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Cat. No.	Product Name	Target	Signaling Pathways
TQ0310	FMK	S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。
T6013	Z-VAD(OMe)-FMK Z-VAD-FMK,Z-Val-Ala-Asp(OMe)-FMK	Caspase	Apoptosis; Proteases/Proteasome
	Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) 是一种 caspase 的广谱抑制剂，具有细胞渗透性和不可逆性。Z-VAD(OMe)-FMK 与活化的 caspase 结合，从而抑制细胞凋亡。
T7020	Z-VAD-FMK Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD	Caspase	Apoptosis; Proteases/Proteasome
	Z-VAD-FMK (Caspase Inhibitor VI) 是一种 caspase 的广谱抑制剂，具有不可逆性。Z-VAD-FMK 与活化的 caspase 结合，从而抑制细胞凋亡。
T7019	Z-IETD-FMK Z-IE(OMe)TD(OMe)-FMK,Caspase-8 Inhibitor	Caspase	Apoptosis; Proteases/Proteasome
	Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) 是一种选择性 caspase 8 抑制剂，具有细胞渗透性。它也是颗粒酶 B 抑制剂。
TP1466	Z-YVAD-FMK	Caspase	Apoptosis; Proteases/Proteasome
	Z-YVAD-FMK 是一种不可逆的 caspase-1 抑制剂，具有抗炎和抗肿瘤活性。
T15303	FMK 9a	Cysteine Protease; Autophagy	Autophagy; Proteases/Proteasome
	FMK 9a 是一种不可逆的 ATG4B 抑制剂，在 TR-FRET 和基于细胞的 LRA 试验中 IC50 值为 80 和 73 nM。
T21835	Z-LEHD-fmk	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Z-LEHD-FMK 是一种具有选择性和有效性的 caspase-9 抑制剂，可防减轻再灌注损伤，减缓细胞凋亡。Z-LEHD-FMK 具有抗肿瘤和神经保护活性，可提高体外生产的水牛（Bubalus bubalis）植入前胚胎的产量并改变细胞应激反应。
T6005	Z-DEVD-FMK Caspase-3 Inhibitor	Caspase	Apoptosis; Proteases/Proteasome
	Z-DEVD-FMK (Caspase-3 Inhibitor) 是一种选择性、不可逆的 Caspase-3 抑制剂，IC50为 18 μM。它也抑制 caspase-6、caspase-7、caspase-8 和 caspase-10。
T6738	Z-FA-FMK	SARS-CoV; Cysteine Protease	Microbiology/Virology; Proteases/Proteasome
	Z-FA-FMK 是一种广谱的卤代甲基酮抑制剂，可抑制冠状病毒蛋白酶3CL，Ki 为 25.7 μM。它可以不可逆地抑制半胱氨酸蛋白酶，也可以抑制效应半胱天冬酶。
T10580	BOC-D-FMK	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Boc-D-FMK 是一种可渗透细胞，不可逆的泛半胱天冬酶抑制剂。它抑制 TNF-α 诱导的细胞凋亡的IC50值为 39 µM。
T36331	Z-AEVD-FMK Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
	Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 &#181M, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]
T11310	FMK-MEA	Others	Others
	FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.
T39308	Boc-Asp(OMe)-fluoromethyl ketone Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK	Caspase	Apoptosis; Proteases/Proteasome
	Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) 是广谱的 caspase 抑制剂，可抑制 Fas 介导的吞噬作用和氧化破裂抑制，但对 IL-8 的趋化活性无影响。
T40602	Z-LEHD-FMK TFA
	Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, offering protection against detrimental reperfusion injury and moderating apoptosis. Additionally, Z-LEHD-FMK TFA demonstrates its neuroprotective potential in a rat model of spinal cord trauma.
T38469	(Rac)-Z-Phe-Phe-FMK Cathepsin L-IN-2	Beta Amyloid; Cysteine Protease	Neuroscience; Proteases/Proteasome
	(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) 是一种 cathepsin L 抑制剂，抑制 β-淀粉样蛋白诱导凋亡变化的倾向。(Rac)-Z-Phe-Phe-FMK 通过 siRNA 敲低 LC3B 表达可抑制 PI 诱导的 IkappaBalpha 降解。
T39344	Z-VDVA-(DL-Asp)-FMK
	Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.
T78185	Ac-PLVE-FMK Ac-Pro-Leu-Val-Glu(OMe)-CH2F	Others	Others
	Ac-PLVE-FMK（Ac-Pro-Leu-Val-Glu(OMe)-CH2F），一种四肽基m-FMK化合物，具有Cats抑制作用，常用于癌症研究。
T23555	Z-VEID-FMK	Others	Others
	When compared to other caspase inhibitors, Z-DRHD-FMK inhibited caspase 6 activity more effectively than the general caspase inhibitor of Z-Val-Ala-Asp (OMe)-fluoromethy ketone (Z-VAD-FMK) or the caspase 6 inhibitor Z-Val-Glu(Ome)-Ile-Asp(OMe)-fluorometh
T10548	Biotin-VAD-FMK	Caspase	Apoptosis; Proteases/Proteasome
	Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates.
TP2161	Z-WEHD-FMK	Caspase	Apoptosis; Proteases/Proteasome
	Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).
TP2101	Z-VRPR-FMK trifluoroacetate salt
	Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.
TP2037	Z-DQMD-FMK
	Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
T71586	Z-VAE(OMe)-fmk
	Z-VAE(OMe)-fmk is a cell-permeable and irreversible UCHL1 inhibitor. The inhibitor approaches the active-site cleft from the opposite side of the crossover loop as compared to the direction of approach of ubiquitin's C-terminal tail, thereby occupying the P1' (leaving group) site, a binding site perhaps used by the unknown C-terminal extension of ubiquitin in the actual in vivo substrate(s) of UCHL1.
TP1014	Z-VRPR-FMK (TFA) VRPR
	Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible inhibitor of lymphoma translocation protein 1 (MALT1) in mucosa-associated lymphoid tissue.
T78186	Ac-VLPE-FMK Ac-Val-Leu-Pro-Glu(OMe)-CH2F
	Ac-VLPE-FMK为一种四肽基单氟甲基酮(m-FMK)，兼作Cat-B及Cat-L抑制剂，适用于癌症侵袭性研究。
T80551	Calpain inhibitor V Mu-Val-HPh-FMK	Antibiotic	Microbiology/Virology
	Calpain inhibitor V (Mu-Val-HPh-FMK) 为具抗衣原体活性的细胞渗透性不可逆钙蛋白酶抑制剂。
T80542	Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK
	Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK)为半胱氨酸蛋白酶抑制剂，可抑制SARS感染，并能保护小鼠免遭T. crassiceps侵害。
T73096	Z-LEVD-FMK
	Z-LEVD-FMK 是一种细胞渗透性的caspase-4抑制剂。 Z-LEVD-FMK 阻断 ER 应激诱导的癌细胞凋亡。
T78632	Z-LLY-FMK Calpain Inhibitor IV	Proteasome	Proteases/Proteasome; Ubiquitination
	Z-LLY-FMK (Calpain Inhibitor IV) 为一种钙蛋白酶抑制剂，涉及调控多个细胞系统的凋亡过程。该化合物能够抑制胆总管结扎所引起的肠细胞凋亡(apoptosis)。
T76665	Z-LEED-FMK
	Z-LEED-FMK 是 caspase-13和 caspase-4抑制剂。Z-LEED-FMK 还能抑制S. typhimurium 感染的巨噬细胞中caspase-1的加工。
T73093	Z-VRPR-FMK
	Z-VRPR-FMK 是一种不可逆地 MALT1蛋白抑制剂。Z-VRPR-FMK 可通过抑制 MALT1诱导的 NF-κB 活化和 MMP 表达来抑制弥漫性大 B 细胞淋巴瘤的生长和侵袭。
T75938	Z-VRPR-FMK TFA
	Z-VRPR-FMK (TFA) (VRPR) 为一种四肽类选择性及不可逆的粘膜相关淋巴组织淋巴瘤易位蛋白1 (MALT1) 抑制剂，具有抵抗甲型流感病毒 (IAV) 感染的能力。
T72435	Z-LE(OMe)TD(OMe)-FMK
	Z-LE(OMe)TD(OMe)-FMK 是一种选择性的 caspase-8抑制剂，可以抑制细胞凋亡。
T83963	Z-DEVD-FMK Caspase-3 Inhibitor
	Z-DEVD-FMK Caspase-3 Inhibitor 是一种可渗透细胞膜的、不可逆的 caspase-3/CPP32 抑制剂，能够抑制肿瘤细胞的凋亡。在动物体内，它在大鼠发作后的海马区具有神经保护作用，且显著减少创伤后的细胞凋亡，并在诱发的大鼠创伤性脑损伤之前和之后改善神经学恢复情况。
T71584	Microtubule Inhibitor 185322
	Microtubule inhibitor 185322 is an inhibitor of microtubule assembly, inducung mitotic arrest and apoptosis of MM cells.
T41345	AFMK Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine	Apoptosis; Free radical scavengers; Antioxidant; Endogenous Metabolite	Apoptosis; Metabolism; oxidation-reduction
	AFMK (Formyl-N-acetyl-5-methoxykynurenamine) 是褪黑激素的活性代谢物，具有抗氧化和自由基清除活性。 AFMK 是一种凋亡调节剂，可提高吉西他滨在 PANC-1 细胞中的抗肿瘤作用。
T10845	CMK	Others	Others
	CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...

化合物

Cat.No: TQ0310

Target: S6 Kinase

Z-VAD(OMe)-FMK

Cat.No: T6013

Synonym: Z-VAD-FMK,Z-Val-Ala-Asp(OMe)-FMK

Target: Caspase

Cat.No: T7020

Synonym: Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD

Target: Caspase

Cat.No: T7019

Synonym: Z-IE(OMe)TD(OMe)-FMK,Caspase-8 Inhibitor

Target: Caspase

Cat.No: TP1466

Target: Caspase

Cat.No: T15303

Target: Cysteine Protease, Autophagy

Cat.No: T21835

Target: Apoptosis, Caspase

Cat.No: T6005

Synonym: Caspase-3 Inhibitor

Target: Caspase

Cat.No: T6738

Target: SARS-CoV, Cysteine Protease

Cat.No: T10580

Target: Apoptosis, Caspase

Cat.No: T36331

Synonym: Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

Cat.No: T11310

Target: Others

Boc-Asp(OMe)-fluoromethyl ketone

Cat.No: T39308

Synonym: Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK

Target: Caspase

Z-LEHD-FMK TFA

Cat.No: T40602

(Rac)-Z-Phe-Phe-FMK

Cat.No: T38469

Synonym: Cathepsin L-IN-2

Target: Beta Amyloid, Cysteine Protease

Z-VDVA-(DL-Asp)-FMK

Cat.No: T39344

Cat.No: T78185

Synonym: Ac-Pro-Leu-Val-Glu(OMe)-CH2F

Target: Others

Cat.No: T23555

Target: Others

Biotin-VAD-FMK

Cat.No: T10548

Target: Caspase

Cat.No: TP2161

Target: Caspase

Z-VRPR-FMK trifluoroacetate salt

Cat.No: TP2101

Cat.No: TP2037

Z-VAE(OMe)-fmk

Cat.No: T71586

Z-VRPR-FMK (TFA)

Cat.No: TP1014

Synonym: VRPR

Cat.No: T78186

Synonym: Ac-Val-Leu-Pro-Glu(OMe)-CH2F

Calpain inhibitor V

Cat.No: T80551

Synonym: Mu-Val-HPh-FMK

Target: Antibiotic

Z-Leu-Leu-Leu-fluoromethyl ketone

Cat.No: T80542

Synonym: Z-LLL-FMK

Cat.No: T73096

Cat.No: T78632

Synonym: Calpain Inhibitor IV

Target: Proteasome

Cat.No: T76665

Cat.No: T73093

Z-VRPR-FMK TFA

Cat.No: T75938

Z-LE(OMe)TD(OMe)-FMK

Cat.No: T72435

Z-DEVD-FMK Caspase-3 Inhibitor

Cat.No: T83963

Microtubule Inhibitor 185322

Cat.No: T71584

Cat.No: T41345

Synonym: Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine

Target: Apoptosis, Free radical scavengers, Antioxidant, Endogenous Metabolite

Cat.No: T10845

Target: Others

Cat.No: T69200

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