EAPB 02303 是一种微管破坏剂和抑制剂。EAPB 02303 诱导有丝分裂停止和纺锤体组装损伤。因此，EAPB 02303 诱导细胞凋亡 (apoptosis) 并表现出抗肿瘤活性。EAPB 02303 在较低浓度下也表现出与紫杉醇的强协同作用。
T35432	α-Conotoxin ImI (trifluoroacetate salt)
	α-Conotoxin ImI is a conotoxin that has been found inC. imperialisand has receptor antagonist and anticancer activities.1It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50= 220 nM). α-Conotoxin ImI is selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 μM but does inhibit homomeric α9 nAChRs (IC50= 1,800 nM). Administration of paclitaxel in micelles containing α-conotoxin ImI decreases tumor growth in ...
T60289	Pemirolast
	Pemirolast 是一种具有口服活性的抗过敏剂。Pemirolast 通过抑制感觉神经肽的释放来减轻紫杉醇超敏反应，可用于对支气管哮喘和结膜炎的研究。
T63608	P-gp inhibitor 5
	P-gp inhibitor 5 是 P 糖蛋白 (P-gp) 的有效抑制剂，在 1.25 μM 和 2.5 μM 时 P-gp 抑制倍数分别为 2.5 和 3.0。P-gp inhibitor 5 对某些癌细胞表现出抗增殖效果。P-gp inhibitor 5 能够恢复细胞对 Vincristine 和 Paclitaxel 的敏感性，进而逆转 ABCB1/Flp-InTM-293 和 KBvin 的多药耐药 (MDR) 表型。
T69976	WS-691
	WS-691 is a highly Potent and Orally Active ABCB1 Modulator. WS-691 significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC50 = 22.02 nM). WS-691 significantly increased the intracellular concentration of PTX and [3H]-PTX while decreasing the efflux of [3H]- PTX in SW620/Ad300 cells by inhibiting the efflux function of ABCB1. WS-691 could stabilize ABCB1 by directly binding to ABCB1 WS-691 increased the sensitivity of SW620/Ad300 cells to PTX in vi...

化合物

7-Troc-paclitaxel

Cat.No: T20864

Target: Others

Paclitaxel-SMCC

Cat.No: T28289

Synonym: SMCC taxol, Taxol-SMCC, Taxol SMCC,Paclitaxel with SMCC linker,SMCC-Taxol,Paclitaxel ADC conjugate.

Paclitaxel-Succinic acid

Cat.No: T33862

Synonym: Paclitaxel-hemisuccinic acid

Paclitaxel octadecanedioate

Cat.No: T36398

DHA-paclitaxel

Cat.No: T70006

Paclitaxel-MVCP

Cat.No: T33861

Paclitaxel Poliglumex

Cat.No: T20265

Synonym: CT2103,Opaxio,PG-TXL,CT-2103,PPX,CT 2103

6α-hydroxy Paclitaxel

Cat.No: T36896

Synonym: 6alpha-hydroxypaclitaxel

Target: Drug Metabolite

Paclitaxel Ceribate

Cat.No: T70114

7-O-(Amino-PEG4)-paclitaxel

Cat.No: T17343

Target: Others

Cat.No: T78546

Synonym: Nab-Paclitaxel

7-O-(Cbz-N-amido-PEG4)-paclitaxel

Cat.No: T17344

Target: Others

Cat.No: T24557

Synonym: NSC-756093,NSC 756093

Target: Others

Cat.No: T70005

(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid

Cat.No: T64325

Target: Others

Cat.No: T60009

Target: P-gp

Cat.No: T15055

Synonym: MMP-13 Inhibitor

Target: MMP

Cat.No: T27405

Synonym: GAT-211,AZ-4,GAT 211,AZ 4,AZ4

Geranylgeranyl pyrophosphate tetrabutylammonium(1:1.5)

Cat.No: T40781L

Target: Others

Cat.No: T9955

Target: NOS

Fmoc-Val-Ala-PAB-OH

Cat.No: T4286

Synonym: Fmoc-Val-Ala-PAB

Target: Others, AChR

Cat.No: T4595

Synonym: YHO 13177,YHO13177

Target: BCRP

Cat.No: T77401

Synonym: Anti-PS MAb 3G4

Target: Others

Geranylgeranyl pyrophosphate tetrabutylammonium(1：2)

Cat.No: T40781L1

Synonym: Geranylgeranyl pyrophosphate tetrabutylammonium（1：2）(6699-20-3 Free base)

Target: Others

Cat.No: T83638

Target: Others

Cat.No: T6075

Synonym: 帕妥匹隆,Patupilone,EPO 906

Target: Apoptosis, Microtubule Associated, Antibiotic, Antifungal

Bz-RS-ISer(3-Ph)-Ome

Cat.No: T7055

Synonym: Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate

Target: Others, HIV Protease

3-AMINO-1,2,4-TRIAZINE

Cat.No: T8826

Target: Others

Biotin-LC-LC-NHS

Cat.No: T41026

Cat.No: T68906

Cat.No: T71875

Hydroxy-PEG10-Boc

Cat.No: T15514

Target: Others

Cat.No: T69415

Geranylgeranyl pyrophosphate

Cat.No: T40781

Cat.No: T21317

Synonym: BAL27862,BAL-27862,BAL 27862

Cat.No: T72866

Microtubule stabilizing agent-1

Cat.No: T79508

CL 82198 hydrochloride

Cat.No: T41179

Encequidar, HCl

Cat.No: T68568

Flutax-2 (5/6-mixture)

Cat.No: T73950

P-gp inhibitor 13

Cat.No: T78974

Cat.No: T69956

Cat.No: T71099

Cat.No: T64016

Cat.No: T76871

Cat.No: T73195

α-Conotoxin ImI (trifluoroacetate salt)

Cat.No: T35432

Cat.No: T60289

P-gp inhibitor 5

Cat.No: T63608

Cat.No: T69976

Cat. No.	Product Name	Target	Signaling Pathways
T0968	Paclitaxel Taxol,紫杉醇,NSC 125973	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Paclitaxel (Taxol) 属于天然产物，是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性；通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等，导致细胞死亡。
T5738	7-Epi 10-desacetyl paclitaxel 10-Deacetyl-7-epipaclitaxel,7-Epi-10-deacetyltaxol,7-表-10-去乙酰基云南紫杉宁A	Others	Others
	7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) 是紫杉醇衍生物，对 HeLa 细胞具有细胞毒性(IC50:85 μM)。
T5749	10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物，具有改进的药理特性和更高的水溶性，用于治疗癌症。
T5165	10-Deacetyltaxol 10-DAT,10-Desacetyl Paclitaxel,去乙酰紫衫醇,Deacetyltaxol,10-去乙酰紫杉醇,10-deacetyl-paclitaxel,Deacetyl Paclitaxel	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	10-Deacetyltaxol (10-DAT) 是从红豆杉中分离得到的一种紫杉醇衍生物，对人脑胶质细胞瘤和神经母细胞瘤细胞具有细胞毒性。它能促进微管蛋白的聚合，在体外抑制由钙离子诱导的微管解聚。
T3S2372	7-epi-Taxol 7-Epitaxol,7-表紫杉醇,7-epi-Paclitaxel	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	7-epi-Taxol (7-Epitaxol) 是在细胞中发现的紫杉醇的主要衍生物，在抑制细胞增殖、微管解离和诱导微管聚合等方面与紫杉醇作用相当。
T2788	Baccatin III 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ	Others	Others
	Baccatin III (Baccatin Ⅲ) 是一种分离自太平洋紫杉树和其近缘种中的天然产物，能够减少 MDSCs 积累并抑制其功能，延缓肿瘤发展进程。
T7054	N-Benzoyl-(2R,3S)-3-phenylisoserine N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸,taxol side chain	Antiviral	Immunology/Inflammation
	N-Benzoyl-(2R,3S)-3-phenylisoserine (taxol side chain) 是一种制备用于研究结合位点位置的强效抗癌药物紫杉醇的中间体。它显示出细胞毒性、抗病毒和免疫调节活性。
T1034	Docetaxel 多西他赛,NSC 628503,RP-56976,多烯紫杉醇	Apoptosis; Microtubule Associated; Endogenous Metabolite	Apoptosis; Cytoskeletal Signaling; Metabolism
	Docetaxel (RP-56976) 是紫杉醇的半合成类似物，是一种微管解聚抑制剂 (IC50=0.2 μM)。Docetaxel 可以减弱 bcl-2 和 bcl-xL 基因表达的影响，具有诱导凋亡、抗肿瘤活性。
T5S0167	Atractylenolide I 白术内酯 I,白术内酯I；苍术内酯I	IL Receptor; TNF; TLR; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Atractylenolide I 是从白术根中得到的一种倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂，在 A375 细胞中，能够降低JAK2和STAT3的磷酸化水平。
TN2254	Taccalonolide A 根薯酮内酯A,根薯酮内酯 A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Taccalonolide A 是从水田七根茎中分离得到的一种类固醇，具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用，抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂，能引起 G2-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。
T2S2378	7-Xylosyltaxol	Others	Others
	7-xylosyltaxol is a taxol (Paclitaxel) derivative, has antineoplastic activity.
T13653	Dihydrocephalomannine	Others	Others
	Dihydrocephalomannine is similar to paclitaxel, showing reduced cytotoxicity and tubulin binding.
TN1335	7-Xylosyl-10-deacetyltaxol B 7-xylosyl-10-Deacetylpaclitaxel B	Others	Others
	7-Xylosyl-10-deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) 是一种来自红豆杉科植物东北红豆杉的紫杉醇衍生物，具有抗肿瘤活性，可用于合成紫杉醇。
TN4616	N-Methyltaxol C	Others	Others
	N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate
T74761	Eleutherobin
	Eleutherobin 是一种有效的 β 微管蛋白 (β-microtubule)，IC50为 2 μM。Eleutherobin 可从海洋软珊瑚中提取。Eleutherobin 对癌细胞的细胞毒活性具有与紫杉醇 (Paclitaxel)) 相似的效力。具有抗癌活性。

天然产物

Cat.No: T0968

Synonym: Taxol,紫杉醇,NSC 125973

Target: Apoptosis, Microtubule Associated, Autophagy

7-Epi 10-desacetyl paclitaxel

Cat.No: T5738

Synonym: 10-Deacetyl-7-epipaclitaxel,7-Epi-10-deacetyltaxol,7-表-10-去乙酰基云南紫杉宁A

Target: Others

10-Deacetyl-7-xylosyl paclitaxel

Cat.No: T5749

Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside

Target: Others, Microtubule Associated

10-Deacetyltaxol

Cat.No: T5165

Synonym: 10-DAT,10-Desacetyl Paclitaxel,去乙酰紫衫醇,Deacetyltaxol,10-去乙酰紫杉醇,10-deacetyl-paclitaxel,Deacetyl Paclitaxel

Target: Others, Microtubule Associated

Cat.No: T3S2372

Synonym: 7-Epitaxol,7-表紫杉醇,7-epi-Paclitaxel

Target: Others, Microtubule Associated

Cat.No: T2788

Synonym: 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ

Target: Others

N-Benzoyl-(2R,3S)-3-phenylisoserine

Cat.No: T7054

Synonym: N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸,taxol side chain

Target: Antiviral

Cat.No: T1034

Synonym: 多西他赛,NSC 628503,RP-56976,多烯紫杉醇

Target: Apoptosis, Microtubule Associated, Endogenous Metabolite

Atractylenolide I

Cat.No: T5S0167

Synonym: 白术内酯 I,白术内酯I；苍术内酯I

Target: IL Receptor, TNF, TLR, JAK, STAT

Taccalonolide A

Cat.No: TN2254

Synonym: 根薯酮内酯A,根薯酮内酯 A

Target: Apoptosis, Microtubule Associated

Cat.No: T2S2378

Target: Others

Dihydrocephalomannine

Cat.No: T13653

Target: Others

7-Xylosyl-10-deacetyltaxol B

Cat.No: TN1335

Synonym: 7-xylosyl-10-Deacetylpaclitaxel B

Target: Others

N-Methyltaxol C

Cat.No: TN4616

Target: Others

Cat.No: T74761

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