刺激性免疫检查点蛋白

刺激性免疫检查点蛋白与抑制途径减弱免疫系统相反，共刺激分子可通过增强免疫反应来对抗恶性细胞。恶性细胞通常通过抑制共刺激途径来促进肿瘤的发生。OX40、GITR、ICOS、4-1BB、CD40 等刺激检查点分子在调节 T 细胞效应功能中发挥关键作用，激活共刺激通路可能提高检查点抑制效果，导致持久的抗肿瘤反应。

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Cat. No.	Product Name / Synonyms	Species	Expression System
TMPY-03203	CD40 Protein, Rat, Recombinant (His) CD40 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-03203	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-01180	CD86 Protein, Human, Recombinant (His) CD86 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01180	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-01612	CD155/PVR Protein, Rhesus, Recombinant (His) CD155/PVR Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
TMPY-01612	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-04064	B7-H3 Protein, Mouse, Recombinant (His) B7-H3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-04064	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-02031	B7-H3 Protein, Human, Recombinant (His) B7-H3 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-02031	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-00674	B7-1 Protein, Human, Recombinant B7-1 Protein, Human, Recombinant	Human	HEK293
TMPY-00674	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-05957	CD40 Protein, Mouse, Recombinant (His) CD40 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-05957	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-04262	B7-H3 Protein, Human, Recombinant (His), Biotinylated B7-H3 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-04262	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-02473	ICOS Protein, Mouse, Recombinant (hFc) ICOS Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-02473	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPY-04832	OX40L/TNFSF4 Protein, Human, Recombinant (hFc) OX40L/TNFSF4 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-04832	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecul...
TMPY-05446	CD200 Protein, Human, Recombinant (hFc) CD200 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05446	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre...
TMPY-04779	BTN3A2 Protein, Human, Recombinant (His) BTN3A2 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-04779	The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
TMPY-05594	4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & Avi), Biotinylated 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
TMPY-05594	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-01941	CD28 Protein, Human, Recombinant (hFc) CD28 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-01941	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-01068	CD70 Protein, Human, Recombinant (hFc) CD70 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-01068	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-03947	CD48 Protein, Human, Recombinant (hFc) CD48 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-03947	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...
TMPY-05767	4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (His) 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-05767	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-00033	4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (hFc) 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-00033	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam...
TMPJ-00103	CD28 Protein, Human/Cynomolgus, Recombinant (His) CD28 Protein, Human/Cynomolgus, Recombinant (His)	Human,Cynomolgus	Human Cells
TMPJ-00103	T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belon...
TMPJ-00139	4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His) 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His)	Human	E. coli
TMPJ-00139	Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1B...