刺激性免疫检查点蛋白与抑制途径减弱免疫系统相反,共刺激分子可通过增强免疫反应来对抗恶性细胞。恶性细胞通常通过抑制共刺激途径来促进肿瘤的发生。OX40、GITR、ICOS、4-1BB、CD40 等刺激检查点分子在调节 T 细胞效应功能中发挥关键作用,激活共刺激通路可能提高检查点抑制效果,导致持久的抗肿瘤反应。
Cat. No. | Product Name / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-03967 | BTN3A3 Protein, Human, Recombinant (His)
BTN3A3 Protein, Human, Recombinant (His)
|
Human | HEK293 |
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the... | |||
TMPY-04951 | CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated
CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated
|
Human | Baculovirus-Insect Cells |
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t... | |||
TMPY-05156 | ICOS Protein, Human, Recombinant (rFc)
ICOS Protein, Human, Recombinant (rFc)
|
Human | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa... | |||
TMPY-05504 | 4-1BB/CD137/TNFRSF9 Protein, Rhesus, Recombinant (His), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Rhesus, Recombinant (His), Biotinylated
|
Rhesus | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-05641 | B7-H3 Protein, Human, Recombinant (His & Avi), Biotinylated
B7-H3 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor... |