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Search Results for " ags "

Targets Recommended: Apoptosis IGF-1R

11

抑制剂 & 化合物

4

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2693	AG1024 Tyrphostin AG 1024,Tyrphostin,AGS 200	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	AG1024 (Tyrphostin) 是一种可逆的，竞争性和选择性的胰岛素样生长因子-1 受体抑制剂，IC50为 7 μM。它抑制胰岛素受体的磷酸化，IC50值为 57 μM。它诱导细胞凋亡并具有抗癌活性。
T3144	BML-284 Wnt agonist 1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 (Wnt agonist 1) 是细胞通透性 Wnt 信号激活剂，能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T1562	Rebamipide Proamipide,OPC12759,瑞巴派特	Free radical scavengers; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。
T6540	Ibuprofen Lysine 布洛芬赖氨酸盐,Neoprofen	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen Lysine (Neoprofen) 是一种非甾体抗炎药。
T1394	Ibuprofen Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID)，具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂，IC50值分别为 13 和 370 μM，导致前列腺素和血栓素前体的形成减少。
T8820	BML-284 hydrochloride BML-284 HCL,Wnt agonist 1 HCL	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 hydrochloride (Wnt agonist 1 HCL) 是细胞通透性 Wnt 信号激活剂。它能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T5858	Sertindole Lu 23-174,舍吲哚	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Sertindole (Lu 23-174) 是一种非典型抗精神病药，可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合，Kd 值分别为 2.7、20、0.14 和 6 nM。
T14775	Bragsin2 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2	Others	Others
	Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) 是非竞争性的核苷酸交换因子 BRAG2选择性抑制剂，其 IC50值为 3 μM。它能够结合到 BRAG2 的 PH 结构域和磷脂双分子层的界面处，使 BRAG2 无法激活磷脂化的 Arf GTPase。它能够影响乳腺癌干细胞。
T71081	Nagstatin
	Nagstatin is an inhibitor of N-acetyl-beta-D-glucosaminidase and is produced by Streptomyces amakusaensis MG846-fF3.
T14774	Bragsin1	Others	Others
	Bragsin1 is a potent and selective and noncompetitive ArfGEF BRAG2 inhibitor, inhibits Arf GTPase activation(IC50 : 3 μM),and with anti-cancer activity.
T79072	KRAS G12D modulator-1	Ras	GPCR/G Protein; MAPK
	KRAS G12D modulator-1（compound 6）是高效KRAS G12D调节剂，NEA-G12D、PPI-G12D 和 pERK-AGS的IC50范围为1-10 μM，适用于癌症研究。

化合物

Cat.No: T2693

Synonym: Tyrphostin AG 1024,Tyrphostin,AGS 200

Target: Apoptosis, IGF-1R

Cat.No: T3144

Synonym: Wnt agonist 1

Target: Wnt/beta-catenin

Cat.No: T1562

Synonym: Proamipide,OPC12759,瑞巴派特

Target: Free radical scavengers, COX, Prostaglandin Receptor

Ibuprofen Lysine

Cat.No: T6540

Synonym: 布洛芬赖氨酸盐,Neoprofen

Target: COX

Cat.No: T1394

Synonym: Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil

Target: COX

BML-284 hydrochloride

Cat.No: T8820

Synonym: BML-284 HCL,Wnt agonist 1 HCL

Target: Wnt/beta-catenin

Cat.No: T5858

Synonym: Lu 23-174,舍吲哚

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Cat.No: T14775

Synonym: 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2

Target: Others

Cat.No: T71081

Cat.No: T14774

Target: Others

KRAS G12D modulator-1

Cat.No: T79072

Target: Ras

Cat. No.	Product Name	Target	Signaling Pathways
TN4629	Nemoralisin C	Others	Others
	Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines.
TN4630	Nemoralisin	Others	Others
	Nemoralisin exhibits weak cytotoxicities (IC50>10 uM) against HepG2, AGS, MCF-7, and A-549 cancer cell lines.
TN4866	Pyracrenic acid	Others	Others
	Pyracrenic acid is a potent elastase inhibitor with an IC50 value of 1.5 mg/mL. Pyracrenic acid shows DPPH radical scavenging activity. It also shows significant cytotoxic activities against human cancer cells COLO 205 and AGS.
T3930	Taraxerol acetate 醋酸蒲公英霜,Taraxeryl acetate	Phosphatase; HSV	Metabolism; Microbiology/Virology
	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activity, could be attributed due to PTP

天然产物

Cat.No: TN4629

Target: Others

Cat.No: TN4630

Target: Others

Pyracrenic acid

Cat.No: TN4866

Target: Others

Taraxerol acetate

Cat.No: T3930

Synonym: 醋酸蒲公英霜,Taraxeryl acetate

Target: Phosphatase, HSV

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01475	Jagged 1 Protein, Human, Recombinant (His) CD339,AHD,HJ1,AGS,AWS,JAGL1,Jagged 1	Human	HEK293 Cells
	Jagged 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 112 kDa and the accession number is P78504-1.
TMPY-01470	Jagged 1 Protein, Human, Recombinant (hFc) AGS,JAGL1,HJ1,Jagged 1,CD339,AHD,AWS	Human	HEK293 Cells
	Jagged 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 137 kDa and the accession number is P78504-1.
TMPY-02857	GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His) galactosidase, alpha,Ags,galactosidase, α,GLA/α-Gal...	Mouse	HEK293 Cells
	GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.6 kDa and the accession number is Q8BGZ6.
TMPY-04930	Notch 2 Protein, Human, Recombinant (His) AGS2,HJCYS,hN2,notch 2	Human	Baculovirus Insect Cells
	NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced express...
TMPK-00465	Notch 2 Protein, Human, Recombinant (His & Avi) N2,Notch-2,HJCYS,AGS2,NOTCH2,N2ECD	Human	HEK293 Cells
	Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intrac...
TMPK-00466	Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated NOTCH2,N2,N2ECD,Notch-2,HJCYS,AGS2	Human	HEK293 Cells
	Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intrac...

重组蛋白

Jagged 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01475

Species: Human

Expression System: HEK293 Cells

Jagged 1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01470

Species: Human

Expression System: HEK293 Cells

GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02857

Species: Mouse

Expression System: HEK293 Cells

Notch 2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04930

Species: Human

Expression System: Baculovirus Insect Cells

Notch 2 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00465

Species: Human

Expression System: HEK293 Cells

Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00466

Species: Human

Expression System: HEK293 Cells

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