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Cat. No.	Product Name	Target	Signaling Pathways
T4369	SCH-23390 hydrochloride R-(+)-SCH23390 hydrochloride	Potassium Channel; Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) 是一种选择性多巴胺 D1样受体拮抗剂，对 D1和 D5受体的Ki 分别为 0.2 和 0.3 nM。它还抑制 G 蛋白偶联的内向整流钾通道，IC50为 268 nM。它与5-HT2和5-HT1C 受体具有高亲和力，是人5-HT2C 受体激动剂，Ki 为 9.3 nM。
T12865	SCH-23390 maleate R-(+)-SCH-23390 maleate	Potassium Channel; Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	SCH-23390 maleate (R-(+)-SCH-23390 maleate) 是多巴胺D1样受体选择性拮抗剂，与D1和D5受体结合的Ki 分别为 0.2 nM 和 0.3 nM。它也是人5-HT2C 受体激动剂，Ki 为 9.3 nM。它与5-HT2和5-HT1C 受体具有高亲和力。它还抑制 G 蛋白偶联的内向整流钾通道，IC50为 268 nM。
T23066	NGD 94-1	Dopamine Receptor	GPCR/G Protein; Neuroscience
	NGD 94-1 是一种选择性的 D4 受体拮抗剂，对D4受体的亲和力为3 nM，而对D1、D2、D3和D5受体的亲和力大于2 pM。NGD 94-1 可用研究认知障碍等精神性疾病。
T6988	SKF 38393 hydrochloride (±)-SKF-38393 hydrochloride,SKF-38393A,SKF38393 HCl	Dopamine Receptor	GPCR/G Protein; Neuroscience
	SKF 38393 hydrochloride (SKF38393 HCl) 是选择性的多巴胺 D1 受体激动剂，IC50=110 nM。
T60835	SKF83959	Dopamine Receptor	GPCR/G Protein; Neuroscience
	SKF83959 是苯并氮平类化合物，是一种具有选择性和有效性的多巴胺D1受体部分激动剂，对大鼠D1，D5，D2和D3受体的Ki 值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 是 sigma (σ)-1受体的有效变构调节剂，可改善认知功能障碍，用于研究抑郁症和阿尔茨海默病。
T16999	Tavapadon PF-6649751,CVL-751	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Tavapadon (CVL-751) 是一种具有口服活性，高选择性的多巴胺 D1/D5受体部分激动剂，它可有效促进运动并减少残疾，对帕金森氏病具有潜在的应用价值。
T28167	NGB 2904 NGB2904 HCl,NGB-2904,NGB2904	Others; Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	NGB 2904 是一种具有口服活性的、选择性的多巴胺(DA) D3受体拮抗剂，可用于具可卡因成瘾。
T22921	LE 300	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	LE 300 是选择性多巴胺 D1 样受体拮抗剂，作用于人多巴胺 D1 和 D5 受体的Kis 分别为 1.9 nM 和 7.5 nM。在大鼠尾动脉实验中，它作用于5-HT2A 受体的pA2 为 8.32。
T31602	Ecopipam Sch-39166,UNII-0X748O646K,Sch 39166	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Ecopipam (UNII-0X748O646K) 是一种有效的、选择性、具有口服活性的多巴胺 D1/D5 受体拮抗剂，Ki 值分别为 1.2 nM 和 2.0 nM。Ecopipam 对 D2、D4、5-HT 和 α2a 受体 (Ki=0.98，5.52，0.08 和 0.73 μM) 显示出超过 40 倍的选择性。Ecopipam 可用于精神分裂症、可卡因成瘾和肥胖症的研究。
T5397	A-381393	Dopamine Receptor	GPCR/G Protein; Neuroscience
	A-381393 是选择性、可透过血脑屏障的多巴胺 D4受体拮抗剂，对人多巴胺 D4.4，D4.2和 D4.7受体的 Ki 分别为 1.5，1.9 和 1.6 nM，选择性是对 D1，D2，D3，D5多巴胺受体的 2700 多倍，对 5-HT2A 的选择性适中，Ki=370 nM。
T7834	ABT-724 2 - [(4-吡啶-2-基哌嗪-1-基)甲基]-1H-苯并咪唑	Dopamine Receptor	GPCR/G Protein; Neuroscience
	ABT-724 是高度选择性的多巴胺D4受体激动剂，对人多巴胺D4受体的EC50=12.4 nM。它是大鼠D4(EC50为 14.3 nM) 和雪貂D4受体 (EC50为 23.2 nM) 的有效部分激动剂，对多巴胺 D1，D2，D3或 D5受体没有影响。它可用于勃起功能障碍的研究，并具有较少的副作用。
T19342	Glycerol phenylbutyrate-D5 HPN-100-D5	Sigma receptor	GPCR/G Protein
	Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T16893	SKF-82958 Chloro-AP,(±)-SKF 82958	Others	Others
	SKF 82958 is a D1/D5 receptor full agonist.
T16892	SKF-82958 hydrobromide (±)-SKF 82958 hydrobromide,Chloro-APB hydrobromide	Others	Others
	SKF-82958 hydrobromide is a D1/D5 receptor full agonist.
T13463L	Dihydrexidine DAR-0100	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Dihydrexidine is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.
T13076	Tamoxifen-d5 ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5	HSP	Cytoskeletal Signaling; Metabolism
	Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.
T10440	Azilsartan-d5 TAK-536 D5	Others	Others
	Azilsartan (TAK-536) D5 is the deuterium-labeled Azilsartan. Azilsartan is a specific antagonist of the angiotensin II type 1 receptor.
T10558	Blonanserin D5 AD-5423 D5	Others	Others
	Blonanserin D5 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect.
T12973	Solifenacin D5 hydrochloride	Others	Others
	Solifenacin D5 hydrochloride is a deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride is an antagonist of muscarinic receptor(pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively).
T67921	Retinoic acid-d5 all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5	Retinoid Receptor	Metabolism
	Retinoic acid-d5 (Vitamin A acid-d5)是视黄酸的氘标记形式。视黄酸是一种天然的RAR 核受体激动剂，对 RARα/β/γ 的 IC50 为 14 nM，与 PPARβ/δ 结合的Kd 为 17 nM。视黄酸是维生素a 的代谢物，在细胞生长、分化和器官发育中起着重要作用。视黄酸通过激活视黄酸受体α作为转录因子Nrf2的抑制剂来发挥作用。
T0074L	Chlorprothixene hydrochloride NSC 78193,Minithixen,泰尔登盐酸盐,Truxal hydrochloride,盐酸氯普噻吨,NSC 56379,NSC 169899,Minithixen hydrochloride	Dopamine Receptor; 5-HT Receptor; Antibacterial; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Chlorprothixene hydrochloride (Truxal hydrochloride) 是一种多巴胺和组胺受体拮抗剂，具有抗精神病作用，高亲和力地结合人 D1，D2，D3，D5，H1 受体，Ki 分别为 18 nM，2.96 nM，4.56 nM，9 nM 和 3.75 nM。
T73823	DETQ
	DETQ是一种具有选择性、变构性和口服活性的多巴胺D1受体增强剂。在表达人类D1受体的HEK293细胞中，通过增加cAMP水平发挥作用，其EC50为5.8nM，Kb为26nM。DETQ对大鼠和小鼠的D1受体效力降低约30倍，对人类D5受体则无活性。
T6647	Rotigotine- Neupro,N-0923,罗替戈汀,N-0437,SPM 962	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Rotigotine (N-0923) 是多巴胺受体激动剂，是5-HT1A receptor 的部分激动剂，以及α2B-肾上腺素受体的拮抗剂，用于治疗帕金森病和不宁腿综合征。
T70035	Tasimelteon-d5
	Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of no...
T21446	Rotigotine Hydrochloride Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,盐酸罗替戈汀,N-0923,罗替戈汀盐酸盐	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Rotigotine Hydrochloride (N-0924) 是多巴胺受体激动剂，是5-HT1A 受体的部分激动剂，以及α2B-肾上腺素受体的拮抗剂，具有抗帕金森病活性。
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A12) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor* (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...
T23364	SKF 83959 hydrobromide	Others	Others
	SKF 83959 hydrobromide is a Dopamine D1-like receptor partial agonist.
T23381	Spiperone hydrochloride	Others	Others
	5-HT2A serotonin and selective D2-like dopamine receptor antagonist
T12676	(Rac)-Rotigotine hydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
T22858	Iloperidone hydrochloride	Others	Others
	Iloperidone hydrochloride is a D(2)/5-HT(2) receptor antagonist. It is also an atypical antipsychotic for the treatment of schizophrenia symptoms.

化合物

SCH-23390 hydrochloride

Cat.No: T4369

Synonym: R-(+)-SCH23390 hydrochloride

Target: Potassium Channel, Dopamine Receptor, 5-HT Receptor

SCH-23390 maleate

Cat.No: T12865

Synonym: R-(+)-SCH-23390 maleate

Target: Potassium Channel, Dopamine Receptor, 5-HT Receptor

Cat.No: T23066

Target: Dopamine Receptor

SKF 38393 hydrochloride

Cat.No: T6988

Synonym: (±)-SKF-38393 hydrochloride,SKF-38393A,SKF38393 HCl

Target: Dopamine Receptor

Cat.No: T60835

Target: Dopamine Receptor

Cat.No: T16999

Synonym: PF-6649751,CVL-751

Target: Dopamine Receptor

Cat.No: T28167

Synonym: NGB2904 HCl,NGB-2904,NGB2904

Target: Others, Dopamine Receptor, 5-HT Receptor

Cat.No: T22921

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T31602

Synonym: Sch-39166,UNII-0X748O646K,Sch 39166

Target: Dopamine Receptor

Cat.No: T5397

Target: Dopamine Receptor

Cat.No: T7834

Synonym: 2 - [(4-吡啶-2-基哌嗪-1-基)甲基]-1H-苯并咪唑

Target: Dopamine Receptor

Glycerol phenylbutyrate-D5

Cat.No: T19342

Synonym: HPN-100-D5

Target: Sigma receptor

Cat.No: T16893

Synonym: Chloro-AP,(±)-SKF 82958

Target: Others

SKF-82958 hydrobromide

Cat.No: T16892

Synonym: (±)-SKF 82958 hydrobromide,Chloro-APB hydrobromide

Target: Others

Cat.No: T13463L

Synonym: DAR-0100

Target: Dopamine Receptor

Cat.No: T13076

Synonym: ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5

Target: HSP

Cat.No: T10440

Synonym: TAK-536 D5

Target: Others

Cat.No: T10558

Synonym: AD-5423 D5

Target: Others

Solifenacin D5 hydrochloride

Cat.No: T12973

Target: Others

Retinoic acid-d5

Cat.No: T67921

Synonym: all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5

Target: Retinoid Receptor

Chlorprothixene hydrochloride

Cat.No: T0074L

Synonym: NSC 78193,Minithixen,泰尔登盐酸盐,Truxal hydrochloride,盐酸氯普噻吨,NSC 56379,NSC 169899,Minithixen hydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, AChR, Histamine Receptor

Cat.No: T73823

Cat.No: T6647

Synonym: Neupro,N-0923,罗替戈汀,N-0437,SPM 962

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T70035

Rotigotine Hydrochloride

Cat.No: T21446

Synonym: Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,盐酸罗替戈汀,N-0923,罗替戈汀盐酸盐

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

SKF 83959 hydrobromide

Cat.No: T23364

Target: Others

Spiperone hydrochloride

Cat.No: T23381

Target: Others

(Rac)-Rotigotine hydrochloride

Cat.No: T12676

Target: Dopamine Receptor

Iloperidone hydrochloride

Cat.No: T22858

Target: Others

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