12
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11580 |
Heme Oxygenase-1-IN-1
HO-1-IN-1 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Heme Oxygenase-1-IN-1 (HO-1-IN-1) 是一种血红素加氧酶 1 (HO-1) 抑制剂,IC50=250 nM。 | |||
T11580L |
Heme Oxygenase-1-IN-1 hydrochloride
HO-1-IN-1 hydrochloride |
Others | Others |
HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM). | |||
T61078 | Heme Oxygenase-1-IN-2 | ||
Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM. | |||
T60847 | Heme Oxygenase-2-IN-1 | ||
Heme Oxygenase-2-IN-1 (Compound 9) 是血红素加氧酶 (HO-2) 的选择性抑制剂。Heme Oxygenase-2-IN-1 对 HO-1和HO-2 的IC50值分别为 14.9 μM 和0.9 μM。 | |||
T4977 |
Sofalcone
索法酮,SU-88 |
Antibacterial; Autophagy | Autophagy; Microbiology/Virology |
Sofalcone (SU-88) 可诱导血红素加氧酶-1在胃肠上皮中的表达,是一种抗胃溃疡剂。 | |||
T75098 |
HIF-PHD-IN-3
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
HIF-PHD-IN-3 是一种有效的 hiPSC-CM 心脏保护支架,对 HIF-PHD 有潜在的抑制作用,可调节血红素加氧酶-1,可用于研究贫血。 | |||
T13161 |
Tin-protoporphyrin IX
锡原卟啉IX,SnPPIX |
Others | Others |
Tin-protoporphyrin IX is a potent inhibitor of Heme oxygenase-1 (HO-1). It sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice models. | |||
T41175 |
OB 24 hydrochloride
|
||
OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferationin vitroand PCA tumor growth and lymph node/lung metastasesin vivo. Synergizes with Taxol. | |||
T78508 |
Delmitide acetate
RDP-58 acetate |
IFNAR | Immunology/Inflammation |
Delmitide acetate (RDP58) 是一种 d-异构体十肽,具有抗炎活性和口服活性。该化合物能够抑制 TNF-α、IFN-γ 以及白细胞介素 (IL)-12 的生成,同时提高血红素加氧酶 1 的活性,可用于针对溃疡性结肠炎的研究。 | |||
T74600 |
Keap1-Nrf2-IN-9
|
||
Keap1-Nrf2-IN-9(compound 11)是一种有效Keap1-Nrf2PPI抑制剂,IC50为0.575 µM。该化合物能够提升Nrf2靶基因表达,涉及血红素加氧酶1 (Hmox1)、谷胱甘肽S转移酶P (GstP) 以及谷氨酸-半胱氨酸连接酶的催化(Gclc)与调节(Gclm)亚基。在ARPE19细胞中,Keap1-Nrf2-IN-9展现出无细胞毒活性。 | |||
T75238 | YS-49 monohydrate | ||
YS-49 (单水合物) 作为PI3K/Akt(RhoA的下游靶点)的激活剂,有效降低3-甲基胆碱处理的细胞中RhoA/PTEN的活性。此外,YS-49通过促进血红素加氧酶(HO-1)的表达,抑制血管紧张素II(Ang II)诱导的血管平滑肌细胞(VSMC)增殖。作为一种异喹啉化合物生物碱,YS-49因激活心脏β-adrenoceptors而显示出显著的正性肌力效应。 | |||
TP2109 |
TAT 14
|
Nrf2 | Immunology/Inflammation |
TAT-14 是 由14 个氨基酸组成的多肽,是 Nrf2激活因子,表现出抗炎活性。它通过靶向 Nrf2 上 Keap1 的结合位点而非 Nrf2 mRNA 表达来提高 Nrf2 蛋白水平。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5515 |
Hemin
氯化血红素,Hemin chloride |
Mitophagy; Ferroptosis; Autophagy | Apoptosis; Autophagy |
Hemin (Hemin chloride) 是一种含有氯的含铁卟啉,一种血红素加氧酶 (HO)-1 诱导剂。Hemin 对卟啉病具有治疗活性,可以减少患者的血红素缺乏,从而通过生物化学反馈抑制 δ-氨基乙酰丙酸合成酶的活性。 | |||
T6S1302 |
Carnosol
|
Nrf2; Endogenous Metabolite; S6 Kinase | Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Carnosol 是 Nrf2激活剂,增加 Nrf2 的水平以及能促进血红素氧合酶 1(HMOX1) 表达。它是核糖体 S6激酶(RSK2)抑制剂,可用于胃癌相关研究,IC50值约为 5.5 μM。 | |||
T2915 |
Bardoxolone
RTA 401,齐墩果烷三萜化合物,CDDO |
Others; Nrf2 | Immunology/Inflammation; Others |
Bardoxolone (CDDO) 是新型核调节因子激活剂。 | |||
T6429 |
Caffeic Acid Phenethyl Ester
Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE |
Apoptosis; NF-κB | Apoptosis; NF-κB |
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) 是咖啡酸的苯乙醇酯,是蜂巢蜂胶的生物活性成分。它抑制核转录因子 NF-kappa B 的激活,具有抗肿瘤、细胞保护和免疫调节活性。它抑制 PDGF 诱导的血管平滑肌细胞增殖。 | |||
TN4064 |
Flavoglaucin
|
Phosphatase; IL Receptor; TNF; NOS; NF-κB; COX; Nrf2; Prostaglandin Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammato |