刺激性免疫检查点蛋白

刺激性免疫检查点蛋白与抑制途径减弱免疫系统相反，共刺激分子可通过增强免疫反应来对抗恶性细胞。恶性细胞通常通过抑制共刺激途径来促进肿瘤的发生。OX40、GITR、ICOS、4-1BB、CD40 等刺激检查点分子在调节 T 细胞效应功能中发挥关键作用，激活共刺激通路可能提高检查点抑制效果，导致持久的抗肿瘤反应。

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Cat. No.	Product Name / Synonyms	Species	Expression System
TMPK-00260	CD155/PVR Protein, Human, Recombinant (His & Avi) CD155/PVR Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00260	CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tum...
TMPK-00280	B7-H6 Protein, Human, Recombinant (His & Avi), Biotinylated B7-H6 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00280	B7-H6 is a glycosylated member of the B7 family of immune co‑stimulatory proteins. which is a ligand for the NK cell activating receptor NKp30, was targeted to c...
TMPK-00314	B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi) B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00314	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-00315	B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00315	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-00463	OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi) OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293
TMPK-00463	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
TMPK-00464	OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi), Biotinylated OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293
TMPK-00464	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
TMPK-00653	B7-2 Protein, Cynomolgus, Recombinant (His) B7-2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPK-00653	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00666	CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His) CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPK-00666	CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a...
TMPK-00860	CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc) CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc)	Mouse	HEK293
TMPK-00860	CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...
TMPK-00880	B7-2 Protein, Human, Recombinant (His & Avi) B7-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00880	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00881	B7-2 Protein, Human, Recombinant (His & Avi), Biotinylated B7-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00881	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00882	B7-2 Protein, Human, Recombinant (hFc) B7-2 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPK-00882	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-01016	B7-H3 Protein, Human, Recombinant (hFc), FITC-Labeled B7-H3 Protein, Human, Recombinant (hFc), FITC-Labeled	Human	HEK293
TMPK-01016	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-01017	B7-H3 Protein, Human, Recombinant (aa 29-245, hFc) B7-H3 Protein, Human, Recombinant (aa 29-245, hFc)	Human	HEK293
TMPK-01017	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-01018	B7-H3 Protein, Human, Recombinant (aa 29-245, His) B7-H3 Protein, Human, Recombinant (aa 29-245, His)	Human	HEK293
TMPK-01018	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-01086	GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His) GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His)	Mouse	HEK293
TMPK-01086	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re...
TMPK-01176	CD28 Protein, Canine, Recombinant (His) CD28 Protein, Canine, Recombinant (His)	Canine	HEK293
TMPK-01176	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present...
TMPK-01177	CD28 Protein, Canine, Recombinant (mFc) CD28 Protein, Canine, Recombinant (mFc)	Canine	HEK293
TMPK-01177	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present...
TMPK-01260	GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His) GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His)	Cynomolgus	HEK293
TMPK-01260	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re...
TMPK-01398	CD40 Ligand Trimer Protein, Human, Recombinant (hFc) CD40 Ligand Trimer Protein, Human, Recombinant (hFc)	Human	HEK293
TMPK-01398	CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...