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18

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5102	TGN-020 TGN020	Aquaporin; PROTAC Linker	Membrane transporter/Ion channel; PROTAC
	TGN-020 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 的合成分子。TGN020 是一种选择性水通道蛋白 4 (AQP4) 抑制剂，IC50为 3.1 μM。TGN020 减轻大鼠脊髓压迫损伤后的水肿并抑制神经胶质瘢痕的形成。
T0220	Foscarnet sodium Phosphonoformate,膦甲酸钠	Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂，可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。
T80477	Muscarinic toxin 3 MT3	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Muscarinic toxin 3 (MT3) 是高效的非竞争性mAChR及adrenoceptors拮抗剂，对M1、M4、α1A、α1B、α1D、α2A、α2B、α2C受体展示出不同程度的选择性，其pIC50值分别为6.71、8.79、8.86、7.57、8.13、8.49、6.5、7.29。该化合物具有显著的肾上腺素受体抑制活性。
T60253	(±)-Muscarine chloride
	(±)-Muscarine chloride 是 Muscarine chloride 的外消旋体。Muscarine 是一种原型毒蕈碱乙酰胆碱受体 (mAChR) 激动剂。
T24507	Muscarine (+)-Muscarine,Muskarin
	Muscarine is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.
T15339	Foscarbidopa Carbidopa 4′-monophosphate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Foscarbidopa is a prodrug of Carbidopa. It acts as a dopamine receptor agonist.
T81893	M1/M4 muscarinic agonist 2
	M1/M4 muscarinic antagonist 2（compound 40）为选择性抑制M1与M4受体的化合物，其IC50值分别为19 nM和42 nM。
T23034	Muscarine iodide (+)-Muscarine iodide	Others	Others
	Muscarinic acetylcholine receptor agonist
T20752	Biebrich scarlet NSC-79710,NSC79710,NSC 79710
	Biebrich scarlet is a scarlet dye, it has been used in Masson’s trichrome stain for the staining of collagen. It has also been used for the staining of eosinophil.
T24508	Muscarine chloride HSDB-3515,(+)-Muscarine chloride,HSDB 3515,L-(+)-Muscarine chloride,EINECS 218-963-2
	Muscarine chloride is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.
T124690	Cascaroside A
	Cascaroside A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124690。
T11000	Descarbamoyl cefuroxime	Others	Others
	Descarbamoyl cefuroxime is also an intermediate in the synthesis of cephalosporin antibiotics. Decarbamyl cefuroxime is a degradation product of cefuroxime.
T80183	Muscarinic toxin 7
	Muscarinic toxin 7，一种肽类毒素，特异性地针对毒蕈碱M1受体表现出选择性和非竞争性的拮抗活性。
T34563	Scaritoxin
	Scaritoxin is a potent toxic substance isolated from poisonous fish.
T2270	Trans-Tranilast Tranilast trans-,反式-曲尼司特,反-曲尼司特	RAAS	Endocrinology/Hormones
	Trans-Tranilast 是抗过敏剂，可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。
T14139	Aganepag AGN 210937	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Aganepag, a potent Prostanoid EP2 receptor agonist, exhibits remarkable selectivity with an EC50 of 0.19 nM, demonstrating no activity at the EP4 receptor. Its applications are primarily in the fields of wound healing, scar reduction, scar prevention, and the treatment and prevention of wrinkles.
T37598	D-Glucosamine-6-sulfate
	D-Glucosamine-6-sulfate is a naturally occurring glycosaminoglycan. It activates the glmS ribozyme from B. subtilis, a Gram-positive bacterium, when used at a concentration of 200 μM. It has been used to form polyvalent dendrimer conjugates that inhibit angiogenesis and endothelial cell proliferation induced by FGF-2 in vitro and prevent scar tissue formation in a rabbit model of glaucoma surgery.
T60438	PXS-6302
	PXS-6302 是不可逆的赖氨酸氧化酶 (LOX) 抑制剂，对Bovine LOX、rh LOXL1、rh LOXL2、rh LOXL3、rh LOXL4的IC50分别为 3.7 μM，3.4 μM，0.4 μM，1.5 μM 和0.3 μM。PXS-6302 可以轻松渗透皮肤，减少胶原蛋白沉积和交联，显着改善疤痕外观而不降低组织强度。 PXS-6302 在其他纤维化疾病中也可能有更广泛的应用。

化合物

Cat.No: T5102

Synonym: TGN020

Target: Aquaporin, PROTAC Linker

Foscarnet sodium

Cat.No: T0220

Synonym: Phosphonoformate,膦甲酸钠

Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis

Muscarinic toxin 3

Cat.No: T80477

Synonym: MT3

Target: Adrenergic Receptor

(±)-Muscarine chloride

Cat.No: T60253

Cat.No: T24507

Synonym: (+)-Muscarine,Muskarin

Cat.No: T15339

Synonym: Carbidopa 4′-monophosphate

Target: Dopamine Receptor

M1/M4 muscarinic agonist 2

Cat.No: T81893

Muscarine iodide

Cat.No: T23034

Synonym: (+)-Muscarine iodide

Target: Others

Biebrich scarlet

Cat.No: T20752

Synonym: NSC-79710,NSC79710,NSC 79710

Muscarine chloride

Cat.No: T24508

Synonym: HSDB-3515,(+)-Muscarine chloride,HSDB 3515,L-(+)-Muscarine chloride,EINECS 218-963-2

Cat.No: T124690

Descarbamoyl cefuroxime

Cat.No: T11000

Target: Others

Muscarinic toxin 7

Cat.No: T80183

Cat.No: T34563

Trans-Tranilast

Cat.No: T2270

Synonym: Tranilast trans-,反式-曲尼司特,反-曲尼司特

Target: RAAS

Cat.No: T14139

Synonym: AGN 210937

Target: Prostaglandin Receptor

D-Glucosamine-6-sulfate

Cat.No: T37598

Cat.No: T60438

Cat. No.	Product Name	Target	Signaling Pathways
T25114	Ascaridole NSC-406266,NSC 406266,NSC406266	Parasite	Microbiology/Virology
	Ascaridole (NSC-406266) 可作为驱虫化合物，能驱除人体和植物中的寄生蠕虫(蠕虫)，具有较弱的抗疟活性。
T3809	Liriope muscari baily saponins C	Others	Others
	Liriope muscari baily saponins C 是一种L. muscari (Decne.) Baily 的主要活性成分。它已被作为肿瘤转移候选药物进行研究。它具有很强的抗炎、免疫药理和心脏保护作用。
T5794	Saponin C from Liriope muscari Liriope muscari baily Saponins C
	Saponin C from Liriope muscari 可从百合科植物 Liriope muscari中提取。
T3876	Loureirin B 龙血素B,龙血素 B	PAI-1; ERK; Potassium Channel; JNK	MAPK; Membrane transporter/Ion channel; Metabolism
	Loureirin B 是从剑叶龙血树中分离到的一种黄酮，是 PAI-1抑制剂，IC50值为 26.10 μM。它抑制 KATP，以及 ERK 和 JNK 的磷酸化，具有抗糖尿病的功效。
T64812	Collagenase Type I Collagenase I,Collagenase Type I (From microorganisms)	Others	Others
	Collagenase Type I 是一种蛋白水解酶，能分解胶原蛋白中的肽键（胶原蛋白是结缔组织的主要结构蛋白）。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质，从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组，潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。

天然产物

Cat.No: T25114

Synonym: NSC-406266,NSC 406266,NSC406266

Target: Parasite

Liriope muscari baily saponins C

Cat.No: T3809

Target: Others

Saponin C from Liriope muscari

Cat.No: T5794

Synonym: Liriope muscari baily Saponins C

Cat.No: T3876

Synonym: 龙血素B,龙血素 B

Target: PAI-1, ERK, Potassium Channel, JNK

Collagenase Type I

Cat.No: T64812

Synonym: Collagenase I,Collagenase Type I (From microorganisms)

Target: Others

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