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38

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4616	Metoclopramide 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Metoclopramide (5-Chloro-2-methoxyprocainamide) 是5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T1069	Metoclopramide hydrochloride 盐酸甲氧氯普胺,Maxolon,Metoclopramide HCl	Dopamine Receptor; 5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	Metoclopramide hydrochloride (Metoclopramide HCl) 是可口服的5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T8385	Metoclopramide hydrochloride hydrate 盐酸甲氧氯普胺,甲氧氯普胺盐酸水合物,Metoclopramide monohydrochloride monohydrate	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) 是5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T1528	Azasetron hydrochloride Y-25130 hydrochloride,Y-25130 HCl,盐酸阿扎司琼,Azasetron HCl	5-HT Receptor	GPCR/G Protein; Neuroscience
	Azasetron hydrochloride (Y-25130 HCl) 是一种苯甲酰胺的衍生物，是有效的、选择性的5-HT3受体拮抗剂，可用于化疗引起的恶心呕吐研究。
T11326	Frovatriptan succinate hydrate Frovelan,夫罗曲坦琥珀酸盐水合物 ,Frova	5-HT Receptor	GPCR/G Protein; Neuroscience
	Frovatriptan succinate hydrate (Frova) 是一种有效、高亲和力、选择性和口服活性的 5-HT1B、HT1D 受体激动剂和中等有效的 5-HT7 受体激动剂，pKi 值分别为 8.6、8.4 和 6.7。它可有效治疗各种偏头痛，包括恶心、呕吐、畏光和畏声等相关症状。
T1478	Ondansetron hydrochloride dihydrate 盐酸昂丹司琼,SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Ondansetron hydrochloride dihydrate (GR 38032) 是5- HT3受体拮抗剂，可治疗化疗后的恶心和呕吐，有抗焦虑和抗精神病作用。
T1790	Fosaprepitant dimeglumine 福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。
T28187	Nonabine
	Nonabine 是一种具有强烈止吐作用的化合物，可用来预防与癌症化疗有关的恶心和呕吐。
T16433	Pancopride LAS 30451	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pancopride（LAS 30451）是一种可口服的新型有长效的选择性 5-HT3 受体拮抗剂，可阻断氮芥和达卡巴嗪诱导的呕吐。
T7569	Clebopride malate 苹果酸氯波必利,氯波必利	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Clebopride malate 是多巴胺拮抗剂，可用于功能性胃肠功能紊乱的研究。
T68068	Ezlopitant CJ 11974,CJ-11974,CJ11974	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Ezlopitant (CJ-11974) 是一种基于喹啉的原型 NK1受体拮抗剂 CP-96345的衍生物。
T13329L	Vofopitant dihydrochloride GR 205171A,Vofopitant 2HCl	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Vofopitant dihydrochloride (GR 205171A) 是一种可口服且具有选择性的速激肽 NK1 受体拮抗剂，对 [3H]SP 与 NK1 结合有抑制作用， pKi 值分别为 9.5 和 10.6。Vofopitant dihydrochloride 是治疗病理性呕吐的潜在化合物。
T6616	Ondansetron hydrochloride SN 307,盐酸昂丹司琼,帕罗西汀杂质A,Ondansetron HCl,Emeset,GR 38032 HCl,NSC 665799,Zofran	5-HT Receptor	GPCR/G Protein; Neuroscience
	Ondansetron hydrochloride (Zofran) 是5-HT3受体的拮抗剂，可用作化疗后止吐剂。
T4568	Dolasetron MDL-73147,多拉司琼	5-HT Receptor	GPCR/G Protein; Neuroscience
	Dolasetron (MDL-73147) 是一种血清素 5-HT3 受体拮抗剂，用于治疗化疗后的恶心和呕吐。
T22313	Dolasetron Mesylate 多拉司琼甲磺酸盐,甲磺酸多拉司琼,Anzemet hydrate,MDL-73147EF	Others; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	Dolasetron Mesylate (MDL-73147EF) 是 5-HT3 受体的拮抗剂，可用于治疗化疗后呕吐和恶心的研究。
T2574	Alizapride hydrochloride 盐酸阿立必利,Alizapride HCl	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Alizapride hydrochloride (Alizapride HCl) 是多巴胺受体拮抗剂，表现出促运动和止吐活性，可用于研究恶心和呕吐，如术后恶心和呕吐。
T5009	Trimethobenzamide hydrochloride 盐酸三甲氧苯酰胺,Ro 2-9578,Tribenzagan Hydrochloride	Dopamine Receptor; Influenza Virus	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Trimethobenzamide hydrochloride (Ro 2-9578) 是一种多巴胺D2受体阻断剂，是一种止吐剂，用于预防恶心和呕吐。
T0976	Propoxur 残杀威,Aprocarb,Propoxure,Baygon	AChR; Antifungal	Microbiology/Virology; Neuroscience
	Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂，用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。
T68068L	(R)-CJ 11974	Neurokinin receptor	GPCR/G Protein; Neuroscience

T6426	Buclizine dihydrochloride 盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Buclizine dihydrochloride (Buclina) 是可口服的一种哌嗪组胺 H1 受体拮抗剂，主要具有止吐和抗眩晕活性。
T67956	Litoxetine	5-HT Receptor	GPCR/G Protein; Neuroscience
	Litoxetine 是一种选择性的5-HT 摄取抑制剂，是具有5-HT3受体拮抗剂。Litoxetine 可作为一种抗抑郁剂，在雪貂身上显示出止吐特性。Litoxetine （1和10毫克/公斤静脉注射）剂量依赖性地减少了反胃和呕吐的次数，延迟了呕吐的发生。Litoxetine 对大脑5HT3受体有亲和力（Ki = 85 nM）。
T0944	Levamisole hydrochloride (-)-Tetramisole hydrochloride,盐酸左旋咪唑	Phospholipase; AChR; Parasite; HSV	Metabolism; Microbiology/Virology; Neuroscience
	Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。
T0385	Prochlorperazine Maleate Prochlorperazin,Capazine,Prochlorperazine dimaleate salt,Stemetil,Compazine,丙氯拉嗪	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Prochlorperazine Maleate (Capazine) 是一种吩噻嗪类抗精神病药，主要用于治疗恶心、呕吐和眩晕。它比氯丙嗪更容易引起锥体外系疾病。
T3716	Rolapitant 罗拉吡坦,SCH619734,罗拉匹坦	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂，Ki 值为0.66 nM。
T2589	Dolasetron Mesylate hydrate Dalasetron Mesylate Hydrate,多拉司琼甲磺酸盐一水合物	5-HT Receptor	GPCR/G Protein; Neuroscience
	Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) 是一种选择性血清素受体拮抗剂，可竞争性阻断血清素对 5HT3 受体的作用，从而抑制化疗和放疗引起的恶心和呕吐。
T0082	Domperidone R33812,多潘立酮	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Domperidone (R33812) 是多巴胺 2 受体拮抗剂，能够影响胃和小肠的化学感受器触发区和运动功能，具有止吐和促动力作用。
T4562	Ramosetron	5-HT Receptor	GPCR/G Protein; Neuroscience
	Ramosetron 是一种血清素 5-HT3 受体拮抗剂，用于治疗恶心和呕吐。它被认为比其他一代 5-HT3 拮抗剂如昂丹司琼具有更高的效力和更长的止吐作用。它还适用于治疗“男性以腹泻为主的肠易激综合征”。它仅获准在日本和选定的东南亚国家使用。
T22393	Palonosetron RS25259,帕洛诺司琼,RS 25259 197	5-HT Receptor	GPCR/G Protein; Neuroscience
	Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
T10515	Anti-Heart Failure Agent 1	Others	Others
	Anti-Heart Failure Agent 1 is an orally available compound suitable for the treatment of heart failure without inducing vomiting, nausea, and restlessness.
T69012	Cinnarizine clofibrate
	Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion sickness. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus
T15743	Levomepromazine Methotrimeprazine	Others	Others
	Methotrimeprazine is an orally available neuroleptic agent. It is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including cholinergic, dopamine
T68371	Rolapitant hydrochloride hydrate
	Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of ...
T26079	RI 61 RI-61,Pro-his-pro-phe-his-leu-phe-val-phe,RI61
	RI 61 (sumatriptan succinate) is utilized in the therapy of migraine, cluster headaches, new daily persistent headache, and cyclic vomiting syndrome.
T38802	Trimethobenzamide Ro 2-9578 free base,Trimethobenzamide
	Trimethobenzamide (Ro 2-9578 free base) is a D2 receptor antagonist and an antiemetic agent. Primarily utilized to mitigate the occurrence of nausea and vomiting, trimethobenzamide effectively blocks the D2 receptor.
T33583	Naldemedine S-297995,S297995,Naldemedine,S 297995,S297,995,S 297,995,S297,995;Naldemedine,S-297,995
	Naldemedine (S 297995) is a peripheral selective μ-opioid receptor antagonist being developed by Shionogi for the treatment of opioid-induced adverse reactions, including constipation, nausea, and vomiting. They are usually well tolerated, mainly with mil
T72820	(R)-Casopitant (R)-GW679769
	(R)-Casopitant ((R)-GW679769) 是Casopitant 的异构体。Casopitant 是一种 NK(1)-受体拮抗剂。Casopitant 可用于化疗引起的恶心和呕吐的研究。
T32171	Iodoalphionic acid NSC 11854,NSC-11854,Pheniodolum,NSC11854,Tenamid
	Iodoalphionic acid is the contrast medium for gallbladder examination. It is rarely found in the colon and can rarely masked the gallbladder. The density of the shadow from Iodoalphionic acid was greater than that produced by iodophthalein. It was reliabl
T31194	Dalapon Basfapon B,Dowpon M,Dawpon-Rae
	Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the

化合物

Cat.No: T4616

Synonym: 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide

Target: Dopamine Receptor, 5-HT Receptor

Metoclopramide hydrochloride

Cat.No: T1069

Synonym: 盐酸甲氧氯普胺,Maxolon,Metoclopramide HCl

Target: Dopamine Receptor, 5-HT Receptor, AChR

Metoclopramide hydrochloride hydrate

Cat.No: T8385

Synonym: 盐酸甲氧氯普胺,甲氧氯普胺盐酸水合物,Metoclopramide monohydrochloride monohydrate

Target: Dopamine Receptor, 5-HT Receptor

Azasetron hydrochloride

Cat.No: T1528

Synonym: Y-25130 hydrochloride,Y-25130 HCl,盐酸阿扎司琼,Azasetron HCl

Target: 5-HT Receptor

Frovatriptan succinate hydrate

Cat.No: T11326

Synonym: Frovelan,夫罗曲坦琥珀酸盐水合物 ,Frova

Target: 5-HT Receptor

Ondansetron hydrochloride dihydrate

Cat.No: T1478

Synonym: 盐酸昂丹司琼,SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride

Target: 5-HT Receptor

Fosaprepitant dimeglumine

Cat.No: T1790

Synonym: 福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt

Target: Neurokinin receptor

Cat.No: T28187

Cat.No: T16433

Synonym: LAS 30451

Target: 5-HT Receptor

Clebopride malate

Cat.No: T7569

Synonym: 苹果酸氯波必利,氯波必利

Target: Dopamine Receptor

Cat.No: T68068

Synonym: CJ 11974,CJ-11974,CJ11974

Target: Neurokinin receptor

Vofopitant dihydrochloride

Cat.No: T13329L

Synonym: GR 205171A,Vofopitant 2HCl

Target: Neurokinin receptor

Ondansetron hydrochloride

Cat.No: T6616

Synonym: SN 307,盐酸昂丹司琼,帕罗西汀杂质A,Ondansetron HCl,Emeset,GR 38032 HCl,NSC 665799,Zofran

Target: 5-HT Receptor

Cat.No: T4568

Synonym: MDL-73147,多拉司琼

Target: 5-HT Receptor

Dolasetron Mesylate

Cat.No: T22313

Synonym: 多拉司琼甲磺酸盐,甲磺酸多拉司琼,Anzemet hydrate,MDL-73147EF

Target: Others, 5-HT Receptor

Alizapride hydrochloride

Cat.No: T2574

Synonym: 盐酸阿立必利,Alizapride HCl

Target: Dopamine Receptor

Trimethobenzamide hydrochloride

Cat.No: T5009

Synonym: 盐酸三甲氧苯酰胺,Ro 2-9578,Tribenzagan Hydrochloride

Target: Dopamine Receptor, Influenza Virus

Cat.No: T0976

Synonym: 残杀威,Aprocarb,Propoxure,Baygon

Target: AChR, Antifungal

Cat.No: T68068L

Target: Neurokinin receptor

Buclizine dihydrochloride

Cat.No: T6426

Synonym: 盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445

Target: 5-HT Receptor, AChR, Histamine Receptor

Cat.No: T67956

Target: 5-HT Receptor

Levamisole hydrochloride

Cat.No: T0944

Synonym: (-)-Tetramisole hydrochloride,盐酸左旋咪唑

Target: Phospholipase, AChR, Parasite, HSV

Prochlorperazine Maleate

Cat.No: T0385

Synonym: Prochlorperazin,Capazine,Prochlorperazine dimaleate salt,Stemetil,Compazine,丙氯拉嗪

Target: Dopamine Receptor

Cat.No: T3716

Synonym: 罗拉吡坦,SCH619734,罗拉匹坦

Target: Neurokinin receptor

Dolasetron Mesylate hydrate

Cat.No: T2589

Synonym: Dalasetron Mesylate Hydrate,多拉司琼甲磺酸盐一水合物

Target: 5-HT Receptor

Cat.No: T0082

Synonym: R33812,多潘立酮

Target: Dopamine Receptor

Cat.No: T4562

Target: 5-HT Receptor

Cat.No: T22393

Synonym: RS25259,帕洛诺司琼,RS 25259 197

Target: 5-HT Receptor

Anti-Heart Failure Agent 1

Cat.No: T10515

Target: Others

Cinnarizine clofibrate

Cat.No: T69012

Levomepromazine

Cat.No: T15743

Synonym: Methotrimeprazine

Target: Others

Rolapitant hydrochloride hydrate

Cat.No: T68371

Cat.No: T26079

Synonym: RI-61,Pro-his-pro-phe-his-leu-phe-val-phe,RI61

Trimethobenzamide

Cat.No: T38802

Synonym: Ro 2-9578 free base,Trimethobenzamide

Cat.No: T33583

Synonym: S-297995,S297995,Naldemedine,S 297995,S297,995,S 297,995,S297,995;Naldemedine,S-297,995

Cat.No: T72820

Synonym: (R)-GW679769

Iodoalphionic acid

Cat.No: T32171

Synonym: NSC 11854,NSC-11854,Pheniodolum,NSC11854,Tenamid

Cat.No: T31194

Synonym: Basfapon B,Dowpon M,Dawpon-Rae

Cat. No.	Product Name	Target	Signaling Pathways
T1156	Palonosetron hydrochloride 盐酸帕洛诺司琼,RS 25259 197,Palonosetron HCl,RS 25259	5-HT Receptor	GPCR/G Protein; Neuroscience
	Palonosetron hydrochloride (RS 25259) 是一种 5-HT3 拮抗剂，用于预防和治疗化疗引起的恶心和呕吐。
T5874	2-Methoxybenzoic acid o-Anisic acid,O-Methylsalicylic acid,邻甲氧基苯甲酸,NSC 3778,Salicylic acid methyl ether	Endogenous Metabolite	Metabolism
	2-Methoxybenzoic acid (o-Anisic acid) 是黄瓜叶中水杨酸以及假定生物合成前体的一个内参，另一个已知的用途是在贝珠单抗的合成中。
T3O2784	Vitamin B6 维生素B6	Others	Others
	Vitamin B6 是人体某些辅酶的成分，参与多种代谢反应，特别是与氨基酸代谢有关。维生素B6在防治妊娠和放射病呕吐中的临床应用。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T15097	Deoxynivalenol Vomitoxin,4-Deoxynivalenol
	Deoxynivalenol (Vomitoxin) 是一种单端孢菌素家族镰刀菌属产生的霉菌毒素，常见于受到污染的食物和饲料中。Deoxynivalenol 通过紧密连接处的细胞旁路来穿过肠粘膜。Deoxynivalenol 转运不受P-糖蛋白 (PgP) 或多药耐药相关蛋白 (MRP) 抑制剂的影响。Deoxynivalenol 通常会导致人类和动物腹泻、呕吐和胃肠道炎症。

天然产物

Palonosetron hydrochloride

Cat.No: T1156

Synonym: 盐酸帕洛诺司琼,RS 25259 197,Palonosetron HCl,RS 25259

Target: 5-HT Receptor

2-Methoxybenzoic acid

Cat.No: T5874

Synonym: o-Anisic acid,O-Methylsalicylic acid,邻甲氧基苯甲酸,NSC 3778,Salicylic acid methyl ether

Target: Endogenous Metabolite

Cat.No: T3O2784

Synonym: 维生素B6

Target: Others

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

Cat.No: T15097

Synonym: Vomitoxin,4-Deoxynivalenol

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