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Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]

Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]

产品编号 TP2260   CAS TP2260

Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] is a fragment (Gly-Val-Ala-Leu-His-Arg-Pro-Asp-Val-Tyr-Leu-Leu-Pro-Pro-Ala-Arg) on the human immunoglobulin micro heavy chain. Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions.

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Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] Chemical Structure
Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens], CAS TP2260
规格 价格/CNY 货期 数量
1 mg ¥ 483 待询
5 mg ¥ 1,383 待询
10 mg ¥ 2,283 待询
25 mg ¥ 3,183 待询
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产品目录号及名称: Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] (TP2260)
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产品描述 Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] is a fragment (Gly-Val-Ala-Leu-His-Arg-Pro-Asp-Val-Tyr-Leu-Leu-Pro-Pro-Ala-Arg) on the human immunoglobulin micro heavy chain. Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions.
体外活性 The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma.
分子量 1774.07
分子式 C82H132N24O20
CAS No. TP2260

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: ≥177.4mg/mL

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Keywords

Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] TP2260 Others Inhibitor inhibitor inhibit

 

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