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Cat. No.	Product Name	Target	Signaling Pathways
T22324	Ensartinib hydrochloride Ensartinib dihydrochloride,X-396 dihydrochloride	Others; Trk receptor; c-Met/HGFR; ALK	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	Ensartinib hydrochloride (X-396 dihydrochloride) 是双重的 ALK/MET 抑制剂，IC50分别 <0.4 nM 和 0.74 nM。
T37585	Ensartinib
	Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or point mutations is tested. Ensartinib is potent in H3122 lung cancer cells harboring EML4-ALK E13;A20 (IC50: 15nM). Ensartinib is also potent in H2228 lung cancer cells harboring EML4-ALK E6a/b; A20 (IC50: 45 nM). Furthermore, X-376 is potent in SUDHL-1 lymphoma cells harboring N...
T3550	X-376 Ensartinib,X-396,恩沙替尼	c-Met/HGFR; ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	X-376 (Ensartinib) 是一种有效的ALK 抑制剂，对许多具有crizotinib 抗性的ALK 突变型和中枢神经系统转移具有高活性。它能有效地抑制野生型ALK 和ALK 变体（F1174, C1156Y, L1196M, S1206R, T1151和G1202R 突变型），IC50小于4 nM。