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Targets Recommended: Free radical scavengers Calcium Channel

42

抑制剂 & 化合物

6

天然产物

8

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T10690 Cav 2.2 blocker 1

Calcium Channel Membrane transporter/Ion channel; Metabolism
Cav 2.2 blocker 1 是一种N 型钙离子通道 (Cav 2.2) 的阻断剂,IC50值为 1 nM,可用于治疗疼痛。
T63606 Cav 3.2 inhibitor 2

Cav 3.2 inhibitor 2 是一种 Cav3.2 T-type Ca2+channels 的抑制剂,-80mV 恒定电位下,其IC50=0.09339 μM。Cav 3.2 inhibitor 2 对小鼠 T 通道依赖性的躯体和内脏疼痛表现出有效的抑制作用。Cav 3.2 inhibitor 2 能够用于研究顽固性疼痛。
T79195 Cav 3.2 inhibitor 4

Calcium Channel Membrane transporter/Ion channel; Metabolism
Cav 3.2 inhibitor 4 (compound 21) 是高效的选择性 T 型钙通道 (Cav3.2) 抑制剂,具有外周限制性,其 IC50 值为 0.6 μM,适用于心房颤动研究。
T36596 Isoprothiolane

Antifungal Microbiology/Virology
Isoprothiolane 是一种叶面喷雾杀菌剂,对由 Pyvioutavia oryzae Cav 引起的水稻真菌病害具有根除和保护作用。
T63186 Cav 3.2 inhibitor 1

Cav 3.2 inhibitor 1为T型钙离子通道(calcium channel)抑制剂,其与多巴胺受体(D2 receptor)的结合亲和力较低,主要应用于研究身体和内脏疼痛。
T63350 Cav 3.2 inhibitor 3

Cav 3.2 inhibitor 3 是 Cav3.2 T-type Ca2+channel 的有效抑制剂 (IC50: 0.1534 μM),且对 D2受体的结合亲和力很低。
T62586 Cav 2.2/3.2 blocker 1

Cav 2.2/3.2 blocker 1 (Compound 9e) 是一种神经钙离子通道 (neuronal calcium channel) 阻断剂,能够作用于 Cav2.2 (IC50: 1.22 μM) 和 Cav3.2 (IC50: 80 μM)。Cav 2.2/3.2 blocker 1 可以穿透中枢神经系统。
T40071 Cavα2δ-IN-1

Cavα2δ-IN-1 demonstrates exceptional specificity for voltage-gated calcium channels Cavα2δ-1 (with a Ki value of 6 nM), in comparison to Cavα2δ-2 (with a Ki value greater than 10,000 nM).
T61026 CaV1.3 antagonist-1

CaV1.3 antagonist-1 是一种具有帕金森病研究潜力的环戊基衍生物。CaV1.3 antagonist-1 抑制 CaV1.3 LTCC 的效率比 CaV1.2 LTCC 高 600 多倍。CaV1.3 antagonist-1 是一种有效的、高度选择性的 CaV1.3L 型钙通道拮抗剂,IC50值为 1.7 μM。
T72700 Cavα2δ1&NET-IN-2

Cavα2δ1&NET-IN-2 是电压门控钙通道 α2δ-1 亚单位 (Cavα2δ-1) 和去甲肾上腺素转运蛋白 (NET) 的双重抑制剂。Cavα2δ1&NET-IN-2 抑制 Cavα2δ-1 的Ki 为 454 nM。Cavα2δ1&NET-IN-2 抑制 NET 的Ki 为 59 nM,IC50为 7 nM。Cavα2δ1&NET-IN-2 可用于疼痛研究。
T72699 Cavα2δ1&NET-IN-1

Cavα2δ1&NET-IN-1 是电压门控钙通道 α2δ-1 亚单位 (Cavα2δ-1) 和去甲肾上腺素转运蛋白 (NET) 的双重抑制剂。Cavα2δ1&NET-IN-1 抑制 Cavα2δ-1 的 Ki 为 112 nM。Cavα2δ1&NET-IN-1 抑制 NET 的 Ki 为 383 nM,IC50为 67 nM。Cavα2δ1&NET-IN-1 可用于疼痛研究。
T72701 Cavα2δ1&NET-IN-3

Cavα2δ1&NET-IN-3 (example 216) 是电压门控钙通道 (VGCC) 的亚基 α2δ 和去甲肾上腺素转运蛋白 (NET) 抑制剂。Cavα2δ1&NET-IN-3 对人的 Cav2.2 钙通道 α2δ-1 亚基和 NET 的 Ki 均为 100-500 nM。
T26955 Cavosonstat

N91115,N 91115,N-91115

GSNOR; CFTR Membrane transporter/Ion channel; Metabolism
Cavosonstat (N91115) 是一种口服活性 S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂,可促进囊性纤维化跨膜传导调节器(CFTR)成熟和质膜稳定。
T0085 Entecavir monohydrate

SQ 34676,BMS-200475,Entecavir hydrate,恩替卡韦 (1水合物),恩替卡韦一水合物

HBV Microbiology/Virology
Entecavir monohydrate (BMS-200475) 是一种选择性HBV 抑制剂,在HepG2细胞中的EC50值为3.75 nM。
T1267 Abacavir

Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate

Apoptosis; HIV Protease; Reverse Transcriptase Apoptosis; Microbiology/Virology; Proteases/Proteasome
Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。
T6367 Abacavir sulfate

Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen

Apoptosis; HIV Protease; Reverse Transcriptase Apoptosis; Microbiology/Virology; Proteases/Proteasome
Abacavir sulfate (Ziagen) 是一种核苷类似物逆转录酶抑制剂,可用于 HIV 和 AIDS。
T0085L Entecavir

BMS200475,SQ34676,恩替卡韦

HBV Microbiology/Virology
Entecavir (SQ34676) 是一种选择性 HBV 抑制剂,在 HepG2细胞中的 EC50值为3.75 nM。
T61913 Cavutilide

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Cavutilide具有抗心律失常活性,抑制 hERG K(+)通道,可用于研究心力衰竭和持续性心房颤动。
T1267L Abacavir acetate

KM-133,KM133,KM 133

Abacavir acetate (Prurisol) has the potential to be used in the treatment of plaque psoriasis.
T77051 Larcaviximab

Larcaviximab (c4G7-N) 是一种IgG1kappa 抗Ebola virus 糖蛋白嵌合单克隆抗体。
T61679 Abacavir monosulfate

Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].
T64644 Abacavir Impurity F

9-((1R,4S)-4-(tert-Butoxymethyl)cyclopent-2-en-1-yl)-N6-cyclopropyl-9H-purine-2,6-diamine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64644。
T19632 Lobucavir

BMS180194,BMS 180194,SQ 34,514,SQ-34514,SQ 34514,SQ34514

Lobucavir inhibits the replication of the HIV virus in T cells, monocytes & macrophages in vitro by inhibiting DNA polymerase and viral DNA synthesis.
T28022 Metacavir

PNA

Metacavir, a reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection.
T65556 Entecavir-9

Entecavir-9 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65556,CAS号为 142217-81-0。
T80521 Caveolin-1 (82-101) amide (human, mouse, rat)

Caveolin-1 scaffolding domain peptide

c-Met/HGFR Tyrosine Kinase/Adaptors
Caveolin-1 (82-101) amide (human, mouse, rat) (Caveolin-1 scaffolding domain peptide) 是抑制酪氨酸激酶的肽,可逆转多器官衰老相关的有害变化。
T70092 ent-Entecavir

ent-Entecavir is an enantiomeric impurity of the antiviral drug Entecavir. Entecavir is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. More specifically, it is a deoxyguanosine analogue belonging to a class of carbocyclic nucleosides, that inhibits reverse transcription, DNA replication and transcription in the viral r...
T125203 Excavatin M

T70859 ent-Abacavir

ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuroni...
T70066 Pecavaptan

Pecavaptan is a vasopressin receptor antagonist.
T82372 Free radical scavenger 1

Free radical scavenger 1 (compound 8) 显示出对DPPH自由基的清除能力,其半数抑制浓度(IC50)为43.39 μg/ml。
T36834 Abacavir Carboxylate

Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.
T30131 Aripiprazole cavoxil

Aripiprazole cavoxil is used in Treatment of Schizophrenia, Bipolar Disorder, and Clinical Depression.
T8944 TTA-A2

Calcium Channel Membrane transporter/Ion channel; Metabolism
TTA-A2 是一种选择性 T 型钙通道拮抗剂,是一种有效的抗惊厥药,可减少孕烷 X 受体的激活。它对 Cav3.1 (a1G) 和 Cav3.2 (a1H) 通道在 -80 mV 和- 100 mV 保持电位上具有同样的作用,IC50 值分别为 89 和 92 nM。它可用于多种人类神经系统疾病的研究,包括睡眠障碍和癫痫。
T0163 Nisoldipine

尼索地平,BAY-k 5552

Calcium Channel; Reactive Oxygen Species Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
Nisoldipine (BAY-k 5552) 是一种高效特异的L 型Cav1.2通道阻断剂,IC50=10 nM。
T80441 FS-2

Calcium Channel Membrane transporter/Ion channel; Metabolism
FS-2,一种特异性L型CaV通道抑制剂,能够阻断RIN beta 细胞中,高K+或葡萄糖刺激导致的L型Ca2+内流。
TP1969 ProTx III

Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes effects of scorpion-venom toxin OD1 a
T14120 ACT-709478

Others Others
ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1].
T12076 ML218 hydrochloride

Others Others
ML218 hydrochloride is a selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor (Cav3.2 and Cav3.3 with IC50s of 310 nM and 270 nM , respectively).
T80457 ω-Conotoxin Bu8

Calcium Channel Membrane transporter/Ion channel; Metabolism
ω-Conotoxin Bu8为含25个氨基酸残基和3个二硫键的ω-芋螺毒素。该化合物能选择性地抑制HEK293T细胞内表达的大鼠CaV2.2介导的Ba2+去极化激活电流,表现出高效的IC50值为89 nM。
T39770 UK-59811 hydrochloride

UK-59811 hydrochloride is a potent inhibitor of the Ca V Ab voltage-gated calcium channels in bacterial homotetrameric models. It is derived from Br-dihydropyridine, possessing significant inhibitory properties with an IC 50 of 194 nM.
T12076L ML218

Calcium Channel Membrane transporter/Ion channel; Metabolism
ML218 是一种具有口服活性、选择性、高效性且可穿透血脑屏障的 T 型 Ca2+ 通道抑制剂(Cav3.2 和 Cav3.3 的 IC50 分别为 310 nM 和 270 nM)。ML218 可抑制丘脑下核(STN)神经元的突发性活动。

化合物

Cav 2.2 blocker 1
Cat.No: T10690
Synonym:
Target: Calcium Channel
Cav 3.2 inhibitor 2
Cat.No: T63606
Synonym:
Target:
Cav 3.2 inhibitor 4
Cat.No: T79195
Synonym:
Target: Calcium Channel
Isoprothiolane
Cat.No: T36596
Synonym:
Target: Antifungal
Cav 3.2 inhibitor 1
Cat.No: T63186
Synonym:
Target:
Cav 3.2 inhibitor 3
Cat.No: T63350
Synonym:
Target:
Cav 2.2/3.2 blocker 1
Cat.No: T62586
Synonym:
Target:
Cavα2δ-IN-1
Cat.No: T40071
Synonym:
Target:
CaV1.3 antagonist-1
Cat.No: T61026
Synonym:
Target:
Cavα2δ1&NET-IN-2
Cat.No: T72700
Synonym:
Target:
Cavα2δ1&NET-IN-1
Cat.No: T72699
Synonym:
Target:
Cavα2δ1&NET-IN-3
Cat.No: T72701
Synonym:
Target:
Cavosonstat
Cat.No: T26955
Synonym: N91115,N 91115,N-91115
Target: GSNOR, CFTR
Entecavir monohydrate
Cat.No: T0085
Synonym: SQ 34676,BMS-200475,Entecavir hydrate,恩替卡韦 (1水合物),恩替卡韦一水合物
Target: HBV
Abacavir
Cat.No: T1267
Synonym: Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate
Target: Apoptosis, HIV Protease, Reverse Transcriptase
Abacavir sulfate
Cat.No: T6367
Synonym: Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen
Target: Apoptosis, HIV Protease, Reverse Transcriptase
Entecavir
Cat.No: T0085L
Synonym: BMS200475,SQ34676,恩替卡韦
Target: HBV
Cavutilide
Cat.No: T61913
Synonym:
Target: EGFR
Abacavir acetate
Cat.No: T1267L
Synonym: KM-133,KM133,KM 133
Target:
Larcaviximab
Cat.No: T77051
Synonym:
Target:
Abacavir monosulfate
Cat.No: T61679
Synonym:
Target:
Abacavir Impurity F
Cat.No: T64644
Synonym:
Target:
Lobucavir
Cat.No: T19632
Synonym: BMS180194,BMS 180194,SQ 34,514,SQ-34514,SQ 34514,SQ34514
Target:
Metacavir
Cat.No: T28022
Synonym: PNA
Target:
Entecavir-9
Cat.No: T65556
Synonym:
Target:
Caveolin-1 (82-101) amide (human, mouse, rat)
Cat.No: T80521
Synonym: Caveolin-1 scaffolding domain peptide
Target: c-Met/HGFR
ent-Entecavir
Cat.No: T70092
Synonym:
Target:
Excavatin M
Cat.No: T125203
Synonym:
Target:
ent-Abacavir
Cat.No: T70859
Synonym:
Target:
Pecavaptan
Cat.No: T70066
Synonym:
Target:
Free radical scavenger 1
Cat.No: T82372
Synonym:
Target:
Abacavir Carboxylate
Cat.No: T36834
Synonym:
Target:
Aripiprazole cavoxil
Cat.No: T30131
Synonym:
Target:
TTA-A2
Cat.No: T8944
Synonym:
Target: Calcium Channel
Nisoldipine
Cat.No: T0163
Synonym: 尼索地平,BAY-k 5552
Target: Calcium Channel, Reactive Oxygen Species
FS-2
Cat.No: T80441
Synonym:
Target: Calcium Channel
ProTx III
Cat.No: TP1969
Synonym:
Target:
ACT-709478
Cat.No: T14120
Synonym:
Target: Others
ML218 hydrochloride
Cat.No: T12076
Synonym:
Target: Others
ω-Conotoxin Bu8
Cat.No: T80457
Synonym:
Target: Calcium Channel
UK-59811 hydrochloride
Cat.No: T39770
Synonym:
Target:
ML218
Cat.No: T12076L
Synonym:
Target: Calcium Channel
Cat. No. Product Name Target Signaling Pathways
TN1139 Dehydrocavidine

Dehydrocorydaline,岩黄连碱

BCL; PARP Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
Dehydrocavidine (Dehydrocorydaline) 具有抗肿瘤活性,它通过诱导调节 Bax/Bcl-2 介导的细胞凋亡、激活半胱天冬酶以及切割 PARP 来抑制 MCF-7 细胞增殖。
T82680 Corycavine

Corycavine为一种从Corydalis remota分离得到的生物碱。
TN5704 Cavaol E

Cavaol E 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5704,CAS号为 1233044-20-6。
TN7005 Cavidine

Cavidine is a natural product.
T75617 Salviandulin E

Salviandulin E 是一种二萜类化合物,可从墨西哥鼠尾草中分离。Salviandulin E 显示出对 T. b. bruceiGUTat 3.1寄生虫 (parasites) 的抗锥虫体活性,IC50值为 0.72 µg/mL。
T81222 Salvifaricin

Salvifaricin是一种口服活性的二萜类化合物,可从墨西哥鼠尾草和西班牙鼠尾草中提取。Salvifaricin能显著降低空腹血糖以及血清甘油三酯(TG)水平,表现出抗糖尿病的效果。

天然产物

Dehydrocavidine
Cat.No: TN1139
Synonym: Dehydrocorydaline,岩黄连碱
Target: BCL, PARP
Corycavine
Cat.No: T82680
Synonym:
Target:
Cavaol E
Cat.No: TN5704
Synonym:
Target:
Cavidine
Cat.No: TN7005
Synonym:
Target:
Salviandulin E
Cat.No: T75617
Synonym:
Target:
Salvifaricin
Cat.No: T81222
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-01877 CA5A Protein, Human, Recombinant (His)

CA5,GS1-21A4.1,CA5AD,carbonic anhydrase VA, mitochondrial,CA...

Human E. coli
Carbonic anhydrase 5A, mitochondrial, also known as Carbonate dehydratase VA, Carbonic anhydrase VA, CA-VA and CA5A, is a member of thealpha-carbonic anhydrase family. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospi...
TMPJ-00640 CTLA-4 Protein, Cavia porcellus, Recombinant (His)

Cytotoxic T-lymphocyte protein 4,CTLA4,Cytotoxic T-lymphocyt...

Cavia porcellus P. pastoris (Yeast)
CTLA-4 Protein, Cavia porcellus, Recombinant (His) is expressed in P. pastoris yeast expression system with C-6xHis tag. The predicted molecular weight is 18-40 KDa and the accession number is H0VUB1.
TMPJ-01392 IL-1 beta/IL-1F2 Protein, Cavia porcellus, Recombinant (His)

IL-1 β,IL1B,IL-1 beta,Interleukin-1 β,Interleukin-1 beta

Cavia porcellus E. coli
Interleukin-1 beta (IL1B) belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and...
TMPJ-00884 CXCL9 Protein, Mouse, Recombinant (His)

Protein m119,C-X-C motif chemokine 9,γ-interferon-induced mo...

Mouse HEK293 Cells
Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour e...
TMPY-01734 CA13 Protein, Human, Recombinant (His)

carbonic anhydrase XIII,FLJ37995,CAXIII,MGC59868

Human E. coli
The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. The CAXIII is a member of th...
TMPH-00366 Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST)

VP3,Apoptin

CAV E. coli
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 40.3 kDa and the accession number is Q99152.
TMPH-00365 Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His)

VP3,Apoptin

CAV E. coli
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P54095.
TMPH-00367 Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO)

Apoptin,VP3

CAV E. coli
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.3 kDa and the accession number is Q99152.

重组蛋白

CA5A Protein, Human, Recombinant (His)
Cat.No: TMPY-01877
Species: Human
Expression System: E. coli
CTLA-4 Protein, Cavia porcellus, Recombinant (His)
Cat.No: TMPJ-00640
Species: Cavia porcellus
Expression System: P. pastoris (Yeast)
IL-1 beta/IL-1F2 Protein, Cavia porcellus, Recombinant (His)
Cat.No: TMPJ-01392
Species: Cavia porcellus
Expression System: E. coli
CXCL9 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00884
Species: Mouse
Expression System: HEK293 Cells
CA13 Protein, Human, Recombinant (His)
Cat.No: TMPY-01734
Species: Human
Expression System: E. coli
Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST)
Cat.No: TMPH-00366
Species: CAV
Expression System: E. coli
Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His)
Cat.No: TMPH-00365
Species: CAV
Expression System: E. coli
Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO)
Cat.No: TMPH-00367
Species: CAV
Expression System: E. coli
TargetMol Loading
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