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32

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T27712	KAR425 KAR-425,KAR 425
	KAR425 is a bipyrrole tambjamines. KAR425 has antimalarial activity against multidrug-resistant P. yoelii in mice.
T31240	Deacetoxyvinzolidine KAR-2,KAR2,KAR 2
	Deacetoxyvinzolidine is a bioactive agent.
T9177	BPAM344	iGluR	Membrane transporter/Ion channel; Neuroscience
	BPAM344 是一种红藻氨酸受体亚基GluK1b、GluK2a 和GluK3a 的正变构调节剂。
T16780	Rodatristat KAR5417	Others	Others
	Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).
T16779	Rodatristat ethyl RVT-014,KAR5585,RVT-1201	5-HT Receptor; Hydroxylase	GPCR/G Protein; Metabolism; Neuroscience
	Rodatristat ethyl (KAR5585) 是一种首新型具有口服活性和有效性的 tryptophan hydroxylase 1 (TPH1) 抑制剂，低浓度下可显著降低 5-hydroxytryptamine (5-HT) 的水平并降低肺动脉高压 (PAH)，
T24398	Lenaldekar LDK	Akt; IGF-1R; S6 Kinase	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Lenaldekar (LDK) 抑制 T 细胞扩增和自身免疫性脑脊髓炎。 Lenaldekar 导致 PI3 激酶/AKT/mTOR 通路成员的去磷酸化并延迟有丝分裂晚期的敏感细胞。
T22774L	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物，负责将氨酰 tRNA 酶促递送至核糖体。这种亚型（α 1）在脑、胎盘、肺、肝、肾和胰腺中表达，另一种亚型（α 2）在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝，其中一些（如果不是全部）代表不同的假基因。
T1748	Kartogenin KGN	TGF-beta/Smad	Stem Cells
	Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A，破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用，并通过调节 CBFβ-RUNX1 转录程序，诱导软骨形成，可用于研究骨关节炎。
T126357	Ikarisoside C
	Ikarisoside C 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126357，CAS号为 113558-11-5。
T123927	Karaviloside V
	Karaviloside V 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123927，CAS号为 922192-72-1。
T32358	Karakin Carakin,NSC279515,Karakine,NSC-279515,NSC 279515
	Karakin is a group of plant growth regulators.
T126290	Okaramine B
	Okaramine B 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126290，CAS号为 117332-63-5。
T61395	Mt KARI-IN-4
	Mt KARI-IN-4 (compound 5c) is a highly effective inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), demonstrating a Ki value of 5.48 μM. Additionally, Mt KARI-IN-4 displays inhibitory properties against Mtb H37Rv, with a minimum inhibitory concentration (MIC) of 0.78 μM. Importantly, this compound exhibits low levels of cytotoxicity, as evident from its half-maximal inhibitory concentration (IC 50 ) value of over 72 μg/mL against human embryonic kidney cells (HEK) [1...
T126358	Ikarisoside B
	Ikarisoside B 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126358，CAS号为 113558-10-4。
T32363	Kartocid Fiton
	Kartocid is bioactive chemical.
T24248	Karetazan Ciobutide
	Karetazan is a pesticide agent.
T20186	Karbutilate Tandex,Tendex,Tanzene
	Karbutilate is an agent of carbamate herbicide.
T24249	Karsil Niagara-4562,Niagara 4562,Erlujixiancaoan,Niagara4562
	Karsil is an agricultural pesticide.
T40953	Karrikinolide
	Karrikinolide, a phytoreactive compound derived from smoke, holds potential in horticulture, ecological restoration, and agriculture. This compound exhibits regulatory properties by influencing endogenous cytokinin concentrations and stimulating plant growth.
T23355	Signal Enhancer Hikari	Others	Others
	Signal enhancer for use in western blotting, dot blotting and ELISA
T125662	Okaramine D
	Okaramine D 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125662，CAS号为 162413-54-9。
T61569	Mt KARI-IN-1
	Mt KARI-IN-1 is a lead compound that demonstrates strong inhibitory activity towards Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 3.06 μM [1].
T32362	Karsoside
	Karsoside is a iridoid glycoside, existed in a wide variety of plants and some animals.
T32359	Karbafos Karbafosem
	Karbafos is a bioactive chemical.
T61570	Mt KARI-IN-2
	Mt KARI-IN-2 (compound 5b) is a highly effective inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 2.02 μM. This compound also exhibits inhibitory activity against Mtb H37Rv, with a MIC value of 0.78 μM. Moreover, Mt KARI-IN-2 demonstrates low cytotoxicity, as evidenced by a HEK IC 50 greater than 86 μg/mL [1].
T62081	Mt KARI-IN-5
	Mt KARI-IN-5 (compound 6c) 是一种结核分歧杆菌酮醇酸还原异构酶 I (MtbKARI) 的有效抑制剂 (Ki: 4.72 μM)。Mt KARI-IN-5 对 MtbH37Rv 的活性表现出抑制作用，其 MIC 值为 1.56 μM，细胞毒性较低，对 HEK 的 IC50 值大于 64 μg/mL。
T22774	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed
T24250	Kartox Kartox 50
	Kartox, an insecticide, is a combination of and lindane & cartap.
T14703	Karenitecin BNP 1350,Cositecan	Topoisomerase	DNA Damage/DNA Repair
	Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
T32360	Karbin
	Karbin is a bioactive chemical.
TP2247	eukaryotic translation initiation factor 3	Others	Others
	Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.
T32361	Karenin
	Karenin is a bioactive chemical.

化合物

Cat.No: T27712

Synonym: KAR-425,KAR 425

Deacetoxyvinzolidine

Cat.No: T31240

Synonym: KAR-2,KAR2,KAR 2

Cat.No: T9177

Target: iGluR

Cat.No: T16780

Synonym: KAR5417

Target: Others

Rodatristat ethyl

Cat.No: T16779

Synonym: RVT-014,KAR5585,RVT-1201

Target: 5-HT Receptor, Hydroxylase

Cat.No: T24398

Synonym: LDK

Target: Akt, IGF-1R, S6 Kinase

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)

Cat.No: T22774L

Target: Others

Cat.No: T1748

Synonym: KGN

Target: TGF-beta/Smad

Cat.No: T126357

Karaviloside V

Cat.No: T123927

Cat.No: T32358

Synonym: Carakin,NSC279515,Karakine,NSC-279515,NSC 279515

Cat.No: T126290

Cat.No: T61395

Cat.No: T126358

Cat.No: T32363

Synonym: Fiton

Cat.No: T24248

Synonym: Ciobutide

Cat.No: T20186

Synonym: Tandex,Tendex,Tanzene

Cat.No: T24249

Synonym: Niagara-4562,Niagara 4562,Erlujixiancaoan,Niagara4562

Karrikinolide

Cat.No: T40953

Signal Enhancer Hikari

Cat.No: T23355

Target: Others

Cat.No: T125662

Cat.No: T61569

Cat.No: T32362

Cat.No: T32359

Synonym: Karbafosem

Cat.No: T61570

Cat.No: T62081

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]

Cat.No: T22774

Target: Others

Cat.No: T24250

Synonym: Kartox 50

Cat.No: T14703

Synonym: BNP 1350,Cositecan

Target: Topoisomerase

Cat.No: T32360

eukaryotic translation initiation factor 3

Cat.No: TP2247

Target: Others

Cat.No: T32361

Cat. No.	Product Name	Target	Signaling Pathways
T4124	IKarisoside A Icarisoside-,Baohuoside II	NO Synthase	Immunology/Inflammation
	IKarisoside A(Baohuoside II) 是一种来自小檗科植物淫羊藿的黄酮醇糖苷，具有抗炎活性。
TN1833	Karacoline	NF-κB	NF-κB
	Karacoline 是发现于植物Aconitum kusnezoffii 中的一种二萜生物碱，通过 NF-κB 信号通路，抑制椎间盘退变中细胞外基质的降解。
TN1025	3,29-O-Dibenzoyloxykarounidiol	Others	Others
	3,29-O-Dibenzoyloxykarounidiol 是一种苯甲酸三萜烯酯，从 Momordica grosvenori 果实中提取。它能够抑制肿瘤启动子 TPA 诱导的 EB 病毒早期抗原活化。
T2S0820	Karanjin 干华豆晶 4,水黄皮素	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Karanjin 是干花豆中的主要活性呋喃黄酮醇成分，可通过细胞周期阻滞诱导癌细胞死亡，促进细胞凋亡，还通过提高AMPK 的方式诱导骨骼肌细胞 GLUT4 易位。
TN1761	Ikarisoside F	Others	Others
	Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level.
TN6314	Karaviloside VIII
	Karaviloside VIII 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6314，CAS号为 934739-32-9。
TN6243	Karaviloside XI
	Karaviloside XI 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6243，CAS号为 934739-35-2。
TN6308	Karavilagenin B 3β,25-Dihydroxy-7β-methoxycucurbita-5,23-diene
	Karavilagenin B 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6308，CAS号为 912329-02-3。
T15556	Ikarugamycin	Others	Others
	Ikarugamycin, an antibiotic, is an inhibitor of clathrin-mediated endocytosis (CME).
TN6288	Karavilagenin F
	Karavilagenin F 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6288，CAS号为 1639024-15-9。
TN6315	25-O-Methylkaravilagenin D
	25-O-Methylkaravilagenin D 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6315，CAS号为 1363422-85-8。
TN6325	Karaviloside X
	Karaviloside X 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6325，CAS号为 934739-34-1。
TN4380	Karavilagenin D	Others	Others
	Karavilagenin D exhibits inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as a promoter. It exhibits inhibition effect against human
TN2747	2-Acetoxy-3-deacetoxycaesaldekarin E	Antifection	Microbiology/Virology
	2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
TN5945	Karavilagenin A 3β-Hydroxy-7β,25-dimethoxycucurbita-5,23-diene
	Karavilagenin A是一种天然产物，属于葫芦科苦瓜属，其产品编号为 TN5945，CAS号为 912329-03-4。Karavilagenin A可用作对照参考。
TN4381	Karounidiol	Others	Others
	Karounidiol exhibits cytotoxicity especially against a human renal cancer, it markedly suppresses the promoting effect of TPA (1 microgram/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse
TN3632	(-)-Chelidonine	Others	Others
	(-)-Chelidonine is a natural product from Glaucium squamigerum KAR. et KIR.

天然产物

Cat.No: T4124

Synonym: Icarisoside-,Baohuoside II

Target: NO Synthase

Cat.No: TN1833

Target: NF-κB

3,29-O-Dibenzoyloxykarounidiol

Cat.No: TN1025

Target: Others

Cat.No: T2S0820

Synonym: 干华豆晶 4,水黄皮素

Target: Apoptosis, AMPK

Cat.No: TN1761

Target: Others

Karaviloside VIII

Cat.No: TN6314

Karaviloside XI

Cat.No: TN6243

Karavilagenin B

Cat.No: TN6308

Synonym: 3β,25-Dihydroxy-7β-methoxycucurbita-5,23-diene

Cat.No: T15556

Target: Others

Karavilagenin F

Cat.No: TN6288

25-O-Methylkaravilagenin D

Cat.No: TN6315

Karaviloside X

Cat.No: TN6325

Karavilagenin D

Cat.No: TN4380

Target: Others

2-Acetoxy-3-deacetoxycaesaldekarin E

Cat.No: TN2747

Target: Antifection

Karavilagenin A

Cat.No: TN5945

Synonym: 3β-Hydroxy-7β,25-dimethoxycucurbita-5,23-diene

Cat.No: TN4381

Target: Others

(-)-Chelidonine

Cat.No: TN3632

Target: Others

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