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Targets Recommended: Discoidin Domain Receptor (DDR) Discoidin Domain Receptor (DDR)

19

抑制剂 & 化合物

19

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10985	DDR Inhibitor	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	DDR Inhibitor 是一种高效的盘状结构域受体 (discoidin domain receptor) 抑制剂，对 DDR2 的 IC50 值为 3.3 nM，在浓度为 1.5 nM 时，对 DDR1 有 53% 的抑制作用。
T10984	DDR-TRK-1	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	DDR-TRK-1 是 DDR1的一个选择性抑制剂，其 IC50 值为 9.4 nM。DDR-TRK-1 也抑制 TRK 激酶家族。
T31234	DDR-TRK-1N DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N
	DDR-TRK-1N is a negative control for DDR-TRK-1.
T3337	Ddr1-In-1	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	DDR1-IN-1 是一种特异性的 DDR1 受体酪氨酸激酶抑制剂，选择性是 DDR2 的 3 倍左右。
T5402	DDR1-IN-2 DDR1 inhibitor 7rh	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	DDR1-IN-2 (DDR1 inhibitor 7rh) 是盘状结构域受体 1 抑制剂 (IC50:13.1 nM)，对 DDR2 的抑制作用相对较弱 (IC50:203 nM)。
T40061	DDR1-IN-6 DDR1-IN-6
	DDR1-IN-6 is a potent and selective inhibitor of Discoidin Domain Receptor family member 1 (DDR1), exhibiting remarkable inhibitory activity at an IC50 of 9.72 nM. It effectively suppresses the auto-phosphorylation of DDR1b (Y513) with an IC50 value of 9.7 nM. Furthermore, DDR1-IN-6 displays strong anti-cancer activity.
T39572	DDR1-IN-4 DDR1-IN-4
	DDR1-IN-4 (Compound 2.45) is a highly potent inhibitor that selectively targets Discoidin Domain Receptor 1 (DDR1) autophosphorylation. This compound demonstrates exceptional efficacy with IC50 values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively.
T40062	DDR1-IN-5 DDR1-IN-5
	DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.
T39047	DDR2-IN-1 DDR2-IN-1
	DDR2-IN-1 (Compound 129) is recognized as a highly effective DDR2 inhibitor, displaying an IC50 value of 26 nM. It is a suitable choice for conducting osteoarthritis research.
T11279	FGFR1/DDR2 inhibitor 1	Discoidin Domain Receptor (DDR); FGFR; Others	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	FGFR1/DDR2 inhibitor 1 是一种具有口服活性的成纤维细胞生长因子受体 1 和盘状蛋白域受体 2 的抑制剂，能够抑制 FGFR1 (IC50:31.1 nM) 和 DDR2 (IC50:3.2 nM)，具有抗肿瘤作用。
T70201	S 16020-2
	S 16020-2 is an olivacine derivative, and DNA topoisomerase II inhibitor endowed with a remarkable antitumor activity against various experimental tumors.
T70202	DDR1-IN-1 dihydrochloride
	DDR1-IN-1 dihydrochloride 是 DDR1受体酪氨酸激酶抑制剂，IC50值为105 nM，而对 DDR2的 IC50为413 nM。
T79811	DDR1/2 inhibitor-2
	DDR1/2 inhibitor-2 (Example 31)，作为一种DDR1/DDR2抑制剂，其IC50值小于100 nM，适用于癌症和纤维化疾病的研究领域。
T23974	DDRI-18 DDRI18,DDRI 18	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DDRI-18 是一种调节 DNA 损伤反应的新型小分子抑制剂，具有增敏活性和抗癌活性，抑制非同源末端连接 (NHEJ) DNA 修复过程，增强抗癌 DNA 损伤化合物的细胞毒性作用。
T9117	BSJ-4-116	CDK; Ligand for E3 Ligase	Cell Cycle/Checkpoint; PROTAC
	BSJ-4-116 是一种高效的选择性 CDK12 降解剂，IC50 为 6 nM，是由 Cereblon 配体和 CDK 配体相连的 PROTAC。它通过提前终止转录来下调 DDR 基因，主要是通过增加聚腺苷酸化，具有抗增殖作用。
T62651	ATR-IN-11
	ATR-IN-11 (Compound Hit01) 是一种共济失调毛细血管扩张症和 Rad3 相关 (ATR) 激酶的有效抑制剂。ATR 激酶是 DNA 损伤反应 (DDR) 中的一个关键调节蛋白，负责感知复制压力 (RS)。ATR-IN-11 是一种有希望的先导化合物，能够用于发现后续针对 ATR 激酶的药物。 ATR-IN-11具有潜力进行癌症疾病的研究。
T78959	ATR-IN-23	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	ATR-IN-23 (Compound 34) 是一种选择性ATR抑制剂，其IC50为 1.5 nM。该化合物对LoVo细胞表现出抗增殖活性，并对HT-29细胞产生合成致死效果，适用于研究DNA损伤反应(DDR)缺陷癌症。
T60478	BTX161
	BTX161 是沙利度胺类似物。BTX161是有效的 CKIα降解剂。在人类 AML 细胞中，BTX161 比来那度胺更好地介导 CKIα 降解，激活 DNA 损伤反应 (DDR) 和 p53，并能稳定 p53 拮抗剂 MDM2。
T36701	Phosphoramide mustard (cyclohexanamine)
	Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce...

化合物

DDR Inhibitor

Cat.No: T10985

Target: Discoidin Domain Receptor (DDR)

Cat.No: T10984

Target: Discoidin Domain Receptor (DDR)

Cat.No: T31234

Synonym: DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N

Cat.No: T3337

Target: Discoidin Domain Receptor (DDR)

Cat.No: T5402

Synonym: DDR1 inhibitor 7rh

Target: Discoidin Domain Receptor (DDR)

Cat.No: T40061

Synonym: DDR1-IN-6

Cat.No: T39572

Synonym: DDR1-IN-4

Cat.No: T40062

Synonym: DDR1-IN-5

Cat.No: T39047

Synonym: DDR2-IN-1

FGFR1/DDR2 inhibitor 1

Cat.No: T11279

Target: Discoidin Domain Receptor (DDR), FGFR, Others

Cat.No: T70201

DDR1-IN-1 dihydrochloride

Cat.No: T70202

DDR1/2 inhibitor-2

Cat.No: T79811

Cat.No: T23974

Synonym: DDRI18,DDRI 18

Target: DNA/RNA Synthesis

Cat.No: T9117

Target: CDK, Ligand for E3 Ligase

Cat.No: T62651

Cat.No: T78959

Target: ATM/ATR

Cat.No: T60478

Phosphoramide mustard (cyclohexanamine)

Cat.No: T36701

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01289	DDR1 Protein, Human, Recombinant (His) RTK6,DDR,TRKE,PTK3,NTRK4,NEP,PTK3A,MCK10,EDDR	Human	HEK293 Cells
	DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1.
TMPY-04382	DDR1 Protein, Human, Recombinant (aa 444-913, His & GST) discoidin domain receptor tyrosine kinase 1,NEP,TRKE,DDR...	Human	Baculovirus Insect Cells
	DDR1 Protein, Human, Recombinant (aa 444-913, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 80 kDa and the accession number is Q08345-1.
TMPY-03541	DDR1 Protein, Rat, Recombinant (hFc) Drd1,Cak,discoidin domain receptor tyrosine kinase 1,PTK3D	Rat	HEK293 Cells
	DDR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.9 kDa and the accession number is Q6MG19.
TMPY-02506	DDR1 Protein, Mouse, Recombinant (hFc) AI323681,CD167a,Nep,Cak,PTK3A,6030432F18,discoidin domain re...	Mouse	HEK293 Cells
	DDR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71 kDa and the accession number is Q03146-1.
TMPY-03642	DDR2 Protein, Rhesus, Recombinant (hFc) discoidin domain receptor tyrosine kinase 2	Rhesus	HEK293 Cells
	DDR2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 7.0 kDa and the accession number is XP_001118219.1.
TMPY-03166	DDR2 Protein, Rat, Recombinant (His) discoidin domain receptor tyrosine kinase 2	Rat	HEK293 Cells
	DDR2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.9 kDa and the accession number is B1WC09.
TMPY-03313	DDR1 Protein, Rat, Recombinant (His) discoidin domain receptor tyrosine kinase 1,Drd1,PTK3D,Cak	Rat	HEK293 Cells
	DDR1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.3 kDa and the accession number is Q6MG19.
TMPY-03593	DDR2 Protein, Rhesus, Recombinant (His) discoidin domain receptor tyrosine kinase 2	Rhesus	HEK293 Cells
	DDR2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.1 kDa and the accession number is XP_001118219.1.
TMPY-03625	DDR2 Protein, Human, Recombinant (His) MIG20a,CD167,discoidin domain receptor tyrosine kinase 2,TKT...	Human	HEK293 Cells
	DDR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.1 kDa and the accession number is Q16832.
TMPY-03098	DDR2 Protein, Rat, Recombinant (hFc) discoidin domain receptor tyrosine kinase 2	Rat	HEK293 Cells
	DDR2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.5 kDa and the accession number is B1WC09.
TMPY-00773	DDR2 Protein, Human, Recombinant (hFc) MIG20a,TYRO10,CD167,NTRKR3,discoidin domain receptor tyrosin...	Human	HEK293 Cells
	DDR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.4 kDa and the accession number is Q16832.
TMPY-01728	DDR2 Protein, Mouse, Recombinant (His) AW495251,discoidin domain receptor tyrosine kinase 2,tyro10,...	Mouse	HEK293 Cells
	DDR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.88 kDa and the accession number is Q62371.
TMPY-02310	DDR1 Protein, Mouse, Recombinant (His) CD167a,discoidin domain receptor tyrosine kinase 1,AI323681,...	Mouse	HEK293 Cells
	DDR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.4 kDa and the accession number is Q03146-1.
TMPY-04442	DDR1 Protein, Mouse, Recombinant (His & GST) 6030432F18,Nep,Cak,AI323681,CD167a,discoidin domain receptor...	Mouse	Baculovirus Insect Cells
	DDR1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.8kDa and the accession number is Q03146-2.
TMPK-00631	DR3/TNFRSF25 Protein, Mouse, Recombinant (His) TRAMP,TNFRSF12,WSL1,LARD,DR3,WSL,DDR3,TR3,TNFRSF25,...	Mouse	HEK293 Cells
	TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3.
TMPY-05760	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated TRAMP,tumor necrosis factor receptor superfamily, member 25,...	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His) EDDR1,MCK-10,Epithelial discoidin domain-containing...	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell...
TMPY-01751	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) TRAMP,TR3,WSL-1,TNFRSF12,DR3,WSL-LR,tumor necrosis factor re...	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-04361	DDR2 Protein, Human, Recombinant (aa 422-855, His & GST) discoidin domain receptor tyrosine kinase 2,NTRKR3,CD167,TYR...	Human	Baculovirus Insect Cells
	DDR2 Protein, Human, Recombinant (aa 422-855, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 77.1 kDa and the accession number is Q16832.

重组蛋白

DDR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01289

Species: Human

Expression System: HEK293 Cells

DDR1 Protein, Human, Recombinant (aa 444-913, His & GST)

Cat.No: TMPY-04382

Species: Human

Expression System: Baculovirus Insect Cells

DDR1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03541

Species: Rat

Expression System: HEK293 Cells

DDR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02506

Species: Mouse

Expression System: HEK293 Cells

DDR2 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03642

Species: Rhesus

Expression System: HEK293 Cells

DDR2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03166

Species: Rat

Expression System: HEK293 Cells

DDR1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03313

Species: Rat

Expression System: HEK293 Cells

DDR2 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-03593

Species: Rhesus

Expression System: HEK293 Cells

DDR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03625

Species: Human

Expression System: HEK293 Cells

DDR2 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03098

Species: Rat

Expression System: HEK293 Cells

DDR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00773

Species: Human

Expression System: HEK293 Cells

DDR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01728

Species: Mouse

Expression System: HEK293 Cells

DDR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02310

Species: Mouse

Expression System: HEK293 Cells

DDR1 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04442

Species: Mouse

Expression System: Baculovirus Insect Cells

DR3/TNFRSF25 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00631

Species: Mouse

Expression System: HEK293 Cells

DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05760

Species: Human

Expression System: HEK293 Cells

DDR1 Protein, Human, Recombinant (aa 21-417, His)

Cat.No: TMPH-01297

Species: Human

Expression System: HEK293 Cells

DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01751

Species: Human

Expression System: HEK293 Cells

DDR2 Protein, Human, Recombinant (aa 422-855, His & GST)

Cat.No: TMPY-04361

Species: Human

Expression System: Baculovirus Insect Cells

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