Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenovin-6 Hydrochloride 是 Tenovin-1 的类似物,能抑制二氢乳清酸脱氢酶。它是一种 p53转录活性的激活剂,抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性,IC50分别为 21 μM、10 μM 和 67 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 549 | 现货 | ||
2 mg | ¥ 798 | 现货 | ||
5 mg | ¥ 1,820 | 现货 | ||
10 mg | ¥ 2,830 | 现货 | ||
25 mg | ¥ 4,720 | 现货 | ||
50 mg | ¥ 6,730 | 现货 | ||
100 mg | ¥ 9,130 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,980 | 现货 |
产品描述 | Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . |
靶点活性 | SIRT1:21 μM, SIRT3:67 μM, SIRT2:10 μM |
体外活性 | Inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in UM cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS).?Tenovin-6 inhibited the growth of UM cells.?Tenovin-6 and vinblastine was synergistic in inducing apoptosis of UM cell line 92.1 and Mel 270.?Furthermore, Tenovin-6 eliminated cancer stem cells in 92.1 and Mel 270 cells.?In conclusion, our findings suggest that Tenovin-6 may be a promising agent to kill UM bulk tumor cells and CSCs[1].tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes.tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1[2]. |
分子量 | 491.09 |
分子式 | C25H35ClN4O2S |
CAS No. | 1011301-29-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (91.63 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0363 mL | 10.1814 mL | 20.3629 mL | 50.9072 mL |
5 mM | 0.4073 mL | 2.0363 mL | 4.0726 mL | 10.1814 mL | |
10 mM | 0.2036 mL | 1.0181 mL | 2.0363 mL | 5.0907 mL | |
20 mM | 0.1018 mL | 0.5091 mL | 1.0181 mL | 2.5454 mL | |
50 mM | 0.0407 mL | 0.2036 mL | 0.4073 mL | 1.0181 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tenovin-6 Hydrochloride 1011301-29-3 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Dehydrogenase Sirtuin HDAC p53 acetylation Dihydroorotate Dehydrogenase protein-deacetylating Tenovin 6 Hydrochloride DHODH Tenovin 6 Inhibitor degradation Tenovin6 Tenovin6 Hydrochloride inhibit MDM2 MDM-2/p53 Tenovin-6 inhibitor