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Search Results for " proapoptotic "

22

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T81283	RGD-targeted Proapoptotic Peptide
	RGD-targeted Proapoptotic Peptide为一肽类化合物，其C端RGD-4C肽段（ACDCRGDCFC）能够特异性地与肿瘤新生血管的整合素结合位点优先结合。
TP2207	Pasireotide Acetate	Somatostatin	GPCR/G Protein
	Pasireotide acetate 是长效的环己肽生长激素抑制素类似物，具有抗分泌、抗增殖和促凋亡活性。它可抑制 GH、IGF-I 和 ACTH 的分泌，可用于研究肢端肥大症和库欣病。它还可以提高生长抑素受体的激动剂活性，对sst1、2、3、4、5的pKi 分别为 8.2、9.0、9.1、小于7.0 和 9.9。
T6641	Rilmenidine Phosphate	Apoptosis; Adrenergic Receptor; Autophagy; Imidazoline Receptor	Apoptosis; Autophagy; GPCR/G Protein; Neuroscience
	Rilmenidine phosphate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体激动剂。它可调节白血病细胞增殖，刺激促凋亡蛋白 Bax，从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。它可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+反向转运而在肾脏中发挥作用。
T12257	NSC 146109 hydrochloride	Apoptosis; Others	Apoptosis; Others
	NSC 146109 hydrochloride 是一种靶向 MDMX 的 p53 激活剂。 NSC 146109 hydrochloride 可用于乳腺癌研究。
T6079	NVP-ADW742 ADW742,ADW,GSK 552602A	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	NVP-ADW742 (ADW) 是一种具有口服活性，选择性的IGF-1R 酪氨酸激酶抑制剂，IC50为 0.17 μM。它抑制胰岛素受体，IC50为 2.8 μM，在肿瘤细胞中诱导多效性抗增殖/促凋亡。
TP2306	Adipotide/FTPP(FatTargetedProapoptoticPeptide) Acetate	Others	Others
	Adipotide/FTPP(FatTargetedProapoptoticPeptide) Acetate 作为一种新型候选药物的原型，可用于治疗人类肥胖症。
T2453	BAM7	BCL	Apoptosis
	BAM7 是一种促凋亡 Bax 的直接和特异性激活剂，IC50为 3.3 μM。
T2111	Sepantronium bromide YM155	Survivin; Autophagy	Apoptosis; Autophagy
	Sepantronium bromide (YM155) 是一种小分子促凋亡剂，具有潜在抗肿瘤活性。它是一种生存素抑制剂，IC50为 0.54 nM。
T13867	RH01386	Others	Others
	RH01386是可以预防 ER 应激诱导的β细胞功能障碍和死亡、抑制促凋亡基因表达的小分子。它恢复内质网应激受损的葡萄糖刺激的胰岛素分泌反应。对2型糖尿病具有潜在的研究价值。
T4400	DIM-C-pPhOH CDIM8	Apoptosis; Others	Apoptosis; Others
	DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂，可降低细胞增殖，对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导，诱导细胞凋亡和细胞应激。
T6301	Tosedostat CHR-2797,托舍多特	Aminopeptidase; AChR	Metabolism; Neuroscience
	Tosedostat (CHR-2797) 是一种具有口服活性的氨基肽酶(aminopeptidase) 抑制剂，对多种肿瘤细胞系均具有抗增殖作用。
T12369	Pasireotide pamoate SOM230 pamoate	Others	Others
	Pasireotide pamoate is a stable cyclohexapeptide somatostatin mimic. Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity.
T15723	LBW242	Others	Others
	LBW242 is a 3-mer and Smac mimetic and is an effective and orally active proapoptotic IAP inhibitor. LBW242 has activity against multiple myeloma and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells. LBW242 displays effec
T82239	HAP-1
	HAP-1为针对滑膜细胞的转导肽，可促进蛋白质复合物在人类及兔子滑膜细胞中的特异性内吞作用。当HAP-1与抗菌肽(KLAK)2融合时，形成促进细胞凋亡的肽DP2。
T72658	cRIPGBM chloride
	cRIPGBM chloride是一种口服有效的促凋亡衍生物，针对多形性胶质母细胞瘤(GBM)中的癌症干细胞(CSC)。该化合物通过靶向受体相互作用蛋白激酶2(RIPK2)，诱导caspase 1依赖的细胞凋亡，抑制RIPK2/TAK1的活性，增加RIPK2/caspase 1复合物的形成，表现出强大的体内抗肿瘤效果。
T26709	Azadirone
	Azadirone is a limonoid tetranortriterpene. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR4 and DR5 signaling, down-regulation of cell survival prot
T19250	cRIPGBM	TNF	Apoptosis
	cRIPGBM 是RIPGBM 的促凋亡衍生物。cRIPGBM 通过与受体相互作用蛋白激酶2(RIPK2)结合，从而选择性诱导 GBM 肿瘤干细胞凋亡，对 GBM-1 细胞的EC50值为 68 nM。
T35588	Ganglioside GM3 Mixture (sodium salt)
	Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. It suppresses angiogenesis and reduces proliferation and migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 20 μM via inhibition of VEGFR2 and Akt phosphorylation. Ganglioside GM3 induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functi...
T70430	XK469
	XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent.
T78708	JAK/HDAC-IN-2	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK/HDAC-IN-2 是一款高效的 JAK/HDAC 双靶点抑制剂，能在纳摩尔浓度范围内有效抑制 HDAC3/6 与 JAK1/2。此化合物不仅促进细胞凋亡，还能抑制组蛋白去乙酰化和 STAT3 磷酸化，对血液肿瘤和实体肿瘤细胞展现出了显著的抗增殖效果。
T75248	Pasireotide (diaspartate)
	Pasireotide (SOM230) diaspartate 是一种长效的环己肽生长激素抑制素类似物，可以提高生长抑素受体的激动剂活性，对sst1/2/3/4/5的pKi 分别为 8.2/9.0/9.1/<7.0/9.9。Pasireotide diaspartate 具有抗分泌、抗增殖和促凋亡活性。
T36963	CAY10503
	CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 μM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight hours following treatment with 50 μM CAY10503, whereas 10 μM CAY10503 required 96 hours for cell cycle arrest to appear. CAY10503 also induces differentiation of HL60 cells into the follo...

化合物

RGD-targeted Proapoptotic Peptide

Cat.No: T81283

Pasireotide Acetate

Cat.No: TP2207

Target: Somatostatin

Rilmenidine Phosphate

Cat.No: T6641

Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor

NSC 146109 hydrochloride

Cat.No: T12257

Target: Apoptosis, Others

Cat.No: T6079

Synonym: ADW742,ADW,GSK 552602A

Target: Apoptosis, IGF-1R

Adipotide/FTPP(FatTargetedProapoptoticPeptide) Acetate

Cat.No: TP2306

Target: Others

Cat.No: T2453

Target: BCL

Sepantronium bromide

Cat.No: T2111

Synonym: YM155

Target: Survivin, Autophagy

Cat.No: T13867

Target: Others

Cat.No: T4400

Synonym: CDIM8

Target: Apoptosis, Others

Cat.No: T6301

Synonym: CHR-2797,托舍多特

Target: Aminopeptidase, AChR

Pasireotide pamoate

Cat.No: T12369

Synonym: SOM230 pamoate

Target: Others

Cat.No: T15723

Target: Others

Cat.No: T82239

cRIPGBM chloride

Cat.No: T72658

Cat.No: T26709

Cat.No: T19250

Target: TNF

Ganglioside GM3 Mixture (sodium salt)

Cat.No: T35588

Cat.No: T70430

Cat.No: T78708

Target: JAK

Pasireotide (diaspartate)

Cat.No: T75248

Cat.No: T36963

Cat. No.	Product Name	Target	Signaling Pathways
T19676	Tributyrin NSC661583,NSC 661583,NSC-661583,甘油三丁酸酯	Apoptosis	Apoptosis
	Tributyrin (Glyceryl tributyrate) 是一种中性短链脂肪酸甘油三酯，是一种稳定且吸收迅速的丁酸前药。它通过生物膜扩散并被细胞内脂肪酶代谢，在体内将有效的丁酸直接释放到细胞中，有抗增殖、促凋亡和诱导分化作用。
T13818	Phytohemagglutinin PHA-M,植物血球凝集素,PHA,植物血凝素	Apoptosis	Apoptosis
	Phytohemagglutinin (PHA-M) 是一种普通豆菜豆的主要种子凝集素，聚集在子叶的薄壁细胞中。它是一种 T 细胞激活剂，能够刺激人单核白细胞，可诱导 ChAT mRNA 表达，增强 ACh 合成。
T40643	Prodigiosin hydrochloride 盐酸灵菌红素,Prodigiosine hydrochloride
	Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this compound possesses antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.
T72916	Justicidin B 爵床脂素B
	Justicidin B是一种高效的抗癌木脂素及促凋亡剂，同时具备显著的骨吸收抑制作用，并展现出强大的抗病毒、杀真菌和抗原虫能力。此外，Justicidin B能显着抑制血小板聚集。
T66078	Cardamonin
	Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin（15μM） in CNE-2 cells.In vivo, cardamonin (25 mg/kg ...

天然产物

Cat.No: T19676

Synonym: NSC661583,NSC 661583,NSC-661583,甘油三丁酸酯

Target: Apoptosis

Phytohemagglutinin

Cat.No: T13818

Synonym: PHA-M,植物血球凝集素,PHA,植物血凝素

Target: Apoptosis

Prodigiosin hydrochloride

Cat.No: T40643

Synonym: 盐酸灵菌红素,Prodigiosine hydrochloride

Cat.No: T72916

Synonym: 爵床脂素B

Cat.No: T66078

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