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Search Results for " muscarinic receptor antagonist "

93

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0218	Biperiden Bipariden,Akineton,KL 373,比哌立登,Biperidine	AChR	Neuroscience
	Biperiden (Bipariden) 是中枢 M1胆碱受体阻断剂，有抗帕金森症活性。
T9771	Velufenacin	AChR	Neuroscience
	Velufenacin 是一种毒蕈碱型受体 (muscarinic receptor) 的拮抗剂。
T16989	Tarafenacin D-tartrate SVT-40776 D-tartrate	Others	Others
	Tarafenacin D-tartrate is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over the M2 receptor.
T13992	CHF5407 SVT-47060	AChR	Neuroscience
	CHF5407（SVT-47060）是一种具有有效性和选择性的毒蕈碱 M3 受体拮抗剂，可长期作用于毒蕈碱受体。CHF5407 对支气管痉挛有作用，可用于研究呼吸系统疾病。
T23297	(S)-(+)-Dimethindene maleate	AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	(S)-(+)-Dimethindene maleate 是一种可口服且具有选择性毒蕈碱 M2 受体和组胺 H1 受体拮抗剂，抑制毒蕈碱 M1，M3 和 M4 受体。
T7895	Syn-Ake acetate 类蛇毒三肽,Dipeptide diaminobutyroyl benzylamide	AChR	Neuroscience
	Syn-Ake acetate (Dipeptide diaminobutyroyl benzylamide) 是一种毒蕈碱乙酰胆碱受体拮抗剂。
T10914L	Cyclodrine Cyclopent	AChR	Neuroscience
	Cyclodrine (Cyclopent) 是一种胆碱能 (毒蕈碱，烟碱) 受体 (mAChR 和 nAChR) 拮抗剂。
T13385	Zamifenacin fumarate 扎非那星富马酸盐,UK-76654 fumarate	AChR	Neuroscience
	Zamifenacin fumarate (UK-76654 fumarate) 是肠道选择性毒蕈碱M3受体的有效拮抗剂，可显著降低肠易激综合症的结肠蠕动。
T10914	Cyclodrine hydrochloride	AChR	Neuroscience
	Cyclodrine hydrochloride 是一种胆毒蕈碱受体（mAChR）和烟碱受体（nAChR）双重拮抗剂，可以用于研究神经系统相关疾病。
T6364	Desfesoterodine 5-HMT,(R)-5-Hydroxymethyl Tolterodine,(R)-5-羟甲基托特罗定,PNU-200577,5-HM,5-hydroxymethyl Tolterodine	AChR	Neuroscience
	Desfesoterodine (5-HMT) 是选择性毒蕈碱受体拮抗剂，Kb 和pA2分别为 0.84 nM 和 9.14。它可改善大鼠脑梗死诱导膀胱过度活动，是 Tolterodine 和 Fesoterodine 的主要药理活性代谢产物。
T1542	Pirenzepine dihydrochloride Pirenzepine HCl,Bisvanil,Tabe,盐酸哌仑西平,LS519	AChR	Neuroscience
	Pirenzepine dihydrochloride (LS519) 是一种选择性 M1 毒蕈碱受体拮抗剂，可抑制胃液分泌。
T5655	mAChR-IN-1 hydrochloride	AChR	Neuroscience
	mAChR-IN-1 hydrochloride 是一种毒蕈碱胆碱能受体抑制剂，IC50值为17nM。
T31207	GSK233705 Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B	AChR	Neuroscience
	GSK233705 (Darotropium bromide) 是一种毒蕈碱受体拮抗剂，可用来与预防和治疗人类的慢性阻塞性肺病(COPD)和哮喘。
T23508	VU 0255035	AChR	Neuroscience
	VU 0255035 是高度选择性、竞争性和血脑屏障通透性的毒蕈碱 M1 受体拮抗剂，IC50为 130 nM，可减少毛果芸香碱诱导的小鼠癫痫发作。
T7079	Batefenterol GSK961081,TD-5959	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Batefenterol (TD-5959) 是一种毒蕈碱受体拮抗剂和β2-肾上腺素受体激动剂，对 hM2、hM3和β2-肾上腺素受体有高亲和力，Ki 值分别为 1.4、1.3 和 3.7 nM。
T1534	Darifenacin hydrobromide 氢溴酸达非那新,Darifenacin HBr,UK-88525	AChR	Neuroscience
	Darifenacin hydrobromide (UK-88525) 是一种选择性 M3 蕈毒碱受体拮抗剂，pKi 为 8.9。
T29687	Afacifenacin Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986	AChR	Neuroscience
	Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂，可用于研究缺血性心脏病，尿失禁和膀胱炎和其他疾病。
T0099	Tolterodine tartrate Detrol LA,PNU-200583E,Kabi-2234,酒石酸托特罗定	AChR	Neuroscience
	Tolterodine tartrate (PNU-200583E) 是毒蕈碱受体的有效拮抗剂。它在体内显示出对膀胱和唾液腺的选择性。
T28722	SCH 57790 SCH57790,SCH-57790	AChR	Neuroscience
	SCH 57790 是一种新型且具有选择性的毒蕈碱 M（2）受体拮抗剂，可释放乙酰胆碱并增强实验动物的认知能力，可用于治疗阿尔茨海默病。
TP1902L1	G-Protein antagonist peptide acetate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	G-Protein antagonist peptide acetate 是一种 substance P 相关肽，可抑制 G 蛋白与其受体的结合。G-Protein antagonist peptide acetate 竞争性和可逆性地抑制毒蕈碱型乙酰胆碱受体 M2 (M2 muscarinic receptor) 对 Gi 或 Go 的激活，并通过 β-肾上腺素受体抑制 Gs 的激活。
T8147	Solifenacin 索利那新,YM905 free base	AChR	Neuroscience
	Solifenacin (YM905 free base) 是一种新型的毒蕈碱受体拮抗剂，对 M1、M2和 M3受体的 pKi 值分别为 7.6、6.9 和 8.0。
T60536	Terodiline	Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Terodiline 是一种可口服的选择性毒蕈碱M1受体和钙通道拮抗剂，可用于研究膀胱功能异常引起的疾病。
T1179	Tiotropium bromide Tiopropium,噻托溴铵,BA679 BR	AChR	Neuroscience
	Tiotropium bromide (BA679 BR) 是一种毒蕈碱乙酰胆碱受体拮抗剂，可阻断乙酰胆碱配体的结合。
T10000	(±)-Tazifylline	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	(±)-Tazifylline 是一种选择性的长效组胺 H1 受体拮抗剂。 Tazifylline 对 H2 受体、α- 和 β-肾上腺素能受体、5-羟色胺和毒蕈碱受体亚型的亲和力要低得多。
T13370	YM-46303	AChR	Neuroscience
	YM-46303 是一种具有选择性和有效性的毒蕈碱受体拮抗剂，对 M3 受体表现出较高的亲和力。YM-46303 可用于研究髓状大鼠心动过缓。
T14345	Atropine methyl bromide 甲溴阿托品,Methylatropine bromide	AChR	Neuroscience
	Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functions as a mydriatic to dilate the pupil during ophthalmic examination. Compared to atropine, it demonstrates reduced penetration into the central nervous system[1][2]. Its high polarity makes it particularly effective in relieving pyloric spasm in infants.
T1475	Fesoterodine fumarate Toviaz,SPM 907,富马酸非索罗定	AChR	Neuroscience
	Fesoterodine fumarate (Toviaz) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T12489L	Pimethixene maleate Pimetixene maleate	Dopamine Receptor; 5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pimethixene maleate (Pimetixene maleate) 是一种高效的 5-HT2B 受体拮抗剂，具有镇静和镇咳活性。Pimethixene maleate 抑制 5-HT1A，5-HT2A，5-HT2B，5-HT2C，组胺 H1，多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2，可用于研究儿童干咳和刺激性咳嗽。
T5051	Isopropamide Iodide	AChR	Neuroscience
	Isopropamide iodide 是长效季铵盐抗胆碱能药物。它用于研究消化性溃疡和其他胃肠道疾病，尤其是胃酸过多和运动过度。
T1006	Propantheline bromide Neopepulsan,溴丙胺太林,Pro-Banthine,Neometantyl	AChR	Neuroscience
	Propantheline bromide (Pro-Banthine) 是一种抗毒蕈碱剂，用于研究多汗症，遗尿，胃肠和膀胱痉挛。
T4494	CLOZAPINE N-OXIDE 氯氮平N-氧化,氯氮平N-氧化物	Dopamine Receptor; 5-HT Receptor; AChR; Drug Metabolite	GPCR/G Protein; Metabolism; Neuroscience
	Clozapine N-oxide 是 Clozapine 的主要代谢产物，具有血脑屏障渗透性。Clozapine N-oxide 是一种 DREADDs 激动剂，可激活 DREADD 受体 hM3Dq 和 hM4Di。Clozapine N-oxide 也是一种多巴胺拮抗剂和选择性毒蕈碱 M4 受体激动剂。
T6426	Buclizine dihydrochloride 盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Buclizine dihydrochloride (Buclina) 是可口服的一种哌嗪组胺 H1 受体拮抗剂，主要具有止吐和抗眩晕活性。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T68599	Orphenadrine Orphenadrine (free base)	Sodium Channel; NMDAR; AChR	Membrane transporter/Ion channel; Neuroscience
	Orphenadrine 是一种非竞争性的 N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，以浓度依赖性方式抑制克隆的 HERG 通道，在 HEK 细胞中产生0.85μM 的 IC。Orphenadrine 是中枢和外周毒蕈碱受体的拮抗剂，通过孔残基 Y652或 F656突变阻断衰减。 Orphenadrine 具有抗痉挛、镇痛和抗胆碱能活性，对在体外和体内对谷氨酸神经毒性具有保护作用。Orphenadrine 对钠离子通道具有抑制作用，可用来治疗帕金森。
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T25697	Levophencynonate Levo-phencynonate
	Levophencynonate is a muscarinic receptor antagonist.
T25697L	Levophencynonate HCl Levophencynonate hydrochloride,R-(-)-Phencynonate hydrochloride
	Levophencynonate HCl is a muscarinic receptor antagonist.
T23124	PD 102807	Others	Others
	M4 muscarinic receptor antagonist
T22709	DAU 5884 hydrochloride	Others	Others
	muscarinic M3 receptor antagonist
T23452	Telenzepine dihydrochloride	Others	Others
	muscarinic M1 receptor antagonist
T22876	J 104129 fumarate	Others	Others
	M3 muscarinic receptor antagonist
T23379	Solifenacin hydrochloride	Others	Others
	Solifenacin Hcl is a muscarinic receptor antagonist.
T15211	Elucaine	Others	Others
	Elucaine is an antagonist of the muscarinic acetylcholine receptor. It has anti-ulcerative activity.
T13372	YM-58790 hydrochloride	Others	Others
	YM-58790 hydrochloride is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).
T12680	(±)-Darifenacin (±)-UK-88525	Others	Others
	(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective antagonist of M3 muscarinic receptor.
T27199	Doxacurium Chloride BW A 938U,BWA938U,Nuromax,BW-A-938U
	Doxacurium Chloride is a muscarinic acetylcholine receptor M2 antagonist.
T29047	UH-AH 37 UH-AH-37,UH-AH37
	UH-AH 37 is a antagonist of human muscarinic acetylcholine receptor.
T71014	Aprophit
	Aprophit is a muscarinic antagonist that has been shown to selectively acylate muscarinic receptor proteins.
T2278L	Piboserod hydrochloride SB 207266 hydrochloride,Piboserod HCl,SB 207266A
	Piboserod HCl is a selective antagonist of 5-HT4 and muscarinic receptor.
T26373	(R)-Mequitazine V-0162,V0162,V 0162
	(R)-Mequitazine, a muscarinic acetylcholine receptor (M-AChRs) antagonist, is used potentially for the treatment of asthma.

化合物

Cat.No: T0218

Synonym: Bipariden,Akineton,KL 373,比哌立登,Biperidine

Target: AChR

Cat.No: T9771

Target: AChR

Tarafenacin D-tartrate

Cat.No: T16989

Synonym: SVT-40776 D-tartrate

Target: Others

Cat.No: T13992

Synonym: SVT-47060

Target: AChR

(S)-(+)-Dimethindene maleate

Cat.No: T23297

Target: AChR, Histamine Receptor

Syn-Ake acetate

Cat.No: T7895

Synonym: 类蛇毒三肽,Dipeptide diaminobutyroyl benzylamide

Target: AChR

Cat.No: T10914L

Synonym: Cyclopent

Target: AChR

Zamifenacin fumarate

Cat.No: T13385

Synonym: 扎非那星富马酸盐,UK-76654 fumarate

Target: AChR

Cyclodrine hydrochloride

Cat.No: T10914

Target: AChR

Desfesoterodine

Cat.No: T6364

Synonym: 5-HMT,(R)-5-Hydroxymethyl Tolterodine,(R)-5-羟甲基托特罗定,PNU-200577,5-HM,5-hydroxymethyl Tolterodine

Target: AChR

Pirenzepine dihydrochloride

Cat.No: T1542

Synonym: Pirenzepine HCl,Bisvanil,Tabe,盐酸哌仑西平,LS519

Target: AChR

mAChR-IN-1 hydrochloride

Cat.No: T5655

Target: AChR

Cat.No: T31207

Synonym: Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B

Target: AChR

Cat.No: T23508

Target: AChR

Cat.No: T7079

Synonym: GSK961081,TD-5959

Target: Adrenergic Receptor, AChR

Darifenacin hydrobromide

Cat.No: T1534

Synonym: 氢溴酸达非那新,Darifenacin HBr,UK-88525

Target: AChR

Cat.No: T29687

Synonym: Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986

Target: AChR

Tolterodine tartrate

Cat.No: T0099

Synonym: Detrol LA,PNU-200583E,Kabi-2234,酒石酸托特罗定

Target: AChR

Cat.No: T28722

Synonym: SCH57790,SCH-57790

Target: AChR

G-Protein antagonist peptide acetate

Cat.No: TP1902L1

Target: Adrenergic Receptor

Cat.No: T8147

Synonym: 索利那新,YM905 free base

Target: AChR

Cat.No: T60536

Target: Calcium Channel, AChR

Tiotropium bromide

Cat.No: T1179

Synonym: Tiopropium,噻托溴铵,BA679 BR

Target: AChR

(±)-Tazifylline

Cat.No: T10000

Target: Histamine Receptor

Cat.No: T13370

Target: AChR

Atropine methyl bromide

Cat.No: T14345

Synonym: 甲溴阿托品,Methylatropine bromide

Target: AChR

Fesoterodine fumarate

Cat.No: T1475

Synonym: Toviaz,SPM 907,富马酸非索罗定

Target: AChR

Pimethixene maleate

Cat.No: T12489L

Synonym: Pimetixene maleate

Target: Dopamine Receptor, 5-HT Receptor, AChR, Histamine Receptor

Isopropamide Iodide

Cat.No: T5051

Target: AChR

Propantheline bromide

Cat.No: T1006

Synonym: Neopepulsan,溴丙胺太林,Pro-Banthine,Neometantyl

Target: AChR

CLOZAPINE N-OXIDE

Cat.No: T4494

Synonym: 氯氮平N-氧化,氯氮平N-氧化物

Target: Dopamine Receptor, 5-HT Receptor, AChR, Drug Metabolite

Buclizine dihydrochloride

Cat.No: T6426

Synonym: 盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445

Target: 5-HT Receptor, AChR, Histamine Receptor

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

Cat.No: T68599

Synonym: Orphenadrine (free base)

Target: Sodium Channel, NMDAR, AChR

Cat.No: T38192

Target: Others

Levophencynonate

Cat.No: T25697

Synonym: Levo-phencynonate

Levophencynonate HCl

Cat.No: T25697L

Synonym: Levophencynonate hydrochloride,R-(-)-Phencynonate hydrochloride

Cat.No: T23124

Target: Others

DAU 5884 hydrochloride

Cat.No: T22709

Target: Others

Telenzepine dihydrochloride

Cat.No: T23452

Target: Others

J 104129 fumarate

Cat.No: T22876

Target: Others

Solifenacin hydrochloride

Cat.No: T23379

Target: Others

Cat.No: T15211

Target: Others

YM-58790 hydrochloride

Cat.No: T13372

Target: Others

(±)-Darifenacin

Cat.No: T12680

Synonym: (±)-UK-88525

Target: Others

Doxacurium Chloride

Cat.No: T27199

Synonym: BW A 938U,BWA938U,Nuromax,BW-A-938U

Cat.No: T29047

Synonym: UH-AH-37,UH-AH37

Cat.No: T71014

Piboserod hydrochloride

Cat.No: T2278L

Synonym: SB 207266 hydrochloride,Piboserod HCl,SB 207266A

(R)-Mequitazine

Cat.No: T26373

Synonym: V-0162,V0162,V 0162

Cat. No.	Product Name	Target	Signaling Pathways
T21532	Anisodamine 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine	AChR	Neuroscience
	Anisodamine (6-beta-Hydroxyhyoscyamine) 是毒蕈碱和烟碱胆碱受体的拮抗剂，对毒蕈碱受体的亲和力与东莨菪碱和阿托品相似。 Anisodamine 改善休克状态下的微循环，可用于有机磷中毒的研究。

天然产物

Cat.No: T21532

Synonym: 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine

Target: AChR

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