10
11
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0031L2 |
Ziprasidone
齐拉西酮,Geodon,Zeldox,CP-88059 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Ziprasidone (Geodon) 是一种联合的 5-HT(5-羟色胺)和多巴胺受体拮抗剂,具有强大的抗精神病活性。它是去甲肾上腺素再摄取抑制剂,对大鼠和人的5-HT1A,5-HT2A 和多巴胺 D2 受体有很高的亲和力。 | |||
T0031 |
Ziprasidone hydrochloride monohydrate
齐拉西酮盐酸盐一水合物,盐酸齐拉西酮水合物,CP 88059 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Ziprasidone hydrochloride monohydrate (CP 88059) 是一种联合 5-HT(5-羟色胺)和多巴胺受体拮抗剂,具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。 | |||
T60523 |
Agomelatine hydrochloride
S-20098 hydrochloride |
MT Receptor | Neuroscience |
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) 是特异性的MT1和MT2受体激动剂,对 CHO-hMT1的Ki 值为0.1 nM,对HEK-hMT1的Ki 值为0.06 nM,对CHO-hMT2的Ki 值为0.12 nM,对HEK-hMT2 的Ki 值为0.27 nM。Agomelatine hydrochloride 是选择性的5-羟色胺2C(5-HT2C)受体拮抗剂,对天然 (猪) 和克隆的人 5-HT2C 受体的pKi 值分别为 6.4 和 6.2。 | |||
T9019 |
JHU37152
JHU 37152 |
AChR | Neuroscience |
JHU37152 (JHU 37152) 是一种可透过血脑屏障的DREADD 激动剂。 在 HEK-293 细胞的荧光和基于 BRET 的测定中,对hM3Dq 和hM4Di DREADDs 的EC50值分别为 5 和 0.5 nM。 | |||
T2092 |
Amitifadine hydrochloride
DOV-21947 hydrochloride,EB-1010 hydrochloride |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Amitifadine hydrochloride (EB-1010 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺的再摄取抑制剂(SNDRI),其在 HEK 293 细胞中测得的 IC50值分别为 12, 23, 96 nM。 | |||
T14190 |
Alniditan
Alnitidan |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively. | |||
T10267 |
Agomelatine (L(+)-Tartaric acid)
阿戈美拉汀 L(+)-酒石酸,S-20098 L(+)-Tartaric acid |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native (porcine) and cloned (human) 5-HT2C receptors). | |||
T62081 |
Mt KARI-IN-5
|
||
Mt KARI-IN-5 (compound 6c) 是一种结核分歧杆菌酮醇酸还原异构酶 I (MtbKARI) 的有效抑制剂 (Ki: 4.72 μM)。Mt KARI-IN-5 对 MtbH37Rv 的活性表现出抑制作用,其 MIC 值为 1.56 μM,细胞毒性较低,对 HEK 的 IC50 值大于 64 μg/mL。 | |||
T63643 |
BI-4142
|
HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
BI-4142 是一种具有口服活性、高效和选择性的 HER2 抑制剂,抑制癌细胞增殖,抑制her2依赖性细胞系并抑制下游信号传导。 | |||
T72830 |
TLR8 agonist 5
|
||
TLR8 agonist5 是有效的 TLR8激动剂,对 HEK-Blue hTLR8 的 EC50值为 20 nM。TLR8 agonist5 激活免疫反应。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01784 |
EphB3 Protein, Mouse, Recombinant (His)
MDK5,Tyro6,Etk2,HEK2,EPH receptor B3,Cek10... |
Mouse | HEK293 Cells |
EphB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P54754. | |||
TMPK-00563 |
EPHB2 Protein, Cynomolgus, Recombinant (His)
DRT,Nuk,Sek3,TYRO5,EPHT3,HEK5,Eph... |
Cynomolgus | HEK293 Cells |
EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2α is required for EPHB2 stabilization by hypoxia. | |||
TMPK-00898 |
EphB3 Protein, Human, Recombinant (His)
EC 2.7.10.1,EPHB3,ETK2,EK2,HEK2,AW45689 |
Human | HEK293 Cells |
Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is contributed to downregulation of EphB3 in CRC. EphB3 expression in tumor cells may be a useful prognostic indicator for patients with CRC. | |||
TMPY-05308 |
CD45 Protein, Human, Recombinant (aa 1-529, His)
GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5. | |||
TMPY-05387 |
SLAMF7 Protein, Human, Recombinant (hFc)
SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPY-04318 |
GRIK2 Protein, Human, Recombinant (hFc)
GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate... |
Human | HEK293 Cells |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl... | |||
TMPY-05547 |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPJ-00854 |
ETS1 Protein, Human, Recombinant (His)
V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),... |
Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As... | |||
TMPY-05498 |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas... |
Human | HEK293 Cells |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5. | |||
TMPK-01357 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal. | |||
TMPK-01363 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... |