135
22
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T32811 |
L-Leucine-1-13C
L-(1-13C)Leucine,(1-13C)Leucine |
Endogenous Metabolite; mTOR | Metabolism; PI3K/Akt/mTOR signaling |
L-Leucine-1-13C (L-Leucine-13C)是一种 13C 标记的 L-Leucine,显著增强了 GLP-4 的亲和力。 | |||
T64400 |
N-Cbz-L-Leucine
N-[(Phenylmethoxy)carbonyl]-L-leucine |
Amino Acids and Derivatives | Metabolism |
N-Cbz-L-Leucine (N-[(Phenylmethoxy)carbonyl]-L-leucine) 是一种亮氨酸衍生物,是一种常用的氨基酸保护基基。 | |||
TP1367 |
[D-Ala2]leucine-enkephalin
(D-ALA2)-亮氨酸脑啡肽 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
[D-Ala2]leucine-enkephalin 是 δ 阿片类激动剂,是能长效抗降解的亮氨酸脑非肽,可用于研究 δ 阿片受体的信号通路。 | |||
T1387 |
Acetylleucine
N-Acetyl-DL-leucine,乙酰亮氨酸,N-acetyl-L-leucine |
Amino Acids and Derivatives | Metabolism |
Acetylleucine (N-Acetyl-DL-leucine) 是一种口服具有活性的化合物,可用于研究急性前庭眩晕,小脑性共济失调和眼球震颤。 | |||
T7739 |
L-Leucyl-L-Leucine methyl ester hydrochloride
Leu-Leu-ome hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物,能够选择性消除具有细胞毒性潜能的淋巴细胞,也能够诱导溶酶体途径应激。 | |||
TP1264 |
Prolylleucine
((Benzyloxy)carbonyl)-L-prolyl-D-leucine |
Others | Others |
Prolylleucine (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) 是一种二肽,含有支链氨基酸,可以影响动物的昼夜节律和行为。 | |||
T35785 |
N-Oleoyl Leucine
|
||
N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro. N-Oleoyl leucine (25 mg/kg, i.p.) decreases body weight and food intake, preferentially decreasing fat mass in a diet-induced obesity mouse model. It improves glucose homeostasis in a fasting glucose tolerance test and increases VO2 while slightly decreasing overall locomotor activity. | |||
TP1367L |
[D-Ala2]leucine-enkephalin acetate
[D-Ala2]leucine-enkephalin acetate(64963-01-5 free base) |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
[D-Ala2]leucine-enkephalin acetate ([D-Ala2]leucine-enkephalin acetate (64963-01-5 free base)) 是一种 delta 阿片受体激动剂,用于研究 delta 阿片受体的信号通路。 | |||
T8638 |
NPC 15199
FMOC-L-Leucine,Fmoc-L-亮氨酸 |
Others | Others |
NPC 15199 (FMOC-L-Leucine) 是选择性的PPARγ调节剂。它对 PPARγ 的激活效果比罗格列酮低,但二者最大效应相似。它能够改善正常、饮食诱导的葡萄糖不耐受和糖尿病 db/db 小鼠的胰岛素敏感性,一定程度上能够诱导脂肪生成。 | |||
T7665 |
[Leu5]-Enkephalin TFA(58822-25-6(free bas))
Leu-enkephalin,Leucine enkephalin,Leucyl-enkephalin |
Opioid Receptor; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience |
[Leu5]-Enkephalin TFA(58822-25-6(free bas)) (Leucyl-enkephalin) 是最有效的 δ 受体。 | |||
T25676 |
Leucine thiorphan
Leu-thiorphan |
||
Leucine thiorphan is an inhibitor of enkephalinase. | |||
T32664 |
Leucine sarcolysine
NSC 167780,NSC-167780,Asaley,NSC167780,Asalex |
||
Leucine sarcolysine is a bioactive chemical. | |||
T7173 |
[Leu5]-Enkephalin
亮氨酸脑啡肽,Leucine enkephalin,Leucyl-enkephalin,Leu-enkephalin |
Opioid Receptor; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience |
[Leu5]-Enkephalin (Leu-enkephalin) 是一种参与伤害感受的内源性神经肽,是 δ-阿片和 μ-阿片受体的激动剂,Ki 值分别为 4.0 和 3.4 nM | |||
T20433 |
Leucyl-leucyl-leucine
Trileucine |
||
Leucyl-leucyl-leucine is may be used for pH-dependent endosomal membrane disruption to release agents. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media. | |||
T31967 |
Glycyl-alanyl-leucine
Gly-ala-leu |
||
Glycyl-alanyl-leucine is a peptide. | |||
T20445 |
L-Leucine-p-nitroanilide
|
||
L-Leucine-p-nitroanilide is a substrate. It is used for the colorimetric determination of leucine aminopeptidase. | |||
T31854 |
Formylmethionyl-alanyl-leucine
Fmet-ala-leu |
||
Formylmethionyl-alanyl-leucine is formed by E coli ribosomal protein L10 gene. | |||
T33612 |
N-Carbomethoxy-L-leucine
|
||
N-Carbomethoxy-L-leucine is a bioactive chemical. | |||
T34622 |
Seryl-lysyl-leucine
Skl tripeptide,Ser-lys-leu |
||
Seryl-lysyl-leucine is a bioactive chemical. | |||
T7173L |
[Leu5]-Enkephalin acetate(58822-25-6 free base)
亮氨酸脑啡肽,Leucine enkephalin,Leu-enkephalin,Leucyl-enkephalin |
Opioid Receptor; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience |
[Leu5]-Enkephalin acetate(58822-25-6 free base) 是一种参与伤害感受的内源性神经肽,是 δ-opioid 和 μ-opioid 受体的激动剂(Kis 分别为 4.0 和 3.4 nM) | |||
T31907 |
Gamma-Methylleucine
L-Neopentylglycine,gamma-Methyl-L-leucine,3-叔丁基-L-丙氨酸,2-Amino-3-tert-butylpropionic acid |
Others | Others |
Gamma-Methylleucine (2-Amino-3-tert-butylpropionic acid) 是铜催化的不对称迈克尔反应的辅助剂。 | |||
T32082 |
Histidyl-aspartyl-glutamyl-leucine
His-asp-glu-leu,Hdel sequence |
||
HDEL intracellular distribution is characteristic of plant endoplasmic reticulum (ER). | |||
T33087 |
Lysyl-aspartyl-glutamyl-leucine
Kdel sequence,Lys-asp-glu-leu |
||
Lysyl-aspartyl-glutamyl-leucine maintains type II surface membrane proteins in the endoplasmic reticulum. | |||
T76108 | Leucine dehydrogenase | ||
Leucine dehydrogenase 能够从球形芽孢杆菌中纯化得到。Leucine dehydrogenase 催化L-亮氨酸、L-缬氨酸、L-异亮氨酸、L-去甲缬氨酸、左旋α-氨基丁酸酯和L-去甲亮氨酸的氧化脱氨,以及它们的酮类似物的还原胺化。 | |||
T20426 |
Dansylleucine
Dns-leucine,Dansyl-leucine |
||
Dansylleucine is an agent of bioactive chemical. | |||
T36879 | L-Leucyl-L-Leucine methyl ester hydrobromide | ||
The lysosomotropic dipeptide LLME has selective toxicity for NK cells, CTL, and M phi without adverse effects on a variety of other lymphoid or nonlymphoid cell types. See also E-2080. | |||
T31948 |
Glutarylleucine
Glutaryl-L-leucine |
||
Glutarylleucine is a bioactive chemical. | |||
T37062 |
L-Leucine-7-amido-4-methylcoumarin hydrochloride
|
||
L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase.1Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Izquierdo, M., Lin, D., O’Neill, S., et al.Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using rapidfire mass spectrometryS... | |||
T64647 |
Boc-L-Leucine
|
||
Boc-L-Leucine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64647,CAS号为 13139-15-6。 | |||
T31711L |
Ethyl L-leucinate
Leucine ethyl ester |
||
Ethyl L-leucinate is a essential amino acid. | |||
T33574 |
N-Acetylmelphalanylleucine
N-Acetyl-melphalan-L-leucine |
||
N-Acetylmelphalanylleucine is a bioactive chemical. | |||
T66098 |
N-Benzyloxycarbonyl-tert-leucine
|
||
N-Benzyloxycarbonyl-tert-leucine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66098,CAS号为 62965-10-0。 | |||
T20443 |
Tyrosylleucine
Tyr-leu,L-Tyrosyl-L-leucine |
||
Tyrosylleucine is a dipeptide composed of tyrosine and leucine. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following | |||
T131571 | N-Benzoyl-L-Leucine | ||
N-Benzoyl-L-Leucine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131571。 | |||
T65366 | N-Methyl-DL-leucine | ||
N-Methyl-DL-leucine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65366,CAS号为 2566-33-8。 | |||
T66941 |
N-Acetyl-R-leucine
|
||
N-Acetyl-R-leucine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66941,CAS号为 19764-30-8。 | |||
T34020 |
Phenylalanylleucine
Phe-leu,L-Phenylalanyl-L-leucine |
||
Phenylalanylleucine is a bioactive chemical. | |||
T29839 |
Albutoin, (S)-
L-Leucine-3-allyl-2-thiohydantoin |
||
Albutoin, (S)- can be used as a new thiohydantoin derivative for grand mal epilepsies. | |||
T66885 |
D-Leucine methyl ester hydrochloride
|
||
D-Leucine methyl ester hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66885,CAS号为 5845-53-4。 | |||
T65805 |
L-Leucine benzyl ester p-toluenesulfonate salt
|
||
L-Leucine benzyl ester p-toluenesulfonate salt 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65805,CAS号为 1738-77-8。 | |||
TP2461 |
Lpigppal
Lysyl-prolyl-isoleucyl-glutamyl-phenylalanyl-4-nitrophenylalanyl-arginyl-leucine |
||
Lysyl-prolyl-isoleucyl-glutamyl-phenylalanyl-4-nitrophenylalanyl-arginyl-leucine is a bioactive chemical. | |||
T83716 |
KSL-128114 TFA
Ac-rRrGrKkRrSHWX1X2DI-OH (X1=tert-Leucine; X2=Cyclohexylglycine) |
||
KSL-128114是一种对膜调节剂syntenin的肽抑制剂(Ki = 300 nM)。它能够依赖浓度降低A2058黑色素瘤和患者来源的多形性胶质母细胞瘤(GBM)细胞的存活率。在使用患者来源的GBM细胞并在颅内植入前用KSL-128114培养的患者衍生异种移植(PDX)小鼠模型中,KSL-128114(50 µM)提高了动物的存活时间。 | |||
T1945 |
GNE-7915
GNE7915 |
LRRK2 | Autophagy |
GNE-7915是一种高效选择性,可渗透大脑的,富含亮氨酸的重复激酶 2 (LRRK2) 抑制剂,IC50值为9 nM。 | |||
T39972 |
EB-42486
|
LRRK2 | Autophagy |
EB-42486 是一种有效且高度选择性的 G2019S-LRRK2 抑制剂,IC50 < 0.2 nM。 | |||
T65042 |
N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-leucine
|
||
N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-leucine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65042,CAS号为 73401-65-7。 | |||
T11996 |
MELK-8a hydrochloride
|
MELK | PI3K/Akt/mTOR signaling |
MELK-8a hydrochloride 是一种有效的母体胚胎亮氨酸拉链激酶抑制剂,IC50 为 2 nM。 | |||
T2050 |
PF-06447475
|
LRRK2 | Autophagy |
PF-06447475是一种高效、特异性的脑渗透性 LRRK2 抑制剂,IC50值为3 nM。 | |||
T16115 |
MLi-2
|
LRRK2 | Autophagy |
MLi-2 是一种结构新颖、高效、选择性的 LRRK2 激酶抑制剂,具有中枢神经系统活性,IC50为 0.76 nM,有潜力用于帕金森氏病。 | |||
T7729 |
PF-06454589
|
LRRK2 | Autophagy |
PF-06447475 是LRRK2激酶选择性抑制剂,可通透血脑屏障,能够抑制 WT LRRK (IC50:3 nM) 和 G2019S LRRK2 (IC50:11 nM) 。它可用于研究帕金森病 (PD) 。 | |||
T8985 |
NSC45586
|
Others | Others |
NSC45586 是一种蛋白磷酸酶 PHLPP 抑制剂,对 PHLPP1 和 PHLPP2 具有选择性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9299 |
D-Leucine
D-亮氨酸,(R)-Leucine |
Endogenous Metabolite | Metabolism |
D-Leucine ((R)-Leucine) 具有抗癫痫特性,活性比L-leucine,能够有效终止癫痫发作。在体外,它能够抑制长期点位,但基底突触传递无影响。 | |||
T4772 |
(±)-Leucine
DL-Leucine,(+/-)-Amino-4-methylpentanoic acid,DL-亮氨酸,DL-2-Aminmo-4-methylvalerianic acid |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
(±)-Leucine (DL-2-Aminmo-4-methylvalerianic acid) 是亮氨酸的异构体,是一种化学杀菌剂和膳食添加剂,存在于青椒、青西葫芦、意大利甜红辣椒和红甜椒中。 | |||
T3O2749 |
L-Leucine
(S)-Leucine,Leu,L-亮氨酸,亮氨酸 |
mTOR | PI3K/Akt/mTOR signaling |
L-Leucine ((S)-Leucine) 是必需的支链氨基酸,能够激活 mTOR 信号通路。 | |||
T4086 |
Glycyl-L-leucine
甘氨酰-L-亮氨酸,Gly-Leu |
Others | Others |
Glycyl-L-leucine (Gly-Leu) 是一种可用作糖基亮氨酸二肽酶底物的二肽。 | |||
T4798 |
N-Acetyl-L-leucine
|
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-leucine 是内源性代谢产物的一种。 | |||
T8373 |
6-Diazo-5-oxo-L-nor-Leucine
DON,L-6-Diazo-5-oxonorleucine,6-重氮-5-氧代-L-正亮氨酸,Diazooxonorleucine |
Influenza Virus; Glutaminase; Antibacterial; Antibiotic | Microbiology/Virology; Proteases/Proteasome |
6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) 是一种谷氨酰胺拮抗剂,具有抗菌、抗病毒和抗癌作用,其Ki 值为 6 μM。它能降低肿瘤细胞的自我更新能力和转移能力 ,在体外表现出遗传毒性。 | |||
T5569 |
3-Amino-4-methylpentanoic acid
DL-Homovaline,3-氨基-4-甲基戊酸,DL-beta-leucine,beta-Aminoisocaproic acid,beta-Leucine |
Endogenous Metabolite | Metabolism |
3-Amino-4-methylpentanoic acid (DL-Homovaline) 是 L-亮氨酸的异构体,是 β 氨基酸,通过亮氨酸 2,3-氨基变位酶在人体中由 L-亮氨酸代谢天然产生。 | |||
TMA2613 |
Cyclo(Pro-Leu)
Cyclo-L-leu-L-pro,Cyclo-L-prolyl-L-leucine,Cyclo(leucyloprolyl) |
Others | Others |
Cyclo(Pro-Leu) (Cyclo-L-prolyl-L-leucine) 是一种源自海洋的天然产物,具有盐水虾的杀伤力。 | |||
T4765 |
L-Norleucine
(S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid,L-2-氨基己酸 |
Influenza Virus; Endogenous Metabolite | Metabolism; Microbiology/Virology |
L-Norleucine ((S)-Norleucine) 是亮氨酸的异构体,特异性影响骨骼肌中的蛋白质合成,具有抗病毒活性。 | |||
T0063 |
L-Isoleucine
异亮氨酸,isoleucine,Ile,L-异亮氨酸 |
Amino Acids and Derivatives; Endogenous Metabolite | Metabolism |
L-Isoleucine (Ile) 是一种非极性疏水性氨基酸。它是必需氨基酸。 | |||
T9143 |
D-Isoleucine
(2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine |
Others | Others |
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) 是一种异亮氨酸立体异构体,是 Asc-1 反转运蛋白的选择性激活剂。它能够释放内源性 D-丝氨酸,提高海马 CA1-CA3 的长期增效作用。 | |||
T7448 |
4-Hydroxyisoleucine
4-羟基-L-异亮氨酸,4-Hydroxy-L-isoleucine |
Others | Others |
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) 是从胡芦巴种子中提取和纯化的一种氨基酸,具有促胰岛素作用。 | |||
T2P2919 |
(2S,3R,4S)-4-Hydroxyisoleucine
(4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine |
PI3K | PI3K/Akt/mTOR signaling |
(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分,具有抗糖尿病、抗糖尿病肾病的作用。 | |||
T5219 |
L-Alloisoleucine
L-别异亮氨酸,L-allo-Isoleucine,(3R)-LS-Isoleucine,L(+)-Alloisoleucine |
Others; Endogenous Metabolite | Metabolism; Others |
L-Alloisoleucine (L-allo-Isoleucine) 是 L-异亮氨酸的立体异构体,是一种支链氨基酸,是人血浆的常见成分 (尽管水平较低)。 | |||
T19384 |
Isovalerylcarnitine
|
Apoptosis; Cysteine Protease | Apoptosis; Proteases/Proteasome |
Isovalerylcarnitine (3-methylbutyrylcarnitine) 是 L-亮氨酸分解代谢和异戊酸的积累产生的小分子化合物,也是一种具有选择性和有效性的钙蛋白酶 (calpain) 激活剂,可促使细胞凋亡,与异戊酸血症有关,可作为异戊酸血症的标志。 | |||
T4766 |
3-Methylglutaric acid
|
Endogenous Metabolite | Metabolism |
3-Methylglutaric acid 是亮氨酸代谢物,是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
T5294 |
(S)-Leucic acid
L-alpha-羟基异己酸,L-LEUCIC ACID,Hydroxyisocaproic acid,(S)-2-羟基-4-甲基戊酸,(S)-(−)-2-Hydroxyisocaproic acid |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Leucic acid (Hydroxyisocaproic acid) 是氨基酸代谢物。 | |||
T5245 |
N-Isovaleroylglycine
N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine |
Others; Endogenous Metabolite | Metabolism; Others |
N-Isovaleroylglycine (Isovaleroylglycine) 是酰基甘氨酸,能够作为体重提高和肥胖的生物标记物。 | |||
T11203 | Enocyanin | Others | Others |
Enocyanin, an anthocyanin extracted from grapes, exhibits inhibitory effects on leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase, and esterase activity. | |||
T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. | |||
TN2408 |
Evofolin B
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Cannabinoid Receptor | GPCR/G Protein |
Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸/cytochalasin B(fMLP/CB)产生的超氧阴离子有抑制作用。 |