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Search Results for " hmt "

Targets Recommended: AChR

23

抑制剂 & 化合物

1

天然产物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6364	Desfesoterodine 5-HMT,(R)-5-Hydroxymethyl Tolterodine,(R)-5-羟甲基托特罗定,PNU-200577,5-HM,5-hydroxymethyl Tolterodine	AChR	Neuroscience
	Desfesoterodine (5-HMT) 是选择性毒蕈碱受体拮抗剂，Kb 和pA2分别为 0.84 nM 和 9.14。它可改善大鼠脑梗死诱导膀胱过度活动，是 Tolterodine 和 Fesoterodine 的主要药理活性代谢产物。
T8548	Metoprine	Histone Methyltransferase; Antifolate; Histamine Receptor	Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Metoprine 是一种有效的组胺 N-甲基转移酶抑制剂，具有抗肿瘤活性。它是一种二氨基嘧啶衍生物，可以透过血脑屏障，并通过抑制 HMT 增加脑组胺水平。
T9419	Fesoterodine (R) Fesoterodine,弗斯特罗定	AChR	Neuroscience
	Fesoterodine ((R) Fesoterodine) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T1475	Fesoterodine fumarate Toviaz,SPM 907,富马酸非索罗定	AChR	Neuroscience
	Fesoterodine fumarate (Toviaz) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T62404	SHMT-IN-2	Others	Others
	SHMT-IN-2 (compound 2) 是一种特异性人 SHMT1/2 小分子抑制剂，能够作用于 SHMT1 (IC50: 13 nM) 和 SHMT2 (IC50: 66 nM)。SHMT-IN-2 对许多人类癌细胞的生长具有抑制作用，对 B 细胞淋巴瘤具有敏感性。
T62512	IHMT-MST1-58	Hippo pathway	Stem Cells
	IHMT-MST1-58 是一种 STE20-like protein 1 kinase (MST1) 抑制剂（IC50 ：23 nM），具有高效性、选择性和口服活性。IHMT-MST1-58 可用于研究 1 型或 2 型糖尿病。
T35530	IHMT-PI3Kδ-372 IHMT-PI3Kδ-372	PI3K	PI3K/Akt/mTOR signaling
	IHMT-PI3Kδ-372 是一种选择性的 PI3Kδ 抑制剂，IC50 为 14 nM，可用于慢性阻塞性肺病的研究。
T12902	SHMT-IN-1	Others	Others
	SHMT-IN-1 是有效的血浆丝氨酸羟甲基转移酶 (SHMT) 抑制剂。SHMT-IN-1 具有抗肿瘤活性。
T60196	IHMT-PI3Kδ-372 S-isomer	PI3K	PI3K/Akt/mTOR signaling
	IHMT-PI3Kδ-372 S-isomer 是一种有效的选择性 PI3Kδ 抑制剂，IC50 为 14 nM。IHMT-PI3Kδ-372 S-isomer 对 PI3Kδ 的选择性高于其他 I 类 PI3K (56-83 倍) 和其他蛋白激酶。IHMT-PI3Kδ-372 S-isomer 可用于慢性阻塞性肺疾病 (COPD )的研究。
T78758	IHMT-IDH1-053	Isocitrate Dehydrogenase (IDH)	Metabolism
	IHMT-IDH1-053（compound 16）为高选择性不可逆IDH1R132H突变抑制剂，IC50值仅为4.7 nM。对IDH1wt和IDH2wt/突变体活性低。该化合物在IDH1R132H突变293T细胞中显著抑制2-羟基戊二酸（2-HG）生成，IC50为28 nM。IHMT-IDH1-053通过与IDH1R132H蛋白的Cys269残基形成共价键，结合至NADPH结合袋附近的变构袋。此外，它能够抑制携带IDH1R132突变的HT1080细胞系及原代AML细胞增殖。
TP1460	NH2-KLGADTDGEQDQHMTYGGQ-COOH
	NH2-QGGYTMHQDQEGDTDAGLK-COOH is a synthetic peptide chain consisting of a primary amine group attached to lysine and a carboxyl group attached to glutamine.
T78836	IHMT-PI3K-455	PI3K	PI3K/Akt/mTOR signaling
	IHMT-PI3K-455（Compound 15u）为一种高效、选择性且具口服活性的PI3Kγ/δ双重抑制剂，其针对PI3Kγ与PI3Kδ的IC50值分别为7.1 nM和0.57 nM。该化合物能够抑制AKT磷酸化，并通过促进CD8+杀伤性T细胞的招募与激活，抑制肿瘤生长，适用于肿瘤学研究领域。
T63076	IHMT-TRK-284
	IHMT-TRK-284 (Compound 34) 是一种有效的、口服具有活力的 type II TRK kinase 抑制剂，能够作用于 TRKA (IC50: 10.5 nM)、TRKB (IC50: 0.7 nM)、TRKC (IC50: 2.6 nM)。IHMT-TRK-284 在激酶组中表现出良好的选择性，体内具有良好的抗肿瘤作用。
T11167	EHMT2-IN-2	Others	Others
	EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.
T11166	EHMT2-IN-1	Others	Others
	EHMT2-IN-1 is a potent EHMT inhibitor, . Used in the research of blood disorder or cancer.with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.
T79780	IHMT-EZH2-426	Histone Methyltransferase	Chromatin/Epigenetic
	IHMT-EZH2-426（compound 38）是一种针对EZH2野生型及其A687V和Y641F/Y641N/Y641S突变体高效的共价降解剂，其IC50值分别为1.3 nM、1.2 nM以及1.7-3.5 nM。该化合物通过下调H3K27me3和EZH2蛋白表达水平，显著抑制B细胞淋巴瘤和三阴性乳腺癌（TNBC）细胞系的增殖。
T67947	WDR5-0102	Histone Methyltransferase	Chromatin/Epigenetic
	WDR5-0102为针对WDR5-MLL1的抑制剂(Kdis=7 μM, Kd=4 μM)。该化合物有效抑制MLL1活性，而对人类H3K4甲基转移酶SETD7及其他六种HMT（G9a、EHMT1、SUV39H2、SETD8、PRMT3、PRMT5）不表现出抑制作用。
T2352	AMI-1	Histone Methyltransferase	Chromatin/Epigenetic
	AMI1 是一种有效的、可逆的、细胞渗透性的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂，对人 PRMT1 和酵母 Hmt1p 作用的 IC50值分别为 8.8 和 3.0 μM。它通过阻断肽-底物结合对 PRMTs 发挥抑制作用。
T8768	MM-102 TFA HMTase Inhibitor IX TFA	Histone Methyltransferase	Chromatin/Epigenetic
	MM-102 TFA (HMTase Inhibitor IX TFA) 是一种有效的 WDR5/MLL 相互作用抑制剂，在 WDR5 结合检测中，IC50为 2.4 nM，Ki 小于 1 nM。
T13334	WDR5-IN-1	Others	Others
	WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50: 2.2 nM).
T38784	Histone H3 (1-25), amide Histone H3 (1-25), amide
	Histone H3 (1-25), amide is a N-terminal peptide fragment of histone H3 that serves as a substrate for histone methyltransferases (HMTs). It can be utilized to identify the substrate for HMTs. Compared to histone H3 (15-39) and full-length histone H3, Histone H3 (1-25), amide proves to be more efficient as a substrate for HMT G9a.
T12091	MM-589	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.
T12091L	MM-589 TFA	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.

化合物

Desfesoterodine

Cat.No: T6364

Synonym: 5-HMT,(R)-5-Hydroxymethyl Tolterodine,(R)-5-羟甲基托特罗定,PNU-200577,5-HM,5-hydroxymethyl Tolterodine

Target: AChR

Cat.No: T8548

Target: Histone Methyltransferase, Antifolate, Histamine Receptor

Cat.No: T9419

Synonym: (R) Fesoterodine,弗斯特罗定

Target: AChR

Fesoterodine fumarate

Cat.No: T1475

Synonym: Toviaz,SPM 907,富马酸非索罗定

Target: AChR

Cat.No: T62404

Target: Others

Cat.No: T62512

Target: Hippo pathway

IHMT-PI3Kδ-372

Cat.No: T35530

Synonym: IHMT-PI3Kδ-372

Target: PI3K

Cat.No: T12902

Target: Others

IHMT-PI3Kδ-372 S-isomer

Cat.No: T60196

Target: PI3K

Cat.No: T78758

Target: Isocitrate Dehydrogenase (IDH)

NH2-KLGADTDGEQDQHMTYGGQ-COOH

Cat.No: TP1460

Cat.No: T78836

Target: PI3K

Cat.No: T63076

Cat.No: T11167

Target: Others

Cat.No: T11166

Target: Others

Cat.No: T79780

Target: Histone Methyltransferase

Cat.No: T67947

Target: Histone Methyltransferase

Cat.No: T2352

Target: Histone Methyltransferase

Cat.No: T8768

Synonym: HMTase Inhibitor IX TFA

Target: Histone Methyltransferase

Cat.No: T13334

Target: Others

Histone H3 (1-25), amide

Cat.No: T38784

Synonym: Histone H3 (1-25), amide

Cat.No: T12091

Target: JAK

Cat.No: T12091L

Target: JAK

Cat. No.	Product Name	Target	Signaling Pathways
T6803	Chaetocin 毛壳素	Histone Methyltransferase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Microbiology/Virology
	Chaetocin 特异性抑制组蛋白甲基转移酶(HMT) SU(VAR)3-9，IC50值为0.6 μM。它还可抑制硫氧还蛋白还原酶，IC50值为4 μM。

天然产物

Cat.No: T6803

Synonym: 毛壳素

Target: Histone Methyltransferase, Antibacterial, Antibiotic

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02340	HNMT Protein, Human, Recombinant (GST) HMT,HNMT-S1,HNMT-S2,histamine N-methyltransferase	Human	E. coli
	HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabolism of histamine in the rat brain, is potently inhibited by 9-amino-1,2,3,4-tetrahydroacridine (tacrine). Methylation is an important pathway in the biotransformation of many drugs, neurotransmitters, and xenobiotic compounds. Histamine N-methyltransferase (HNMT) catalyzes the N ...
TMPY-02386	PTP4A2 Protein, Human, Recombinant (GST) HNMT-S2,PRL-2,HNMT-S1,protein tyrosine phosphatase type IVA,...	Human	E. coli
	PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeu...
TMPK-01552	HLA-A02:01&B2M&P53 R175H (HMT*EVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated TP53,TRP53,HLA-A,MHC,Antigen NY-CO-13,BCC7,LFS1,P53,FLJ92943	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01442	HLA-A02:01&B2M&P53 WT (HMT*EVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled HLA-A,P53,TP53,LFS1,MHC,BCC7,TRP53,FLJ92943,Antigen NY-CO-13	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01437	HLA-A02:01&B2M&P53 R175H (HMT*EVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled FLJ92943,HLA-A,TP53,Antigen NY-CO-13,TRP53,MHC,BCC7,P53,LFS1	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01531	HLA-A02:01&B2M&P53 R175H (HMT*EVVRHC) Tetramer Protein, Human, MHC (His & Avi) Antigen NY-CO-13,MHC,FLJ92943,TRP53,HLA-A,BCC7,TP53,LFS1,P53	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01538	HLA-A02:01&B2M&P53 WT (HMT*EVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,LFS1,Antigen NY-CO-13,HLA-A,BCC7,TP53,TRP53,FLJ92943,P53	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01509	HLA-A02:01&B2M&P53 WT (HMT*EVVRRC) Monomer Protein, Human, MHC (His & Avi) TRP53,HLA-A,TP53,LFS1,P53,MHC,FLJ92943,BCC7,Antigen NY-CO-13	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01532	HLA-A02:01&B2M&P53 R175H (HMT*EVVRHC) Monomer Protein, Human, MHC (His & Avi) Antigen NY-CO-13,BCC7,FLJ92943,HLA-A,LFS1,P53,TP53,TRP53,MHC	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPJ-00484	SHMT1 Protein, Human, Recombinant (His) Serine Methylase,Glycine Hydroxymethyltransferase,Serine Hyd...	Human	HEK293 Cells
	Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ...
TMPK-01508	HLA-A02:01&B2M&P53 WT (HMT*EVVRRC) Tetramer Protein, Human, MHC (His & Avi) TP53,Antigen NY-CO-13,P53,MHC,HLA-A,BCC7,LFS1,FLJ92943,TRP53	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPH-02105	ASH2L Protein, Human, Recombinant (His & SUMO) ASH2-like protein,ASH2L,ASH2L1,Set1/Ash2 histone methyltrans...	Human	E. coli
	Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May p...

重组蛋白

HNMT Protein, Human, Recombinant (GST)

Cat.No: TMPY-02340

Species: Human

Expression System: E. coli

PTP4A2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02386

Species: Human

Expression System: E. coli

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01552

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01442

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01437

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01531

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01538

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01509

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01532

Species: Human

Expression System: HEK293 Cells

SHMT1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00484

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01508

Species: Human

Expression System: HEK293 Cells

ASH2L Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02105

Species: Human

Expression System: E. coli

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