Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T81264 | RLY-2608
化合物 RLY-2608
|
2733573-94-7 | 98% |
|
RLY-2608为首个靶向PI3Ka的选择性变构抑制剂,具有高度专一性。 | ||||
T81453 | PITCOIN4
化合物 PITCOIN4
|
98% |
|
|
PITCOIN4,一种II类PI3K-C2α高选择性抑制剂,具有对PI3K-C2α纳米摩尔级别的显著抑制活性。 | ||||
T81467 | PI3Kδ-IN-18
化合物 PI3Kδ-IN-18
|
98% |
|
|
Se15作为PI3Kδ选择性抑制剂展现出高度效力,具有小于0.1nM的IC50值,主要应用于自身免疫反应研究领域。 | ||||
T81468 | PI3Kδ-IN-17
化合物 PI3Kδ-IN-17
|
2768181-63-9 | 98% |
|
PI3Kδ-IN-17 (Compound S5) 是一种PI3Kδ抑制剂,其IC50值为2.82 nM。该化合物在SU-DHL-6细胞中对增殖活性具有显著抑制效果,IC50为0.035 μM。 | ||||
T81469 | PI3Kα-IN-14
化合物 PI3Kα-IN-14
|
98% |
|
|
PI3Kα-IN-14(复合物F8)是一款高度选择性的PI3Kα抑制剂,其IC50值为0.14 nM 。此化合物能显著降低线粒体膜的完整性,并在U87-MG细胞中引起G1期细胞周期的停滞以及凋亡现象。此外,PI3Kα-IN-14在不同来源的肿瘤细胞系中均展现出明显的抗增殖能力,其中PC-3的IC50为0.28 μM,HC... | ||||
T81470 | PI3K/mTOR Inhibitor-14
化合物 PI3K/mTOR Inhibitor-14
|
2919684-77-6 | 98% |
|
PI3K/mTOR Inhibitor-14(化合物 Y-2)是一种针对PI3K和mTOR的双重抑制剂,其IC50值分别为171.4 nM 和10.1 nM ,具备抗肿瘤活性。 | ||||
T81499 | PH14
化合物 PH14
|
98% |
|
|
PH14,作为一种PI3K/HDAC双重抑制剂,对PI3Kα和HDAC3表现出强效抑制能力,其IC50值分别为20.3 nM 和24.5 nM 。该化合物不仅具备抗增殖特性,还能有效诱导Jeko-1细胞走向凋亡,是研究癌症(例如淋巴瘤)的有力工具。 | ||||
TN4263 | Isoangustone A
化合物 TN4263
|
129280-34-8 | 98% |
|
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ... | ||||
T12460 | PI3K/mTOR Inhibitor-1
化合物 T12460
|
1949802-49-6 | 98% |
|
PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM) | ||||
T12461 | PI3Kdelta inhibitor 1
化合物 T12461
|
2242109-74-4 | 98% |
|
PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM. | ||||
TN1376 | α-Solanine
α-茄碱
|
20562-02-1 | 98% |
|
Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut. | ||||
TN3691 | Communic acid
化合物 TN3691
|
2761-77-5 | 98% |
|
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic... | ||||
TN4652 | Niazimicin
化合物 TN4652
|
147821-49-6 | 98% |
|
Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in... | ||||
T28297 | Parsaclisib hydrochloride
化合物Parsaclisib HCl
|
1995889-48-9 | 98% |
|
Parsaclisib hydrochloride (INCB050465 HCl) 是一种选择性的、有效的,具有口服活性的 PI3Kδ抑制剂,IC50=1 nM。它相对于其他 PI3K I 类同工型的选择性约为 20000 倍。它可用于复发或难治性 B 细胞恶性肿瘤的研究。 | ||||
T6850 | GSK2292767
化合物GSK2292767
|
1254036-66-2 | 98% |
|
GSK2292767 是选择性的PI3Kδ的抑制剂,pIC50=10.1。它的选择性比其他 PI3K 亚型高的 500 倍以上。它可用于研究呼吸系统疾病。 | ||||
T2S0606 | Bakkenolide A
蜂斗菜内酯A
|
19906-72-0 | 98% |
|
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign... | ||||
TN1347 | 8-Prenylkaempferol
化合物8-Prenylkaempferol
|
28610-31-3 | 98% |
|
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in... | ||||
TQ0313 | NVP-BAG956
化合物NVP-BAG956
|
853910-02-8 | 98% |
|
NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ). | ||||
T10660L | CAL-130 Hydrochloride
化合物 T10660L
|
1431697-78-7 | 98% |
|
CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM). | ||||
TN2328 | Zeylenone
山椒子烯酮
|
193410-84-3 | 98% |
|
Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物,具有抗肿瘤和抗癌细胞增殖活性,通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖,诱导细胞凋亡 (apoptosis)。 |