Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Piperazine Erastin 是erastin 的类似物。它会导致一种铁依赖形式的非凋亡性细胞死亡,称为铁死亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 685 | 现货 | ||
5 mg | ¥ 1,690 | 现货 | ||
10 mg | ¥ 2,680 | 现货 | ||
25 mg | ¥ 4,760 | 现货 | ||
50 mg | ¥ 6,790 | 现货 | ||
100 mg | ¥ 9,210 | 现货 | ||
200 mg | ¥ 12,400 | 现货 | ||
500 mg | ¥ 18,400 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,330 | 现货 |
产品描述 | Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis. |
体外活性 | Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable [1]. |
体内活性 | A significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group, in the xenograft mouse model. Ptgs2 is upregulated in mouse liver with piperazine erastin (10 or 60 mg/kg) administration[1]. |
分子量 | 645.19 |
分子式 | C35H41ClN6O4 |
CAS No. | 1538593-71-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (51.66 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5499 mL | 7.7497 mL | 15.4993 mL | 38.7483 mL |
5 mM | 0.31 mL | 1.5499 mL | 3.0999 mL | 7.7497 mL | |
10 mM | 0.155 mL | 0.775 mL | 1.5499 mL | 3.8748 mL | |
20 mM | 0.0775 mL | 0.3875 mL | 0.775 mL | 1.9374 mL | |
50 mM | 0.031 mL | 0.155 mL | 0.31 mL | 0.775 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Piperazine Erastin 1538593-71-3 Apoptosis Ferroptosis Inhibitor inhibitor inhibit