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Search Results for " piperazine "

109

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12186	Navitoclax-piperazine ABT-263-piperazine	BCL; Ligands for Target Protein for PROTAC	Apoptosis; PROTAC
	Navitoclax-piperazine (ABT-263-piperazine) 是一种特大型 B 细胞淋巴瘤(BCL-XL)抑制剂。它和 E3 泛素连接酶的 VHL 配体可用来合成 PROTAC DT2216。
T21569	1-(1-Naphthyl) piperazine hydrochloride 1-naphthalen-1-ylpiperazine hydrochloride,1-(Naphthalen-1-yl)piperazine hydrochloride	Others	Others
	1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) 是一种 5-羟色胺能配体，可与多种 5-羟色胺 (5-HT) 受体非选择性结合。
T16540	Piperazine Erastin	Ferroptosis	Apoptosis
	Piperazine Erastin 是erastin 的类似物。它会导致一种铁依赖形式的非凋亡性细胞死亡，称为铁死亡。
T7146	Piperazine adipate	Parasite	Microbiology/Virology
	Piperazine adipate 是一种广谱驱虫剂，可抵抗哺乳动物中很多常见的寄生虫感染。
T50020	1-(1-phenyltetrazol-5-yl)piperazine;hydrochloride 1-(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)piperazine hydrochloride	Others	Others
	1-(1-phenyltetrazol-5-yl)piperazine;hydrochloride (1-(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)piperazine hydrochloride) 是一种哌嗪的化学衍生物，已被用作合成其他化合物的起始材料，如抗炎剂。它通过与酶和蛋白质的活性位点结合来调节其活性，已被用于酶抑制和蛋白质结构的研究，以及药物代谢的研究。
T8582	1-[(5-methylisoxazol-3-yl)methyl]piperazine Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI)	P2Y Receptor	GPCR/G Protein; Neuroscience
	1-[(5-methylisoxazol-3-yl)methyl]piperazine (Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI)) 是一种 P2Y12 抑制剂。
T16539	Piperazine citrate	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Piperazine citrate 是一种六元环化合物，有驱虫的作用。
T5105	1-(2-Pyridyl)piperazine 1-(2-吡啶基)哌嗪,NSC13778	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	1-(2-Pyridyl)piperazine (NSC-13778) 是一种选择性的 α2-肾上腺素受体拮抗剂。它显示出交感神经活性。它也是 Azaperone 的代谢物。
T0615	1-(3-Chlorophenyl)piperazine hydrochloride M-CPP hydrochloride,间氯苯基哌嗪	Others	Others
	1-(3-Chlorophenyl)piperazine hydrochloride (M-CPP hydrochloride) 用于合成 trazodone, Etoperidone, Nefazodone 等。
T50018	1-(3-chloropyridin-2-yl)piperazine dihydrochloride	Others	Others
	1-(3-chloropyridin-2-yl)piperazine dihydrochloride 是一种哌嗪类化合物，常被用作有机合成中的试剂，配位化学中的配体，以及制药中的药物。它是DPP4的抑制剂，DPP4的抑制已被证明在治疗某些疾病（如2型糖尿病和肥胖症）方面具有有益效果。
T40034	GNF-8625 monopyridin-N-piperazine hydrochloride	Trk receptor	Tyrosine Kinase/Adaptors
	GNF-8625 monopyridin-N-piperazine hydrochloride 是一种原肌球蛋白受体激酶（TRK）的抑制剂。
T60231	N-[2-nitro-4-(trifluoromethyl)phenyl]piperazine	Others	Others
	N-[2-nitro-4-(trifluoromethyl)phenyl]piperazine 是一种生物活性化合物，属于哌嗪类。它是一种重要的合成中间体，用于制备多种药物、农用化学品和其他化学品。它被认为是参与药物代谢的某些酶的抑制剂，例如细胞色素P450酶，也已被证明具有抗炎和抗肿瘤作用。
T9876	Piperazine, 1-(4-fluorophenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-	Others	Others
	Piperazine,1-(4-fluorophenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-是一种哌嗪衍生物，显示出抗 SARS-CoV-2活性。
T50034	1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride	Others	Others
	1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride （1-PPZ-DHC）是一种用作分子结构单元的化合物。它是天然产物哌嗪的类似物，具有广泛的生物活性，包括抗炎、抗肿瘤和抗菌活性，同时还被研究用于治疗神经系统疾病，如阿尔茨海默氏症和帕金森氏症。
T40111L	BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 是一种基于间苯二酚二Ph醚支架的程序性细胞死亡-1（PD-1）/程序性细胞死亡配体1（PD-L1）抑制剂, 抑制 PD-1/PD-L1 相互作用，IC50 值为 39.2 nM.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 包含靶蛋白 PD-1/PD-L1 配体和 PROTAC linker。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可用于合成 PROTAC PD-1/PD-L1 degrader-1。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 具有抗癌活性。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可作为稀释剂，用于用于直接压缩制备片剂。
T39895	Thalidomide-Piperazine-PEG3-NH2 Thalidomide-Piperazine-PEG3-NH2
	Thalidomide-Piperazine-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that combines the Thalidomide-based cereblon ligand with a linker commonly used in PROTAC technology, serving as an E3 ligase recruiter.
T39893	Thalidomide-Piperazine-PEG2-NH2 Thalidomide-Piperazine-PEG2-NH2
	Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Thalidomide with a linker commonly utilized in PROTAC technology.
T28882	Sultosilic acid, piperazine salt A-585,Mimedran,piperazine-sultosylate,A585,A 585
	Sultosilic acid piperazine salt is a drug with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically significant decrease of triglycerides, to
T67739	BMY-14802 alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol	Sigma receptor	GPCR/G Protein
	BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol)是一种选择性的、口服活性的sigma-1拮抗剂，IC50为112nM。
T39711	Thalidomide-Piperazine-Piperidine
	Thalidomide-Piperazine-Piperidine is a compound composed of a synthesized E3 ligase ligand-linker conjugate. It combines a cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology.
T40645	PIPES 1,4-Piperazinediethanesulfonic acid,1,4-piperazine bis(ethanesulfonic acid),1,4-Piperazinebis(ethanesulfonic acid),PIPES	Others	Others
	PIPES (1,4-Piperazinediethanesulfonic acid) 作为PIPES缓冲液的关键成分，广泛应用于生化领域作为试剂。
T39697	Thalidomide-piperazine-Boc
	Thalidomide-piperazine-Boc is an intermediate utilized for synthesizing BCL6 PROTAC, which targets B-cell lymphoma 6 protein.
T70097	Acefylline piperazine
	Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimula...
T34069	Piperazine sebacate Nematorazine
	Piperazine sebacate has anthelminthic activity. it be studie for therapy of trichocephalosis.
T39696	Thalidomide-Piperazine 5-fluoride
	Thalidomide-Piperazine 5-fluoride is a compound developed by synthesizing an E3 ligase ligand-linker conjugate. It incorporates a cereblon ligand derived from Thalidomide and utilizes a linker commonly employed in PROTAC technology.
T40231	Thalidomide-Piperazine-Piperidine hydrochloride
	Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized compound that serves as an E3 ligase ligand-linker conjugate. It combines the cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology.
T16277	NCT-502 N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide	Dehydrogenase	Metabolism
	NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) 是磷酸甘油酸脱氢酶 (PHGDH) 抑制剂(IC50:3.7 μM)，对 PHGDH 依赖性癌细胞具有细胞毒性，能够减少葡萄糖衍生的丝氨酸的产生，。
T37373	4-hydroxy-3-Methoxyphenylglycol (piperazine salt)
	4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermediate. It is released into the blood and cerebrospinal fluid and has been used as a biochemical index of recent sympathetic nervous system activity.
T34935	Triclofenol piperazine CI 416,Triclofenol piperazina,CI-416,CI416,Triclofenol piperazate
	Triclofenol piperazine helps with the treatment of patients imfected with parasite such as hookworms.
T64340	ML267 4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate	Others	Others
	ML267 (4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate) 是一种有效的细菌磷酸泛酰氨基转移酶抑制剂，可减弱二次代谢并阻碍细菌生长。
T40111	BMS-1166-N-piperidine-CO-N-piperazine
	BMS-1166-N-piperidine-CO-N-piperazine is a chemical compound that contains a PD-1/PD-L1 immune checkpoint ligand and a PROTAC linker. It can be utilized in the synthesis of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits the PD-1/PD-L1 interaction, demonstrating an IC50 value of 39.2 nM.
T20999	1-(2,3-Dichlorphenyl)-piperazine 1-(2,3-二氯苯基)哌嗪,DCPP,1-(2,3-二氯苯基)哌嗪盐酸盐	Others	Others
	1-(2,3-Dichlorphenyl)-piperazine (DCPP) 是一种有效的 DHCR7 抑制剂。 DHCR7 是胆固醇生物合成中的一种酶。
T77598	Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine (4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone	Others	Others
	Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine ((4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone) 是一种生物合成的原材料，可用于合成多种化合物。
T62461	Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine	Others	Others
	Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine 可用于改变真核生物寿命。
T32187	Ipexidine mesylate Guanidino propyl piperazine,UNII-CI8CT0864P
	Ipexidine mesylate is a bio-active chemical.
T65396	Piperazine 2HCl
	Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected an...
T66810	1-(Cyclopropylcarbonyl)piperazine
	1-(Cyclopropylcarbonyl)piperazine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66810，CAS号为 59878-57-8。
T66552	N-Boc-piperazine
	N-Boc-piperazine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66552，CAS号为 57260-71-6。
T61592	Thalidomide-piperazine hydrochloride
	Thalidomide-piperazine hydrochloride is a chemical compound with potential applications in the research of leprosy and multiple myeloma. It serves as a valuable tool in developmental biology, facilitating significant discoveries in the biochemical pathways of limb development [1].
T67903	11β-HSD1 inibitor 17	Dehydrogenase	Metabolism
	11β-HSD1 inibitor 17 是11β-羟基类固醇脱氢酶（11β-HSD1）抑制剂。
T65657	N-(2-Hydroxyethyl)piperazine
	N-(2-Hydroxyethyl)piperazine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65657，CAS号为 103-76-4。
T83932	Phenyl-glutarimide 4'-piperazine
	Phenyl-glutarimide 4'-piperazine是一种具有piperazine功能化的cereblon配体，可用于PROTACDegrader的开发。该化合物可用于开发PG-PROTACs，与使用IMiD（immunomodulatory imide drug）类似物合成的PROTACs相比，展示出改善的水解稳定性和效力。
T66506	Boc-piperazine-benzoic acid
	Boc-piperazine-benzoic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66506，CAS号为 162046-66-4。
T67044	1-(4-Methoxybenzyl)piperazine
	1-(4-Methoxybenzyl)piperazine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67044，CAS号为 21867-69-6。
T66693	1-(2-Methoxyethyl)piperazine
	1-(2-Methoxyethyl)piperazine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66693，CAS号为 13484-40-7。
T65059	1-(2,4-Difluorophenyl)piperazine
	1-(2,4-Difluorophenyl)piperazine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65059，CAS号为 115761-79-0。
T65963	1-(2-Chlorophenyl)piperazine hydrochloride
	1-(2-Chlorophenyl)piperazine hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65963，CAS号为 41202-32-8。
T65071	1-(4-Bromophenyl)piperazine (hydrochloride)
	1-(4-Bromophenyl)piperazine (hydrochloride) 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65071，CAS号为 68104-62-1。
T64843	1,4-Bis(4-nitrophenethyl)piperazine
	1,4-Bis(4-nitrophenethyl)piperazine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64843。
T64560	1,4-Bis(4-nitrophenyl)piperazine
	1,4-Bis(4-nitrophenyl)piperazine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64560，CAS号为 16264-05-4。

化合物

Navitoclax-piperazine

Cat.No: T12186

Synonym: ABT-263-piperazine

Target: BCL, Ligands for Target Protein for PROTAC

1-(1-Naphthyl) piperazine hydrochloride

Cat.No: T21569

Synonym: 1-naphthalen-1-ylpiperazine hydrochloride,1-(Naphthalen-1-yl)piperazine hydrochloride

Target: Others

Piperazine Erastin

Cat.No: T16540

Target: Ferroptosis

Piperazine adipate

Cat.No: T7146

Target: Parasite

1-(1-phenyltetrazol-5-yl)piperazine;hydrochloride

Cat.No: T50020

Synonym: 1-(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)piperazine hydrochloride

Target: Others

1-[(5-methylisoxazol-3-yl)methyl]piperazine

Cat.No: T8582

Synonym: Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI)

Target: P2Y Receptor

Piperazine citrate

Cat.No: T16539

Target: GABA Receptor

1-(2-Pyridyl)piperazine

Cat.No: T5105

Synonym: 1-(2-吡啶基)哌嗪,NSC13778

Target: Adrenergic Receptor

1-(3-Chlorophenyl)piperazine hydrochloride

Cat.No: T0615

Synonym: M-CPP hydrochloride,间氯苯基哌嗪

Target: Others

1-(3-chloropyridin-2-yl)piperazine dihydrochloride

Cat.No: T50018

Target: Others

GNF-8625 monopyridin-N-piperazine hydrochloride

Cat.No: T40034

Target: Trk receptor

N-[2-nitro-4-(trifluoromethyl)phenyl]piperazine

Cat.No: T60231

Target: Others

Piperazine, 1-(4-fluorophenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-

Cat.No: T9876

Target: Others

1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride

Cat.No: T50034

Target: Others

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride

Cat.No: T40111L

Target: PD-1/PD-L1

Thalidomide-Piperazine-PEG3-NH2

Cat.No: T39895

Synonym: Thalidomide-Piperazine-PEG3-NH2

Thalidomide-Piperazine-PEG2-NH2

Cat.No: T39893

Synonym: Thalidomide-Piperazine-PEG2-NH2

Sultosilic acid, piperazine salt

Cat.No: T28882

Synonym: A-585,Mimedran,piperazine-sultosylate,A585,A 585

Cat.No: T67739

Synonym: alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol

Target: Sigma receptor

Thalidomide-Piperazine-Piperidine

Cat.No: T39711

Cat.No: T40645

Synonym: 1,4-Piperazinediethanesulfonic acid,1,4-piperazine bis(ethanesulfonic acid),1,4-Piperazinebis(ethanesulfonic acid),PIPES

Target: Others

Thalidomide-piperazine-Boc

Cat.No: T39697

Acefylline piperazine

Cat.No: T70097

Piperazine sebacate

Cat.No: T34069

Synonym: Nematorazine

Thalidomide-Piperazine 5-fluoride

Cat.No: T39696

Thalidomide-Piperazine-Piperidine hydrochloride

Cat.No: T40231

Cat.No: T16277

Synonym: N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide

Target: Dehydrogenase

4-hydroxy-3-Methoxyphenylglycol (piperazine salt)

Cat.No: T37373

Triclofenol piperazine

Cat.No: T34935

Synonym: CI 416,Triclofenol piperazina,CI-416,CI416,Triclofenol piperazate

Cat.No: T64340

Synonym: 4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate

Target: Others

BMS-1166-N-piperidine-CO-N-piperazine

Cat.No: T40111

1-(2,3-Dichlorphenyl)-piperazine

Cat.No: T20999

Synonym: 1-(2,3-二氯苯基)哌嗪,DCPP,1-(2,3-二氯苯基)哌嗪盐酸盐

Target: Others

Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine

Cat.No: T77598

Synonym: (4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone

Target: Others

Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine

Cat.No: T62461

Target: Others

Ipexidine mesylate

Cat.No: T32187

Synonym: Guanidino propyl piperazine,UNII-CI8CT0864P

Piperazine 2HCl

Cat.No: T65396

1-(Cyclopropylcarbonyl)piperazine

Cat.No: T66810

N-Boc-piperazine

Cat.No: T66552

Thalidomide-piperazine hydrochloride

Cat.No: T61592

11β-HSD1 inibitor 17

Cat.No: T67903

Target: Dehydrogenase

N-(2-Hydroxyethyl)piperazine

Cat.No: T65657

Phenyl-glutarimide 4'-piperazine

Cat.No: T83932

Boc-piperazine-benzoic acid

Cat.No: T66506

1-(4-Methoxybenzyl)piperazine

Cat.No: T67044

1-(2-Methoxyethyl)piperazine

Cat.No: T66693

1-(2,4-Difluorophenyl)piperazine

Cat.No: T65059

1-(2-Chlorophenyl)piperazine hydrochloride

Cat.No: T65963

1-(4-Bromophenyl)piperazine (hydrochloride)

Cat.No: T65071

1,4-Bis(4-nitrophenethyl)piperazine

Cat.No: T64843

1,4-Bis(4-nitrophenyl)piperazine

Cat.No: T64560

Cat. No.	Product Name	Target	Signaling Pathways
T0345	Estropipate 雌酮硫酸酯哌嗪,Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Estropipate (Piperazine estrone sulfate) 是一种由硫酸雌酮和哌嗪组成的天然雌激素物质。
TN3107	5-Deoxystrigol	Others	Others
	5-Deoxystrigol 是一种高活性的独脚金发芽刺激剂。对 D-半乳糖胺（D-GalN）诱导的小鼠急性肝损伤有保护作用，对 CCl4诱导的小鼠急性肝损伤有保护作用。

天然产物

Cat.No: T0345

Synonym: 雌酮硫酸酯哌嗪,Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: TN3107

Target: Others

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