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64

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1117	IFN-α Receptor Recognition Peptide 1 IRRP1
	IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions.
T8506	THPP-1	PDE	Metabolism
	THPP-1 是一种 SGC 推荐的化学探针，是一种口服具有活性的磷酸二酯酶10A 抑制剂，其对人和大鼠的Ki 分别为 1 nM 和 1.3 nM。它的药理学特性良好。
T8561	Apcin	APC	Cell Cycle/Checkpoint
	Apcin 是后期促进复合物/环体 (APC/C(Cdc20)) E3 连接酶活性的有效竞争性抑制剂，可通过与 Cdc20 结合并阻止底物识别竞争性地抑制 APC/C 依赖性泛素化。它占据 WD40 结构域侧面的 D-box 结合口袋，并可以延长有丝分裂。它通过阻断有丝分裂退出并通过共同添加 Ts-Arg-OMe 协同放大而起作用。
T28531	Facinicline hydrochloride RG3487	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	Facinicline hydrochloride (RG3487) 是一种口服有效的烟碱α7 receptor 部分激动剂，对人 nAChR 的 Ki 值为 6 nM。它可改善啮齿类动物的认知和感觉运动门控。它与5-HT3受体结合的 Ki 为 1.2 nM。
T2306	Brexpiprazole 依匹哌唑,OPC-34712,依匹唑派	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Brexpiprazole (OPC-34712) 是人5-HT1A 和多巴胺受体的部分激动剂，Ki 分别为0.12 和 0.3 nM。它也是5-HT2A 受体的拮抗剂，Ki 为 0.47 nM，可作为非典型抗精神病药。
T8690	Brexpiprazole HCl OPC 34712 dihydrochloride	Others	Others
	Brexpiprazole HCl (OPC 34712 dihydrochloride) 是一种新型抗精神病药物。
T5474	D159687 D 159687	PDE	Metabolism
	D159687 是一种PDE4D 选择性抑制剂。
T60096	EN106 ZINC3888023	Others	Others
	EN106 是一种有效的 FEMIB 抑制剂，一种半胱氨酸反应性共价配体。EN106 破坏了对 FEM1B、FNIP1 的关键还原应力底物的识别。
T16816	S 18986	GluR	Neuroscience
	S 18986是一种选择性、可口服活性、能渗透大脑的AMPA型受体阳性异构体调节剂，在啮齿动物中展示出增强认知的特性。它在大鼠海马体内诱导去甲肾上腺素和乙酰胆碱的释放，从而提高了对象识别记忆能力。
TP2131L	Rac1 Inhibitor W56 acetate(1095179-01-3 free base)	Rho	Cell Cycle/Checkpoint
	Rac1 Inhibitor W56 acetate(1095179-01-3 free base) 包含 Rac1 的鸟嘌呤核苷酸交换因子 (GEF) 识别/激活位点的残基 45-60 的肽；选择性抑制 Rac1 与 Rac1 特异性 GEF TrioN、GEF-H1 和 Tiam1 的相互作用。
T8873	Bractoppin	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂，IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募，进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。
TP1570	Cortistatin-14	Somatostatin	GPCR/G Protein
	Cortistatin-14 是一种与生长抑素-14结构相似的神经肽，具有抗惊厥和神经保护作用，通过激活 sst（2）、生长素释放肽和 GABA（A/B）受体损害小鼠的识别记忆巩固，可用于研究脓毒症引发的认知障碍。
T32191	Irdabisant CEP-26401,CEP 26401,CEP26401	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Irdabisant (CEP-26401) 是选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂。Irdabisant 显示人 H3R 和大鼠 H3R 的 Ki 分别为 2.0 nM 和 7.2 nM。Irdabisant 抑制 hERG 电流的活性相对较低 (IC50= 13.8 μM)。在大鼠社会认知模型中，Irdabisant 具有认知增强和唤醒作用。Irdabisant 可用于研究精神分裂症或认知障碍。
T0910	Terpin hydrate Terpin Monohydrate,cis-Terpin hydrate,萜品(水合结晶)	Others	Others
	Terpin hydrate 是一种祛痰药，可除去急慢性支气管炎病人的黏液。
T26100	RLH 033 RLH033,RLH-033
	RLH 033 is a selective ligand for the sigma 1 recognition site.
T34431	RU 27849 RU-27849,RU27849
	RU 27849 is used to study the binding of tryptamine recognition sites.
T31040	CP-18 F-18 CP18 F-18,CP 18 F-18,(18F)-CP18
	CP-18 F-18 is a DEVD (the caspase 3 substrate recognition motif) that is an imaging tracer for caspase-3 activity in apoptotic cells.
T25286	DANP
	DANP is a bulge base recognition probe. It is a potent and specific ligand of the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.
TP1778	Fibrinogen Binding Inhibitor Peptide
	Fibrinogen Binding Inhibitor Peptide, a synthetic dodecapeptide, represents the specific platelet receptor recognition site of the human fibrinogen g-chain (residues 400-411).
T25287	Dansyllysine Dns-lysine
	Dansyllysine is utilized to study binding conformations of drugs to human serum albumin and is utilized as a template molecule to form molecularly imprinted monolayers (MIMs) useful to produce optical biosensor recognition elements.
T2507L2	Azeliragon HCl TTP488 HCl,Azeliragon hydrochloride,TTP 488,Azeliragon dihydrochloride,TTP-488
	Azeliragon is a potent and orally active inhibitor of RAGE (receptor for advanced glycation endproducts), a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain.
T41019	Histone H1-derived Peptide Histone H1-derived Peptide
	Histone H1-derived peptide is a phosphopeptide with peptide substrates that consist of a sequence aligned with the optimal recognition motif for cyclin-dependent kinases (CDKs).
TP2131	Rac1 Inhibitor W56
	Rac1 Inhibitor W56 is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.
T61376	Opipramol
	Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].
T17296	Zotatifin eFT226	Others	Others
	Zotatifin is a potent and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM). Zotatifin effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein b
T25050	Alloferon 3
	Alloferon 3 is a natural peptide that mediates signaling by the NF-kappa B pathway to enhance the recognition of viral and tumor antigens. It is known to induce the production of endogenic interferons that promote a cascade of defense responses and also e
T31963	Glyco-lipid Glycolipid,Glyco lipid
	Glycolipids are lipids with a carbohydrate attached by a glycosidic (covalent) bond. Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response and in the connections that allow cells to connect to one another to form tissues.
T81282	RGDV
	RGDV为血小板聚集抑制剂，能够抑制血小板依赖性血栓形成，并通过靶向效应进行肿瘤识别。
T76378	RGD-4C
	RGD-4C（ACDCRGDCFC）是一种携带Arg-Gly-Asp（RGD）序列的肽，具备与αv整合素结合的能力，用于模拟细胞外基质蛋白的整合素识别特性。作为αv整合素的配体，它能够与生物活性分子进行偶联，进而在动物模型中展现出抗肿瘤活性。
T39234	BODIPY-TS Thiol-green 2,BODIPY-TS
	BODIPY-TS (also known as Thiol-green 2) is a highly efficient thiol-specific turn-on probe with a fast response. It incorporates a thiosulfonate scaffold as its thiol recognition unit. BODIPY-TS displays excellent selectivity, low detection limit, and quantitative reactivity towards thiols. Moreover, it exhibits low toxicity. Notably, BODIPY-TS exhibits excitation at 490 nm and emission at 515 nm.
T38303	Apramycin (Nebramycin II)
	Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A bas...
T27195	DNS-8254
	DNS-8254 is a potent and selective Phosphodiesterase 2 (PDE2) inhibitor for the treatment of Memory Disorders (hPDE2a IC50 = 8 nM, Rat Cl-int = 25.6 uL/min/mg). DNS-8254 demonstrated significant memory enhancing effects in a rat model of novel object reco
T80089	HCV-1 e2 Protein (554-569) (TFA)
	HCV-1 e2 Protein (554-569) TFA 为丙型肝炎病毒（HCV）e2 蛋白关键抗原区段，含一个假定 N-糖基化位点，该位点早先推测会影响 e2 蛋白的免疫识别。
T72793	YEATS4 binder-1
	YEATS4 binder-1(4e) 是一种有效的选择性YEATS4结合剂，可以与 YEATS 结构域的 KAc 识别位点结合，其Ki 值为37 nM。
T74726	CL845
	CL845 是 STING 激动剂 CL656 的类似物。CL845 可用于合成靶向 STING（干扰素基因刺激物）的可结合 PRR 配体。CL845 可用于癌症、免疫系统疾病或感染的研究。
T14593	Biotin-PEG3-Mal	Others	Others
	Biotin-PEG3-Mal is a biotinylated polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs). By introducing the biotin moiety, it enables specific recognition and binding to target proteins. Additionally, the PEG spacer contributes to improved solubility and flexibility of the linker. This compound offers a valuable tool for constructing PROTACs, which hold great potential in targeted protein degradation strategies[1].
T74538	Galectin-3 antagonist 2	Galectin	Immunology/Inflammation
	Galectin-3，作为β-半乳糖苷特异性的识别蛋白（凝集素），具备促进B细胞前体急性淋巴细胞白血病（BCP-ALL）细胞迁移及耐受药物治疗的功能。
T81356	PTBP1-RNA-binding inhibitor P6 TFA PTBP1 α3-helix derived peptide P6 TFA
	PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA 为剪接因子PTBP1的特定钉合肽抑制剂，用于抑制PTBP1调控的RNA选择性剪接事件。该抑制剂通过与PTBP1的RNA识别基序相结合，从而发挥其作用。
T76514	HCV-1 e2 Protein (554-569)
	HCV-1 e2 Protein (554-569) 是一段重要的丙型肝炎病毒(HCV) e2 蛋白的抗原区域，具有一个推定的 N-糖基化位点，这个位点被认为之前影响了e2蛋白的免疫识别。
T60693	Glutamate-5-kinase-IN-1
	Glutamate-5-kinase-IN-1 (compound 50) 是谷氨酸-5-激酶 (G5K)的有效抑制剂，它通过改变 ATP 结合位点构象发挥抑制作用，其抑制浓度为 4.1 μM。Glutamate-5-kinase-IN-1 具有研究抗结核的潜力
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr...
T36764	PAF C-18:1
	PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration. PAF C-18:1 activates the PAF receptor and has been used in antibody binding experiments to determine the importance of an acyl linkage at the sn-2 position for recogn...
T30825	Cgp 31358 Cgp31358,Cgp-31358
	CGP 31358 is a new chemical entity with a novel mechanism of action at the NMDA receptor, and as such may form a tool for understanding the molecular pharmacology of this receptor-channel complex. It binds to a site on the NMDA receptor that is coupled to
T71325	ANA-773
	ANA773 is a Toll-like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which...
T70210	FT-1101 free base
	FT-1101 is an orally bioavailable, potent and selective BET inhibitor. FT-1101 binds to the acetylated lysine recognition motifs in the bromodomain sites of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to the inhibition of tumor cell growth. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional r...
T83718	5-FAM-LPETGG TFA 5-Carboxyfluorescein-LPETGG
	5-FAM-LPETGG是一种荧光肽，由排序酶识别序列LPETGG与荧光标记5-carboxyfluorescein (5-FAM) 结合而成，其激发/发射最大值分别为492/518 nm。通过排序酶催化的转肽连接，它已被用于靶蛋白的特异性标记。
TP2259	immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]	Others	Others
	Immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] is a fragment on the variable region of the human and mouse immunoglobulin light chain. Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule
T81176	Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2
	Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2 是一种具备生物活性的肽。研究凝血酶受体束缚配体 SFLLRNP 的结构活性表明，Phe-2-苯基在受体识别过程中具有关键作用。研究还发现，将 Phe-2 替换为对氟苯丙氨酸 [(pF)Phe]，可以提升其生物活性。
T76273	Pep19-2.5
	Pep19-2.5为合成抗毒素肽，能阻断内毒素信号级联。通过抑制跨膜及胞质模式识别受体（PRRs）介导的脂肽（LP）与脂多糖（LPS）的信号通路，Pep19-2.5关键调控与炎症及细胞焦亡（pyroptosis）相关的信号级联。
TP2260	Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]	Others	Others
	Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] is a fragment (Gly-Val-Ala-Leu-His-Arg-Pro-Asp-Val-Tyr-Leu-Leu-Pro-Pro-Ala-Arg) on the human immunoglobulin micro heavy chain. Immunoglobulins (Ig) are the antigen recognition molecules of B cell

化合物

IFN-α Receptor Recognition Peptide 1

Cat.No: TP1117

Synonym: IRRP1

Cat.No: T8506

Target: PDE

Cat.No: T8561

Target: APC

Facinicline hydrochloride

Cat.No: T28531

Synonym: RG3487

Target: 5-HT Receptor, AChR

Cat.No: T2306

Synonym: 依匹哌唑,OPC-34712,依匹唑派

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Brexpiprazole HCl

Cat.No: T8690

Synonym: OPC 34712 dihydrochloride

Target: Others

Cat.No: T5474

Synonym: D 159687

Target: PDE

Cat.No: T60096

Synonym: ZINC3888023

Target: Others

Cat.No: T16816

Target: GluR

Rac1 Inhibitor W56 acetate(1095179-01-3 free base)

Cat.No: TP2131L

Target: Rho

Cat.No: T8873

Target: Others, DNA/RNA Synthesis

Cat.No: TP1570

Target: Somatostatin

Cat.No: T32191

Synonym: CEP-26401,CEP 26401,CEP26401

Target: Histamine Receptor

Cat.No: T0910

Synonym: Terpin Monohydrate,cis-Terpin hydrate,萜品(水合结晶)

Target: Others

Cat.No: T26100

Synonym: RLH033,RLH-033

Cat.No: T34431

Synonym: RU-27849,RU27849

Cat.No: T31040

Synonym: CP18 F-18,CP 18 F-18,(18F)-CP18

Cat.No: T25286

Fibrinogen Binding Inhibitor Peptide

Cat.No: TP1778

Cat.No: T25287

Synonym: Dns-lysine

Cat.No: T2507L2

Synonym: TTP488 HCl,Azeliragon hydrochloride,TTP 488,Azeliragon dihydrochloride,TTP-488

Histone H1-derived Peptide

Cat.No: T41019

Synonym: Histone H1-derived Peptide

Rac1 Inhibitor W56

Cat.No: TP2131

Cat.No: T61376

Cat.No: T17296

Synonym: eFT226

Target: Others

Cat.No: T25050

Cat.No: T31963

Synonym: Glycolipid,Glyco lipid

Cat.No: T81282

Cat.No: T76378

Cat.No: T39234

Synonym: Thiol-green 2,BODIPY-TS

Apramycin (Nebramycin II)

Cat.No: T38303

Cat.No: T27195

HCV-1 e2 Protein (554-569) (TFA)

Cat.No: T80089

YEATS4 binder-1

Cat.No: T72793

Cat.No: T74726

Biotin-PEG3-Mal

Cat.No: T14593

Target: Others

Galectin-3 antagonist 2

Cat.No: T74538

Target: Galectin

PTBP1-RNA-binding inhibitor P6 TFA

Cat.No: T81356

Synonym: PTBP1 α3-helix derived peptide P6 TFA

HCV-1 e2 Protein (554-569)

Cat.No: T76514

Glutamate-5-kinase-IN-1

Cat.No: T60693

TNF-α Antagonist

Cat.No: T36127

Cat.No: T36764

Cat.No: T30825

Synonym: Cgp31358,Cgp-31358

Cat.No: T71325

FT-1101 free base

Cat.No: T70210

5-FAM-LPETGG TFA

Cat.No: T83718

Synonym: 5-Carboxyfluorescein-LPETGG

immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]

Cat.No: TP2259

Target: Others

Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2

Cat.No: T81176

Cat.No: T76273

Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]

Cat.No: TP2260

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2783	Methyl dihydrojasmonate Methyl Dihydrojasmonate,Kharismal,Hedione,二氢茉莉酮酸甲酯	Others	Others
	Methyl dihydrojasmonate (Kharismal) 是一种香料成分，具有茉莉花香气，常用于许多香料混合物中。
T4S1999	Valepotriate 戊曲酯/缬草素,Valtrate	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Valepotriate (Valtrate) 是从蜘蛛香分离而来的一种天然产物，是一类新的细胞毒剂和抗肿瘤剂，对 HTC 肝癌细胞是非常有效的细胞毒剂。它可能对焦虑的精神症状具有潜在的抗焦虑作用。
T1638	N-Acetylneuraminic acid 唾液酸,Acide aceneuramique,N-乙酰神经氨酸,NeuAc,Lactaminic acid	Others; Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	N-Acetylneuraminic acid (Acide aceneuramique) 是一种九碳唾液酸单糖，通常存在于细胞膜上的糖蛋白和哺乳动物细胞中的神经节苷脂等糖脂中。它可用于神经传递、白细胞外渗、病毒或细菌感染以及碳水化合物-蛋白质识别。
T81016	Terrelumamide A
	Terrelumamide A是一种带有lumazine结构的肽类化合物，从海洋真菌Aspergillus terreus的培养物中提取分离得到。该化合物因增强胰岛素敏感性而显示出药理作用，并在DNA序列识别方面具有潜在应用价值。
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...

天然产物

Methyl dihydrojasmonate

Cat.No: T2783

Synonym: Methyl Dihydrojasmonate,Kharismal,Hedione,二氢茉莉酮酸甲酯

Target: Others

Cat.No: T4S1999

Synonym: 戊曲酯/缬草素,Valtrate

Target: Apoptosis, HIV Protease

N-Acetylneuraminic acid

Cat.No: T1638

Synonym: 唾液酸,Acide aceneuramique,N-乙酰神经氨酸,NeuAc,Lactaminic acid

Target: Others, Influenza Virus, Endogenous Metabolite

Terrelumamide A

Cat.No: T81016

Cat.No: T36295

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