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191

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1483L	Abl Cytosolic Substrate acetate Abl Cytosolic Substrate acetate(168202-46-8 free base)	Others	Others
	Abl Cytosolic Substrate acetate(168202-46-8 free base) 是 Abelson 酪氨酸激酶 (Abl) 的底物。
T10800	CHMFL-ABL-121	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CHMFL-ABL-121 是一种 II 型 ABL 激酶高效抑制剂，抑制纯化的非活性 ABL wt 和 T315I 激酶蛋白的 IC50 值分别为 2 nM 和 0.2 nM。
T10799	CHMFL-ABL-039	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CHMFL-ABL-039 是一种具有高效选择性的 Ⅱ 型野生型 ABL 激酶和耐药 V299L 突变型 BCR-ABL 激酶的抑制剂，IC50 分别为 7.9 nM、27.9 nM。CHMFL-ABL-039 可用于慢性粒细胞白血病 (CML) 的研究。
T10801	CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155	c-Kit	Tyrosine Kinase/Adaptors
	CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.
T18595	Dasatinib carbaldehyde PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde	Others; Ligands for Target Protein for PROTAC	Others; PROTAC
	Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) 基于 ABL 抑制剂达沙替尼，通过接头与 IAP 配体结合，形成 SNIPER [1]。
T72958	BCR-ABL-IN-7	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	BCR-ABL-IN-7 是一种 WT 和 T315I 突变体 ABL 激酶抑制剂。BCR-ABL-IN-7 有效抑制 WT 和 T315I 突变体 ABL 激酶的活性。BCR-ABL-IN-7 可以用于慢性髓系白血病 (CML) 的研究。
T18685	SNIPER(ABL)-015	Others	Others
	SNIPER(ABL)-015, conjugating GNF5 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5 μM [1].
T18687	SNIPER(ABL)-020	Others	Others
	SNIPER(ABL)-020 is a chemical compound consisting of Dasatinib, an ABL inhibitor, and Bestatin, an IAP ligand, conjugated with a linker. This compound effectively reduces the BCR-ABL protein[1].
T34670	SNIPER(ABL)-38
	SNIPER(ABL)-38 is a specific and nongenetic IAP-dependent protein eraser (SNIPER) which acts as a protein degradation inducer of oncogenic BCR-ABL protein.
T18693	SNIPER(ABL)-049	Others	Others
	SNIPER(ABL)-049, conjugating Imatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 100 μM[1].
T18691	SNIPER(ABL)-044	Others	Others
	SNIPER(ABL)-044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].
T39732	BCR-ABL-IN-3
	BCR-ABL-IN-3 is a highly effective and irreversibly binding inhibitor of Bcr-Abl, displaying a remarkable potency with an IC50 value of ≤100 nM for Ba/F3 Bcr-Abl T3151. This compound exhibits significant anti-cancer activity.
T39827	c-ABL-IN-1
	C-ABL-IN-1 is a new and specific inhibitor of the c-Abl protein, which effectively prevents the progression of neurodegeneration observed in Parkinson's disease.
T18690	SNIPER(ABL)-039	Others	Others
	SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].
T18684	SNIPER(ABL)-013	Others	Others
	SNIPER(ABL)-013, conjugating GNF5 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 20 μM[1].
T18686	SNIPER(ABL)-019	Others	Others
	SNIPER(ABL)-019, conjugating Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM[1].
T18688	SNIPER(ABL)-024	Others	Others
	SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM[1].
T18694	SNIPER(ABL)-050	Others	Others
	SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker. This conjugation results in the reduction of BCR-ABL protein[1].
T18689	SNIPER(ABL)-033	Others	Others
	SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM[1].
T18695	SNIPER(ABL)-058	Others	Others
	SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].
T18692	SNIPER(ABL)-047	Others	Others
	SNIPER(ABL)-047, conjugating HG-7-85-01 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 2 μM[1].
T22067	CHMFL-ABL-053
	CHMFL-ABL-053 (Compound 18a) 是一种有效的、选择性的、具有口服活性的 BCR-ABL、SRC 和 p38激酶抑制剂，IC50值分别为 70、90 和 62 nM。CHMFL-ABL-053 是一种潜在有效的慢性粒细胞白血病 (CML) 候选药物 [1]。
TP1483	Abl Cytosolic Substrate
	Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl ).
T18907	ABL-001-Amide-PEG3-acid	Others	Others
	ABL-001-Amide-PEG3-acid, an analogue to ABL-001, primarily serves as a labeled chemical or fluorescent probe.
T10488	BCR-ABL-IN-1	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.
T10489	BCR-ABL-IN-2	Others	Others
	BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).
T63297	ABL-L
	ABL-L 能够利用 p53 依赖的途径，诱导人喉癌细胞凋亡。
T5177	Asciminib ABL001	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Asciminib (ABL001) 是一种有效的、选择性的变构BCR-ABL1抑制剂，能够抑制 Ba/F3 细胞生长 (IC50:0.25 nM)。
T18593	GNF5-amido-Me PROTAC ABL binding moiety 2	Others	Others
	GNF5-amido-Me, the moiety based on GNF5 (ABL inhibitor),binds through a linker to the IAP ligand forming SNIPER[1].
T63932	BCR-ABL-IN-4
	BCR-ABL-IN-4 是 BCR-ABLL 抑制剂，表现出抗癌活性。BCR-ABL-IN-4 对癌细胞生长具有抑制作用，能够作用于 K562 细胞 (IC50: 0.67 nM) 和 BCR-ABL T315I 转染的 Ba/F3 细胞 (IC50: 16 nM)。
T61546	c-ABL-IN-3
	c-ABL-IN-3, a highly effective c-Abl inhibitor, exhibits promising potential for studying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer [1]. The activation of c-Abl has been strongly implicated in a range of diseases, notably cancer [1]. It offers valuable opportunities for research in these fields [1].
T63332	BCR-ABL-IN-5
	BCR-ABL-IN-5 是一种 Bcr-Abl (Breakpoint cluster region-Abelson) 激酶抑制剂，能够作用于 Bcr-AblWT (IC50: 0.014 μM)和 Bcr-AblT3151 (IC50: 0.45 μM)，表现出一定的抗白血病细胞增殖作用。
T61128	c-ABL-IN-2
	C-ABL-IN-2 is a highly effective inhibitor of the c-Abl protein, which plays a significant role in the development of several diseases, including cancer. This compound exhibits promise for investigating neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer. (Source: WO2020260871A1, compound 25) [1].
T18594	HG-7-85-01-Decyclopropane PROTAC ABL binding moiety 3	Others	Others
	Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the formation of SNIPER [1].
T62065	c-ABL-IN-4
	c-ABL-IN-4 是有效的c-Abl 抑制剂。
T83711	Abl Substrate Peptide TFA
	Abl底物多肽是酪氨酸激酶Abl的多肽底物。在20 µM浓度下，相较于c-Src激酶，它被Abl选择性磷酸化。Abl底物多肽已被用于体外定量Abl激酶活性。
T82909	BCR-ABL-IN-8	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	BCR-ABL-IN-8（化合物26f）是一种具有三甲氧基基团（trimethoxy group）的BCR-ABL抑制剂。
T63450	BCR-ABL-IN-6
	BCR-ABL-IN-6 (9h) 是一种伊马替尼衍生物，也是 Bcr-Abl 激酶的选择性抑制剂，能够作用于 Bcr-AblWT (IC50: 4.6 nM) 和 Bcr-AblT3151 (IC50: 277 nM)。BCR-ABL-IN-6 (9h)对 Bcr-Abl 激酶具有较强的细胞内亲和力 (EC50: 14.6 nM)。BCR-ABL-IN-6 (9h) 能够用于研究慢性髓细胞性白血病治疗。
T79716	c-ABL-IN-5	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	c-ABL-IN-5是一种选择性c-Abl抑制剂，具有神经保护功能。该化合物显示出血脑屏障渗透性、代谢稳定性和优良的药物动力学特性。经[18F]标记的c-ABL-IN-5（化合物[18F]3）可用作PET示踪剂，以评估疾病改善的功效。此外，c-ABL-IN-5适用于帕金森病（PD）等神经退行性疾病的研究。
T18592	Imatinib carbaldehyde CGP-57148B carbaldehyde,STI571 carbaldehyde,PROTAC ABL binding moiety 1	Others	Others
	Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds to the IAP ligand with the assistance of a linker, resulting in the formation of SNIPER[1].
T0152	Bosutinib 伯舒替尼,SKI-606	Bcr-Abl; Src; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Bosutinib (SKI-606) 是一种合成的喹诺酮衍生物和双激酶抑制剂，靶向 Abl 和 Src 激酶的 IC50分别为 1 nM 和 1.2 nM。
T77974	PROTAC BCR-ABL Degrader-1	PROTACs	PROTAC
	PROTACBCR-ABLDegrader-1（化合物PROTAC1）是一种含有2-oxoethyl linker的PROTAC。该化合物能通过泛素蛋白酶体（ubiquitinproteasom）系统诱导Bcr-Abl的降解，并对K562细胞表现出抗增殖效果，显示出其在癌症研究中的应用潜力。
T8488	GMB-475	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	GMB-475 是一种基于PROTAC 的BCR-ABL1酪氨酸激酶降解剂，克服了BCR-ABL1依赖的耐药性。 GMB-475 靶向 BCR-ABL1 蛋白并募集 E3 连接酶 Von Hippel Lindau (VHL)。导致泛素化和随后的致癌融合蛋白降解
T21785	AG957	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG957 是一种酪氨酸激酶抑制剂，具有抗BCR/ABL 酪氨酸激酶活性。它能够抑制p210bcr/abl 酶活性 (IC50:2.9 μM)。
T3063	PD173955 PD-173955,PD 173955	Apoptosis; Bcr-Abl; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PD173955是一种Src 激酶家族选择性抑制剂，对Src、Yes 和Abl 激酶IC50值约为22nM，对 FGFRα 的效力较低，对InsR 和PKC 无活性。
T17267	XL228	IGF-1R; Bcr-Abl; Src; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	XL228 是一种多靶点酪氨酸激酶抑制剂，对 Bcr-Abl、Aurora A、IGF-1R、Src 和 Lyn 的 IC50 分别为 5、3.1、1.6、6.1和 2 nM。
T6300	Degrasyn WP1130	Apoptosis; JAK; Bcr-Abl; DUB; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors; Ubiquitination
	Degrasyn (WP1130) 是一种可渗透细胞的去泛素化酶(DUB)抑制剂，直接抑制USP9x，USP5，USP14和UCH37的DUB 活性。它减弱抗细胞凋亡蛋白Bcr-Abl 和JAK2。
T2429	Olverembatinib dimesylate GZD824 Dimesylate,HQP1351	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Olverembatinib dimesylate (GZD824 Dimesylate) 是一种高效的、口服具有活性的pan-Bcr-Abl 抑制剂，具有抗肿瘤活性。它能广泛而有效地抑制突变型 Bcr-Abl。它对天然的 Bcr-Abl 和 Bcr-AblT315I 作用的IC50值分别为 0.34 nM 和 0.68 nM。
T11916	Lyn-IN-1 巴非替尼,Bafetinib analog	Bcr-Abl; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Lyn-IN-1 (Bafetinib analog) 是一种高活性 Bcr-Abl 和 Lyn 双重抑制剂。
T2372	Ponatinib 帕纳替尼,AP24534,普纳替尼	VEGFR; FGFR; Bcr-Abl; PDGFR; Src; c-Kit; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Ponatinib (AP24534) 是一种有口服活性的多靶点激酶抑制剂，抑制Abl、PDGFRα、VEGFR2、FGFR1和Src 的IC50分别为 0.37 nM、1.1 nM、1.5 nM、2.2 nM 和 5.4 nM。

化合物

Abl Cytosolic Substrate acetate

Cat.No: TP1483L

Synonym: Abl Cytosolic Substrate acetate(168202-46-8 free base)

Target: Others

CHMFL-ABL-121

Cat.No: T10800

Target: Bcr-Abl

CHMFL-ABL-039

Cat.No: T10799

Target: Bcr-Abl

CHMFL-ABL/KIT-155

Cat.No: T10801

Synonym: CHMFL-ABL-KIT-155

Target: c-Kit

Dasatinib carbaldehyde

Cat.No: T18595

Synonym: PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde

Target: Others, Ligands for Target Protein for PROTAC

Cat.No: T72958

Target: Bcr-Abl

SNIPER(ABL)-015

Cat.No: T18685

Target: Others

SNIPER(ABL)-020

Cat.No: T18687

Target: Others

SNIPER(ABL)-38

Cat.No: T34670

SNIPER(ABL)-049

Cat.No: T18693

Target: Others

SNIPER(ABL)-044

Cat.No: T18691

Target: Others

Cat.No: T39732

Cat.No: T39827

SNIPER(ABL)-039

Cat.No: T18690

Target: Others

SNIPER(ABL)-013

Cat.No: T18684

Target: Others

SNIPER(ABL)-019

Cat.No: T18686

Target: Others

SNIPER(ABL)-024

Cat.No: T18688

Target: Others

SNIPER(ABL)-050

Cat.No: T18694

Target: Others

SNIPER(ABL)-033

Cat.No: T18689

Target: Others

SNIPER(ABL)-058

Cat.No: T18695

Target: Others

SNIPER(ABL)-047

Cat.No: T18692

Target: Others

CHMFL-ABL-053

Cat.No: T22067

Abl Cytosolic Substrate

Cat.No: TP1483

ABL-001-Amide-PEG3-acid

Cat.No: T18907

Target: Others

Cat.No: T10488

Target: Bcr-Abl

Cat.No: T10489

Target: Others

Cat.No: T63297

Cat.No: T5177

Synonym: ABL001

Target: Bcr-Abl

Cat.No: T18593

Synonym: PROTAC ABL binding moiety 2

Target: Others

Cat.No: T63932

Cat.No: T61546

Cat.No: T63332

Cat.No: T61128

HG-7-85-01-Decyclopropane

Cat.No: T18594

Synonym: PROTAC ABL binding moiety 3

Target: Others

Cat.No: T62065

Abl Substrate Peptide TFA

Cat.No: T83711

Cat.No: T82909

Target: Bcr-Abl

Cat.No: T63450

Cat.No: T79716

Target: Bcr-Abl

Imatinib carbaldehyde

Cat.No: T18592

Synonym: CGP-57148B carbaldehyde,STI571 carbaldehyde,PROTAC ABL binding moiety 1

Target: Others

Cat.No: T0152

Synonym: 伯舒替尼,SKI-606

Target: Bcr-Abl, Src, Autophagy

PROTAC BCR-ABL Degrader-1

Cat.No: T77974

Target: PROTACs

Cat.No: T8488

Target: Bcr-Abl

Cat.No: T21785

Target: Bcr-Abl

Cat.No: T3063

Synonym: PD-173955,PD 173955

Target: Apoptosis, Bcr-Abl, Src

Cat.No: T17267

Target: IGF-1R, Bcr-Abl, Src, Aurora Kinase

Cat.No: T6300

Synonym: WP1130

Target: Apoptosis, JAK, Bcr-Abl, DUB, Autophagy

Olverembatinib dimesylate

Cat.No: T2429

Synonym: GZD824 Dimesylate,HQP1351

Target: Bcr-Abl

Cat.No: T11916

Synonym: 巴非替尼,Bafetinib analog

Target: Bcr-Abl, Src

Cat.No: T2372

Synonym: 帕纳替尼,AP24534,普纳替尼

Target: VEGFR, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Autophagy

Cat. No.	Product Name	Target	Signaling Pathways
T3S1553	trans-Cinnamaldehyde Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein	COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience
	trans-Cinnamaldehyde (Phenylacrolein) 是一种能够用于合成反式肉桂醛-β-环糊精复合物，一种能够食用的抗菌涂层，能够延长鲜切水果的保质期。它是一种能够通过烷基异氰化物与乙炔二羧酸二烷基酯的反应来合成高度多官能的呋喃环。

天然产物

trans-Cinnamaldehyde

Cat.No: T3S1553

Synonym: Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

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