刺激性免疫检查点蛋白与抑制途径减弱免疫系统相反,共刺激分子可通过增强免疫反应来对抗恶性细胞。恶性细胞通常通过抑制共刺激途径来促进肿瘤的发生。OX40、GITR、ICOS、4-1BB、CD40 等刺激检查点分子在调节 T 细胞效应功能中发挥关键作用,激活共刺激通路可能提高检查点抑制效果,导致持久的抗肿瘤反应。
Cat. No. | Product Name / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-06209 | ICOS Protein, Mouse, Recombinant (His)
ICOS Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa... | |||
TMPY-06279 | 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (His), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (His), Biotinylated
|
Mouse | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-06280 | 2B4/CD244 Protein, Human, Recombinant (hFc & Avi), Biotinylated
2B4/CD244 Protein, Human, Recombinant (hFc & Avi), Biotinylated
|
Human | HEK293 |
The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of... | |||
TMPY-06283 | CD48 Protein, Human, Recombinant (His & Avi), Biotinylated
CD48 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami... | |||
TMPY-06294 | 2B4/CD244 Protein, Human, Recombinant (His & Avi), Biotinylated
2B4/CD244 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of... | |||
TMPY-06298 | B7-1 Protein, Human, Recombinant (His & Avi), Biotinylated
B7-1 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ... | |||
TMPY-06299 | CD48 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD48 Protein, Human, Recombinant (hFc & Avi), Biotinylated
|
Human | HEK293 |
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami... | |||
TMPY-06329 | 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-211, His&AVI), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-211, His&AVI), Biotinylated
|
Mouse | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-06363 | B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
|
Cynomolgus | HEK293 |
B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 29.76 kDa. Access... | |||
TMPY-06374 | CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (mFc)
CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (mFc)
|
Human,Cynomolgus,Rhesus | HEK293 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ... | |||
TMPY-06382 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His & Avi), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-06528 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (soluble CD137, His)
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (soluble CD137, His)
|
Human | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-06581 | B7-H3 Protein, Human, Recombinant (isoform 2, His)
B7-H3 Protein, Human, Recombinant (isoform 2, His)
|
Human | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor... | |||
TMPY-06622 | CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His & Avi), Biotinylated
CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His & Avi), Biotinylated
|
Human,Cynomolgus,Rhesus | HEK293 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ... | |||
TMPY-06687 | CD40 Ligand Protein, Mouse, Recombinant (His)
CD40 Ligand Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-06711 | B7-1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
B7-1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
|
Mouse | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ... | |||
TMPY-06770 | CD70 Protein, Mouse, Recombinant (His & Avi), Biotinylated
CD70 Protein, Mouse, Recombinant (His & Avi), Biotinylated
|
Mouse | HEK293 |
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept... | |||
TMPY-06790 | CD70 Protein, Mouse, Recombinant (His)
CD70 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept... | |||
TMPY-06791 | CD200 Protein, Human, Recombinant (His & Avi), Biotinylated
CD200 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre... | |||
TMPY-06794 | 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-187, His & Avi), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-187, His & Avi), Biotinylated
|
Mouse | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... |