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Search Results for " histamine dihydrochloride "

31

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22724	Dimaprit dihydrochloride	NOS; NO Synthase; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dimaprit dihydrochloride 是组胺H2受体的一种选择性激动剂，可刺激胃酸的分泌。它还抑制nNOS，IC50值为 49 μM。
T8822	JNJ-5207852 dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	JNJ-5207852 dihydrochloride 是一种新型的非咪唑组胺 H3 受体拮抗剂，对大鼠和人类 H3受体的 pKi 值分别为 8.9 和 9.24。
T5495	Decloxizine dihydrochloride 盐酸去氯羟嗪,UCB 1402 dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Decloxizine dihydrochloride (UCB 1402 dihydrochloride) 是组胺 1 受体拮抗剂。
T6562	Latrepirdine dihydrochloride Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin	Beta Amyloid; 5-HT Receptor; Adrenergic Receptor; GluR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Latrepirdine dihydrochloride (Dimebolin dihydrochloride) 是一种具有口服活性和神经活性的多种药物靶点的拮抗剂，可刺激淀粉样前体蛋白分解代谢和 β-淀粉样蛋白分泌。
T2200	Hydroxyzine dihydrochloride Hydroxyzine 2HCl,盐酸羟嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) 是一种苯二氮卓抗组胺剂，是可口服的组胺 H1 受体和血清素拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它还可以作为止吐剂和镇静剂，有缓解焦虑和紧张的作用。
T1110	Meclizine dihydrochloride Meclozine dihydrochloride,NSC28728,Meclizine 2HCl,盐酸美克洛嗪	Apoptosis; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Meclizine dihydrochloride (NSC28728) 是一种组胺 H1 拮抗剂，用于治疗妊娠期间的晕动病、眩晕和恶心以及放射病。它是小鼠组成型雄甾烷受体激动剂，是人 CAR 的反向激动剂。它可透过血脑屏障，可用于多聚谷氨酰胺毒性障碍方面的研究。
T8599	Betazole dihydrochloride 盐酸倍他唑,Betazole hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betazole dihydrochloride (Betazole hydrochloride) 是吡唑类组胺，是一种口服活性 H2受体激动剂，能诱导胃酸分泌，导致胆总管压力立即显著升高。它作为一种诊断剂，用于研究胃酸分泌能力。
T0089	Cetirizine dihydrochloride 盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cetirizine dihydrochloride (UCB P071) 是羟嗪的羧化代谢物，是特异性口服有效的 H1 受体长效拮抗剂。它标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化，可有效治疗过敏性鼻炎、确诊荨麻疹和花粉诱发的哮喘。
T0246	Betahistine dihydrochloride PT-9,Betahistine 2HCl,盐酸倍他司汀	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betahistine dihydrochloride (Betahistine 2HCl) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。
T6426	Buclizine dihydrochloride 盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Buclizine dihydrochloride (Buclina) 是可口服的一种哌嗪组胺 H1 受体拮抗剂，主要具有止吐和抗眩晕活性。
T24698	(R)-(-)-α-Methylhistamine dihydrochloride HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL
	R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.
T22501	2-Pyridylethylamine dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	2-Pyridylethylamine dihydrochloride 是一种组胺 H1 受体激动剂。
T29096	Vapitadine dihydrochloride Vapitadine 2HCl,R129160,R-129160 2HCl,Vapitadine HCl,R 129160 2HCl,R-129160,R 129160,R129160 2HCl	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Vapitadine dihydrochloride(R-129160 2HCl) 是一种新型强效且具有选择性和非镇静性的化合物，对组胺 H1 具有抑制作用。
T22354	Levocetirizine Dihydrochloride Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
T9084	Cetirizine Impurity B dihydrochloride De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride,西替利嗪杂质B二盐酸盐,西替利嗪杂质04	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cetirizine Impurity B dihydrochloride (De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride) 是 Cetirizine dihydrochloride 的杂质。Cetirizine 是一种抗组胺剂，是口服有活力的、特异性 H1受体拮抗剂。它能够抑制过敏反应期间嗜酸性粒细胞趋化，可以标记抗过敏特性。
T0806	Flunarizine dihydrochloride Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪	Calcium Channel; Dopamine Receptor; Sodium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Flunarizine dihydrochloride (R14950) 是 Na+/Ca2+(T 型) 通道双重阻滞剂。它也是 D2多巴胺受体拮抗剂。它具有用于扩张外周血管和预防偏头痛的潜力。
T4195	Betahistine PT 9 base,倍他司汀,Vasomotal,Serc base	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betahistine (Vasomotal) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。
T22878	JNJ 10181457 dihydrochloride	Others	Others
	JNJ 10181457 dihydrochloride is a Histamine H3 receptor antagonist.
T23038	Nα-Methylhistamine dihydrochloride	Others	Others
	Nα-Methylhistamine dihydrochloride is a histamine H3 receptor agonist.
T71928	Nordimaprit dihydrochloride
	Nordimaprit dihydrochloride is a metabolite of Dimaprit -- a histamine analog and selective H2 histamine receptor agonist.
T22983	Mizolastine dihydrochloride	Others	Others
	Mizolastine dihydrochloride is a histamine H1-receptor antagonist (IC50: 47 nM). It also used in the treatment of hay fever, hives, and other allergic reactions.
T19234	Cetirizine D8 dihydrochloride 盐酸西替利嗪 D8	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cetirizine D8 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
TMIH-0271	Hydroxyzine dihydrochloride-d4 (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy-1,1,2,2-d4)ethan-1-ol dihydrochloride
	Hydroxyzine dihydrochloride-d4 是 Hydroxyzine dihydrochloride 的氘代化合物。Hydroxyzine dihydrochloride 的 CAS 号为 2192-20-3。Hydroxyzine dihydrochloride是一种苯二氮卓抗组胺剂，是可口服的组胺 H1 受体和血清素拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它还可以作为止吐剂和镇静剂，有缓解焦虑和紧张的作用。
T19233	Cetirizine D4 dihydrochloride Cetirizine D4 dihydrochloride (1219803-84-5 free base)	Others	Others
	Cetirizine D4 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
T63115	Perphenazine dihydrochloride
	Perphenazine dihydrochloride 是一种口服具有活力的多巴胺受体 (dopamine receptor) 和组胺-1 受体 (histamine-1 receptor) 拮抗剂，作用于 D2 (Ki: 0.56 nM)、D3 (Ki: 0.43 nM)、5-HT2A (Ki: 0.6 nM)。Perphenazine dihydrochloride 也能够结合 Alpha-1A 肾上腺素受体。Perphenazine dihydrochloride 能够诱导细胞凋亡，并抑制癌细胞增殖。Perphenazine dihydrochloride 能够用于研究精神疾病、癌症、炎症。
T19366	Hydroxyzine D4 dihydrochloride Hydroxyzine D4 dihydrochloride (2070014-84-3 free base)	Others	Others
	Hydroxyzine D4 dihydrochloride is deuterium-labeled Hydroxyzine. Hydroxyzine is a heterocyclic histamine H1-receptor antagonist. Hydroxyzine has anxiolytic, anticholinergic, and analgesic properties.
T34752	Samelisant dihydrochloride SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl
	Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, obesity, schizophrenia, eating disorders, and pain.
T22242	Amodiaquine hydrochloride
	Amodiaquine dihydrochloride (Amodiaquin dihydrochloride) 是一种4-氨基喹啉类抗疟剂，是一种有效的口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂，Ki 值为 18.6 nM。Amodiaquine dihydrochloride 也是一种Nurr1激动剂，可特异性结合Nurr1的配体结合域，EC50约为20 μM，具有抗炎作用。
T73962	Cetirizine Impurity C dihydrochloride
	Cetirizine Impurity C dihydrochloride 为Cetirizine杂质之一，属于羟嗪的羧化代谢物，是第二代抗组胺剂中的一个。其为具有特异性且口服有效的H1受体(histamine H1-receptor)长效拮抗剂。
T73981	Deschloro Cetirizine dihydrochloride
	Deschloro Cetirizine Dihydrochloride 为 Cetirizine 杂质(impurity)。Cetirizine 属于第二代抗组胺药，作为羟嗪羧化代谢物，它表现为特异性、口服活性的长效组胺 H1 受体(histamine H1-receptor)拮抗剂。
TMIH-0028	2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl 1-Methylhistamine-d3 Dihydrochloride
	2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl 是 2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl 的氘代化合物。2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl 的 CAS 号为 6481-48-7。1-Methylhistamine dihydrochloride 是组胺代谢物。

化合物

Dimaprit dihydrochloride

Cat.No: T22724

Target: NOS, NO Synthase, Histamine Receptor

JNJ-5207852 dihydrochloride

Cat.No: T8822

Target: Histamine Receptor

Decloxizine dihydrochloride

Cat.No: T5495

Synonym: 盐酸去氯羟嗪,UCB 1402 dihydrochloride

Target: Histamine Receptor

Latrepirdine dihydrochloride

Cat.No: T6562

Synonym: Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin

Target: Beta Amyloid, 5-HT Receptor, Adrenergic Receptor, GluR, Autophagy, Histamine Receptor

Hydroxyzine dihydrochloride

Cat.No: T2200

Synonym: Hydroxyzine 2HCl,盐酸羟嗪

Target: Histamine Receptor

Meclizine dihydrochloride

Cat.No: T1110

Synonym: Meclozine dihydrochloride,NSC28728,Meclizine 2HCl,盐酸美克洛嗪

Target: Apoptosis, Histamine Receptor

Betazole dihydrochloride

Cat.No: T8599

Synonym: 盐酸倍他唑,Betazole hydrochloride

Target: Histamine Receptor

Cetirizine dihydrochloride

Cat.No: T0089

Synonym: 盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl

Target: Histamine Receptor

Betahistine dihydrochloride

Cat.No: T0246

Synonym: PT-9,Betahistine 2HCl,盐酸倍他司汀

Target: Histamine Receptor

Buclizine dihydrochloride

Cat.No: T6426

Synonym: 盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445

Target: 5-HT Receptor, AChR, Histamine Receptor

(R)-(-)-α-Methylhistamine dihydrochloride

Cat.No: T24698

Synonym: HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL

2-Pyridylethylamine dihydrochloride

Cat.No: T22501

Target: Histamine Receptor

Vapitadine dihydrochloride

Cat.No: T29096

Synonym: Vapitadine 2HCl,R129160,R-129160 2HCl,Vapitadine HCl,R 129160 2HCl,R-129160,R 129160,R129160 2HCl

Target: Histamine Receptor

Levocetirizine Dihydrochloride

Cat.No: T22354

Synonym: Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride

Target: Histamine Receptor

Cetirizine Impurity B dihydrochloride

Cat.No: T9084

Synonym: De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride,西替利嗪杂质B二盐酸盐,西替利嗪杂质04

Target: Histamine Receptor

Flunarizine dihydrochloride

Cat.No: T0806

Synonym: Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪

Target: Calcium Channel, Dopamine Receptor, Sodium Channel

Cat.No: T4195

Synonym: PT 9 base,倍他司汀,Vasomotal,Serc base

Target: Histamine Receptor

JNJ 10181457 dihydrochloride

Cat.No: T22878

Target: Others

Nα-Methylhistamine dihydrochloride

Cat.No: T23038

Target: Others

Nordimaprit dihydrochloride

Cat.No: T71928

Mizolastine dihydrochloride

Cat.No: T22983

Target: Others

Cetirizine D8 dihydrochloride

Cat.No: T19234

Synonym: 盐酸西替利嗪 D8

Target: Histamine Receptor

Hydroxyzine dihydrochloride-d4

Cat.No: TMIH-0271

Synonym: (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy-1,1,2,2-d4)ethan-1-ol dihydrochloride

Cetirizine D4 dihydrochloride

Cat.No: T19233

Synonym: Cetirizine D4 dihydrochloride (1219803-84-5 free base)

Target: Others

Perphenazine dihydrochloride

Cat.No: T63115

Hydroxyzine D4 dihydrochloride

Cat.No: T19366

Synonym: Hydroxyzine D4 dihydrochloride (2070014-84-3 free base)

Target: Others

Samelisant dihydrochloride

Cat.No: T34752

Synonym: SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl

Amodiaquine hydrochloride

Cat.No: T22242

Cetirizine Impurity C dihydrochloride

Cat.No: T73962

Deschloro Cetirizine dihydrochloride

Cat.No: T73981

2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl

Cat.No: TMIH-0028

Synonym: 1-Methylhistamine-d3 Dihydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T6534	Histamine dihydrochloride 组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl	Endogenous Metabolite; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Histamine dihydrochloride (Ceplene) 是 Histamine 的二盐酸形式。Histamine 是一种有机氮化合物，是一种强效的胃分泌兴奋剂，支气管平滑肌收缩剂，血管舒张剂，也是一种中枢作用的神经递质。
T4940	3-Methylhistamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	3-Methylhistamine dihydrochloride 是一种组胺的降解产物，与免疫反应有关，并在接种过疫苗的小鼠中表现出上调作用。
T4899	L-Histidinol dihydrochloride	Endogenous Metabolite	Metabolism
	L-Histidinol dihydrochloride 是内源性代谢产物的一种。
T8790	1-Methylhistamine dihydrochloride	Endogenous Metabolite	Metabolism
	1-Methylhistamine dihydrochloride 是组胺代谢物。

天然产物

Histamine dihydrochloride

Cat.No: T6534

Synonym: 组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl

Target: Endogenous Metabolite, Histamine Receptor

3-Methylhistamine dihydrochloride

Cat.No: T4940

Target: Others, Endogenous Metabolite

L-Histidinol dihydrochloride

Cat.No: T4899

Target: Endogenous Metabolite

1-Methylhistamine dihydrochloride

Cat.No: T8790

Target: Endogenous Metabolite

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