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Cat. No.	Product Name	Target	Signaling Pathways
T4598	BMS-5 BMS5,LIMKi 3	LIM Kinase	Cell Cycle/Checkpoint
	BMS-5 (LIMKi 3) 是一种有效的 LIMK 抑制剂，抑制LIMK1和LIMK2的IC50分别为 7 nM 和 8 nM。
T22277	BMS-P5	PAD	Chromatin/Epigenetic
	BMS-P5 是一种特异性具有口服活性的肽精氨酸二亚胺酶 4抑制剂。它可阻断多发性骨髓瘤诱导的 NET 形成，并延缓肿瘤进程。
T22277L	BMS-P5 free base	PAD	Chromatin/Epigenetic
	BMS-P5 free base 是一种特异性，可口服的肽精氨酸二亚胺酶抑制剂，可阻断多发性骨髓瘤诱导的 NET 形成，并延缓肿瘤进程。
T7787	BMS817378 [3-[[4-((2-氨基-3-氯吡啶-4-基)氧基)-3-氟苯基]氨基甲酰基]-5-(4-氟苯基)-4-氧代-4H-吡啶-1-基]甲基磷酸二氢酯	c-Met/HGFR	Tyrosine Kinase/Adaptors
	BMS817378 是一种有效的选择性 MET 抑制剂 (IC50 : 1.7 nM)。
T6420	BMS-707035 N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	BMS707035是一种 HIV-1 整合酶抑制剂，IC50为15 nM。
T4696	BMS202 hydrochloride (1675203-84-5(free base)) PD-1/PD-L1 inhibitor 2 hydrochloride	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS202 hydrochloride (1675203-84-5(free base)) (PD-1/PD-L1 inhibitor 2 hydrochloride) 是一种小分子 PD-1/PD-L1 相互作用抑制剂 (IC50: 18 nM)。生物物理研究表明 BMS202 直接与 PD-L1 结合。 BMS202 的结合促进 PD-L1 二聚化并阻断 PD-L1/PD1 相互作用。
T10958	Dapagliflozin-d5 BMS-512148 D5	Others	Others
	Dapagliflozin D5 (BMS-512148 D5) is deuterated Dapagliflozin. Dapagliflozin is a competitive SGLT2 inhibitor.
T14685	BMS-986158	Epigenetic Reader Domain	Chromatin/Epigenetic
	BMS-986158 是一种BET 抑制剂，在 MDA-MB231 三阴性乳腺癌细胞和 NCI-H211 小细胞肺癌细胞中，对 BET 的IC50分别为 5 和 6.6 nM。
T22612	BMY-14802 hydrochloride BMS 181100 hydrochloride,BMY-14802-1,BMY 14802 hydrochloride	Sigma receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	BMY-14802 hydrochloride (BMS 181100 hydrochloride) 是一种选择性的 σ 受体拮抗剂 (IC50 = 112 nM)，具有抗精神病作用。 BMY-14802 hydrochloride 是 α1-肾上腺素能受体和 5-HT1A 的激动剂。
T4600	BMS-3	LIM Kinase	Cell Cycle/Checkpoint
	BMS3 是一种有效的 LIMK 抑制剂，抑制 LIMK1和 LIMK2的 IC50分别为 5 nM 和 6 nM。
T30525	BMS-442608 UNII-93881477KV
	BMS-442608 is a 5-HT1A part agonist.
T30524	BMS-442606 UNII-97L718J5KP,97L718J5KP,ZINC22060380
	BMS-442606 is a 5-HT1A part agonist.
T30489	BMS 181101 BMS181101,BMS-181101
	BMS-181101 is a novel antidepressant that has pharmacological characteristics as a serotonin reuptake inhibitor and a serotonin 5-HT receptor agonist.
T26862	BMS-902483
	BMS-902483 is a potent α7 partial agonist. BMS-902483 improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm.
T26847	BMS-281384
	BMS-281384 is a highly potent, phosphodiesterase 5 (PDE 5)-selective inhibitor.
T71085	BMS-824
	BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active against several other RNA and DNA viruses.
T63246	BMS-566419
	BMS-566419 是基于吖啶酮的肌苷 5'-一磷酸脱氢酶 (IMPDH) 抑制剂。其中肌苷一磷酸脱氢酶 (IMPDH) 是一种鸟苷核苷酸从头合成的关键酶。BMS-566419 在临床上具有研究移植排斥的实用性。
T14677	BMS-690514	EGFR; VEGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BMS-690514是可口服的EGFR 和VEGFR 抑制剂，对于EGFR、HER2和HER4的IC50值分别为5、9 和 60 nM。
T68235	Beclabuvir HCl
	Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) ...
T70257	Avitriptan HCl
	Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.
T30511	BMS-279700
	BMS-279700 is a potent oral activity inhibitor that is part of a new family of aniline 5-azimidazolaquoxaline analogs and has excellent anti-inflammatory activity in vivo, as well as in vitro activity against p56LCK and T cell proliferation, blocking the
T39129	BMS-986143
	BMS-986143 是一种口服有效的、可逆的BTK 抑制剂，IC50为 0.26 nM，具有自身免疫性疾病的研究潜力。BMS-986143 还抑制 TEC、BLK、BMX、TXK FGR、YES1、ITK，IC50分别为 3 nM、5 nM、7 nM、10 nM、15 nM、19 nM、21 nM。
T37604	ITK inhibitor
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminome...

化合物

Cat.No: T4598

Synonym: BMS5,LIMKi 3

Target: LIM Kinase

Cat.No: T22277

Target: PAD

BMS-P5 free base

Cat.No: T22277L

Target: PAD

Cat.No: T7787

Synonym: [3-[[4-((2-氨基-3-氯吡啶-4-基)氧基)-3-氟苯基]氨基甲酰基]-5-(4-氟苯基)-4-氧代-4H-吡啶-1-基]甲基磷酸二氢酯

Target: c-Met/HGFR

Cat.No: T6420

Synonym: N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺

Target: HIV Protease

BMS202 hydrochloride (1675203-84-5(free base))

Cat.No: T4696

Synonym: PD-1/PD-L1 inhibitor 2 hydrochloride

Target: PD-1/PD-L1

Dapagliflozin-d5

Cat.No: T10958

Synonym: BMS-512148 D5

Target: Others

Cat.No: T14685

Target: Epigenetic Reader Domain

BMY-14802 hydrochloride

Cat.No: T22612

Synonym: BMS 181100 hydrochloride,BMY-14802-1,BMY 14802 hydrochloride

Target: Sigma receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T4600

Target: LIM Kinase

Cat.No: T30525

Synonym: UNII-93881477KV

Cat.No: T30524

Synonym: UNII-97L718J5KP,97L718J5KP,ZINC22060380

Cat.No: T30489

Synonym: BMS181101,BMS-181101

Cat.No: T26862

Cat.No: T26847

Cat.No: T71085

Cat.No: T63246

Cat.No: T14677

Target: EGFR, VEGFR, HER

Cat.No: T68235

Cat.No: T70257

Cat.No: T30511

Cat.No: T39129

Cat.No: T37604

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