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Search Results for " carcinogen "

21

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4169	N-Nitroso-N-methylurea 1-甲基-1-亚硝基脲,1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	N-Nitroso-N-methylurea (Methylnitrosourea) 是一种具有烷基化、致癌和致突变特性的亚硝基脲化合物。它靶向多种动物器官，可引起各种癌症和变性疾病，可用于重氮甲烷合成。
T20889	AalphaC 2-Amino-alpha-carboline,Aalpha C,2-氨基-9H-吡啶[2,3-b]吲哚,Aalpha-C	Others	Others
	AalphaC (2-Amino-alpha-carboline) 是一种潜在的致癌物质。
T40684	N-Nitrosomorpholine	Others	Others
	N-Nitrosomorpholine 是一种亚硝胺，具有光敏感性。它对动物有强致癌作用。
T19857	Glyphosate Atila,Lancer,Folusen,草甘膦	Apoptosis; Autophagy	Apoptosis; Autophagy
	Glyphosate (Atila) 是氨基酸甘氨酸的衍生物。它是一种除草剂，靶向并阻断植物合成芳香氨基酸所必需的莽草酸途径。
T35366	4-Nitroquinoline 1-oxide 4-Nitroquinoline 1-oxide,4Nqo,NQO,4-NQO,4-Nitroquinoline-N-oxide,NQNO,4-硝基喹啉-N-氧化物	Others	Others
	4-Nitroquinoline 1-oxide (4-NQO) 是一种化学致癌物，可通过形成大量嘌呤加合物来诱导细菌、真菌和动物的突变。
T1386	Phenazopyridine hydrochloride Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶	Sodium Channel	Membrane transporter/Ion channel
	Phenazopyridine hydrochloride (Pyridium) 是一种具有局部止痛作用的化学物质，常被用于缓解手术、损伤尿道及尿路感染引起的疼痛、刺激、不适和尿急。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
T0153	Oltipraz 吡噻硫酮,NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活，IC50为 10 μM，浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。
T25242	Chlornaphazine CB 1048,CB-1048,R 48,Erysan,CB1048
	Chlornaphazine is an antineoplastic and has been identified as a human carcinogen.
T69044	Hexestrol dipropionate
	Hexestrol dipropionate is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.
T70251	Hexestrol diphosphate tetrasodium
	Hexestrol diphosphate tetrasodium is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.
T31954	Glycidamide LS1386,HSDB 7804,LS-1386,HSDB7804,HSDB-7804
	Glycidamide is a carcinogen and metabolite of acrylamide that induces DNA adduct formation and mutations.
T69352	Hexestrol dibutyrate
	Hexestrol dibutyrate is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.
T71609	Hexestrol diphosphate sodium
	Hexestrol diphosphate sodium is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.
T60277	2-Acetamidofluorene
	2-Acetamidofluorene 是一种强致癌物。2-Acetamidofluorene 可用于诱导肝细胞癌 (HCC) 和多原发肿瘤。
T36414	N-Nitroso Sarcosine
	N-Nitroso sarcosine is a carcinogen and nitrosation product of sarcosine that has been found in cured meat products.1,2In vivo, N-nitroso sarcosine (225 mg/kg) induces the formation of metastatic liver carcinomas in mice.2 1.Janzowski, C., Eisenbrand, G., and Preussmann, R.Occurrence of N-nitrosamino acids in cured meat products and their efffect on formation of N-nitrosamines during heatingFood Cosmet. Toxicol.16(4)343-348(1978) 2.Wogan, G.N., Paglialunga, S., Archer, M.C., et al.Carcinogenicit...
T81720	N,N'-Dinitrosopiperazine 1,4-Dinitrosopiperazine,DNP
	N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 为已知致癌物，与鼻咽癌发展及其转移关联。该化合物通过影响包括LYRIC在内的多条信号通路，特别是通过蛋白磷酸化作用于丝氨酸568位，发挥作用。
T36415	N-Nitroso-N-methyl-4-Aminobutyric Acid
	N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3
T36709	N’-Nitrosonornicotine
	N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N’-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N’-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S....
T35681	MeIQx
	MeIQx (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3
T78460	1-Methylpyrene
	1-Methylpyrene是一种环境污染物和已知的啮齿动物致癌物，它的诱变活性依赖于CYP和磺酰转移酶（SULT）系列酶的连续活化。该化合物可诱导染色体缺失和有丝分裂障碍，可能机制为对有丝分裂纺锤体和中心粒的干扰。

化合物

N-Nitroso-N-methylurea

Cat.No: T4169

Synonym: 1-甲基-1-亚硝基脲,1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea

Target: Others, DNA Alkylator/Crosslinker

Cat.No: T20889

Synonym: 2-Amino-alpha-carboline,Aalpha C,2-氨基-9H-吡啶[2,3-b]吲哚,Aalpha-C

Target: Others

N-Nitrosomorpholine

Cat.No: T40684

Target: Others

Cat.No: T19857

Synonym: Atila,Lancer,Folusen,草甘膦

Target: Apoptosis, Autophagy

4-Nitroquinoline 1-oxide

Cat.No: T35366

Synonym: 4-Nitroquinoline 1-oxide,4Nqo,NQO,4-NQO,4-Nitroquinoline-N-oxide,NQNO,4-硝基喹啉-N-氧化物

Target: Others

Phenazopyridine hydrochloride

Cat.No: T1386

Synonym: Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶

Target: Sodium Channel

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Cat.No: T0153

Synonym: 吡噻硫酮,NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

Cat.No: T25242

Synonym: CB 1048,CB-1048,R 48,Erysan,CB1048

Hexestrol dipropionate

Cat.No: T69044

Hexestrol diphosphate tetrasodium

Cat.No: T70251

Cat.No: T31954

Synonym: LS1386,HSDB 7804,LS-1386,HSDB7804,HSDB-7804

Hexestrol dibutyrate

Cat.No: T69352

Hexestrol diphosphate sodium

Cat.No: T71609

2-Acetamidofluorene

Cat.No: T60277

N-Nitroso Sarcosine

Cat.No: T36414

N,N'-Dinitrosopiperazine

Cat.No: T81720

Synonym: 1,4-Dinitrosopiperazine,DNP

N-Nitroso-N-methyl-4-Aminobutyric Acid

Cat.No: T36415

N’-Nitrosonornicotine

Cat.No: T36709

Cat.No: T35681

Cat.No: T78460

Cat. No.	Product Name	Target	Signaling Pathways
TN1070	Aristolochic acid D	Others	Others
	Aristolochic acid D 是一种马兜铃酸衍生物，从 Aristolochia indica 茎中分离得到。其中马兜铃酸是一种肾毒素和致癌物。
T7913	2-Bromobiphenyl	Others	Others
	2-Bromobiphenyl 是一种持久性有机污染物，主要存在于土壤和水中。它是一种已知的人类致癌物，与生殖和发育毒性等多种健康影响有关。
T16525	PhIP	Others	Others
	PhIP 是来源于熟肉的一种杂环芳香胺(HAA)，属于吡啶类杂环胺，是2B 类致癌物，具有雌激素活性。PhIP 可与 DNA 形成加合物，从而促进癌症发生。
TN1853	Lariciresinol (+)-落叶松树脂醇	VEGFR; Antifection	Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Lariciresinol 是一种肠木脂素前体，它通过破坏真菌质膜具有杀真菌活性，并具有作为治疗人类真菌感染性疾病的新型抗真菌剂的治疗潜力。膳食 lariciresinol 可以减缓乳腺肿瘤的生长并降低人 MCF-7 乳腺癌异种移植物和致癌物诱导的大鼠乳腺肿瘤的血管密度。
T2S2104	Sinigrin hydrate 黑芥子苷,Sinigrin monohydrate,芥子甙单水合物,Allylglucosinolate monohydrate	Antibacterial	Microbiology/Virology
	Sinigrin hydrate (Allylglucosinolate monohydrate) 是一种天然脂肪族芥子油苷，存在于十字花科植物中。它具有消炎、抗癌、抗真菌、抗菌、抗氧化作用。

天然产物

Aristolochic acid D

Cat.No: TN1070

Target: Others

2-Bromobiphenyl

Cat.No: T7913

Target: Others

Cat.No: T16525

Target: Others

Cat.No: TN1853

Synonym: (+)-落叶松树脂醇

Target: VEGFR, Antifection

Sinigrin hydrate

Cat.No: T2S2104

Synonym: 黑芥子苷,Sinigrin monohydrate,芥子甙单水合物,Allylglucosinolate monohydrate

Target: Antibacterial

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