首页工具

登录

搜索结果

Search Results for " menin "

35

抑制剂 & 化合物

14

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T2649	Menin-MLL inhibitor MI-2 Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用，IC50为 446±28 nM。
T9399	Menin-MLL inhibitor 20	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	Menin-MLL inhibitor 20 是一种不可逆的menin-MLL 相互作用抑制剂，具有抗肿瘤活性。
T2643	MI-3 Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	MI-3 (Menin-MLL Inhibitor)是一种有高亲和力的 menin-MLL 抑制剂，IC50值为 648 nM，Kd 值为 201 nM。
T12002	Menin-MLL inhibitor 4	Others	Others
	Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction .
T78151	Bleximenib oxalate Menin-MLL inhibitor 24 oxalate	Epigenetic Reader Domain	Chromatin/Epigenetic
	Bleximenib (Menin-MLL inhibitor 24) oxalate 是一种用于癌症研究的menin-mixed-lineage leukemia 1（menin-MLL）抑制剂。
T72360	Menin-MLL inhibitor 26
	Menin-MLL inhibitor 26 是一种 Menin-MLL 抑制剂。Menin-MLL inhibitor 26 也是一个活性参照物。 Menin-MLL inhibitor 26 可以抑制细胞生长。Menin-MLL inhibitor 26 可用于白血病的研究。
T79117	Menin-MLL inhibitor 27	Epigenetic Reader Domain	Chromatin/Epigenetic
	Menin-MLL inhibitor 27 是一种化合物，它能有效抑制Menin-MLL之间的相互作用，对于研究癌症具有潜在价值，尤其是在急性骨髓性白血病方面。
T79737	Menin-MLL inhibitor 29	Epigenetic Reader Domain	Chromatin/Epigenetic
	Menin-MLL inhibitor 29（Compound C1）是一种选择性Menin-MLLPPI抑制剂。该化合物与Menin紧密结合，具有138 nM的KD值，并以46 nM的IC50值明显抑制Menin与MBM1（Menin结合motif 1）的相互作用。在体外条件下，Menin-MLL inhibitor 29对HepG2和Hep3B肝癌细胞系表现出抑制增殖的作用（IC50s分别为0.31 μM和0.71 μM），也能有效抑制肿瘤生长。
T12943	SNDX-5613	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	SNDX-5613 是一种 Menin-MLL 特异性抑制剂，Ki 为 0.149 nM，IC50 为 10 在 20 nM 之间，可用于 MLL 基因重排的急性白血病研究。
T72135	(1s,4s)-Menin-MLL inhibitor-23
	(1s,4s)-Menin-MLL inhibitor-23 是Menin-MLL inhibitor-23 的对应异构体。Menin-MLL inhibitor-23 (Example 99A) 是一种menin-MLL 相互作用抑制剂。
T13336	VTP50469	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	VTP50469 是一种高选择性和口服活性的Menin-MLL 相互作用抑制剂，具有有效的抗白血病活性，Ki 为 104 pM。
T28036	MI-2-2 MI22,MI 2 2	Histone Methyltransferase	Chromatin/Epigenetic
	MI-2-2 是一种抑制 menin 和 MLL 之间二价蛋白质-蛋白质相互作用的抑制剂，IC50 为 46 nM。 MI-2-2 与 menin 结合，Kd 为 22 nM。
T69628	Iptacopan hydrochloride hydrate
	Iptacopan hydrochloride hydrate is a highly potent and highly selective factor B inhibitor.
T20705	Desmeninol
	Desmeninol 是一种活性内源性代谢物，主要在尿液中检测到，在细胞内主要位于细胞质和脂肪体中。在有机合成中可作催化剂、氯化剂、固化剂和稳定剂；在染料工业中可作为生产分散红343的原料；在医药方面可用于生产奥沙拉秦等；可作为彩色照片的发色调节剂；也可作杀菌剂等。
T124064	Chamaejasmenin D
	Chamaejasmenin D 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124064。
T124063	Isochamaejasmenin B
	Isochamaejasmenin B 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124063。
TQ0069	MI-503	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-503 是一种高效且可口服的 menin-mLL 相互作用抑制剂。
T16072	MI-538	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-538是一种menin 和MLL 融合蛋白相互作用的抑制剂，IC50值为 21 nM。
T11925	M‑89	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	M-89 可抑制 Menin-MLL 蛋白之间的相互作用，有研究混合谱系白血病的潜力。它是一种强特异性 menin 抑制剂，结合到 menin 的Kd 值为 1.4 nM。
T39584	MI-3454
	MI-3454 is a highly potent, orally active, and selective inhibitor of the interaction between menin and MLL1, with an IC50 of 0.51 nM. This compound effectively inhibits the proliferation of leukemic cells and promotes their differentiation, leading to the regression or complete remission of leukemia in mouse models featuring MLL1 rearrangements or NPM1 mutations. This remarkable therapeutic effect is achieved through the downregulation of key genes involved in the development of leukemia.
TQ0058	MI-463	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-463 是一种有口服活性的menin-mLL 相互作用的高效小分子抑制剂，IC50为15.3 nM。
T6889	MI-136	Apoptosis; Epigenetic Reader Domain; Androgen Receptor	Apoptosis; Chromatin/Epigenetic; Endocrinology/Hormones
	MI136 是 menin-MLL(PPI) 蛋白互作的抑制剂，其 IC50值为31 nM，Kd 值为23.6 nM。它可抑制 DHT 诱导的雄激素受体 (AR) 靶基因的表达，有用于去势抵抗性肿瘤的潜能。
T24471	MIV-6
	MIV-6 is an inhibitor of the menin-mixed lineage leukemia interaction.
T39938	M-1211
	M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.
T13336L	VTP50469 fumarate	Others	Others
	VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.
T39937	M-808
	M-808 is a potent and efficacious covalent inhibitor, targeting the interaction between Menin and MLL. It demonstrates a high binding affinity with an IC50 value of 2.6 nM.
T61735	MI-1
	MI-1 抑制 Menin-MLL 相互作用，IC50为 1.9 μM。
T15831	M-525	Others	Others
	M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL
T22978	MI-2 (hydrochloride)	Others	Others
	MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM).
T27134	DCYM21 DC YM 21,DC-YM21,DCYM-21,DC_YM21,DC YM21
	DCYM21 is an inhibitor of menin-MLL interaction. DCYM21 demonstrates potent and selective blockage of proliferation and induces both cell cycle arrest and differentiation of leukemia cells harboring MLL translocations.
T24472	MIV-6R MIV6R,VU05163101,VU0516310-1,VU0516310 1,MIV 6R
	MIV-6R is an inhibitor of the menin- MLL interaction that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanisms of action.
T39585	Ziftomenib KO-539	Histone Methyltransferase	Chromatin/Epigenetic
	Ziftomenib (KO-539) 是一种具有抗肿瘤活性的 menin-MLL 相互作用抑制剂，可以用于研究白血病。
T69629	M‑89 MLL inhibitor
	M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion.
T24484	ML399 VU-0516340,VU 0516340,ML-399,VU0516340,ML 399
	ML399 is the menin-- MLL interaction inhibitor that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanism of action.
T24463	MI-1481 MI 1481
	MI-1481 is an effective MML1 inhibitor (IC50: 3.6 nM). MI-1481 showed very potent inhibition of the menin-MLL1 interaction (IC50: 3.6 nM). MI-1481 also demonstrates pronounced activity in MLL leukemia cells and in vivo in MLL leukemia models.

化合物

Menin-MLL inhibitor MI-2

Cat.No: T2649

Synonym: Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Menin-MLL inhibitor 20

Cat.No: T9399

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T2643

Synonym: Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Menin-MLL inhibitor 4

Cat.No: T12002

Target: Others

Bleximenib oxalate

Cat.No: T78151

Synonym: Menin-MLL inhibitor 24 oxalate

Target: Epigenetic Reader Domain

Menin-MLL inhibitor 26

Cat.No: T72360

Menin-MLL inhibitor 27

Cat.No: T79117

Target: Epigenetic Reader Domain

Menin-MLL inhibitor 29

Cat.No: T79737

Target: Epigenetic Reader Domain

Cat.No: T12943

Target: Epigenetic Reader Domain, Histone Methyltransferase

(1s,4s)-Menin-MLL inhibitor-23

Cat.No: T72135

Cat.No: T13336

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T28036

Synonym: MI22,MI 2 2

Target: Histone Methyltransferase

Iptacopan hydrochloride hydrate

Cat.No: T69628

Cat.No: T20705

Chamaejasmenin D

Cat.No: T124064

Isochamaejasmenin B

Cat.No: T124063

Cat.No: TQ0069

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T16072

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T11925

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T39584

Cat.No: TQ0058

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T6889

Target: Apoptosis, Epigenetic Reader Domain, Androgen Receptor

Cat.No: T24471

Cat.No: T39938

VTP50469 fumarate

Cat.No: T13336L

Target: Others

Cat.No: T39937

Cat.No: T61735

Cat.No: T15831

Target: Others

MI-2 (hydrochloride)

Cat.No: T22978

Target: Others

Cat.No: T27134

Synonym: DC YM 21,DC-YM21,DCYM-21,DC_YM21,DC YM21

Cat.No: T24472

Synonym: MIV6R,VU05163101,VU0516310-1,VU0516310 1,MIV 6R

Cat.No: T39585

Synonym: KO-539

Target: Histone Methyltransferase

M‑89 MLL inhibitor

Cat.No: T69629

Cat.No: T24484

Synonym: VU-0516340,VU 0516340,ML-399,VU0516340,ML 399

Cat.No: T24463

Synonym: MI 1481

Cat. No.	Product Name	Target	Signaling Pathways
T2726	Sinomenine Cucoline,Kukoline,青藤碱	Apoptosis; Others; NF-κB; Opioid Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; NF-κB; Others
	Sinomenine (Kukoline) 是来自汉防己的一种生物碱，是 μ 阿片受体激活剂，也是NF-κB 活化的阻断剂。
T2921	Sinomenine hydrochloride 盐酸青藤碱,Sabianine A hydrochloride,Cucoline hydrochloride,Kukoline hydrochloride	Apoptosis; NF-κB; Opioid Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; NF-κB
	Sinomenine hydrochloride (Kukoline hydrochloride) 是来自汉防己的一种生物碱，是NF-κB 活化的阻断剂。Sinomenine 也是一种 μ 阿片受体激活剂。
TN3628	Chamaejasmenin B	Others	Others
	Chamaejasmenin B 是一种从 Stellera chamaejasme L 中分离得到的化合物。Chamaejasmenin B 具有抗癌和抗肿瘤活性，可抑制癌细胞迁移和侵袭，抑制肿瘤转移。Chamaejasmenin B 可用于研究如乳腺癌类的癌症。
TN7068	Sinomenine N-oxide	Others	Others
	Sinomenine N-oxide 是青藤碱循环代谢机制的主要代谢产物之一。
TN4547	Methyl isodrimeninol	Others	Others
	Methyl isodrimeninol是一种天然产物，属于蓼科蓼属，其产品编号为 TN4547，CAS号为 442851-27-6。Methyl isodrimeninol可用作对照参考。
TN5381	7-Ketoisodrimenin
	7-Ketoisodrimenin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5381，CAS号为 73036-54-1。
TN4651	Neuchromenin	Others	Others
	(-)-Neuchromenin is an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 ug/ml.
T83449	14-Episinomenine
	14-Episinomenine为Stephania cepharantha所含生物碱，具可提取性质。
TN4802	Plathymenin	Others	Others
	Plathymenin 是一种从 Spatholobus suberectus 中分离出来的天然产物。
TN2620	14,15-Didehydrovincamenine	Others	Others
	14,15-Didehydrovincamenine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2620，CAS号为 112219-48-4。
TN2599	12-Hydroxyisodrimenin	Others	Others
	12-Hydroxyisodrimenin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2599，CAS号为 218780-16-6。
TN3629	Chamaejasmenin C	Others	Others
	Chamaejasmenin C 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3629，CAS号为 89595-70-0。
T83255	7(R)-7,8-Dihydrosinomenine
	7(R)-7,8-Dihydrosinomenine是从青藤中分离出的异喹啉生物碱，具备抗破骨细胞活性。
T83481	1,1′-Disinomenine
	1,1'-Disinomenine，一种从Sinomenium acutum茎部分离得到的生物碱，对A549和Hela细胞表现出较弱的抑制效果。

天然产物

Cat.No: T2726

Synonym: Cucoline,Kukoline,青藤碱

Target: Apoptosis, Others, NF-κB, Opioid Receptor, Autophagy

Sinomenine hydrochloride

Cat.No: T2921

Synonym: 盐酸青藤碱,Sabianine A hydrochloride,Cucoline hydrochloride,Kukoline hydrochloride

Target: Apoptosis, NF-κB, Opioid Receptor, Autophagy

Chamaejasmenin B

Cat.No: TN3628

Target: Others

Sinomenine N-oxide

Cat.No: TN7068

Target: Others

Methyl isodrimeninol

Cat.No: TN4547

Target: Others

7-Ketoisodrimenin

Cat.No: TN5381

Cat.No: TN4651

Target: Others

14-Episinomenine

Cat.No: T83449

Cat.No: TN4802

Target: Others

14,15-Didehydrovincamenine

Cat.No: TN2620

Target: Others

12-Hydroxyisodrimenin

Cat.No: TN2599

Target: Others

Chamaejasmenin C

Cat.No: TN3629

Target: Others

7(R)-7,8-Dihydrosinomenine

Cat.No: T83255

1,1′-Disinomenine

Cat.No: T83481

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼