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Search Results for " promoters "

10

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2040	OAC1 BAS 00287861	OCT	Membrane transporter/Ion channel
	OAC1 (BAS 00287861) 是一种能够激活 Octamer 结合转录因子 4 的化合物。它提高了 iPSC 重编程效率并加速重编程过程。
T15014	CTPB	Histone Acetyltransferase	Chromatin/Epigenetic
	CTPB 是一种有效的 p300 组蛋白乙酰转移酶 (HAT) 活化剂，可用于制备毛发生长促进剂和/或脱发治疗剂。
T9707	DB2313 Carboximidamide	Apoptosis	Apoptosis
	DB2313 (Carboximidamide) 是一种有效的转录因子 PU.1 抑制剂，IC50 为 14 nM。DB2313 破坏了 PU.1 与靶基因启动子的相互作用。DB2313 可诱导急性髓细胞性白血病 (AML) 细胞凋亡 (apoptosis)，并具有抗癌作用。
TP1267L	CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base)	Others	Others
	CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base) 对应于 BRLF1 的氨基酸 148-156。 BRLF1 是一种转录激活因子，可直接与一些 Epstein-Barr 病毒 (EBV) 裂解基因启动子中的富含 GC 的基序结合。
T41068	P53R3	p53	Apoptosis
	P53R3是一种有效的 p53再激活剂。P53R3可恢复 p53热点突变体的序列特异性 DNA 结合，包括p53 R175H、p53 R248W 和p53 R273H。P53R3特异性诱导p53依赖性抗增殖作用，其特异性比PRIMA-1高得多的。P53R3增强野生型p53和p53 M237I 向靶基因启动子的募集。P53R3强烈增强死亡受体死亡受体5（DR5）的mRNA、总蛋白和细胞表面的水平。P53R3用于癌症研究。
T17146	TPO agonist 1	Others	Others
	TPO agonist 1 is a thrombopoietin agonist. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.
T69842	DB2313 HCl
	DB2313 is a first-in-class potent small-molecule inhibitor of PU.1. DB2313 disrupts the interaction of PU.1 with target gene promoters and leads to down-regulation of canonical PU.1 transcriptional targets.
T69193	SN-28049
	SN-28049 SN is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. SN 28049 has a complex action that may involve poisoning of topo IIalpha, suppression of topo I and inhibition of gene transcription from promoters with SP-1 sites. These actions may contribute to the promising experimental solid tumour anticancer activity of SN 28049.
T71890	F5446
	F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.
T79801	TCIP 1	Epigenetic Reader Domain	Chromatin/Epigenetic
	TCIP 1是一款转录/表观遗传CIPs（TCIP）小分子，结构上为能够分别与BCL6和BRD4结合的小分子共价连接而成。该分子通过募集内源性癌症驱动因子或下游转录因子至细胞死亡基因的启动子，促进胞死亡基因的表达。TCIP 1能形成功能性三元复合物，特异性地与BCL6和BRD4作用，从而取消BCL6对凋亡基因的抑制，增强促凋亡基因的转录活性，并触发细胞凋亡。此外，TCIP 1有效降低致癌基因MYC的表达，并抑制弥漫大B细胞淋巴瘤（DLBCL）的增长。

化合物

Cat.No: T2040

Synonym: BAS 00287861

Target: OCT

Cat.No: T15014

Target: Histone Acetyltransferase

Cat.No: T9707

Synonym: Carboximidamide

Target: Apoptosis

CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate

Cat.No: TP1267L

Synonym: CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base)

Target: Others

Cat.No: T41068

Target: p53

Cat.No: T17146

Target: Others

Cat.No: T69842

Cat.No: T69193

Cat.No: T71890

Cat.No: T79801

Target: Epigenetic Reader Domain

Cat. No.	Product Name	Target	Signaling Pathways
TN1025	3,29-O-Dibenzoyloxykarounidiol	Others	Others
	3,29-O-Dibenzoyloxykarounidiol 是一种苯甲酸三萜烯酯，从 Momordica grosvenori 果实中提取。它能够抑制肿瘤启动子 TPA 诱导的 EB 病毒早期抗原活化。
TN1816	Kadsurin	Antioxidant	oxidation-reduction
	Kadsurin 是一种提取自异形南五味子茎中的天然产物，能够显著降低小鼠肝脏中CCL4诱导的脂质过氧化产物（例如TBA-RS、共轭二烯和荧光产物）。
TN1334	7-Methoxyrosmanol 7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol	cAMP	GPCR/G Protein
	7-Methoxyrosmanol (7-O-Methylrosmanol) 是一种酚类二萜，从迷迭香中分离得到，可抑制 PEPCK 和 G6Pase 启动子的 cAMP 反应。
T3524	Halofuginone hydrobromide 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐	Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells
	Halofuginone hydrobromid 是Febrifugine 的衍生物，是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂，并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。
TN4255	Interiotherin C	Others	Others
	Interiotherin C may be valuable antitumor promoters or chemopreventors.
TN2799	20-Deoxyingenol 3-angelate	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant platelet aggregation accompanied by induction of phosphorylation of PKC substrates in platelets,

天然产物

3,29-O-Dibenzoyloxykarounidiol

Cat.No: TN1025

Target: Others

Cat.No: TN1816

Target: Antioxidant

7-Methoxyrosmanol

Cat.No: TN1334

Synonym: 7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol

Target: cAMP

Halofuginone hydrobromide

Cat.No: T3524

Synonym: 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Interiotherin C

Cat.No: TN4255

Target: Others

20-Deoxyingenol 3-angelate

Cat.No: TN2799

Target: PKC

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